Stellar population gradients in brightest cluster galaxies

We present the stellar population and velocity dispersion gradients for a sample of 24 brightest cluster galaxies (BCGs) in the nearby Universe for which we have obtained high quality long-slit spectra at the Gemini telescopes. With the aim of studying the possible connection between the formation of the BCGs and their host clusters, we explore the relations between the stellar population gradients and properties of the host clusters as well as the possible connections between the stellar population gradients and other properties of the galaxies. We find mean stellar population gradients (negative {\Delta}[Z/H]/log r gradient of -0.285{\pm}0.064; small positive {\Delta}log (age)/log r gradient of 0.069{\pm}0.049; and null {\Delta}[E/Fe]/log r gradient of -0.008{\pm}0.032) that are consistent with those of normal massive elliptical galaxies. However, we find a trend between metallicity gradients and velocity dispersion (with a negative slope of -1.616{\pm}0.539) that is not found for the most massive ellipticals. Furthermore, we find trends between the metallicity gradients and K-band luminosities (with a slope of 0.173{\pm}0.081) as well as the distance from the BCG to the X-ray peak of the host cluster (with a slope of -7.546{\pm}2.752). The latter indicates a possible relation between the formation of the cluster and that of the central galaxy.Comment: 23 pages, 18 figures, accepted for publication in MNRAS. arXiv admin note: text overlap with arXiv:1104.2376v

Retinal microvasculature in acute lacunar stroke: a cross-sectional study

10.1016/S1474-4422(09)70131-0The Lancet Neurology87628-634LNAE

Sorting of Human Peripheral Blood T-Cell Subsets Using Immunomagnetic Beads

Immunomagnetic beads are uniform, polymer particles coated with a polystyrene shell that provides both a smooth, hydrophobic surface to facilitate absorption of molecules, such as antibodies, and surface hydroxyl groups that allow covalent chemical binding of other bioreactive molecules, such as streptavidin, lectins, and peptides. Iron (III) oxide (Fe2O3) deposited in the core gives the beads superparamagnetic properties that lead to consistent and reproducible reactions to a magnetic field without permanent magnetization of the particles. These are the two qualities on which immunomagnetic separation (IMS) depends

Benfotiamine increases glucose oxidation and downregulates NADPH oxidase 4 expression in cultured human myotubes exposed to both normal and high glucose concentrations

The aim of the present work was to study the effects of benfotiamine (S-benzoylthiamine O-monophosphate) on glucose and lipid metabolism and gene expression in differentiated human skeletal muscle cells (myotubes) incubated for 4 days under normal (5.5 mM glucose) and hyperglycemic (20 mM glucose) conditions. Myotubes established from lean, healthy volunteers were treated with benfotiamine for 4 days. Glucose and lipid metabolism were studied with labeled precursors. Gene expression was measured using real-time polymerase chain reaction (qPCR) and microarray technology. Benfotiamine significantly increased glucose oxidation under normoglycemic (35 and 49% increase at 100 and 200 μM benfotiamine, respectively) as well as hyperglycemic conditions (70% increase at 200 μM benfotiamine). Benfotiamine also increased glucose uptake. In comparison, thiamine (200 μM) increased overall glucose metabolism but did not change glucose oxidation. In contrast to glucose, mitochondrial lipid oxidation and overall lipid metabolism were unchanged by benfotiamine. The expression of NADPH oxidase 4 (NOX4) was significantly downregulated by benfotiamine treatment under both normo- and hyperglycemic conditions. Gene set enrichment analysis (GSEA) showed that befotiamine increased peroxisomal lipid oxidation and organelle (mitochondrial) membrane function. In conclusion, benfotiamine increases mitochondrial glucose oxidation in myotubes and downregulates NOX4 expression. These findings may be of relevance to type 2 diabetes where reversal of reduced glucose oxidation and mitochondrial capacity is a desirable goal