Design of an analog/digital truly random number generator

An analog-digital system is presented for the generation of truly random (aperiodic) digital sequences. This model is based on a very simple piecewise-linear discrete map which is suitable for implementation using monolithic analog sampled-data techniques. Simulation results are given illustrating the optimum choice of the model parameters. Circuit implementations are reported for the discrete map using both switched-capacitor (SC) and switched-current (SI) techniques. The layout of a SI prototype in a 3-μm n-well double-polysilicon double-metal technology is included

Loop Corrections and Naturalness in a Chiral Effective Field Theory

The loop expansion is applied to a chiral effective hadronic lagrangian; with the techniques of Infrared Regularization, it is possible to separate out the short-range contributions and to write them as local products of fields that are already present in our lagrangian. (The appropriate field variables must be re-defined at each order in loops.) The corresponding parameters implicitly include short-range effects to all orders in the interaction, so these effects need not be calculated explicitly. The remaining (long-range) contributions that must be calculated are nonlocal and resemble those in conventional nuclear-structure calculations. Nonlinear isoscalar scalar $(\sigma)$ and vector $(\omega)$ meson interactions are included, which incorporate many-nucleon forces and nucleon substructure. Calculations are carried out at the two-loop level to illustrate these techniques at finite nuclear densities and to verify that the coupling parameters remain natural when fitted to the empirical properties of equilibrium nuclear matter. Contributions from the $\omega N$ tensor coupling are also discussed.Comment: 22 pages, 6 figure

A Population Density Model of the Driven LGN/PGN

The interaction of two populations of integrate-and-fire-or-burst neurons representing thalamocortical cells from the dorsal lateral geniculate nucleus (dLGN) and thalamic reticular cells from the perigeniculate nucleus (PGN) is studied using a population density approach. A two-dimensional probability density function that evolves according to a time-dependent advection-reaction equation gives the distribution of cells in each population over the membrane potential and de-inactivation level of a low-threshold calcium current. In the absence of retinal drive, the population density network model exhibits rhythmic bursting. In the presence of constant retinal input, the aroused LGN/PGN population density model displays a wide range of responses depending on cellular parameters and network connectivity.https://scholarworks.wm.edu/asbookchapters/1130/thumbnail.jp

A robust morphological classification of high-redshift galaxies using support vector machines on seeing limited images. II. Quantifying morphological k-correction in the COSMOS field at 1<z<2: Ks band vs. I band

We quantify the effects of \emph{morphological k-correction} at $1<z<2$ by comparing morphologies measured in the K and I-bands in the COSMOS area. Ks-band data have indeed the advantage of probing old stellar populations for $z<2$, enabling a determination of galaxy morphological types unaffected by recent star formation. In paper I we presented a new non-parametric method to quantify morphologies of galaxies on seeing limited images based on support vector machines. Here we use this method to classify $\sim$$50 000$ $Ks$ selected galaxies in the COSMOS area observed with WIRCam at CFHT. The obtained classification is used to investigate the redshift distributions and number counts per morphological type up to $z\sim2$ and to compare to the results obtained with HST/ACS in the I-band on the same objects from other works. We associate to every galaxy with $Ks<21.5$ and $z<2$ a probability between 0 and 1 of being late-type or early-type. The classification is found to be reliable up to $z\sim2$. The mean probability is $p\sim0.8$. It decreases with redshift and with size, especially for the early-type population but remains above $p\sim0.7$. The classification is globally in good agreement with the one obtained using HST/ACS for $z<1$. Above $z\sim1$, the I-band classification tends to find less early-type galaxies than the Ks-band one by a factor $\sim$1.5 which might be a consequence of morphological k-correction effects. We argue therefore that studies based on I-band HST/ACS classifications at $z>1$ could be underestimating the elliptical population. [abridged]Comment: accepted for publication in A&A, updated with referee comments, 12 pages, 10 figure

Proximity effect gaps in S/N/FI structures

We study the proximity effect in hybrid structures consisting of superconductor and ferromagnetic insulator separated by a normal diffusive metal (S/N/FI structures). These stuctures were proposed to realize the absolute spin-valve effect. We pay special attention to the gaps in the density of states of the normal part. We show that the effect of the ferromagnet is twofold: It not only shifts the density of states but also provides suppression of the gap. The mechanism of this suppression is remarkably similar to that due to magnetic impurities. Our results are obtained from the solution of one-dimensional Usadel equation supplemented with boundary conditions for matrix current at both interfaces.Comment: Published in The European Physical Journal

Wave energy in Europe: Views on experiences and progress to date

publisher: Elsevier articletitle: Wave energy in Europe: Views on experiences and progress to date journaltitle: International Journal of Marine Energy articlelink: http://dx.doi.org/10.1016/j.ijome.2015.09.001 content_type: article copyright: © 2015 Elsevier Ltd. All rights reserved

Ca2+ Alternans in a Cardiac Myocyte Model that Uses Moment Equations to Represent Heterogeneous Junctional SR Ca2+

AbstractMultiscale whole-cell models that accurately represent local control of Ca2+-induced Ca2+ release in cardiac myocytes can reproduce high-gain Ca2+ release that is graded with changes in membrane potential. Using a recently introduced formalism that represents heterogeneous local Ca2+ using moment equations, we present a model of cardiac myocyte Ca2+ cycling that exhibits alternating sarcoplasmic reticulum (SR) Ca2+ release when periodically stimulated by depolarizing voltage pulses. The model predicts that the distribution of junctional SR [Ca2+] across a large population of Ca2+ release units is distinct on alternating cycles. Load-release and release-uptake functions computed from this model give insight into how Ca2+ fluxes and stimulation frequency combine to determine the presence or absence of Ca2+ alternans. Our results show that the conditions for the onset of Ca2+ alternans cannot be explained solely by the steepness of the load-release function, but that changes in the release-uptake process also play an important role. We analyze the effect of the junctional SR refilling time constant on Ca2+ alternans and conclude that physiologically realistic models of defective Ca2+ cycling must represent the dynamics of heterogeneous junctional SR [Ca2+] without assuming rapid equilibration of junctional and network SR [Ca2+]

A robust morphological classification of high-redshift galaxies using support vector machines on seeing limited images. I Method description

We present a new non-parametric method to quantify morphologies of galaxies based on a particular family of learning machines called support vector machines. The method, that can be seen as a generalization of the classical CAS classification but with an unlimited number of dimensions and non-linear boundaries between decision regions, is fully automated and thus particularly well adapted to large cosmological surveys. The source code is available for download at http://www.lesia.obspm.fr/~huertas/galsvm.html To test the method, we use a seeing limited near-infrared ($K_s$ band, $2,16\mu m$) sample observed with WIRCam at CFHT at a median redshift of $z\sim0.8$. The machine is trained with a simulated sample built from a local visually classified sample from the SDSS chosen in the high-redshift sample's rest-frame (i band, $0.77\mu m$) and artificially redshifted to match the observing conditions. We use a 12-dimensional volume, including 5 morphological parameters and other caracteristics of galaxies such as luminosity and redshift. We show that a qualitative separation in two main morphological types (late type and early type) can be obtained with an error lower than 20% up to the completeness limit of the sample ($KAB\sim 22$) which is more than 2 times better that what would be obtained with a classical C/A classification on the same sample and indeed comparable to space data. The method is optimized to solve a specific problem, offering an objective and automated estimate of errors that enables a straightforward comparison with other surveys.Comment: 11 pages, 7 figures, 3 tables. Submitted to A&A. High resolution images are available on reques

Proximity effect-assisted absorption of spin currents in superconductors

The injection of pure spin current into superconductors by the dynamics of a ferromagnetic contact is studied theoretically. Taking into account suppression of the order parameter at the interfaces (inverse proximity effect) and the energy-dependence of spin-flip scattering, we determine the temperature-dependent ferromagnetic resonance linewidth broadening. Our results agree with recent experiments in Nb|permalloy bilayers [C. Bell et al., arXiv:cond-mat/0702461].Comment: 4 page

UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors

Genomic instability can be a hallmark of both human genetic disease and cancer. We identify a deleterious UBQLN4 mutation in families with an autosomal recessive syndrome reminiscent of genome instability disorders. UBQLN4 deficiency leads to increased sensitivity to genotoxic stress and delayed DNA double-strand break (DSB) repair. The proteasomal shuttle factor UBQLN4 is phosphorylated by ATM and interacts with ubiquitylated MRE11 to mediate early steps of homologous recombination-mediated DSB repair (HRR). Loss of UBQLN4 leads to chromatin retention of MRE11, promoting non-physiological HRR activity in vitro and in vivo. Conversely, UBQLN4 overexpression represses HRR and favors non-homologous end joining. Moreover, we find UBQLN4 overexpressed in aggressive tumors. In line with an HRR defect in these tumors, UBQLN4 overexpression is associated with PARP1 inhibitor sensitivity. UBQLN4 therefore curtails HRR activity through removal of MRE11 from damaged chromatin and thus offers a therapeutic window for PARP1 inhibitor treatment in UBQLN4-overexpressing tumors