The Jefferson Medical College of Philadelphia: From 1825 to 1908

This brief 1908 history of Jefferson Medical College was written by James W. Holland. An 1868 graduate, Holland went on to become the Dean of Jefferson Medical College in 1887https://jdc.jefferson.edu/jeffersonhistorybooks/1007/thumbnail.jp

Small grain and annual forage legume intercrops for Iowa

Current cropping practices in Iowa have reduced diversity in crop production to predominantly corn and soybean. Low prices, weed and pest control problems, and erosion have plagued these monoculture crop systems. Small grains and forages represent potentially viable alternative crops to corn and soybean in Iowa. Producers could opt for an annual intercrop that provides grain and forage without taking land out of corn and soybean for more than one year. This project tested the possibilities for combining small grains with a forage crop for a one-year intercrop

Economic Impact of Wildlife-Associated Recreation Expenditures in the Southeast United States: A General Equilibrium Analysis

The economic impact of wildlife-associated recreation in the Southeast United States was evaluated using a general equilibrium model. Exogenous demand shocks to the regional economy were based on estimates of expenditures by wildlife recreationists on hunting, fishing, and wildlife watching activities. Counterfactual simulations were carried out, making alternative assumptions about labor and capital mobility and their supply. Without wildlife-associated recreation expenditures, regional employment would have been smaller by up to 783 thousand jobs, and value added would have been $22 to$48 billion less. These findings underscore the significance of regional factor market conditions in economic impact and general equilibrium analysis.general equilibrium modeling, input-output analysis, regional economic impact, wildlife-associated recreation activities, Resource /Energy Economics and Policy, R13, R15, Q26,

Going Beyond NCAA Bylaw 5-1-(j): Developing Learning Prescriptions for Student-Athletes

In recent years academic support programs for the student-athlete have become an integral component of athletic departments at major colleges and universities. This study reports the use of a test-scoring procedure called Modified Confidence Weighted-Admissible Probability Measurement (MCW-APM) to assist athletic department academic support personnel in diagnosing student-athlete knowledge gaps. A series of nine criterion-­referenced tests (CRT) in fundamental knowledge-base areas of mathematics, language arts, and reading at the elementary, secondary and junior college skill levels was administered to a group of freshmen student­ athletes at UCLA. The MCW-APM test-scoring analysis generated specific learning prescriptions for each student-athlete along with information use­cognitive maps to indicate those knowledge-base areas where the student­-athlete was informed, partially informed, uninformed, or misinformed. The learning prescription was then used by the tutorial program staff for developing an individualized instruction plan. Subsequent clustering of student-athletes by information type was used to design courses, workshops, and special programs with instructional objectives towards reeducation (for misinformed areas), instruction (for areas with lack of information) and review (for areas with partial information)

Bone density of the femoral neck following Birmingham hip resurfacing: A 2-year prospective study in 27 hips

Background Resurfacing is a popular alternative to a standard hip replacement in young arthritic patients. Despite bone preservation around the femoral component, there is little information regarding the bone quality

Rotating Scatter Mask Optimization for Gamma Source Direction Identification

Rotating scattering masks have shown promise as an inexpensive, lightweight method with a large field-of-view for identifying the direction of a gamma emitting source or sources. However, further examination of the current rotating scattering mask design shows that changing the geometry may improve the identification by reducing or eliminating degenerate solutions and lower required count times. These changes should produce more linearly independent characteristics for the mask, resulting in a decrease in the mis-identification probability. Three approaches are introduced to generate alternative mask geometries. The eigenvector method uses a spring–mass system to create a geometry basis. The binary approach uses ones and zeros to represent the geometry with many possible combinations allowing for additional design flexibility. Finally, a Hadamard matrix is modified to examine a decoupled geometric solution. Four criteria are proposed for evaluating these methodologies. An analysis of the resulting detector response matrices demonstrates that these methodologies produced masks with superior identification characteristics than the original design. The eigenvector approach produces the least linearly dependent results, but exhibits a decrease in average efficiency. The binary results are more linearly dependent than the eigenvector approach, but this design achieves a higher average efficiency than original. The Hadamard-based method produced a lower maximum, but a higher average linear dependence than the original design. Further possible design enhancements are discussed

The Melanocortin-4 Receptor Integrates Circadian Light Cues and Metabolism

The melanocortin system directs diverse physiological functions from coat color to body weight homoeostasis. A commonality among melanocortin-mediated processes is that many animals modulate similar processes on a circannual basis in response to longer, summer days, suggesting an underlying link between circadian biology and the melanocortin system. Despite key neuroanatomical substrates shared by both circadian and melanocortin-signaling pathways, little is known about the relationship between the two. Here we identify a link between circadian disruption and the control of glucose homeostasis mediated through the melanocortin-4 receptor (Mc4r). Mc4r-deficient mice exhibit exaggerated circadian fluctuations in baseline blood glucose and glucose tolerance. Interestingly, exposure to lighting conditions that disrupt circadian rhythms improve their glucose tolerance. This improvement occurs through an increase in glucose clearance by skeletal muscle and is food intake and body weight independent. Restoring Mc4r expression to the paraventricular nucleus prevents the improvement in glucose tolerance, supporting a role for the paraventricular nucleus in the integration of circadian light cues and metabolism. Altogether these data suggest that Mc4r signaling plays a protective role in minimizing glucose fluctuations due to circadian rhythms and environmental light cues and demonstrate a previously undiscovered connection between circadian biology and glucose metabolism mediated through the melanocortin system

Impact of Neutron Energy on Asteroid Deflection Performance

In the future, a hazardous asteroid will find itself on a collision course with Earth. For asteroids of moderate size or larger, a nuclear device is one of humanity\u27s only technologies capable of mitigating this threat via deflection on a timescale of less than a decade. This work examined how the output neutron energy from a nuclear device standoff detonation affects the deflection of a notional asteroid that is 300 meters in diameter and composed of silicon dioxide at a bulk density of 1.855 g/cm3. 14.1 MeV and 1 MeV neutron energy sources were modeled in MCNP to quantify the energy deposition in the asteroid target. The asteroid\u27s irradiated region was discretized in angle by tracing the rays emanating from the point of detonation and in depth by considering the neutron mean-free-paths. This high-fidelity approach was shown to deviate from previous analytic approximations commonly used for asteroid energy deposition. 50 kt and 1 Mt neutron yields of the energy deposition mappings were imported into a hydrodynamic asteroid model in ALE3D to simulate the deflective response due to blow-off ejecta. Underexplored in literature, changing the neutron energy was found to have up to a 70% impact on deflection performance due to induced differences in the energy deposition profile and in the energy coupling efficiency. The magnitude of energy deposition accounted for most of the observed variation in the asteroid velocity change, making the coupling efficiency more significant than the spatial profile characteristics. These findings are vital for determining the optimal source neutron energy spectrum for asteroid deflection applications

Patients with Diabetes and Significant Epicardial Coronary Artery Disease have Increased Systolic Left Ventricular Apical Rotation and Rotation Rate at Rest

Objective The purpose of this study was to determine whether resting myocardial deformation and rotation may be altered in diabetic patients with significant epicardial coronary artery disease (CAD) with normal left ventricular ejection fraction. Design A prospective observational study. Setting Diagnosis of epicardial CAD in patients with diabetes. Patients and Methods Eighty-four patients with diabetes suspected of epicardial CAD scheduled for cardiac catheterization had a resting echocardiogram performed prior to their procedure. Echocardiographic measurements were compared between patients with and without significant epicardial CAD as determined by cardiac catheterization. Main Outcome Measures Measurement of longitudinal strain, strain rate, apical rotation, and rotation rate, using speckle tracking echocardiography. Results Eighty-four patients were studied, 39 (46.4%) of whom had significant epicardial CAD. Global peak systolic apical rotation was significantly increased (14.9 ± 5.1 vs. 11.0 ± 4.8 degrees, P < 0.001) in patients with epicardial CAD along with faster peak systolic apical rotation rate (90.4 ± 29 vs. 68.1 ± 22.2 degrees/sec, P < 0.001). These findings were further confirmed through multivariate logistic regression analysis (global peak systolic apical rotation OR = 1.17, P = 0.004 and peak systolic apical rotation rate OR = 1.05, P < 0.001). Conclusions Patients with diabetes with significant epicardial CAD and normal LVEF exhibit an increase in peak systolic apical counterclockwise rotation and rotation rate detected by echocardiography, suggesting that significant epicardial CAD and its associated myocardial effects in patients with diabetes may be detected noninvasively at rest