Daejeon smart city operation center, 2010-2017

Thesis(Master) --KDI School:Master of Development Policy,2020"Help me! Save me! Please!” Imagine that you witness an urgent situation and call 119, the emergency call number in the Republic of Korea (hereafter “Korea”). What if the emergency services team arrived on-site within six minutes, already recognized the situation and immediately began taking action? Daejeon, Korea’s fifth-largest city, successfully improved the quality and efficiency of its urban public services with a smart solution. Daejeon was the first city in Korea to integrate Information and Communications Technology (hereafter “ICT”) infrastructure such as municipal networks and Closed-Circuit Televisions (hereafter “CCTV”) at the metropolitan level. By 2013, Daejeon opened the Daejeon Smart City Operation Center, persuading relevant agencies on the need for equity in urban services and sustainably operating ICT devices. The relevant institutes combined their budgets and 10 departments with similar responsibilities from different organizations joined the center. Soon after, the Ministry of Land, Infrastructure, and Transport (hereafter “MOLIT”) selected Daejeon as its research and development pilot smart city in 2014. The Daejeon local government and the national government worked together to introduce and customize the integration platform that connected five safety services for citizens. This collaborative work filled the gap of local government’s lack of authority or financial capacity to accomplish its smart city goals with technical, financial, and institutional support from the national government. From 2015 to 2017, the average response time for 119 emergencies in Daejeon decreased from about seven and a half minutes to less than six minutes. The city’s crime decreased by about 5% and the arrest rate increased by about 7.7% over the same period. As of 2019, 49 local governments in Korea had adopted Daejeon’s “smart city” model.I. Introduction II. Literature Review III. Delivery Challenges IV. Tracing the Implementation Process V. Lessons LearnedOutstandingmasterpublishedHyelim KIM

An Oscillatory Path to Vaccination: The Roles of Normative and Epistemic Factors in Explaining Vaccination Hesitancy in COVID-19.

This study examined the roles of normative and epistemic factors in influencing individuals\u27 reluctance to be vaccinated during the COVID-19 pandemic. Individuals\u27 ethical orientations (IEO; teleology vs. deontology) were introduced as normative characteristics, while COVID-19 vaccine conspiracy beliefs and vaccine knowledge were addressed as issue-specific epistemic factors. We conducted two online surveys to investigate each of these three factors\u27 influences on the level of Americans\u27 reluctance to receive COVID-19 vaccines. Combinations of these factors that predict COVID-19 vaccination hesitancy levels were also explored to provide integrated perspectives in the specific vaccination context. Our findings demonstrated the positive association between IEO and reluctance to receive COVID-19 vaccines. Significant interactions between 1) COVID-19 vaccine conspiracy beliefs and IEO and 2) conspiracy beliefs and vaccine knowledge were also identified. Implications, limitations, and suggestions for future study were addressed

All-American high school basketball star to attend University of Montana next fall

Voluntary citizen attention and actions are key to successful public-sector communication. We investigated the conditions which increase such attention and actions using the situational theory of problem solving (STOPS) and government-citizen relationships (GCRs). Using three national issues consisting of an environmental issue, a social issue, and a political issue from South Korea (N=275), this study examined three hypotheses regarding public engagement effect (the effect of GCRs on political conversations on national issues), government empowerment effect (the effects of GCRs and issue-specific trust toward government on constraint recognition), and public serenity effect (the effect of issue-specific trust on problem recognition and involvement recognition). We found significant public engagement and government empowerment effects and partially significant public serenity effect. The results of the public serenity investigation found that issue-specific trust toward government was significant with problem recognition but insignificant with involvement recognition. Consequently, the findings illustrate strategic values in government-citizen relationships on public engagement, empowerment, and serenity to enable participatory democracy

Visual Honey Encryption: Application to Steganography

Honey encryption (HE) is a new technique to overcome the weakness of conventional password-based encryption (PBE). However, conventional honey encryption still has the limitation that it works only for binary bit streams or integer sequences because it uses a fixed distribution-transforming encoder (DTE). In this paper, we propose a variant of honey encryption called visual honey encryption which employs an adaptive DTE in a Bayesian framework so that the proposed approach can be applied to more complex domains including images and videos. We applied this method to create a new steganography scheme which significantly improves the security level of traditional steganography

IL-6-mediated cross-talk between human preadipocytes and ductal carcinoma in situ in breast cancer progression

Background The function of preadipocytes in the progression of early stage breast cancer has not been fully elucidated at the molecular level. To delineate the role of preadipocytes in breast cancer progression, we investigated the cross-talk between human breast ductal carcinoma in situ (DCIS) cells and preadipocytes with both an in vitro culture and xenograft tumor model. Methods GFP or RFP was transduced into human DCIS cell line MCF10DCIS.com cells or preadipocytes using lentivirus. Cell sorter was used to separate pure, viable populations of GFP- or RFP-transduced cells. Cell viability and proliferation was assessed by crystal violet assays and cell migration and invasion capability was assayed by the transwell strategy. Gene and protein levels were measured by western blot, RT-PCR and immunostaining. Adipokines and cytokines were quantified using ELISA. Human tumor xenografts in a nude mice model were used. Ultrasound imaging of tumors was performed to evaluate the therapeutic potential of a IL-6 neutralizing antibody. Results In the co-culture system with the MCF10DCIS.com and preadipocytes, MCF10DCIS.com proliferation, migration and invasion were enhanced by preadipocytes. Preadipocytes exhibited in an increased IL-6 secretion and cancer-associated fibroblast markers expression, FSP1 and α-SMC in co-culture with MCF10DCIS.com or in MCF10DCIS.com conditioned media, whereas the adipocyte differentiation capacity was suppressed by co-culture with MCF10DCIS.com. A neutralizing antibody of IL-6 or IL-6R suppressed the promotion of MCF10DCIS.com proliferation and migration by co-culture with preadipocytes. In the xenograft tumor model, the tumor growth of MCF10DCIS.com was enhanced by the co-injection of preadipocytes, and the administration of IL-6 neutralizing antibodies resulted in potent effects on tumor inhibition. Conclusions Our findings suggest that IL-6-mediated cross-talk between preadipocytes and breast DCIS cells can promote the progression of early stage breast cancer. Therefore, blocking IL-6 signaling might be a potential therapeutic strategy for breast DCIS characterized by pathological IL-6 overproduction.This work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and future Planning (2015R1A2A1A05001860) and by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2015R1D1A1A01059376). Sul Ki Choi, Hyelim Kim and Yin Ji Piao are the awardees of graduate student fellowship funded by Brain Korea 21 Plus (BK21 Plus)

Identification of RipAZ1 as an avirulence determinant of Ralstonia solanacearum in Solanum americanum

Ralstonia solanacearum causes bacterial wilt disease in many plant species. Type III-secreted effectors (T3Es) play crucial roles in bacterial pathogenesis. However, some T3Es are recognized by corresponding disease resistance proteins and activate plant immunity. In this study, we identified the R. solanacearum T3E protein RipAZ1 (Ralstonia injected protein AZ1) as an avirulence determinant in the black nightshade species Solanum americanum. Based on the S. americanum accession-specific avirulence phenotype of R. solanacearum strain Pe_26, 12 candidate avirulence T3Es were selected for further analysis. Among these candidates, only RipAZ1 induced a cell death response when transiently expressed in a bacterial wilt-resistant S. americanum accession. Furthermore, loss of ripAZ1 in the avirulent R. solanacearum strain Pe_26 resulted in acquired virulence. Our analysis of the natural sequence and functional variation of RipAZ1 demonstrated that the naturally occurring C-terminal truncation results in loss of RipAZ1-triggered cell death. We also show that the 213 amino acid central region of RipAZ1 is sufficient to induce cell death in S. americanum. Finally, we show that RipAZ1 may activate defence in host cell cytoplasm. Taken together, our data indicate that the nucleocytoplasmic T3E RipAZ1 confers R. solanacearum avirulence in S. americanum. Few avirulence genes are known in vascular bacterial phytopathogens and ripAZ1 is the first one in R. solanacearum that is recognized in black nightshades. This work thus opens the way for the identification of disease resistance genes responsible for the specific recognition of RipAZ1, which can be a source of resistance against the devastating bacterial wilt disease

Post-intervention Status in Patients With Refractory Myasthenia Gravis Treated With Eculizumab During REGAIN and Its Open-Label Extension

OBJECTIVE: To evaluate whether eculizumab helps patients with anti-acetylcholine receptor-positive (AChR+) refractory generalized myasthenia gravis (gMG) achieve the Myasthenia Gravis Foundation of America (MGFA) post-intervention status of minimal manifestations (MM), we assessed patients' status throughout REGAIN (Safety and Efficacy of Eculizumab in AChR+ Refractory Generalized Myasthenia Gravis) and its open-label extension. METHODS: Patients who completed the REGAIN randomized controlled trial and continued into the open-label extension were included in this tertiary endpoint analysis. Patients were assessed for the MGFA post-intervention status of improved, unchanged, worse, MM, and pharmacologic remission at defined time points during REGAIN and through week 130 of the open-label study. RESULTS: A total of 117 patients completed REGAIN and continued into the open-label study (eculizumab/eculizumab: 56; placebo/eculizumab: 61). At week 26 of REGAIN, more eculizumab-treated patients than placebo-treated patients achieved a status of improved (60.7% vs 41.7%) or MM (25.0% vs 13.3%; common OR: 2.3; 95% CI: 1.1-4.5). After 130 weeks of eculizumab treatment, 88.0% of patients achieved improved status and 57.3% of patients achieved MM status. The safety profile of eculizumab was consistent with its known profile and no new safety signals were detected. CONCLUSION: Eculizumab led to rapid and sustained achievement of MM in patients with AChR+ refractory gMG. These findings support the use of eculizumab in this previously difficult-to-treat patient population. CLINICALTRIALSGOV IDENTIFIER: REGAIN, NCT01997229; REGAIN open-label extension, NCT02301624. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that, after 26 weeks of eculizumab treatment, 25.0% of adults with AChR+ refractory gMG achieved MM, compared with 13.3% who received placebo