Revisión de los sistemas venosos de larga duración: Port-a-Cath

El uso de los catéteres venosos de larga duración en pacientes oncológicos pediátricos permite extracciones múltiples de sangre, infusión de fármacos quimioterápicos y nutrición por vía parenteral, mejorando su calidad de vida. El objetivo principal de este estudio es conocer las complicaciones más comunes relacionadas con la implantación de catéteres venosos en pacientes pediátricos y compararlas con estudios previos realizados en cohortes más heterogéneas.Grado en Medicin

Synthesis of novel organic solvent-free waterborne poly(urethane-urea)s. Nanocomposites, hydrogels and adhesives

249 p.El Capítulo 1 es introductorio y detalla los aspectos principales relacionados con la tesis, mientras que en el Capítulo 2 se describen los materiales y las técnicas experimentales empleadas a lo largo de la tesis. El Capítulo 3 es el primero en el que se detallan los resultados experimentales obtenidos, centrándose en la síntesis y caracterización de poli(uretano-urea)s en base agua sintetizados mediante un proceso amigable con el medioambiente y empleando un macrodiol procedente del maíz. Por su parte, el Capítulo 4 consiste en la síntesis y caracterización de poli(uretano-urea)s en base agua sintetizados mediante el mismo proceso que en el Capítulo 3, pero empleando copolímeros de bloque como macrodioles. En elCapítulo 5 se preparan y caracterizan nanocomposites mediante la incorporación de nanopartículas deTiO2 a los poli(uretano-urea)s previamente sintetizados, mientras que en el Capítulo 6 se evalúa lacapacidad de autorreparación de los films, tanto de los poli(uretano-urea)s como de los nanocomposites.En el Capítulo 7 se preparan hidrogeles basados en los poli(uretano-urea)s sintetizados, caracterizándolos y evaluando su viabilidad como biomateriales. El Capítulo 8 es el último de corte experimental,estudiándose y mejorándose las propiedades adhesivas de los poli(uretano-urea)s sintetizados a lo largode la tesis. Por último, el Capítulo 9 enumera las publicaciones que han tenido lugar gracias a los resultados de la elaboración de la presente tesis doctoral, así como las participaciones en congresos y las estancias de investigación realizadas

Warps in disk galaxies

Volgens de huidige inzichten is het universum zo’n 15 miljard jaar geleden ontstaan als een grote explosie die de Oerknal wordt genoemd. Sinds de oerknal dijt het universum uit, hoewel de zwaartekracht van de materie in het heelal deze uitdijing wat afremt. De wet van de zwaartekracht zegt dat materie andere materie aantrekt, waardoor niet lang na de oerknal atomen zich op verschillende plaatsen in het universumbegonnen op te hopen. Dit was het begin van de vorming van melkwegstelsels. Zie: Samenvattin

Enactive and simondonian reflections on mental disorders

As an alternative to linear and unidimensional perspectives focused mainly on either organic or psychological processes, the enactive approach to life and mind-a branch of 4-E (embodied, embedded, enactive, extended) cognitive theories-offers an integrative framework to study mental disorders that encompasses and articulates organic, sensorimotor, and intersubjective dimensions of embodiment. These three domains are deeply entangled in a non-trivial manner. A question remains on how this systemic and multi-dimensional approach may be applied to our understanding of mental disorders and symptomatic behavior. Drawing on Gilbert Simondon's philosophy of individuation (focusing particularly on the concepts of tension, metastability, and preindividual), we provide some enactive conceptual tools to better understand the dynamic, interactive, and multi-dimensional nature of human bodies in mental disorders and psychopathological symptoms. One of such tools cursiva is sense-making, a key notion that captures the relational process of generating meaning by interacting with the sociomaterial environment. The article analyzes five aspects related to sense-making: temporality, adaptivity, the multiplicity of normativities it involves, the fundamental role of tension, and its participatory character. On this basis, we draw certain implications for our understanding of mental disorders and diverse symptoms, and suggest their interpretation in terms of difficulties to transform tensions and perform individuation processes, which result in a reduction of the field of potentialities for self-individuation and sense-making.This work was supported by the Basque Government under grant IT 1668-22 to the IAS-Research group and the research project "Outonomy" PID2019-104576GB-I00 by the Spanish Ministry of Science and Innovation. IA was supported by a Juan de la Cierva-Formacion Research Fellowship by the Spanish Ministry of Economy and Competitiveness. EG was supported by the Specialization of Postdoctoral Researchers Fellowship of the University of the Basque Country

Ononis azcaratei: Devesa especie andaluza en peligro crítico

Ononis azcaratei Devesa a critically endangered Andalusian species.Palabras clave. Ononis, flora amenazada, Andalucía.Key words. Ononis, endangered flora, Andalusia

A Precise Electrical Disturbance Generator for Neural Network Training with Real Level Output

Power Quality is defined as the study of the quality of electric power lines. The detection and classification of the different disturbances which cause power quality problems is a difficult task which requires a high level of engineering expertise. Thus, neural networks are usually a good choice for the detection and classification of these disturbances. This paper describes a powerful tool, developed by the Institute for Natural Resources and Agrobiology at the Scientific Research Council (CSIC) and the Electronic Technology Department at the University of Seville, which generates electrical patterns of disturbances for the training of neural networks for PQ tasks. This system has been expanded to other applications (as comparative test between PQ meters, or test of effects of power-line disturbances on equipment) through the addition of a specifically developed high fidelity power amplifier, which allows the generation of disturbed signals at real levels.Ministerio de Ciencia y Tecnología DPI2006-15467-C02-0

Neuropilin-1: A feasible link between liver pathologies and COVID-19

[EN] The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has a tremendous impact on the health of millions of people worldwide. Unfortunately, those suffering from previous pathological conditions are more vulnerable and tend to develop more severe disease upon infection with the new SARS-CoV- 2. This coronavirus interacts with the angiotensin-converting enzyme 2 receptor to invade the cells. Recently, another receptor, neuropilin-1 (NRP-1), has been reported to amplify the viral infection. Interestingly, NRP-1 is expressed in nonparenchymal liver cells and is related to and upregulated in a wide variety of liver-related pathologies. It has been observed that SARS-CoV-2 infection promotes liver injury through several pathways that may be influenced by the previous pathological status of the patient and liver expression of NRP-1. Moreover, coronavirus disease 2019 causes an inflammatory cascade called cytokine storm in patients with severe disease. This cytokine storm may influence liver sinusoidal-cell phenotype, facilitating viral invasion. In this review, the shreds of evidence linking NRP-1 with liver pathologies such as hepatocellular carcinoma, liver fibrosis, nonalcoholic fatty liver disease and inflammatory disorders are discussed in the context of SARS-CoV-2 infection. In addition, the involvement of the infection-related cytokine storm in NRP-1 overexpression and the subsequent increased risk of SARS-CoV-2 infection are also analyzed. This review aims to shed some light on the involvement of liver NRP-1 during SARSCoV- 2 infection and emphasizes the possible involvement this receptor with the observed liver damage

Treatment of end-of-life concrete in an innovative heating-air classification system for circular cement-based products

A stronger commitment towards Green Building and circular economy, in response to environmental concerns and economic trends, is evident in modern industrial cement and concrete production processes. The critical demand for an overall reduction in the environmental impact of the construction sector can be met through the consumption of high-grade supplementary raw materials. Advanced solutions are under development in current research activities that will be capable of up-cycling larger quantities of valuable raw materials from the fine fractions of End-of-Life (EoL) concrete waste. New technology, in particular the Heating-Air classification System (HAS), simultaneously applies a combination of heating and separation processes within a fluidized bed-like chamber under controlled temperatures (±600 °C) and treatment times (25–40 s). In that process, moisture and contaminants are removed from the EoL fine concrete aggregates (0–4 mm), yielding improved fine fractions, and ultrafine recycled concrete particles (<0.125 mm), consisting mainly of hydrated cement, thereby adding value to finer EoL concrete fractions. In this study, two types of ultrafine recycled concrete (either siliceous or limestone EoL concrete waste) are treated in a pilot HAS technology for their conversion into Supplementary Cementitious Material (SCM). The physico-chemical effect of the ultrafine recycled concrete particles and their potential use as SCM in new cement-based products is assessed by employing substitutions of up to 10% of the conventional binder. The environmental viability of their use as SCM is then evaluated in a Life Cycle Assessment (LCA). The results demonstrated accelerated hydration kinetics of the mortars that incorporated these SCMs at early ages and higher mechanical strengths at all curing ages. Optimal substitutions were established at 5%. The results suggested that the overall environmental impact could be reduced by up to 5% when employing the ultrafine recycled concrete particles as SCM in circular cement-based products, reducing greenhouse gas emissions by as much as 41 kg CO2 eq./ton of cement (i.e. 80 million tons CO2 eq./year). Finally, the environmental impacts were reduced even further by running the HAS on biofuel rather than fossil fuel.The authors of the present paper, prepared in the framework ofthe Project VEEP "Cost-Effective Recycling of C&DW in High AddedValue Energy Efficient Prefabricated Concrete Components forMassive Retrofitting of our Built Environment", wish to acknowl-edge the European Commission for its support. This project hasreceived funding from the European Union’s Horizon 2020 researchand innovation programme under grant agreement No 723582.This paper reflects only the author’s view and the European Com-mission is not responsible for any use that may be made of theinformation it contains.The authors are also grateful to the Spanish Ministry of Science,Innovation and Universities (MICIU) and the European RegionalDevelopment Fund (FEDER) for funding this line of research(RTI2018-097074-B-C21)