Disease mapping of early- and late-stage cancer to monitor inequalities in early detection: a study of cutaneous malignant melanoma

We consider disease mapping of early- and late-stage cancer, in order to identify and monitor inequalities in early detection. Our method is demonstrated by mapping cancer incidence at high geographical resolution using data on 10,302 cutaneous malignant melanoma (CMM) cases within the 3.7 million population of South-West Sweden. The cases were geocoded into small-areas, each with a population size between 600 and 2600 and accessible socio-demographic data. Using the disease mapping application Rapid Inquiry Facility (RIF) 4.0, we produced regional maps to visualise spatial variations in stage I, II and III–IV CMM incidences, complemented by local maps to explore the variations within two urban areas. Pronounced spatial disparities in stage I CMM incidence were revealed by the regional and local maps. Stage I CMM incidence was markedly higher in wealthier small-areas, in particular within each urban area. A twofold higher stage I incidence was observed, on average, in the wealthiest small-areas (upper quintile) than in the poorest small-areas (lower quintile). We identified in the regional map of stage III–IV CMM two clusters of higher or lower than expected late-stage incidences which were quite distinct from those identified for stage I. In conclusion, our analysis of CMM incidences supported the use of this method of cancer stage incidence mapping for revealing geographical and socio-demographic disparities in cancer detection

HST/STIS Imaging of the Host Galaxy of GRB980425/SN1998bw

We present HST/STIS observations of ESO 184-G82, the host galaxy of the gamma-ray burst GRB 980425 associated with the peculiar Type Ic supernova SN1998bw. ESO 184-G82 is found to be an actively star forming SBc sub-luminous galaxy. We detect an object consistent with being a point source within the astrometric uncertainty of 0.018 arcseconds of the position of the supernova. The object is located inside a star-forming region and is at least one magnitude brighter than expected for the supernova based on a simple radioactive decay model. This implies either a significant flattening of the light curve or a contribution from an underlying star cluster.Comment: 12 pages, 2 figures, AASTeX v5.02 accepted for publication in ApJ Letter

Description of even-even triaxial Nuclei within the Coherent State and the Triaxial Rotation-Vibration Models

The coherent state model (CSM) and the triaxial rotation-vibration model (TRVM) are alternatively used to describe the ground, gamma and beta bands of 228Th. CSM is also applied to the nuclei 126Xe and 130Ba, which were recently considered in TRVM. The two models are compared with respect to both their underlying assumptions and to their predicted results for energy levels and E2 branching ratios. Both models describe energies and quadrupole transitions of 228Th equally well and in good agreement with experiment, if the 0$_3^+$ level at 1120 keV is interpreted as the head of the beta band. The other two 0$^+$ levels at 832 and 939 keV are most likely not of a pure quadrupole vibration nature as has already been pointed out in the literature.Comment: 31 pages, RevTeX, 6 figure

Colorectal cancer screening with fecal immunochemical testing or primary colonoscopy:An analysis of health equity based on a randomised trial

Background: We have addressed health equity attained by fecal immunochemical testing (FIT) and primary colonoscopy (PCOL), respectively, in the randomised controlled screening trial SCREESCO conducted in Sweden. Methods: We analysed data on the individuals recruited between March 2014, and March 2020, within the study registered with ClinicalTrials.gov, NCT02078804. Swedish population registry data on educational level, household income, country of birth, and marital status were linked to each 60-year-old man and woman who had been randomised to two rounds of FIT 2 years apart (n = 60,123) or once-only PCOL (n = 30,390). Furthermore, we geo-coded each study individual to his/her residential area and assessed neighbourhood-level data on deprivation, proportion of non-Western immigrants, population density, and average distance to healthcare center for colonoscopy. We estimated adjusted associations of each covariate with the colonoscopy attendance proportion out of all invited to respective arms; ie, the preferred outcome for addressing health equity. In the FIT arm, the test uptake and the colonoscopy uptake among the test positives were considered as the secondary outcomes. Findings: We found a marked socioeconomic gradient in the colonoscopy attendance proportion in the PCOL arm (adjusted odds ratio [95% credibility interval] between the groups categorised in the highest vs. lowest national quartile for household income: 2.20 [2.01-2.42]) in parallel with the gradient in the test uptake of the FIT x 2 screening (2.08 [1.96-2.20]). The corresponding gradient in the colonoscopy attendance proportion out of all invited to FIT was less pronounced (1.29 [1.16-1.42]), due to higher proportions of FIT positives in socioeconomically disadvantaged groups. Interpretation: The unintended risk of exacerbating inequalities in health by organised colorectal cancer screening may be higher with a PCOL strategy than a FIT strategy, despite parallel socioeconomic gradients in uptake

Optimal Control of Fed-Batch Fermenters

Optimal control of fed-batch fermenters S. Valentinotti† C. Cannizzaro‡ M.Rhiel‡ U. Holmberg† U. von Stockar‡ D. Bonvin† †Institut d’Automatique, EPFL, 1015 Lausanne, Switzerland ‡Institut de Genie Chimique, EPFL, 1015 Lausanne, Switzerland Fermentors are often run in a fed-batch manner to avoid the formation of overflow metabolites. At a high growth rate, the most efficient metabolic pathway(s) of certain microorganisms become saturated resulting in overflow metabolite production. These byproducts are undesirable since their accumulation in the reactor may be inhibitory and the productivity of biomass and growth-associated products is reduced. The ideal way to run such fed-batch fermentation is to grow the cells in the reactor at the critical growth rate, i.e., the point at which overflow metabolite production begins. However, since this value changes from run to run, or even during a given fermentation, its identification is not trivial. A simple way to overcome this difficulty is to maintain a very small, but constant overflow metabolite concentration in the reactor, ensuring that most of the substrate is consumed efficiently. However due to exponential cell growth, standard controllers can maintain a constant concentration only for a limited time period. In this work an adaptive control strategy to maintain a constant overflow metabolite concentration in fed-batch fermentation is presented. The proposed approach requires the knowledge of only two system parameters: the yield coefficient, expressing the relation between overflow metabolite and substrate, and the instantaneous concentration of the overflow metabolite. Baker’s yeast fed-batch experiments were performed with the ob jective of maximizing biomass productivity and minimizing ethanol production. Mid-infrared spectroscopy was used to measure the ethanol concentration that was provided on-line to the controller. The results from numerous experiments have demonstrated the effectiveness of the proposed control strategy. The specific growth rate was maintained constant, at a value close to the critical point, until oxygen transfer limitation occurred. Then, the controller automatically reduced the feed rate to prevent excess ethanol production. The biomass increased from 0.5 to 65 grams per liter during the exponential growth phase. Simulation results based on this control strategy show its applicability to other overflow metabolite organisms, such as Escherichia coli

The galaxies in the field of the nearby GRB980425/SN1998bw

We present spectroscopic observations of ESO 184-G82, the host galaxy of GRB980425/SN1998bw, and six galaxies in its field. A host redshift of z=0.0087+/-0.0006 is derived, consistent with that measured by Tinney et al. (1998). Redshifts are obtained for the six surrounding galaxies observed. Three of these galaxies lie within 11 Mpc of each other, confirming the suggestion that some of these galaxies form a group. However, all of the field galaxies observed lie at significantly greater distances than ESO 184-G82 and are therefore not associated with it. The host galaxy of GRB980425/SN1998bw thus appears to be an isolated dwarf galaxy and interactions with other galaxies do not seem to be responsible for its star formation.Comment: 5 pages, 2 figures, accepted for publication in A&

A generic C1C^1 map has no absolutely continuous invariant probability measure

Let $M$ be a smooth compact manifold (maybe with boundary, maybe disconnected) of any dimension $d \ge 1$. We consider the set of $C^1$ maps $f:M\to M$ which have no absolutely continuous (with respect to Lebesgue) invariant probability measure. We show that this is a residual (dense $G_\delta) set in the$C^1$ topology. In the course of the proof, we need a generalization of the usual Rokhlin tower lemma to non-invariant measures. That result may be of independent interest.Comment: 12 page

Compact Zernike phase contrast X-ray microscopy using a single-element optic

We demonstrate Zernike phase contrast in a compact soft x-ray microscope using a single-element optic. The optic is a combined imaging zone plate and a Zernike phase plate and does not require any additional alignment or components. Contrast is increased and inversed in an image of a test object using the Zernike zone plate. This type of optic may be implemented into any existing x-ray microscope where phase contrast is of interest