Polarization of superfluid turbulence

We show that normal fluid eddies in turbulent helium II polarize the tangle of quantized vortex lines present in the flow, thus inducing superfluid vorticity patterns similar to the driving normal fluid eddies. We also show that the polarization is effective over the entire inertial range. The results help explain the surprising analogies between classical and superfluid turbulence which have been observed recently.Comment: 3 figure

Rapidly changing subglacial hydrological pathways at a tidewater glacier revealed through simultaneous observations of water pressure, supraglacial lakes, meltwater plumes and surface velocities

This work was funded by the Conoco Phillips-Lundin Northern Area Program through the CRIOS project (Calving Rates and Impact On Sea level, http://www.researchinsvalbard.no/project/7037). Penelope How is supported by a NERC PhD studentship.Subglacial hydrological processes at tidewater glaciers remain poorly understood due to the difficulty in obtaining direct measurements and lack of empirical verification for modelling approaches. Here, we investigate the subglacial hydrology of Kronebreen, a fast-flowing tidewater glacier in Svalbard during the 2014 melt season. We combine observations of borehole water pressure, supraglacial lake drainage, surface velocities and plume activity with modelled run-off and water routing to develop a conceptual model that thoroughly encapsulates subglacial drainage at a tidewater glacier. Simultaneous measurements suggest that an early-season episode of subglacial flushing took place during our observation period, and a stable efficient drainage system effectively transported subglacial water through the northern region of the glacier tongue. Drainage pathways through the central and southern regions of the glacier tongue were disrupted throughout the following melt season. Periodic plume activity at the terminus appears to be a signal for modulated subglacial pulsing, i.e. an internally driven storage and release of subglacial meltwater that operates independently of marine influences. This storage is a key control on ice flow in the 2014 melt season. Evidence from this work and previous studies strongly suggests that long-term changes in ice flow at Kronebreen are controlled by the location of efficient/inefficient drainage and the position of regions where water is stored and released.Publisher PDFPeer reviewe

Pediatr Nephrol

BACKGROUND: In patients with primary hyperoxaluria (PH), endogenous oxalate overproduction increases urinary oxalate excretion, leading to compromised kidney function and often kidney failure. Highly elevated plasma oxalate (Pox) is associated with systemic oxalate deposition in patients with PH and severe chronic kidney disease (CKD). The relationship between Pox and estimated glomerular filtration rate (eGFR) in patients with preserved kidney function, however, is not well established. Our analysis aimed to investigate a potential correlation between these parameters in PH patients from three randomized, placebo-controlled trials (studies OC3-DB-01, OC3-DB-02, and OC5-DB-01). METHODS: Baseline data from patients with a PH diagnosis (type 1, 2, or 3) and eGFR > 40 mL/min/1.73 m(2) were analyzed for a correlation between eGFR and Pox using Spearman's rank and Pearson's correlation coefficients. Data were analyzed by individual study and additionally were pooled for Studies OC3-DB-02 and OC5-DB-01 in which the same Pox assay was used. RESULTS: A total of 106 patients were analyzed. A statistically significant inverse Spearman's correlation between eGFR and Pox was observed across all analyses; correlation coefficients were - 0.44 in study OC3-DB-01, - 0.55 in study OC3-DB-02, - 0.51 in study OC5-DB-01, and - 0.49 in the pooled studies (p < 0.0064). CONCLUSIONS: Baseline evaluations showed a moderate and statistically significant inverse correlation between eGFR and Pox in patients with PH already at early stages of CKD (stages 1-3b), demonstrating that a correlation is present before substantial loss in kidney function occurs

Cyclosporine-A-induced nephrotoxicity in children with minimal-change nephrotic syndrome: long-term treatment up to 10 years

The impact of cyclosporine A (CsA) therapy in patients with steroid-dependent nephrotic-syndrome (SDNS) on long-term renal function is controversial. Data beyond 5 years are rare. Long-term renal function was evaluated in children with SDNS with and without CsA therapy, especially beyond 5 years. Twenty children were treated with CsA (study group) for a mean of 5.4 ± 2.2 years (ten patients for 5–11 years). Glomerular filtration rate (GFR) was calculated before and after 3 and 12 months and at latest follow-up of therapy. Fifteen children with cyclophosphamide-treated SDNS without CsA served as controls. In the study group, GFR decreased within 12 months from 136 ± 19 to 120 ± 31, to 114 ± 14 ml/min per 1.73 m2 at latest follow-up (p < 0.0001). Patients with CsA > 5 years had a GFR of 111 ± 14 ml/min per 1.73 m2 at latest follow-up without a GFR below 90 ml/min per 1.73 m2. No CsA toxicity was found in biopsies. In the control group, GFR dropped within 3 months, from 137 ± 27 to 130 ± 24, to 126 ± 19 ml/min per 1.73 m2 at latest follow-up (p = 0.1). Patients with and without nephrotoxic CsA therapy showed a drop in GFR. In CsA-treated patients, GFR was about 12% lower at latest follow-up compared with patients without nephrotoxic therapy but always remained within normal range. CsA seems to be safe, even in long-term treatment for more than 5 years

Automatic detection of calving events from time-lapse imagery at Tunabreen, Svalbard

Calving is an important process in glacier systems terminating in the ocean, and more observations are needed to improve our understanding of the undergoing processes and parameterize calving in larger-scale models. Time-lapse cameras are good tools for monitoring calving fronts of glaciers and they have been used widely where conditions are favourable. However, automatic image analysis to detect and calculate the size of calving events has not been developed so far. Here, we present a method that fills this gap using image analysis tools. First, the calving front is segmented. Second, changes between two images are detected and a mask is produced to delimit the calving event. Third, we calculate the area given the front and camera positions as well as camera characteristics. To illustrate our method, we analyse two image time series from two cameras placed at different locations in 2014 and 2015 and compare the automatic detection results to a manual detection. We find a good match when the weather is favourable, but the method fails with dense fog or high illumination conditions. Furthermore, results show that calving events are more likely to occur (i) close to where subglacial meltwater plumes have been observed to rise at the front and (ii) close to one another.Publisher PDFPeer reviewe

Women’s Perception of Quality of Maternity Services: A Longitudinal Survey in Nepal

Background: In the context of maternity service, the mother’s assessment of quality is central because emotional, cultural and respectful supports are vital during labour and the delivery process. This study compared client-perceived quality of maternity services between birth centres, public and private hospitals in a central hills district of Nepal. Methods: A cohort of 701 pregnant women of 5 months or more gestational age were recruited and interviewed, followed by another interview within 45 days of delivery. Perception of quality was measured by a 20-item scale with three sub-scales: health facility, health care delivery, and interpersonal aspects. Perceived quality scores were analysed by ANOVA with post-hoc comparisons and multiple linear regression.Results: Within the health facility sub-scale, birth centre was rated lowest on items ‘adequacy of medical equipment’, ‘health staff suited to women’s health’ and ‘adequacy of health staff’, whereas public hospital was rated the lowest with respect to ‘adequacy of room’, ‘adequacy of water’, ‘environment clean’, ‘privacy’ and ‘adequacy of information’. Mean scores of total quality and sub-scales health facility and health care delivery for women attending private hospital were higher (p < 0.001) than those using birth centre or public hospital. Mean score of the sub-scale interpersonal aspects for public hospital users was lower (p < 0.001) than those delivered at private hospital and birth centre. However, perception on interpersonal aspects by women using public hospital improved significantly after delivery (p< 0.001). Conclusions: Overall, perception of quality differed significantly by types of health facility used for delivery. They rated lowest the supplies and equipment in birth centres and the amenities and interpersonal aspects in the public hospital. Accordingly, attention to these aspects is needed to improve the quality

Glacier Calving Rates Due to Subglacial Discharge, Fjord Circulation, and Free Convection

Tidewater glacier calving provides the most direct mechanism of ice transfer from land to the ocean. However, the physical melt processes influencing calving remain challenging to constrain. In this study we focus on calving rates at Kongsbreen, a tidewater glacier in Svalbard, due to three mechanisms of submarine melt: (1) free convection, (2) horizontal fjord circulation, and (3) meltwater discharge. To calculate an overall calving rate, we measure glacier velocity and terminus change using Sentinel imagery. We calculate free convection, fjord circulation, and meltwater discharge calving using mooring data for mid-fjord ocean temperature (30–80 m depth), reanalysis results for meltwater runoff, and georectified time-lapse imagery to track icebergs and infer surface circulation. Results show that the total glacier calving rate is highly correlated with ocean temperature during the 2016 melt season. When runoff was present, we found that subglacial discharge accounted for calving rates an order of magnitude greater than the maximum calving rates assigned to the other two melting mechanisms combined. Further, subglacial discharge at Kongsbreen was more efficient in inducing calving later in the season than earlier in the season, implying that the increase in ocean temperatures, the timing of meltwater discharge within a melt season, and/or the development of discrete meltwater exit channels are critical components to calving rates. As the recent atmospheric warming trend and subsequent increase in meltwater discharge is expected to continue, it is essential to understand the processes contributing to an increase in glacier calving and incorporate these processes into predictive models

Experience with tacrolimus in children with steroid-resistant nephrotic syndrome

Children with steroid-resistant nephrotic syndrome (SRNS) are at risk of developing renal failure. We report here the results of a single-center retrospective observational study of the remission rate in pediatric patients with SNRS receiving tacrolimus. Serial renal biopsies from children on tacrolimus therapy were evaluated for tubulointerstitial fibrosis and transforming growth factor-β immunostaining. Of the 16 children with SRNS, 15 went into complete remission after a median of 120 days of therapy. Nine children were able to stop steroids, while the others were on tapering doses. Forty-seven percent had relapses, most of which were steroid-responsive. Serial renal biopsies were obtained from seven children after a median treatment duration of 24 months; two of these children had increased tubulointerstitial fibrosis and four showed increased transforming growth factor-β tissue staining. Children with worsening histological findings were younger. There was no significant association between tacrolimus exposure and biopsy changes, although the average trough level was higher in those children with worsening histological findings. In conclusion, tacrolimus may be a safe and effective alternative agent for inducing remission in children with SRNS. However, caution needs to be taken when prescribing this agent due to its narrow therapeutic index. Serial renal biopsies are necessary to check for subclinical nephrotoxicity, especially in younger children and those with higher trough levels