Continuous borehole optical televiewing reveals variable englacial debris concentrations at Khumbu Glacier, Nepal

Surface melting of High Mountain Asian debris-covered glaciers shapes the seasonal water supply to millions of people. This melt is strongly influenced by the spatially variable thickness of the supraglacial debris layer, which is itself partially controlled by englacial debris concentration and melt-out. Here, we present measurements of deep englacial debris concentrations from debris-covered Khumbu Glacier, Nepal, based on four borehole optical televiewer logs, each up to 150 m long. The mean borehole englacial debris content is ≤ 0.7% by volume in the glacier’s mid-to-upper ablation area, and increases to 6.4% by volume near the terminus. These concentrations are higher than those reported for other valley glaciers, although those measurements relate to discrete samples while our approach yields a continuous depth profile. The vertical distribution of englacial debris increases with depth, but is also highly variable, which will complicate predictions of future rates of surface melt and debris exhumation at such glaciers

The Role of Differential Ablation and Dynamic Detachment in Driving Accelerating Mass Loss From a Debris-Covered Himalayan Glacier

Sustained mass loss from Himalayan glaciers is causing supraglacial debris to expand and thicken, with the expectation that thicker debris will suppress ablation and extend glacier longevity. However, debris-covered glaciers are losing mass at similar rates to clean-ice glaciers in High Mountain Asia. This rapid mass loss is attributed to the combined effects of; (a) low or reversed mass balance gradients across debris-covered glacier tongues, (b) differential ablation processes that locally enhance ablation within the debris-covered section of the glacier, for example, at ice cliffs and supraglacial ponds, and (c) a decrease in ice flux from the accumulation area in response to climatic warming. Adding meter-scale spatial variations in supraglacial debris thickness to an ice-flow model of Khumbu Glacier, Nepal, increased mass loss by 47% relative to simulations assuming a continuous debris layer over a 31-year period (1984–2015 CE) but overestimated the reduction in ice flux. Therefore, we investigated if simulating the effects of dynamic detachment of the upper active glacier from the debris-covered tongue would give a better representation of glacier behavior, as suggested by observations of change in glacier dynamics and structure indicating that this process occurred during the last 100 years. Observed glacier change was reproduced more reliably in simulations of the active, rather than entire, glacier extent, indicating that Khumbu Glacier has passed a dynamic tipping point by dynamically detaching from the heavily debris-covered tongue that contains 20% of the former ice volume

Be‐10 dating of ice‐marginal moraines in the Khumbu Valley, Nepal, Central Himalaya, reveals the response of monsoon‐influenced glaciers to Holocene climate change

The dynamic response of large mountain glaciers to climatic forcing operates over timescales of several centuries and therefore understanding how these glaciers change requires observations of their behavior through the Holocene. We used Be-10 exposure-age dating and geomorphological mapping to constrain the evolution of glaciers in the Khumbu Valley in the Everest region of Nepal. Khumbu and Lobuche Glaciers are surrounded by high-relief lateral and terminal moraines from which seven glacial stages were identified and dated to 7.4 ± 0.2, 5.0 ± 0.3, 3.9 ± 0.1, 2.8 ± 0.2, 1.3 ± 0.1, 0.9 ± 0.02, and 0.6 ± 0.16 ka. These stages correlate to each of the seven latest Holocene regional glacial stages identified across the monsoon-influenced Himalaya, demonstrating that a coherent record of high elevation terrestrial palaeoclimate change can be extracted from dynamic mountain landscapes. The time-constrained moraine complex represents a catchment-wide denudation rate of 0.8–1.4 mm a−1 over the last 8 kyr. The geometry of the ablation area of Khumbu Glacier changed around 4 ka from a broad, shallow ice tongue to become narrower and thicker as restricted by the topographic barrier of the terminal moraine complex

Correlation of gene expression with magnetic resonance imaging features of retinoblastoma: a multi-center radiogenomics validation study

OBJECTIVES To validate associations between MRI features and gene expression profiles in retinoblastoma, thereby evaluating the repeatability of radiogenomics in retinoblastoma. METHODS In this retrospective multicenter cohort study, retinoblastoma patients with gene expression data and MRI were included. MRI features (scored blinded for clinical data) and matched genome-wide gene expression data were used to perform radiogenomic analysis. Expression data from each center were first separately processed and analyzed. The end product normalized expression values from different sites were subsequently merged by their Z-score to permit cross-sites validation analysis. The MRI features were non-parametrically correlated with expression of photoreceptorness (radiogenomic analysis), a gene expression signature informing on disease progression. Outcomes were compared to outcomes in a previous described cohort. RESULTS Thirty-six retinoblastoma patients were included, 15 were female (42%), and mean age was 24 (SD 18) months. Similar to the prior evaluation, this validation study showed that low photoreceptorness gene expression was associated with advanced stage imaging features. Validated imaging features associated with low photoreceptorness were multifocality, a tumor encompassing the entire retina or entire globe, and a diffuse growth pattern (all p < 0.05). There were a number of radiogenomic associations that were also not validated. CONCLUSIONS A part of the radiogenomic associations could not be validated, underlining the importance of validation studies. Nevertheless, cross-center validation of imaging features associated with photoreceptorness gene expression highlighted the capability radiogenomics to non-invasively inform on molecular subtypes in retinoblastoma. CLINICAL RELEVANCE STATEMENT Radiogenomics may serve as a surrogate for molecular subtyping based on histopathology material in an era of eye-sparing retinoblastoma treatment strategies. KEY POINTS - Since retinoblastoma is increasingly treated using eye-sparing methods, MRI features informing on molecular subtypes that do not rely on histopathology material are important. - A part of the associations between retinoblastoma MRI features and gene expression profiles (radiogenomics) were validated. - Radiogenomics could be a non-invasive technique providing information on the molecular make-up of retinoblastoma

Individuals in urban dwelling primate species face unequal benefits associated with living in an anthropogenic environment

In primates, living in an anthropogenic environment can significantly improve an individual’s fitness, which is likely attributed to access to anthropogenic food resources. However, in non-professionally provisioned groups, few studies have examined whether individual attributes, such as dominance rank and sex, affect primates’ ability to access anthropogenic food. Here, we investigated whether rank and sex explain individual differences in the proportion of anthropogenic food consumed by macaques. We observed 319 individuals living in nine urban groups across three macaque species. We used proportion of anthropogenic food in the diet as a proxy of access to those food resources. Males and high-ranking individuals in both sexes had significantly higher proportions of anthropogenic food in their diets than other individuals. We speculate that unequal access to anthropogenic food resources further increases within-group competition, and may limit fitness benefits in an anthropogenic environment to certain individuals.This work was supported by the U.S. National Science Foundation (Grant no. 1518555)

SRT1720 improves survival and healthspan of obese mice

Sirt1 is an NAD+-dependent deacetylase that extends lifespan in lower organisms and improves metabolism and delays the onset of age-related diseases in mammals. Here we show that SRT1720, a synthetic compound that was identified for its ability to activate Sirt1 in vitro, extends both mean and maximum lifespan of adult mice fed a high-fat diet. This lifespan extension is accompanied by health benefits including reduced liver steatosis, increased insulin sensitivity, enhanced locomotor activity and normalization of gene expression profiles and markers of inflammation and apoptosis, all in the absence of any observable toxicity. Using a conditional SIRT1 knockout mouse and specific gene knockdowns we show SRT1720 affects mitochondrial respiration in a Sirt1- and PGC-1α-dependent manner. These findings indicate that SRT1720 has long-term benefits and demonstrate for the first time the feasibility of designing novel molecules that are safe and effective in promoting longevity and preventing multiple age-related diseases in mammals

SRT1720 improves survival and healthspan of obese mice

Sirt1 is an NAD1-dependent deacetylase that extends lifespan in lower organisms and improves metabolism and delays the onset of age-related diseases in mammals. Here we show that SRT1720, a synthetic compound that was identified for its ability to activate Sirt1 in vitro, extends both mean and maximum lifespan of adult mice fed a high-fat diet. This lifespan extension is accompanied by health benefits including reduced liver steatosis, increased insulin sensitivity, enhanced locomotor activity and normalization of gene expression profiles and markers of inflammation and apoptosis, all in the absence of any observable toxicity. Using a conditional SIRT1 knockout mouse and specific gene knockdowns we show SRT1720 affects mitochondrial respiration in a Sirt1- and PGC-1a-dependent manner. These findings indicate that SRT1720 has long-term benefits and demonstrate for the first time the feasibility of designing novel molecules that are safe and effective in promoting longevity and preventing multiple age-related diseases in mammals