Evaluation of a spring-powered captive bolt gun for killing kangaroo pouch young

Context: During commercial harvesting or non-commercial kangaroo culling programs, dependent young of shot females are required to be euthanased to prevent suffering and because they would be unlikely to survive. However, the current method for killing pouch young, namely a single, forceful blow to the base of the skull, is applied inconsistently by operators and perceived by the public to be inhumane. Aims: To determine whether an alternative method for killing pouch young, namely a spring-operated captive bolt gun, is effective at causing insensibility in kangaroo pouch young. Methods: Trials of spring-operated captive bolt guns were conducted first on the heads of 15 dead kangaroo young and then on 21 live pouch young during commercial harvesting. We assessed the effectiveness at causing insensibility in live animals and damage caused to specific brain areas. We also measured depth of bolt penetration and skull thickness. Performance characteristics (e.g. bolt velocity) of two types of spring-operated guns were also measured and compared with cartridge-powered devices. Key results: When tested on the heads of dead animals, the spring-operated captive bolt gun consistently produced a large entrance cavity and a well defined wound tract, which extended into the cerebrum, almost extending the full thickness of the brain, including the brainstem. When tested on live pouch young, the captive bolt gun caused immediate insensibility in only 13 of 21 animals. This 62% success rate is significantly below the 95% minimum acceptable threshold for captive bolt devices in domestic animal abattoirs. Failure to stun was related to bolt placement, but other factors such as bolt velocity, bolt diameter and skull properties such as thickness and hardness might have also contributed. Spring-operated captive bolt guns delivered 20 times less kinetic energy than did cartridge-powered devices. Conclusions: Spring-operated captive bolt guns cannot be recommended as an acceptable or humane method for stunning or killing kangaroo pouch young. Implications: Captive bolt guns have potential as a practical alternative to blunt head trauma for effective euthanasia and reducing animal (and observer) distress. However, operators must continue to use the existing prescribed killing methods until cartridge-powered captive bolt guns have been trialled as an alternative bolt propelling method. Additional keywords: animal welfare, blunt trauma, culling, euthanasia, humaneness, kangaroo harvesting

Constraints on thick disc and halo parameters from HST photometry of field stars in the Galaxy

We analyse a sample of over 1000 stars from 32 fields imaged in the V and I bands with the Wide Field and Planetary Camera, on board of the Hubble Space Telescope. The fields are located at Galactic latitudes | b | >= 15deg and in various directions on the sky. We consider models for the structure of the Galaxy with different choices for the main parameters governing the shape and luminosity function of the thick disk and stellar halo. Comparing model predictions with the observed colour-magnitude diagram we are able to rule out an increasing or flat stellar luminosity function at the low-luminosity end. We also rule out large values of the vertical scale height of the thick disc, z_0, finding it to be in the range 800 <= z_0 <= 1200 pc. As for the local density normalization, values within the range 4 % <= n_0 <= 8 % seem to better reproduce the data. Our data essentially rule out a flattened stellar halo (c/a <~ 0.5) or models with both large local normalization and effective radii.Comment: 7 pages LaTeX, 9 Postscript figure

Bose condensates in a harmonic trap near the critical temperature

The mean-field properties of finite-temperature Bose-Einstein gases confined in spherically symmetric harmonic traps are surveyed numerically. The solutions of the Gross-Pitaevskii (GP) and Hartree-Fock-Bogoliubov (HFB) equations for the condensate and low-lying quasiparticle excitations are calculated self-consistently using the discrete variable representation, while the most high-lying states are obtained with a local density approximation. Consistency of the theory for temperatures through the Bose condensation point requires that the thermodynamic chemical potential differ from the eigenvalue of the GP equation; the appropriate modifications lead to results that are continuous as a function of the particle interactions. The HFB equations are made gapless either by invoking the Popov approximation or by renormalizing the particle interactions. The latter approach effectively reduces the strength of the effective scattering length, increases the number of condensate atoms at each temperature, and raises the value of the transition temperature relative to the Popov approximation. The renormalization effect increases approximately with the log of the atom number, and is most pronounced at temperatures near the transition. Comparisons with the results of quantum Monte Carlo calculations and various local density approximations are presented, and experimental consequences are discussed.Comment: 15 pages, 11 embedded figures, revte

GRB 010921: Strong Limits on an Underlying Supernova from HST

GRB 010921 was the first HETE-2 GRB to be localized via its afterglow emission. The low-redshift of the host galaxy, z=0.451, prompted us to undertake intensive multi-color observations with the Hubble Space Telescope with the goal of searching for an underlying supernova component. We do not detect any coincident supernova to a limit 1.34 mag fainter than SN 1998bw at 99.7% confidence, making this one of the most sensitive searches for an underlying SN. Analysis of the afterglow data allow us to infer that the GRB was situated behind a net extinction (Milky Way and the host galaxy) of A_V ~ 1.8 mag in the observer frame. Thus, had it not been for such heavy extinction our data would have allowed us to probe for an underlying SN with brightness approaching those of more typical Type Ib/c supernovae

Broadband Observations of the Afterglow of GRB 000926: Observing the Effect of Inverse Compton Scattering and Evidence for a High-Density Environment

GRB 000926 has one of the best-studied afterglows to-date, with multiple X-ray observations, as well as extensive multi-frequency optical and radio coverage. Broadband afterglow observations, spanning from X-ray to radio frequencies, provide a probe of the density structure of the circumburst medium, as well as of the ejecta energetics, geometry, and the physical parameters of the relativistic blastwave resulting from the explosion. We present an analysis of {\em Chandra X-ray Observatory} observations of this event, along with {\em Hubble Space Telescope} and radio monitoring. We combine these data with ground-based optical and IR observations and fit the synthesized afterglow lightcurve using models where collimated ejecta expand into a surrounding medium. We find that we can explain the broadband lightcurve with reasonable physical parameters only if the cooling is dominated by inverse Compton scattering. Excess X-ray emission in the broadband spectrum indicates that we are directly observing a contribution from inverse Compton scattering. It is the first time this has been observed in a GRB afterglow, and it implies that the GRB exploded in a reasonably dense (n~30 cm^{-3}) medium, consistent with a diffuse interstellar cloud environment.Comment: 16 pages, 5 figures Accepted for publication in the Astrophysical Journa

Exploring venlafaxine pharmacokinetic variability with a phenotyping approach, a multicentric french-swiss study (MARVEL study).

It is well known that the standard doses of a given drug may not have equivalent effects in all patients. To date, the management of depression remains mainly empirical and often poorly evaluated. The development of a personalized medicine in psychiatry may reduce treatment failure, intolerance or resistance, and hence the burden and costs of mood depressive disorders. The Geneva Cocktail Phenotypic approach presents several advantages including the "in vivo" measure of different cytochromes and transporter P-gp activities, their simultaneous determination in a single test, avoiding the influence of variability over time on phenotyping results, the administration of low dose substrates, a limited sampling strategy with an analytical method developed on DBS analysis. The goal of this project is to explore the relationship between the activity of drug-metabolizing enzymes (DME), assessed by a phenotypic approach, and the concentrations of Venlafaxine (VLX) + O-demethyl-venlafaxine (ODV), the efficacy and tolerance of VLX. This study is a multicentre prospective non-randomized open trial. Eligible patients present a major depressive episode, MADRS over or equal to 20, treatment with VLX regardless of the dose during at least 4 weeks. The Phenotype Visit includes VLX and ODV concentration measurement. Following the oral absorption of low doses of omeprazole, midazolam, dextromethorphan, and fexofenadine, drug metabolizing enzymes activity is assessed by specific metabolite/probe concentration ratios from a sample taken 2 h after cocktail administration for CYP2C19, CYP3A4, CYP2D6; and by the determination of the limited area under the curve from the capillary blood samples taken 2-3 and 6 h after cocktail administration for CYP2C19 and P-gp. Two follow-up visits will take place between 25 and 40 days and 50-70 days after inclusion. They include assessment of efficacy, tolerance and observance. Eleven french centres are involved in recruitment, expected to be completed within approximately 2 years with 205 patients. Metabolic ratios are determined in Geneva, Switzerland. By showing an association between drug metabolism and VLX concentrations, efficacy and tolerance, there is a hope that testing drug metabolism pathways with a phenotypical approach would help physicians in selecting and dosing antidepressants. The MARVEL study will provide an important contribution to increasing the knowledge of VLX variability and in optimizing the use of methods of personalized therapy in psychiatric settings. ClinicalTrials.gov NCT02590185 (10/27/2015). This study is currently recruiting participants