146 research outputs found
The Certification of a European Reference Plasma for Factor VIII, BCR-629.
Abstract not availableJRC.D-Institute for Reference Materials and Measurements (Geel
Do working practices of cancer nurse specialists improve clinical outcomes? Retrospective cohort analysis from the English National Lung Cancer Audit
Background
Cancer nurse specialists are advanced practitioners who offer continuity of care and expert support for people diagnosed with specific cancers. Health Education England's Cancer Workforce Plan prioritises expansion of cancer nurse specialist numbers by 2021 as part of the Cancer Taskforce Strategy for England.
Objective
To assess whether working practices of advanced practice specialist nurses are associated with clinical outcomes for people with lung cancer.
Methods
Adults with non-small cell lung cancer followed from 30 days post-diagnosis in English secondary care were obtained from the English National Lung Cancer Audit, 2007 to 2011. A national survey of lung cancer nurse specialists provided information on self-reported working practices. Mortality and unplanned admissions from 30 days to 12 months post diagnosis were respectively analysed using Cox and Poisson regression. Outcomes were assessed according to patients’ receipt of initial assessments by a lung cancer nurse specialist and according to trust-level reported working practices. Regression models were adjusted for individual sociodemographic and clinical characteristics, error adjusted for intracorrelations within regional cancer networks, and presented separately according to patients’ treatment pathways (surgery, chemotherapy, radiotherapy, or no anti-cancer therapy).
Results
Data for 108,115 people with lung cancer were analysed and associations with mortality and unplanned admissions were infrequent. Among people receiving only radiotherapy, however, the hazard for death was 17% lower among those who received an assessment by a lung cancer nurse specialist, compared with no assessment (hazard ratio = 0.83, 95% confidence interval 0.73–0.94; p = 0.003). The hazard was also lower among those receiving surgery (hazard ratio = 0.91, 0.84–0.99; p = 0.028). Among those receiving radiotherapy, nurse specialists’ reported confidence within multidisciplinary team settings was associated with a lower risk of death (hazard ratio = 0.88, 0.78–1.00; p = 0.049) and a lower rate of unplanned cancer-related admissions (incidence rate ratio = 0.83, 0.73–0.95; p = 0.007). Lung cancer nurse specialist assessments before/at diagnosis, were associated with a 5% lower rate of unplanned admissions, compared to when assessments occurred after diagnosis.
Conclusion
The contribution of nurse specialist working practices was occasionally associated with better outcomes for people with lung cancer. These were not limited to a single treatment pathway, but do indicate discrete relationships within pathways. Our study provides initial measures of overall lung cancer nurse specialist working practices at trusts, however, more detailed studies with longitudinal measurement of lung cancer nurse specialist-patient interaction are needed to better ascertain impacts on long-term patient outcomes. The findings highlight opportunities for potential improvement in effectiveness of service and care management
Statistical Theory of Spin Relaxation and Diffusion in Solids
A comprehensive theoretical description is given for the spin relaxation and
diffusion in solids. The formulation is made in a general
statistical-mechanical way. The method of the nonequilibrium statistical
operator (NSO) developed by D. N. Zubarev is employed to analyze a relaxation
dynamics of a spin subsystem. Perturbation of this subsystem in solids may
produce a nonequilibrium state which is then relaxed to an equilibrium state
due to the interaction between the particles or with a thermal bath (lattice).
The generalized kinetic equations were derived previously for a system weakly
coupled to a thermal bath to elucidate the nature of transport and relaxation
processes. In this paper, these results are used to describe the relaxation and
diffusion of nuclear spins in solids. The aim is to formulate a successive and
coherent microscopic description of the nuclear magnetic relaxation and
diffusion in solids. The nuclear spin-lattice relaxation is considered and the
Gorter relation is derived. As an example, a theory of spin diffusion of the
nuclear magnetic moment in dilute alloys (like Cu-Mn) is developed. It is shown
that due to the dipolar interaction between host nuclear spins and impurity
spins, a nonuniform distribution in the host nuclear spin system will occur and
consequently the macroscopic relaxation time will be strongly determined by the
spin diffusion. The explicit expressions for the relaxation time in certain
physically relevant cases are given.Comment: 41 pages, 119 Refs. Corrected typos, added reference
Final NOMAD results on nu_mu->nu_tau and nu_e->nu_tau oscillations including a new search for nu_tau appearance using hadronic tau decays
Results from the nu_tau appearance search in a neutrino beam using the full
NOMAD data sample are reported. A new analysis unifies all the hadronic tau
decays, significantly improving the overall sensitivity of the experiment to
oscillations. The "blind analysis" of all topologies yields no evidence for an
oscillation signal. In the two-family oscillation scenario, this sets a 90%
C.L. allowed region in the sin^2(2theta)-Delta m^2 plane which includes
sin^2(2theta)<3.3 x 10^{-4} at large Delta m^2 and Delta m^2 < 0.7 eV^2/c^4 at
sin^2(2theta)=1. The corresponding contour in the nu_e->nu_tau oscillation
hypothesis results in sin^2(2theta)<1.5 x 10^{-2} at large Delta m^2 and Delta
m^2 < 5.9 eV^2/c^4 at sin^2(2theta)=1. We also derive limits on effective
couplings of the tau lepton to nu_mu or nu_e.Comment: 46 pages, 16 figures, Latex, to appear on Nucl. Phys.
Inclusive production of and mesons in charged current interactions
The inclusive production of the meson resonances ,
and in neutrino-nucleus charged current interactions has been
studied with the NOMAD detector exposed to the wide band neutrino beam
generated by 450 GeV protons at the CERN SPS. For the first time the
meson is observed in neutrino interactions. The statistical
significance of its observation is 6 standard deviations. The presence of
in neutrino interactions is reliably established. The average
multiplicity of these three resonances is measured as a function of several
kinematic variables. The experimental results are compared to the
multiplicities obtained from a simulation based on the Lund model. In addition,
the average multiplicity of in antineutrino - nucleus
interactions is measured.Comment: 23 pages, 14 figures, 8 tables. To appear in Nucl. Phys.
Prediction of Neutrino Fluxes in the NOMAD Experiment
The method developed for the calculation of the flux and composition of the
West Area Neutrino Beam used by NOMAD in its search for neutrino oscillations
is described. The calculation is based on particle production rates computed
using a recent version of FLUKA and modified to take into account the cross
sections measured by the SPY and NA20 experiments. These particles are
propagated through the beam line taking into account the material and magnetic
fields they traverse. The neutrinos produced through their decays are tracked
to the NOMAD detector. The fluxes of the four neutrino flavours at NOMAD are
predicted with an uncertainty of about 8% for nu(mu) and nu(e), 10% for
antinu(mu), and 12% for antinu(e). The energy-dependent uncertainty achieved on
the R(e, mu) prediction needed for a nu(mu)->nu(e) oscillation search ranges
from 4% to 7%, whereas the overall normalization uncertainty on this ratio is
4.2%.Comment: 43 pages, 20 figures. Submitted to Nucl. Phys.
Search for the exotic resonance in the NOMAD experiment
A search for exotic Theta baryon via Theta -> proton +Ks decay mode in the
NOMAD muon neutrino DIS data is reported. The special background generation
procedure was developed. The proton identification criteria are tuned to
maximize the sensitivity to the Theta signal as a function of xF which allows
to study the Theta production mechanism. We do not observe any evidence for the
Theta state in the NOMAD data. We provide an upper limit on Theta production
rate at 90% CL as 2.13 per 1000 of neutrino interactions.Comment: Accepted to European Physics Journal
Search for nu(mu)-->nu(e) Oscillations in the NOMAD Experiment
We present the results of a search for nu(mu)-->nu(e) oscillations in the
NOMAD experiment at CERN. The experiment looked for the appearance of nu(e) in
a predominantly nu(mu) wide-band neutrino beam at the CERN SPS. No evidence for
oscillations was found. The 90% confidence limits obtained are delta m^2 < 0.4
eV^2 for maximal mixing and sin^2(2theta) < 1.4x10^{-3} for large delta m^2.
This result excludes the LSND allowed region of oscillation parameters with
delta m^2 > 10 eV^2.Comment: 19 pages, 8 figures. Submitted to Phys. Lett.
A Study of Strange Particles Produced in Neutrino Neutral Current Interactions in the NOMAD Experiment
Results of a detailed study of strange particle production in neutrino
neutral current interactions are presented using the data from the NOMAD
experiment. Integral yields of neutral strange particles (K0s, Lambda,
Lambda-bar) have been measured. Decays of resonances and heavy hyperons with an
identified K0s or Lambda in the final state have been analyzed. Clear signals
corresponding to K* and Sigma(1385) have been observed. First results on the
measurements of the Lambda polarization in neutral current interactions have
been obtained.Comment: Accepted for publication in Nuclear Physics B as a rapid
communicatio
Search for heavy neutrinos mixing with tau neutrinos
We report on a search for heavy neutrinos (\nus) produced in the decay
D_s\to \tau \nus at the SPS proton target followed by the decay \nudecay in
the NOMAD detector. Both decays are expected to occur if \nus is a component
of .\
From the analysis of the data collected during the 1996-1998 runs with
protons on target, a single candidate event consistent with
background expectations was found. This allows to derive an upper limit on the
mixing strength between the heavy neutrino and the tau neutrino in the \nus
mass range from 10 to 190 . Windows between the SN1987a and Big Bang
Nucleosynthesis lower limits and our result are still open for future
experimental searches. The results obtained are used to constrain an
interpretation of the time anomaly observed in the KARMEN1 detector.\Comment: 20 pages, 7 figures, a few comments adde
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