Chytrid fungus infection in alpine tree frogs is associated with individual heterozygosity and population isolation but not population-genetic diversity

Chytridiomycosis, a disease caused by the emerging fungus Batrachochytrium dendrobatidis (Bd), has been implicated in the decline of over 500 amphibian species. Population declines could have important genetic consequences, including reduced genetic diversity. We contrasted genetic diversity among both long-Bd-exposed and unexposed populations of the south-east Australian alpine tree frog (Litoria verreauxii alpina) across its range. At the population level, we found no significant differences in genetic diversity between Bd-exposed and unexposed populations. Encouragingly, even Bd-infected remnant populations that are now highly isolated maintain genetic diversity comparable to populations in which Bd is absent. Spatial genetic structure among populations followed an isolation-by-distance pattern, suggesting restricted movement among remnant populations. At the individual level, greater heterozygosity was associated with reduced probability of infection. Loss of genetic diversity in remnant populations that survived chytridiomycosis epidemics does not appear to be a threat to L. v. alpina. We suggest several factors underpinning maintenance of genetic diversity: (1) remnant populations have remained large enough to avoid losses of genetic diversity; (2) many individuals in the population are able to breed once before succumbing to disease; and (3) juveniles in the terrestrial environment have low exposure to Bd, providing an annual ‘reservoir’ of genetic diversity. The association between individual heterozygosity and infection status suggests that, while other work has shown all breeding adults are typically killed by Bd, males with greater heterozygosity may survive longer and obtain fitness benefits through extended breeding opportunities. Our results highlight the critical role of life history in mitigating the impacts of Bd infection for some amphibian species, but we infer that increased isolation as a result of disease-induced population extirpations will enhance population differentiation and thus biogeographic structure

A Citizens Compact: Reaching out to the Citizens of Europe. CEPS EPIN Working Papers No. 14, 1 September 2005

[Executive Summary]. How can the deadlock after the ‘no’ to the European Constitutional Treaty in France and the Netherlands be overcome? What should be the aim of the ‘period of reflection’ that has been agreed by the European Council? The authors of this paper propose the adoption of a ‘Citizens Compact’, which should directly address the larger malaise among citizens that underlies the Constitutional crisis. It should contribute to the reduction of the EU’s democratic deficit without treaty reform. The following measures should be envisaged: • National parliaments should participate more strongly in the controversies on core European issues through earlier and intensive debates about EU initiatives. • Every six months governments should explain their positions on the priorities of the EU-presidency in their national parliaments. • EU-actors (MEPs, Commissioners and top officials) should participate more intensively in national debates about European issues and contribute to a better understanding of the European political processes among citizens. • National governments should regularly publish information bulletins about the latest EU initiatives and –decisions. • Public fora about European issues should be established in every member state with speakers coming from national politics, from the EU level and other member states as well as representatives from civil society. • Uncontroversial elements of the Constitutional Treaty that strengthen EU democracy could already be adopted through inter-institutional agreements. • A White Paper on the establishment of a ‘European Democratic and Civic Space’ in the EU should be elaborated. • In the future important legislative acts should contain an impact assessment of the consequences on citizens’ lives

Effects of climate extremes on the terrestrial carbon cycle : concepts, processes and potential future impacts

This article is protected by copyright. All rights reserved. Acknowledgements This work emerged from the CARBO-Extreme project, funded by the European Community’s 7th framework programme under grant agreement (FP7-ENV-2008-1-226701). We are grateful to the Reviewers and the Subject Editor for helpful guidance. We thank to Silvana Schott for graphic support. Mirco Miglivacca provided helpful comments on the manuscript. Michael Bahn acknowledges support from the Austrian Science Fund (FWF; P22214-B17). Sara Vicca is a postdoctoral research associate of the Fund for Scientific Research – Flanders. Wolfgang Cramer contributes to the Labex OT-Med (n° ANR-11- LABX-0061) funded by the French government through the A*MIDEX project (n° ANR-11-IDEX-0001-02). Flurin Babst acknowledges support from the Swiss National Science Foundation (P300P2_154543).Peer reviewedPublisher PD

Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells

The anti-diabetic drug metformin regulates T-cell responses to immune activation and is proposed to function by regulating the energy-stress-sensing adenosine-monophosphate-activated protein kinase (AMPK). However, the molecular details of how metformin controls T cell immune responses have not been studied nor is there any direct evidence that metformin acts on T cells via AMPK. Here, we report that metformin regulates cell growth and proliferation of antigen-activated T cells by modulating the metabolic reprogramming that is required for effector T cell differentiation. Metformin thus inhibits the mammalian target of rapamycin complex I signalling pathway and prevents the expression of the transcription factors c-Myc and hypoxia-inducible factor 1 alpha. However, the inhibitory effects of metformin on T cells did not depend on the expression of AMPK in T cells. Accordingly, experiments with metformin inform about the importance of metabolic reprogramming for T cell immune responses but do not inform about the importance of AMPK

Survival of a submarine canyon during long-term outbuilding of a continental margin

Net-depositional submarine canyons are common in continental slope strata, but how they survive and prograde on constructional margins is poorly understood. In this study we present field evidence for the coevolution of a submarine canyon and the adjacent continental slope. Using a three-dimensional seismic data cube that images the Ebro margin (northwest Mediterranean), we identify a preserved canyon on a middle Pleistocene paleosurface and relate it directly to its expression on the present-day seafloor. A subparallel stacking pattern of seismic reflectors, similar to that seen between prograding clinoforms in intercanyon areas, is observed between the modern and paleocanyon thalwegs. The concavity of the modern long profile differs from the convex-concave long profile on the middle Pleistocene surface, suggesting a long-term change in canyon sedimentation. We interpret this change as a shift to a canyon dominated by turbidity currents from one strongly influenced by the pattern of sedimentation that built the open-slope canyon interfluves. We find support for our interpretation in previous studies of the Ebro margin

Bubbles and jackets: new scaling bounds in topological group field theories

We use a reformulation of topological group field theories in 3 and 4 dimensions in terms of variables associated to vertices, in 3d, and edges, in 4d, to obtain new scaling bounds for their Feynman amplitudes. In both 3 and 4 dimensions, we obtain a bubble bound proving the suppression of singular topologies with respect to the first terms in the perturbative expansion (in the cut-off). We also prove a new, stronger jacket bound than the one currently available in the literature. We expect these results to be relevant for other tensorial field theories of this type, as well as for group field theory models for 4d quantum gravity.Comment: v2: Minor modifications to match published versio

Biallelic mutations in valyl-tRNA synthetase gene VARS are associated with a progressive neurodevelopmental epileptic encephalopathy.

Aminoacyl-tRNA synthetases (ARSs) function to transfer amino acids to cognate tRNA molecules, which are required for protein translation. To date, biallelic mutations in 31 ARS genes are known to cause recessive, early-onset severe multi-organ diseases. VARS encodes the only known valine cytoplasmic-localized aminoacyl-tRNA synthetase. Here, we report seven patients from five unrelated families with five different biallelic missense variants in VARS. Subjects present with a range of global developmental delay, epileptic encephalopathy and primary or progressive microcephaly. Longitudinal assessment demonstrates progressive cortical atrophy and white matter volume loss. Variants map to the VARS tRNA binding domain and adjacent to the anticodon domain, and disrupt highly conserved residues. Patient primary cells show intact VARS protein but reduced enzymatic activity, suggesting partial loss of function. The implication of VARS in pediatric neurodegeneration broadens the spectrum of human diseases due to mutations in tRNA synthetase genes

The WiggleZ Dark Energy Survey: Star-formation in UV-luminous galaxies from their luminosity functions

We present the ultraviolet (UV) luminosity function of galaxies from the GALEX Medium Imaging Survey with measured spectroscopic redshifts from the first data release of the WiggleZ Dark Energy Survey. This sample selects galaxies with high star formation rates: at 0.6 < z < 0.9 the median star formation rate is at the upper 95th percentile of optically-selected (r<22.5) galaxies and the sample contains about 50 per cent of all NUV < 22.8, 0.6 < z < 0.9 starburst galaxies within the volume sampled. The most luminous galaxies in our sample (-21.0>M_NUV>-22.5) evolve very rapidly with a number density declining as (1+z)^{5\pm 1} from redshift z = 0.9 to z = 0.6. These starburst galaxies (M_NUV<-21 is approximately a star formation rate of 30 \msuny) contribute about 1 per cent of cosmic star formation over the redshift range z=0.6 to z=0.9. The star formation rate density of these very luminous galaxies evolves rapidly, as (1+z)^{4\pm 1}. Such a rapid evolution implies the majority of star formation in these large galaxies must have occurred before z = 0.9. We measure the UV luminosity function in 0.05 redshift intervals spanning 0.1<z<0.9, and provide analytic fits to the results. At all redshifts greater than z=0.55 we find that the bright end of the luminosity function is not well described by a pure Schechter function due to an excess of very luminous (M_NUV<-22) galaxies. These luminosity functions can be used to create a radial selection function for the WiggleZ survey or test models of galaxy formation and evolution. Here we test the AGN feedback model in Scannapieco et al. (2005), and find that this AGN feedback model requires AGN feedback efficiency to vary with one or more of the following: stellar mass, star formation rate and redshift.Comment: 27 pages; 13 pages without appendices. 22 figures; 11 figures in the main tex

Global Fluctuation Spectra in Big Crunch/Big Bang String Vacua

We study Big Crunch/Big Bang cosmologies that correspond to exact world-sheet superconformal field theories of type II strings. The string theory spacetime contains a Big Crunch and a Big Bang cosmology, as well as additional ``whisker'' asymptotic and intermediate regions. Within the context of free string theory, we compute, unambiguously, the scalar fluctuation spectrum in all regions of spacetime. Generically, the Big Crunch fluctuation spectrum is altered while passing through the bounce singularity. The change in the spectrum is characterized by a function $\Delta$, which is momentum and time-dependent. We compute $\Delta$ explicitly and demonstrate that it arises from the whisker regions. The whiskers are also shown to lead to ``entanglement'' entropy in the Big Bang region. Finally, in the Milne orbifold limit of our superconformal vacua, we show that $\Delta\to 1$ and, hence, the fluctuation spectrum is unaltered by the Big Crunch/Big Bang singularity. We comment on, but do not attempt to resolve, subtleties related to gravitational backreaction and light winding modes when interactions are taken into account.Comment: 68 pages, 1 figure; typos correcte

Empirical Models for Dark Matter Halos. III. The Kormendy relation and the log(rho_e)-log(R_e) relation

We have recently shown that the 3-parameter density-profile model from Prugniel & Simien provides a better fit to simulated, galaxy- and cluster-sized, dark matter halos than an NFW-like model with arbitrary inner profile slope gamma (Paper I). By construction, the parameters of the Prugniel-Simien model equate to those of the Sersic R^{1/n} function fitted to the projected distribution. Using the Prugniel-Simien model, we are therefore able to show that the location of simulated (10^{12} M_sun) galaxy-sized dark matter halos in the _e-log(R_e) diagram coincides with that of brightest cluster galaxies, i.e., the dark matter halos appear consistent with the Kormendy relation defined by luminous elliptical galaxies. These objects are also seen to define the new, and equally strong, relation log(rho_e) = 0.5 - 2.5log(R_e), in which rho_e is the internal density at r=R_e. Simulated (10^{14.5} M_sun) cluster-sized dark matter halos and the gas component of real galaxy clusters follow the relation log(rho_e) = 2.5[1 - log(R_e)]. Given the shapes of the various density profiles, we are able to conclude that while dwarf elliptical galaxies and galaxy clusters can have dark matter halos with effective radii of comparable size to the effective radii of their baryonic component, luminous elliptical galaxies can not. For increasingly large elliptical galaxies, with increasingly large profile shapes `n', to be dark matter dominated at large radii requires dark matter halos with increasingly large effective radii compared to the effective radii of their stellar component.Comment: AJ, in press. (Paper I can be found at astro-ph/0509417