1,204 research outputs found
Interference between magnetic field and cavity modes in an extended Josephson junction
An extended Josephson junction consists of two superconducting electrodes
that are separated by an insulator and it is therefore also a microwave cavity.
The superconducting phase difference across the junction determines the
supercurrent as well as its spatial distribution. Both, an external magnetic
field and a resonant cavity intrafield produce a spatial modification of the
superconducting phase along the junction. The interplay between these two
effects leads to interference in the critical current of the junction and
allows us to continuously tune the coupling strength between the first cavity
mode and the Josephson phase from 1 to -0.5. This enables static and dynamic
control over the junction in the ultra-strong coupling regime.Comment: 4 pages, 3 figure
Exceptional Laguerre and Jacobi polynomials and the corresponding potentials through Darboux-Crum Transformations
Simple derivation is presented of the four families of infinitely many shape
invariant Hamiltonians corresponding to the exceptional Laguerre and Jacobi
polynomials. Darboux-Crum transformations are applied to connect the well-known
shape invariant Hamiltonians of the radial oscillator and the
Darboux-P\"oschl-Teller potential to the shape invariant potentials of
Odake-Sasaki. Dutta and Roy derived the two lowest members of the exceptional
Laguerre polynomials by this method. The method is expanded to its full
generality and many other ramifications, including the aspects of generalised
Bochner problem and the bispectral property of the exceptional orthogonal
polynomials, are discussed.Comment: LaTeX2e with amsmath, amssymb, amscd 26 pages, no figure
Exact and explicit probability densities for one-sided Levy stable distributions
We study functions g_{\alpha}(x) which are one-sided, heavy-tailed Levy
stable probability distributions of index \alpha, 0< \alpha <1, of fundamental
importance in random systems, for anomalous diffusion and fractional kinetics.
We furnish exact and explicit expression for g_{\alpha}(x), 0 \leq x < \infty,
satisfying \int_{0}^{\infty} exp(-p x) g_{\alpha}(x) dx = exp(-p^{\alpha}),
p>0, for all \alpha = l/k < 1, with k and l positive integers. We reproduce all
the known results given by k\leq 4 and present many new exact solutions for k >
4, all expressed in terms of known functions. This will allow a 'fine-tuning'
of \alpha in order to adapt g_{\alpha}(x) to a given experimental situation.Comment: 4 pages, 3 figures and 1 tabl
Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling
Activating mutations in genes of the Ras-mitogen-activated protein kinase (MAPK) pathway occur in approximately 30% of all human cancers; however, mutation of Ras alone is rarely sufficient to induce tumour development. Scribble is a polarity regulator recently isolated from a Drosophila screen for events that cooperate with Ras mutation to promote tumour progression and cell invasion. In mammals, Scribble regulates directed cell migration and wound healing in vivo; however, no role has been identified for mammalian Scribble in oncogenic transformation. Here we show that in human epithelial cells expressing oncogenic Ras or Raf, loss of Scribble promotes invasion of cells through extracellular matrix in an organotypic culture system. Further, we show that the mechanism by which this occurs is in the regulation of MAPK signalling by Scribble. The suppression of MAPK signalling is a highly conserved function of Scribble as it also prevents Raf-mediated defects in Drosophila wing development. Our data identify Scribble as an important mediator of MAPK signalling and provide a molecular basis for the observation that Scribble expression is decreased in many invasive human cancers. © 2008 Macmillan Publishers Limited All rights reserved
SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia
Loss of cellular polarity is a hallmark of epithelial cancers, raising the possibility that regulators of polarity have a role in suppressing tumorigenesis. The Scribble complex is one of at least three interacting protein complexes that have a critical role in establishing and maintaining epithelial polarity. In human colorectal, breast, and endometrial cancers, expression of the Scribble complex member SCRIB is often mislocalized and deregulated. Here, we report that Scrib is indispensable for prostate homeostasis in mice. Scrib heterozygosity initiated prostate hyperplasia, while targeted biallelic Scrib loss predisposed mice to prostate intraepithelial neoplasia. Mechanistically, Scrib was shown to negatively regulate the MAPK cascade to suppress tumorigenesis. Further analysis revealed that prostate-specific loss of Scrib in mice combined with expression of an oncogenic Kras mutation promoted the progression of prostate cancer that recapitulated the human disease. The clinical significance of the work in mice was highlighted by our observation that SCRIB deregulation strongly correlated with poor survival in human prostate cancer. These data suggest that the polarity network could provide a new avenue for therapeutic intervention
Three-body Faddeev Calculation for 11Li with Separable Potentials
The halo nucleus Li is treated as a three-body system consisting of an
inert core of Li plus two valence neutrons. The Faddeev equations are
solved using separable potentials to describe the two-body interactions,
corresponding in the n-Li subsystem to a p resonance plus a
virtual s-wave state. The experimental Li energy is taken as input and
the Li transverse momentum distribution in Li is studied.Comment: 6 pages, RevTeX, 1 figur
Proceedings of the third French-Ukrainian workshop on the instrumentation developments for HEP
The reports collected in these proceedings have been presented in the third
French-Ukrainian workshop on the instrumentation developments for high-energy
physics held at LAL, Orsay on October 15-16. The workshop was conducted in the
scope of the IDEATE International Associated Laboratory (LIA). Joint
developments between French and Ukrainian laboratories and universities as well
as new proposals have been discussed. The main topics of the papers presented
in the Proceedings are developments for accelerator and beam monitoring,
detector developments, joint developments for large-scale high-energy and
astroparticle physics projects, medical applications.Comment: 3rd French-Ukrainian workshop on the instrumentation developments for
High Energy Physics, October 15-16, 2015, LAL, Orsay, France, 94 page
Technical design and performance of the NEMO3 detector
The development of the NEMO3 detector, which is now running in the Frejus
Underground Laboratory (L.S.M. Laboratoire Souterrain de Modane), was begun
more than ten years ago. The NEMO3 detector uses a tracking-calorimeter
technique in order to investigate double beta decay processes for several
isotopes. The technical description of the detector is followed by the
presentation of its performance.Comment: Preprint submitted to Nucl. Instrum. Methods A Corresponding author:
Corinne Augier ([email protected]
Author correction : a global database for metacommunity ecology, integrating species, traits, environment and space
Correction to: Scientific Data https://doi.org/10.1038/s41597-019-0344-7, published online 08 January 202
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