Mechanical dynamic load of the LHC arc cryo-magnets during the installation

About 1700 LHC main superconducting dipoles and quadrupoles will have to be transported and handled between the assembly, the magnet measurements and the storage that precedes the final installation in the LHC tunnel. To ensure the required mechanic and geometric integrity of the cryo-magnets, transport specifications and allowed acceleration loads were defined after detailed dynamic analysis. A large number of cryo-magnets are now arriving at CERN on a regular basis. The logistics for the handling and transport are monitored with tri-axial acceleration monitoring devices that are installed on each cryo-magnet. Measurements are made to commission new equipment like overhead cranes, tunnel transport and handling devices to guarantee that the defined acceleration limits are respected. The results from the acceleration monitoring that are stored in the same quality assurance system as the cryo-magnets allowed to give a first idea of the level of the mechanical dynamic load on each magnet throughout the logistics chain and were used to detect details such as out-of-specification accelerations that needed improvement

Overview of the CLEF 2023 SimpleText Lab:Automatic Simplification of Scientific Texts

There is universal consensus on the importance of objective scientific information, yet the general public tends to avoid scientific literature due to access restrictions, its complex language or their lack of prior background knowledge. Academic text simplification promises to remove some of these barriers, by improving the accessibility of scientific text and promoting science literacy. This paper presents an overview of the CLEF 2023 SimpleText track addressing the challenges of text simplification approaches in the context of promoting scientific information access, by providing appropriate data and benchmarks, and creating a community of IR and NLP researchers working together to resolve one of the greatest challenges of today. The track provides a corpus of scientific literature abstracts and popular science requests. It features three tasks. First, content selection (what is in, or out?) challenges systems to select passages to include in a simplified summary in response to a query. Second, complexity spotting (what is unclear?) given a passage and a query, aims to rank terms/concepts that are required to be explained for understanding this passage (definitions, context, applications). Third, text simplification (rewrite this!) given a query, asks to simplify passages from scientific abstracts while preserving the main content.</p

Enhanced reaction kinetics in biological cells

The cell cytoskeleton is a striking example of "active" medium driven out-of-equilibrium by ATP hydrolysis. Such activity has been shown recently to have a spectacular impact on the mechanical and rheological properties of the cellular medium, as well as on its transport properties : a generic tracer particle freely diffuses as in a standard equilibrium medium, but also intermittently binds with random interaction times to motor proteins, which perform active ballistic excursions along cytoskeletal filaments. Here, we propose for the first time an analytical model of transport limited reactions in active media, and show quantitatively how active transport can enhance reactivity for large enough tracers like vesicles. We derive analytically the average interaction time with motor proteins which optimizes the reaction rate, and reveal remarkable universal features of the optimal configuration. We discuss why active transport may be beneficial in various biological examples: cell cytoskeleton, membranes and lamellipodia, and tubular structures like axons.Comment: 10 pages, 2 figure

Testing the ΔS=ΔQ\Delta S=\Delta Q Rule with Exclusive Semi-Leptonic Kaon Decays

We consider the possibility of violations of the selection rule $\Delta S=\Delta Q$ at an appreciable level in {\it exclusive} semi-leptonic decays of Kaons. At $\Phi$-Factories, intense Kaon beams will be available and will probe among others, the semi-leptonic decays $K_{l4}$ and $K_{l3\gamma}$ in addition to $K_{l3}$ and could provide novel testing grounds for the $\Delta S=\Delta Q$ rule. In particular, the branching ratio of $K_{l3\gamma}$ is non-negligible and could be used to probe new phenomena associated with the violation of this selection rule. Furthermore, we modify certain di-lepton event rate ratios and asymmetries and time asymmetries that have been constructed by Dass and Sarma for di-lepton events from Beon decays to test the $\Delta B=\Delta Q$ at the $\Upsilon (4S)$, to the Kaon system at the $\phi(1020)$. We find that the large width of the $K_S$ relative to that of $K_L$ plays an important role in enhancing some of the time asymmetries.Comment: 10 pages, Plain Latex, To be run twice

Kinetics of active surface-mediated diffusion in spherically symmetric domains

We present an exact calculation of the mean first-passage time to a target on the surface of a 2D or 3D spherical domain, for a molecule alternating phases of surface diffusion on the domain boundary and phases of bulk diffusion. We generalize the results of [J. Stat. Phys. {\bf 142}, 657 (2011)] and consider a biased diffusion in a general annulus with an arbitrary number of regularly spaced targets on a partially reflecting surface. The presented approach is based on an integral equation which can be solved analytically. Numerically validated approximation schemes, which provide more tractable expressions of the mean first-passage time are also proposed. In the framework of this minimal model of surface-mediated reactions, we show analytically that the mean reaction time can be minimized as a function of the desorption rate from the surface.Comment: Published online in J. Stat. Phy

The cyclic ground state structure of the HF trimer revealed by far infrared jet-cooled Fourier transform spectroscopy.

International audienceThe rovibrationally resolved Fourier transform (FT) far infrared (FIR) spectra of two intermolecular librations of (HF)3, namely the in-plane ν6 and out-of-plane ν4 bending fundamentals centered, respectively, at about 494 cm(-1) and 602 cm(-1), have been recorded for the first time under jet-cooled conditions using the supersonic jet of the Jet-AILES apparatus. The simultaneous rotational analysis of 245 infrared transitions belonging to both bands enabled us to determine the ground state (GS), ν6 and ν4 rotational and centrifugal distortion constants. These results provided definite experimental answers to the structure of such a weakly bound trimer: firstly the vibrationally averaged planarity of cyclic (HF)3, also supported by the very small value of the inertia defect obtained in the GS, secondly the slight weakening of the hydrogen bond in the intermolecular excited states evidenced from the center of mass separations of the HF constituents determined in the ground, ν6 = 1 and ν4 = 1 states of (HF)3 as well as the decrease of the fitted rotational constants upon excitation. Finally, lower bounds of about 2 ns on ν6 and ν4 state lifetimes could be derived from the deconvolution of experimental linewidths. Such long lifetimes highlight the interest in probing low frequency intermolecular motions of molecular complexes to get rid of constraints related to the vibrational dynamics of coupled anharmonic vibrations at higher energy, resulting in loss of rotational information

The finite temperature real time \hbar^2 corrections in quantum mechanics

We study non-perturbative real time correlation functions at finite temperature. In order to see whether the classical term gives a good approximation in the high temperature limit T >> \hbar\omega, we consider the first \hbar^2 quantum corrections. We find that for the simplest non-trivial case, the quantum mechanical anharmonic oscillator, the classical result is reliable only for moderately large times: after some time t_* the classical approximation breaks down even at high temperatures. Moreover, the result for the first quantum corrections cannot, in general, be reproduced by modifying the parameters of the classical theory.Comment: 28 pages, 7 figure

SST-GATE: A dual mirror telescope for the Cherenkov Telescope Array

The Cherenkov Telescope Array (CTA) will be the world's first open observatory for very high energy gamma-rays. Around a hundred telescopes of different sizes will be used to detect the Cherenkov light that results from gamma-ray induced air showers in the atmosphere. Amongst them, a large number of Small Size Telescopes (SST), with a diameter of about 4 m, will assure an unprecedented coverage of the high energy end of the electromagnetic spectrum (above ~1TeV to beyond 100 TeV) and will open up a new window on the non-thermal sky. Several concepts for the SST design are currently being investigated with the aim of combining a large field of view (~9 degrees) with a good resolution of the shower images, as well as minimizing costs. These include a Davies-Cotton configuration with a Geiger-mode avalanche photodiode (GAPD) based camera, as pioneered by FACT, and a novel and as yet untested design based on the Schwarzschild-Couder configuration, which uses a secondary mirror to reduce the plate-scale and to allow for a wide field of view with a light-weight camera, e.g. using GAPDs or multi-anode photomultipliers. One objective of the GATE (Gamma-ray Telescope Elements) programme is to build one of the first Schwarzschild-Couder prototypes and to evaluate its performance. The construction of the SST-GATE prototype on the campus of the Paris Observatory in Meudon is under way. We report on the current status of the project and provide details of the opto-mechanical design of the prototype, the development of its control software, and simulations of its expected performance.Comment: In Proceedings of the 33rd International Cosmic Ray Conference (ICRC2013), Rio de Janeiro (Brazil). All CTA contributions at arXiv:1307.223

Renal ammonium excretion after an acute acid load: Blunted response in uric acid stone formers but not in patients with type 2 diabetes

Idiopathic uric acid nephrolithiasis is characterized by elevated urinary net acid excretion and insufficient buffering by ammonium, resulting in excessively acidic urine and titration of the relatively soluble urate anion to insoluble uric acid. Patients with type 2 diabetes have similar changes in urinary pH, net acid excretion, and ammonium in 24-h urine collections at baseline, even after controlling for dietary factors, and are at increased risk for uric acid nephrolithiasis. However, not all patients with type 2 diabetes develop kidney stones, suggesting that uric acid stone formers may have additional urinary defects, perhaps not apparent at baseline. We performed a metabolic study of 14 patients with idiopathic uric acid nephrolithiasis, 13 patients with type 2 diabetes, and 8 healthy control subjects of similar body mass index. After equilibration on a fixed diet for 5 days, subjects were given a single oral acid load (50 meq ammonium chloride), and urine was collected hourly for 4 h. Uric acid stone formers had a lower ammonium excretory response to acute acid loading compared with diabetic and nondiabetic nonstone formers, suggesting that an ammonium excretory defect unique to uric acid stone formers was unmasked by the acid challenge. The Zucker diabetic fatty rat also did not show impaired urinary ammonium excretion in response to acute acid challenge. A blunted renal ammonium excretory response to dietary acid loads may contribute to the pathogenesis of idiopathic uric acid nephrolithiasis. © 2013 the American Physiological Society

Impact of Acute Kidney Injury and CKD on Adverse Outcomes in Critically Ill Septic Patients

Introduction: Chronic kidney disease (CKD) and acute kidney injury (AKI) are strongly associated with excess morbidity and mortality and frequently co-occur in critically ill septic patients, but how their interplay affects clinical outcomes is not well elucidated. Methods: We conducted a single-center, retrospective cohort study of 2632 adult patients admitted to the intensive care unit (ICU) with severe sepsis or septic shock. Subjects were classified into 6 groups according to baseline CKD (no-CKD: estimated glomerular filtration rate [eGFR] ≥60; CKD: eGFR 15−59 ml/min per 1.73 m2) and incident AKI by the Kidney Disease: Improving Global Outcomes (KDIGO) serum creatinine criteria (no-AKI, AKI stage 1, AKI stages ≥2) during ICU stay. Study outcomes were 90-day mortality (in hospital or within 90 days of discharge) and incident/progressive CKD. Results: Prevalent CKD was 46% and incident AKI was 57%. Adjusted hazard ratios (95% confidence intervals) for 90-day mortality relative to the reference group of no-CKD/no-AKI were 1.5 (1.1−2.0) in no-CKD/AKI stage 1, 2.4 (1.9−3.1) in no-CKD/AKI stages≥2, 1.1 (0.8−1.4) in CKD/no-AKI, 1.2 (0.9−1.6) in CKD/AKI stage 1, and 2.2 (1.7−2.9) in CKD/AKI stages ≥2. A similar trend was observed for incident/progressive CKD during a median follow-up of 15.3 months. Conclusion: Stage 1 AKI on CKD was not associated with an independent increased risk of adverse outcomes in critically ill septic patients. AKI stages ≥2 on CKD and any level of AKI in no-CKD patients were strongly and independently associated with adverse outcomes. Sepsis-associated stage 1 AKI on CKD may represent distinct underlying pathophysiology, with more prerenal cases and less severe de novo intrinsic damage, which needs further investigation