A eficiência da suplementação de vitamina c na prevenção e combate do estresse oxidativo em tabagistas

Smoking is responsible for causing adverse effects on tissues through oxidative damage. The consumption of vitamin C inhibits oxidative damage in molecules by intercepting free radicals generated by cellular metabolism or by exogenous sources. Objectives: To verify the efficiency of vitamin supplementation in combating oxidative stress in smokers. Data source: Meta-analysis of studies identified through research in the databases Pubmed, Europa PMC, Web of Science and Scielo until 2021.Data synthesis: 306 articles were identified, of which 4 characteristics are relevant to the objectives of this study. Results: The intervention with vitamin C supplementation did not alter the oxidative stress caused by smoking (MD 2.45, 95% CI -1.51; 6.40; p=0.23; I2 = 92%). Conclusions: Based on the results found, we can conclude that vitamin C supplementation is not an efficient strategy to combat the oxidative stress caused by smoking.O tabagismo é responsável por ocasionar efeitos adversos sobre os tecidos por meio do dano oxidativo. Por outro lado, o consumo de vitamina C se apresenta como um antioxidante o qual poderia inibir os danos oxidativos nas moléculas através da interceptação dos radicais livres gerados pelo metabolismo celular ou por fontes exógenas. Objetivo: Analisar a eficiência da suplementação da vitamina C no combate ao estresse oxidativo em tabagistas. Fonte de dados: Metánalise de estudos identificados por meio de pesquisa nas bases de dados Pubmed, Europe PMC, Web of Science e Scielo até 2021.Síntese de dados: Foram identificados 306 artigos dos quais 4 mostraram-se relevantes aos objetivos deste estudo. Resultados: Os estudos levantados demonstraram que a intervenção com suplementação de vitamina C não alterou o estresse oxidativo provocado pelo tabagismo (MD 2,45, 95% IC -1,51; 6,40; p=0.23; I2 = 92%). Conclusão: A partir dos resultados encontrados podemos concluir que a suplementação de vitamina C não se apresenta como estratégia eficiente para o combate ao estresse oxidativo provocado pelo tabagismo

Planejamento Reprodutivo: Perfil de adesão aos métodos contraceptivos / Reproductive Planning: Adherence Profile to Contraceptive Methods

Este estudo tem como objetivo identificar o perfil de escolha e adesão aos métodos contraceptivos específicos oferecidos no Centro de Referência Integrada a Saúde da Mulher no município de Marabá estado do Pará. Trata-se de um estudo de caso com 148 clientes, sendo 142 do sexo feminino e 6 do sexo masculino, de forma descritiva, com abordagem quantitativa. Os resultados obtidos expressaram extrema relevância e importância para a identificação e compreensão do perfil de escolha dos clientes após a apresentação de 4 métodos contraceptivos, sendo eles cirúrgicos e não cirúrgicos, analisados por faixa etária, sexo e opção contraceptiva apresentada. Concluiu-se que a política de planejamento familiar  que instituí os métodos contraceptivos no âmbito do SUS desde sua implementação em 1996, tem demonstrado efetiva aplicabilidade em meio social, contudo os índices revelam que os métodos contraceptivos com maior representatividade de escolha social ainda são os cirúrgicos, falta de educação em saúde e problemas com a cobertura e captação de adesão do público masculino nos serviços de planejamento reprodutivo, podem estar relacionados aos números de escolha por realização de método cirúrgico de laqueadura de trompas em mulheres. Medidas de educação em saúde no âmbito da Atenção Primária devem ser encorajadas para difusão social de outros métodos contraceptivos e provável redução dos índices por escolha de métodos cirúrgicos

SARS-CoV-2 introductions and early dynamics of the epidemic in Portugal

Genomic surveillance of SARS-CoV-2 in Portugal was rapidly implemented by the National Institute of Health in the early stages of the COVID-19 epidemic, in collaboration with more than 50 laboratories distributed nationwide. Methods By applying recent phylodynamic models that allow integration of individual-based travel history, we reconstructed and characterized the spatio-temporal dynamics of SARSCoV-2 introductions and early dissemination in Portugal. Results We detected at least 277 independent SARS-CoV-2 introductions, mostly from European countries (namely the United Kingdom, Spain, France, Italy, and Switzerland), which were consistent with the countries with the highest connectivity with Portugal. Although most introductions were estimated to have occurred during early March 2020, it is likely that SARS-CoV-2 was silently circulating in Portugal throughout February, before the first cases were confirmed. Conclusions Here we conclude that the earlier implementation of measures could have minimized the number of introductions and subsequent virus expansion in Portugal. This study lays the foundation for genomic epidemiology of SARS-CoV-2 in Portugal, and highlights the need for systematic and geographically-representative genomic surveillance.We gratefully acknowledge to Sara Hill and Nuno Faria (University of Oxford) and Joshua Quick and Nick Loman (University of Birmingham) for kindly providing us with the initial sets of Artic Network primers for NGS; Rafael Mamede (MRamirez team, IMM, Lisbon) for developing and sharing a bioinformatics script for sequence curation (https://github.com/rfm-targa/BioinfUtils); Philippe Lemey (KU Leuven) for providing guidance on the implementation of the phylodynamic models; Joshua L. Cherry (National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health) for providing guidance with the subsampling strategies; and all authors, originating and submitting laboratories who have contributed genome data on GISAID (https://www.gisaid.org/) on which part of this research is based. The opinions expressed in this article are those of the authors and do not reflect the view of the National Institutes of Health, the Department of Health and Human Services, or the United States government. This study is co-funded by Fundação para a Ciência e Tecnologia and Agência de Investigação Clínica e Inovação Biomédica (234_596874175) on behalf of the Research 4 COVID-19 call. Some infrastructural resources used in this study come from the GenomePT project (POCI-01-0145-FEDER-022184), supported by COMPETE 2020 - Operational Programme for Competitiveness and Internationalisation (POCI), Lisboa Portugal Regional Operational Programme (Lisboa2020), Algarve Portugal Regional Operational Programme (CRESC Algarve2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF), and by Fundação para a Ciência e a Tecnologia (FCT).info:eu-repo/semantics/publishedVersio

Miradas desde la historia social y la historia intelectual: América Latina en sus culturas: de los procesos independistas a la globalización

Fil: Benito Moya, Silvano G. A. Universidad Católica de Córdoba. Facultad de Filosofía y Humanidades; Argentina.Fil: Universidad Católica de Córdoba. Facultad de Filosofía y Humanidades; Argentina

Body Composition and Physical Fitness in Madeira Youth

Background: Research on composition and physical fitness is lacking in school-aged children from Madeira. This study aimed to examine the frequencies of overweight and obese participants and, in addition, to compare the fitness levels of Madeira youth with reference data. Methods: The sample comprised 521 participants (n = 258 boys; n = 263 girls) aged 10.0–18.9 years old. Methods: Height and weight were measured. Body mass index (BMI) was calculated, and percent fat was derived from skinfolds. Tests detailed on FITESCOLA battery were performed. BMI was plotted against U.S. reference data and physical assessment contrasted with the cut-off points of FITESCOLA protocol and corresponding data developed in Portuguese youth. Results: The percentages of overweight and obesity were 15% (overweight) and 14% (obesity) for boys and 16% (overweight) and 6% (obesity) for girls. The median values of fat mass percentage were closely related to the cut-off standards; however, substantial variation was noted. Boys and girls tended to be below the recommendations of cardiorespiratory fitness. Conclusions: Sport participation should be promoted in Madeira to attain acceptable values of body composition and physical fitness levels

Portal vein embolization with n-butyl-cyanoacrylate through an ipsilateral approach before major hepatectomy: single center analysis of 50 consecutive patients

Abstract Purpose To evaluate the efficacy of portal vein embolization (PVE) with n-Butyl-cyanoacrylate (NBCA) through an ipsilateral approach before major hepatectomy. Secondary end-points were PVE safety, liver resection and patient outcome. Methods Over a 5-year period 50 non-cirrhotic consecutive patients were included with primary or secondary liver cancer treatable by hepatectomy with a liver remnant (FLR) volume less than 25% or less than 40% in diseased livers. Results There were 37 men and 13 women with a mean age of 57 years. Colorectal liver metastases were the most frequent tumor and patients were previously exposed to chemotherapy. FLR increased from 422 ml to 629 ml (P < 0.001) after PVE, corresponding to anincrease of 52%. The FLR ratio increased from 29.6% to 42.3% (P < 0.001). Kinetic growth rate was 2.98%/week. A negative association was observed between increase in the FLR and FLR ratio and FLR volume before PVE (P = 0.002). In 31 patients hepatectomy was accomplished and only one patient presented with liver insufficiency within 30 days after surgery. Conclusions PVE with NBCA through an ipsilateral puncture is effective before major hepatectomy. Meticulous attention is needed especially near the end of the embolization procedure to avoid complications. Trial registration Clinical Study ISRCTN registration number: ISRCTN39855523 . Registered March 13th 2017