Unaccommodated man: the pastoral care of the mentally handicapped

This thesis attempts to look at the issue of pastoral care of the mentally handicapped from various angles raising question like the following: “Is it necessary to care pastorally for mentally handicapped people?” ”Can they be regarded as persons?” “If so, what are their special needs and how can we meet them?” “Is it possible for them to develop their potential?” “Are they educable so that they can be helped to do this?” “What methods can best be used to help them achieve this potential?” “How will an understanding of such methods affect the pastoral care of such people?” “Have they any contribution to make to the church and their community?”.The method used to raise these questions and to arrive at some of the answers is one of personal reflection upon actual experience coupled with current thinking on the issues involved in philosophy, psychology, education, theology and spirituality. From this approach it is hoped to demonstrate that he answer to the questions above can be positive, and that a key factor in developing the potential of the mentally handicapped, as for anyone, is the relationship which an individual has with other people and with God. If we do justice to what we discover by examination we will see that the potential contribution of the mentally handicapped to the church is vitally important at three levels, namely, theological, spiritual and practical (i.e. in terms of actual workship). We will see that a church which has no place for such people is deficient and unbalanced. We will also discover that the community is similarly deficient if it cannot provide the opportunities for these people to develop their potential and if it cannot accept the vital contribution they have to offer

Binding of bacteria to poly (N-isopropylacrylamide) modified with vancomycin: Comparison of behavior of linear and highly branched polymers

YesThe behavior of a linear copolymer of N-isopropyl acrylamide with pendant vancomycin functionality was compared to an analogous highly branched copolymer with vancomycin functionality at the chain ends. Highly branched poly(N-isopropylacrylamide) modified with vancomycin (HB-PNIPAM-van) was synthesized by functionalization of the HB-PNIPAM, prepared using reversible addition-fragmentation chain transfer polymerization. Linear PNIPAM with pendant vancomycin functionality (L-PNIPAM-van) was synthesized by functionalization of poly(N-isopropyl acrylamide-co-vinyl benzoic acid). HB-PNIPAM-van aggregated S. aureus effectively whereas the L-PNIPAM-van polymer did not. It was found that when the HB-PNIPAM-van was incubated with S. aureus the resultant phase transition provided an increase in the intensity of fluorescence of a solvatochromic dye, nile red, added to the system. In contrast, a significantly lower increase in fluorescence intensity was obtained when L-PNIPAM-van was incubated with S. aureus. These data showed that the degree of desolvation of HB-PNIPAM-van was much greater than the desolvation of the linear version. Using microCalorimetry it was shown that there were no significant differences in the affinities of the polymer ligands for D-Ala-D-Ala and therefore differences in the interactions with bacteria were associated with changes in the probability of access of the polymer bound ligands to the D-Ala-D-Ala dipeptide. The data support the hypothesis that generation of polymer systems that respond to cellular targets, for applications such as cell targeting, detection of pathogens etc., requires the use of branched polymers with ligands situated at the chain ends.MR

Subsurface structure in polished fused silica and diamond turned single crystal silicon

The surface and near surface structure of glass and other optical materials is greatly influenced by the nature of the processes used to generate that surface. In high quality optics, the effects of process changes are often subtle and cannot be seen with conventional metrology. The presence of process induced damage in the near surface region is felt in a number of ways. Damage thresholds for optics subjected to high fluences are a particular problem in UV or high-powered laser systems. In high quality glass, the chemical and material composition of the outermost layer is influenced principally by the grinding, lapping and polishing processes used in fabrication. Performance in high fluence applications is often dominated by these process-induced inhomogeneities in the first few hundred nanometers of material. Each succeeding step in a process is designed to remove the damage from the previous operation. However, any force against the surface, no matter how slight will leave evidence of damage. Fabrication processes invariably create dislocations, cracks and plastic deformation between 100 nm and 500 nm below the surface. In glass polishing, the first 100 nm is comprised of material redeposited from the polishing solution. This redeposition layer is responsible for the extremely smooth surfaces that can be generated on glass. Unfortunately, this layer also conceals many flaws present in the deeper surface regions

Seasonal evolution of Aleutian low pressure systems: Implications for the North Pacific subpolar circulation

The seasonal change in the development of Aleutian low pressure systems from early fall to early winter is analyzed using a combination of meteorological reanalysis fields, satellite sea surface temperature (SST) data, and satellite wind data. The time period of the study is September–December 2002, although results are shown to be representative of the long-term climatology. Characteristics of the storms were documented as they progressed across the North Pacific, including their path, central pressure, deepening rate, and speed of translation. Clear patterns emerged. Storms tended to deepen in two distinct geographical locations—the Gulf of Alaska in early fall and the western North Pacific in late fall. In the Gulf of Alaska, a quasi-permanent “notch” in the SST distribution is argued to be of significance. The signature of the notch is imprinted in the atmosphere, resulting in a region of enhanced cyclonic potential vorticity in the lower troposphere that is conducive for storm development. Later in the season, as winter approaches and the Sea of Okhotsk becomes partially ice covered and cold, the air emanating from the Asian continent leads to enhanced baroclinicity in the region south of Kamchatka. This corresponds to enhanced storm cyclogenesis in that region. Consequently, there is a seasonal westward migration of the dominant lobe of the Aleutian low. The impact of the wind stress curl pattern resulting from these two regions of storm development on the oceanic circulation is investigated using historical hydrography. It is argued that the seasonal bimodal input of cyclonic vorticity from the wind may be partly responsible for the two distinct North Pacific subarctic gyres

Citizenship and Identity: the self-image of secondary school students in England and Catalonia

© 2015 Society for Educational Studies We discuss the ways in which English and Catalan students perceive themselves as members of communities and as citizens and the role of schools in these perceptions. Questionnaire and interview data were collected and analysed from 583 secondary school students in a total of 9 schools that were known for their commitment to citizenship education in England and Catalonia. The research took place when issues of national and other identities were prominently discussed in the media and elsewhere and when significant changes were being introduced in both locations regarding citizenship education as a specific curriculum subject and also in the wider context of education and schooling. Our results suggest that while the English students in our sample understand citizenship in terms of a subjective identification, our Catalan students perceive citizenship as a legal and externally assigned status. We did not intend to obtain nationally representative samples but rather to gain in-depth knowledge of the data and to discuss the implications of these results for the differing purposes of citizenship education. We make recommendations for how school-based citizenship education may contribute to current challenges related to citizenship and identities

CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers

Funder: Breast Cancer Now (BCN); doi: https://doi.org/10.13039/100009794Funder: Cancer Research UK (CRUK); doi: https://doi.org/10.13039/501100000289Funder: RCUK | Medical Research Council (MRC); doi: https://doi.org/10.13039/501100000265Funder: U.S. Department of Health & Human Services | National Institutes of Health (NIH)Funder: Wellcome Trust (Wellcome); doi: https://doi.org/10.13039/100004440Funder: EC | EC Seventh Framework Programm | FP7 Ideas: European Research Council (FP7-IDEAS-ERC - Specific Programme: "Ideas" Implementing the Seventh Framework Programme of the European Community for Research, Technological Development and Demonstration Activities (2007 to 2013)); doi: https://doi.org/10.13039/100011199; Grant(s): HEALTH-F2-2009-223175, HEALTH-F2-2009-223175Funder: Genome Canada (Génome Canada); doi: https://doi.org/10.13039/100008762Funder: Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada); doi: https://doi.org/10.13039/501100000024Funder: Quebec Breast cancer Foundation Genome QuebecFunder: U.S. Department of Health & Human Services | NIH | U.S. National Library of Medicine (NLM); doi: https://doi.org/10.13039/100000092Funder: EC | EC Seventh Framework Programm | FP7 Ideas: European Research Council (FP7-IDEAS-ERC - Specific Programme: "Ideas" Implementing the Seventh Framework Programme of the European Community for Research, Technological Development and Demonstration Activities (2007 to 2013))Funder: European Union’s Horizon 2020Funder: Deutsche Krebshilfe (German Cancer Aid); doi: https://doi.org/10.13039/501100005972Funder: BCAST - European Union’s Horizon 2020Funder: Breast Cancer Now; doi: https://doi.org/10.13039/501100007913Abstract: Background: Epidemiological studies provide strong evidence for a role of endogenous sex hormones in the aetiology of breast cancer. The aim of this analysis was to identify genetic variants that are associated with urinary sex-hormone levels and breast cancer risk. Methods: We carried out a genome-wide association study of urinary oestrone-3-glucuronide and pregnanediol-3-glucuronide levels in 560 premenopausal women, with additional analysis of progesterone levels in 298 premenopausal women. To test for the association with breast cancer risk, we carried out follow-up genotyping in 90,916 cases and 89,893 controls from the Breast Cancer Association Consortium. All women were of European ancestry. Results: For pregnanediol-3-glucuronide, there were no genome-wide significant associations; for oestrone-3-glucuronide, we identified a single peak mapping to the CYP3A locus, annotated by rs45446698. The minor rs45446698-C allele was associated with lower oestrone-3-glucuronide (−49.2%, 95% CI −56.1% to −41.1%, P = 3.1 × 10–18); in follow-up analyses, rs45446698-C was also associated with lower progesterone (−26.7%, 95% CI −39.4% to −11.6%, P = 0.001) and reduced risk of oestrogen and progesterone receptor-positive breast cancer (OR = 0.86, 95% CI 0.82–0.91, P = 6.9 × 10–8). Conclusions: The CYP3A7*1C allele is associated with reduced risk of hormone receptor-positive breast cancer possibly mediated via an effect on the metabolism of endogenous sex hormones in premenopausal women

COMT integrative MAVEs dataset

<p>Data to reproduce <i>COMT</i> integrative MAVEs analysis</p&gt

Devaluations, Revaluations and Stock Market Prices.

Ph.D.FinanceUniversity of Michiganhttp://deepblue.lib.umich.edu/bitstream/2027.42/157373/1/7510177.pd

ijhoskins/satmut_utils: v1.1.0-dev

Added support for simple insertion and deletion calling. Added MAVE-HGVS annotations

ijhoskins/satmut_utils: v1.1.3-dev

<p>Ensure HGVS annotations use uppercase bases to ensure compatibility with MAVEdb.</p> <p>Fixed run_mave_hgvs_annot.py script to require target BED and fix bug in deletion-insertion MAVE-HGVS string.</p&gt