Dystonia and Paroxysmal Dyskinesias: Under-Recognized Movement Disorders in Domestic Animals? A Comparison with Human Dystonia/Paroxysmal Dyskinesias

Dystonia is defined as a neurological syndrome characterized by involuntary sustained or intermittent muscle contractions causing twisting, often repetitive movements, and postures. Paroxysmal dyskinesias are episodic movement disorders encompassing dystonia, chorea, athetosis, and ballism in conscious individuals. Several decades of research have enhanced the understanding of the etiology of human dystonia and dyskinesias that are associated with dystonia, but the pathophysiology remains largely unknown. The spontaneous occurrence of hereditary dystonia and paroxysmal dyskinesia is well documented in rodents used as animal models in basic dystonia research. Several hyperkinetic movement disorders, described in dogs, horses and cattle, show similarities to these human movement disorders. Although dystonia is regarded as the third most common movement disorder in humans, it is often misdiagnosed because of the heterogeneity of etiology and clinical presentation. Since these conditions are poorly known in veterinary practice, their prevalence may be underestimated in veterinary medicine. In order to attract attention to these movement disorders, i.e., dystonia and paroxysmal dyskinesias associated with dystonia, and to enhance interest in translational research, this review gives a brief overview of the current literature regarding dystonia/paroxysmal dyskinesia in humans and summarizes similar hereditary movement disorders reported in domestic animals

Atmospheric controls on hydrogen and oxygen isotope composition of meteoric and surface waters in Patagonia

The southern tip of South America, commonly referred to as Patagonia, is a key area to understand SouthernHemisphere Westerlies (SHW) dynamics and orographic isotope effects in precipitation. However, only few studies haveaddressed these topics. We evaluated the stable isotope (2H, 18O) compositions of precipitation, lentic waters, and lotic waters in that area to characterize and understand isotope fractionation processes associated with orographic rainout, moisture 20 recycling and moisture sources. Observational data were interpreted with the help of backward trajectory modelling of moisturesources using reanalysis climate data. While the Pacific serves as the exclusive moisture source for sites upwind of the Andes and on the immediate downwind area of the Andes, recycled moisture from the continent seems to be the main humidity source at the Patagonian Atlantic coast. In contrast, the Pampean Atlantic coast north of Patagonia obtains moisture from the Atlantic Ocean. In the core zone of the SHW at a latitude of 50° S, a depletion in the heavy isotopes of 10 ? and 85 ?, for 18O and 25 2H, respectively, occurs due to orographic rainout corresponding to a drying ratio of 0.45.Fil: Mayr, Christoph. Universitat Erlangen-Nuremberg; Alemania. Universitat Technical Zu Munich; AlemaniaFil: Langhamer, Lukas. Universidad de Innsbruck; AustriaFil: Wissel, Holger. Universitat Erlangen-Nuremberg; AlemaniaFil: Meier, Wolfgang. Universitat Erlangen-Nuremberg; AlemaniaFil: Sauter, Tobias. Universitat Erlangen-Nuremberg; AlemaniaFil: Laprida, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; ArgentinaFil: Massaferro, Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Administración de Parques Nacionales. Delegación Regional Patagonia; ArgentinaFil: Försterra, Günter. Pontificia Universidad Católica de Valparaíso; ChileFil: Lücke, Andreas. Universitat Erlangen-Nuremberg; Alemani

Stable Oxygen Isotope Records (δ18O) of a High-Andean Cushion Peatland in NW Argentina (24° S) Imply South American Summer Monsoon Related Moisture Changes During the Late Holocene

High-elevation cushion peatlands are promising archives for paleoenvironmental studies in their extreme habitat of the Central Andean highlands between ∼4000 and 4800 m a.s.l. The Cerro Tuzgle cushion peatland (CTP, 24°09′ S, 66°24′ W), located in the NW Argentine Andes, is formed by the vascular cushion plants Oxychloe andina (O. andina) and Zameioscirpus muticus (Z. muticus). To extend the knowledge base on the modern ecology of these peatlands, we investigated the stable isotope composition of bulk material and cellulose (δ18O, δ13C, δ15N) of the dominant cushion-forming species O. andina (Juncaceae) and Z. muticus (Cyperaceae) as well as water samples (δ18O, δ2H) of several pools interspersed within the peatland. We further applied a multiproxy approach for a peat core from CTP spanning the last 2900 years with XRF scanning, bulk geochemistry and stable isotope analyses on bulk peat and cellulose size fractions. Modern samples of O. andina and Z. muticus expose significant differences in cellulose δ18O, e.g., between leaves and rhizomes of O. andina (Δδ18Ol-r = 4.11‰) and between leaves of O. andina and Z. muticus (Δδ18Ol-l = 2.8‰). Modern water samples exhibit strong isotopic differences between single water pools (max. Δδ18O = 13.09‰) due to local variable evaporative enrichment. Within the peat core, we observe considerable multi-centennial variations in δ18O composition of cellulose confirmed by all size fractions. Based on the regional relation between decreasing δ18Oprec values with increasing precipitation amounts and 18O enrichment in the peatland waters due to evaporation, we suggest an interpretation of our δ18O cellulose record as moisture proxy for CTP. This interpretation is corroborated by a high correlation between oxygen isotopes, peat growth and geochemical data. Accordingly, CTP indicates dryer conditions between 2190 and 2120, 1750 and 1590, 1200 and 1080 and since 130 cal. yr BP, whereas periods with increased humidity prevailed from 2750 to 2250 and from 600 to 130 cal. yr BP. Temporal changes in the match to South American Summer Monsoon (SASM) reconstructions suggest impacts of other large-scale atmospheric variability modes or a different SASM expression at our southerly location

Hybrid SPECT/CT for the assessment of a painful hip after uncemented total hip arthroplasty

Background The diagnosis of hip pain after total hip replacement (THR) represents a highly challenging question that is of increasing concern to orthopedic surgeons. This retrospective study assesses bone scintigraphy with Hybrid SPECT/CT for the diagnosis of painful THR in a selected cohort of patients. Methods Bone SPECT/CT datasets of 23 patients (mean age 68.9 years) with a painful hip after THR were evaluated. Selection of the patients required an inconclusive radiograph, normal serum levels of inflammatory parameters (CRP and ESR) or a negative aspiration of the hip joint prior to the examination. The standard of reference was established by an interdisciplinary adjudication-panel using all imaging data and clinical follow-up data (>12 month). Pathological and physiological uptake patterns were defined and applied. Results The cause of pain in this study group could be determined in 18 out of 23 cases. Reasons were aseptic loosening (n = 5), spine-related (n = 5), heterotopic ossification (n = 5), neuronal (n = 1), septic loosening (n = 1) and periprosthetic stress fracture (n = 1). In (n = 5) cases the cause of hip pain could not be identified. SPECT/CT imaging correctly identified the cause of pain in (n = 13) cases, in which the integrated CT-information led to the correct diagnosis in (n = 4) cases, mainly through superior anatomic correlation. Loosening was correctly assessed in all cases with a definite diagnosis. Conclusions SPECT/CT of THA reliably detects or rules out loosening and provides valuable information about heterotopic ossifications. Furthermore differential diagnoses may be detected with a whole-body scan and mechanical or osseous failure is covered by CT- imaging. SPECT/CT holds great potential for imaging-based assessment of painful prostheses

Analysis of hydrological components of the Wüstebach catchment by means of stable isotope measurements

Over the past decades, interpretation of changes in stable isotope signatures of catchment waters have beenused to assess hydrological flow paths under different flow conditions and estimating mean catchment residencetimes. However, despite of the many studies the timing, flow path, and source behavior of catchments are stillnot well understood. In this study we investigate the hydrological components of the Erkensruhr catchment (45km2), Germany, and the Wüstebach sub-catchment (10 ha2) using stable isotopes of water (D/H and Oxygen-18/Oxygen-16) as tracers. We present first results of a more than two-year long measurement campaign in theWüstebach catchment with respect to the magnitude and the temporal characteristics of isotope variations inprecipitation, throughfall, groundwater and the Wüstebach stream. Later research will also incorporate soil wateranalysis and focus on the isotopic behavior and the hydrological components (slow and fast runoff components)of the Erkensruhr catchment.First results demonstrate the expected seasonal effect on precipitation isotope ratio (Summer: -4.00h Oxygen-18toWinter: -11.00hOxygen-18) and that throughfall undergoes evaporation (differences up to +2.00hOxygen-18to precipitation). It is important to quantify this isotopic enrichment and the amount of throughfall to estimatethe effect of evaporative changes in throughfall compared to unchanged precipitation on the isotope ratios of theoutlets hydrograph. Both groundwater and streamflow samples show a tendency of lower isotope values over thecourse of the two-year long time series (linearly declining approximately -0.4h Oxygen-18). As precipitationdoes not show the same decline, ecological changes of the Wüstebach catchment might be the origin of this effect.A clear seasonal effect on streamflow can be observed at the source of the Wüstebach, with higher concentrationsin summer due to higher precipitation isotope concentrations and a fast decrease in concentration at the end ofwinter, probably due to snow melt. We observed a mixing effect of two separated stream sources. One sourceshows a clear seasonal behavior whereas the other source shows quasi-constant concentrations over time. Themixing of both sources leads to a dampening of the seasonal effect of isotope concentrations in the Wüstebachstream that does not disappear over the course of the measured stream (approximately 400 m). We argue thatthe invariable source is fed by deeper groundwater, whereas the seasonally variable source is fed by a shallowgroundwater aquifer.Our work indicates different groundwater sources for the Wüstebach river and shows an evaporative effect onthroughfall. A decline of isotope concentrations for streamwater and groundwater has been found that might bedue to ecological changes in the catchment. Future research will focus on hydrological modeling of the Wüstebachsub-catchment which will then be expanded to hydrological modeling of the Erkensruhr catchment

Improving nitrogen retention of cattle slurry with oxidized biochar: An incubation study with three different soils

The application of livestock slurry in soils can lead to nitrogen (N) losses through ammonia (NH3) emission or nitrate (NO3−) leaching. Oxidized biochar has great potential to mitigate N losses due to its strong adsorption capacity; however, the effects of oxidized biochar in different soils treated with slurry are currently unclear. Here, we investigated the effect of untreated and oxidized biochar (applied at a rate of 50 kg C m−3 slurry) on reducing N losses in a laboratory experiment with three different soils (loamy sand, sandy loam, loam) amended with cattle slurry at an application rate of 73 kg N ha−1. Oxidized biochar reduced NH3 emissions by 64–75% in all soils, whereas untreated biochar reduced NH3 emissions by 61% only in the loamy sand. Oxidized biochar significantly reduced the NO3− content in the soil solution of the loamy sand in the early phase of the incubation and led to a significantly higher NO3− concentration in the same soil compared with the slurry-only treatment at the end of the experiment, indicating a significant increase in NO3− retention in this organic C–poor soil. We conclude that oxidized biochar can reduce N losses, both in the form of NH3 emission and NO3− leaching, from cattle slurry applied to soil, particularly in soil with soil organic carbon content <1% and pH <5 (i.e., oxidized biochar can serve as a means for improving the quality of marginal and acidic soils)

Dystonia and Paroxysmal Dyskinesias: Under-Recognized Movement Disorders in Domestic Animals? A Comparison with Human Dystonia/Paroxysmal Dyskinesias

Dystonia is defined as a neurological syndrome characterized by involuntary sustained or intermittent muscle contractions causing twisting, often repetitive movements, and postures. Paroxysmal dyskinesias are episodic movement disorders encompassing dystonia, chorea, athetosis, and ballism in conscious individuals. Several decades of research have enhanced the understanding of the etiology of human dystonia and dyskinesias that are associated with dystonia, but the pathophysiology remains largely unknown. The spontaneous occurrence of hereditary dystonia and paroxysmal dyskinesia is well documented in rodents used as animal models in basic dystonia research. Several hyperkinetic movement disorders, described in dogs, horses and cattle, show similarities to these human movement disorders. Although dystonia is regarded as the third most common movement disorder in humans, it is often misdiagnosed because of the heterogeneity of etiology and clinical presentation. Since these conditions are poorly known in veterinary practice, their prevalence may be underestimated in veterinary medicine. In order to attract attention to these movement disorders, i.e., dystonia and paroxysmal dyskinesias associated with dystonia, and to enhance interest in translational research, this review gives a brief overview of the current literature regarding dystonia/paroxysmal dyskinesia in humans and summarizes similar hereditary movement disorders reported in domestic animals

Dystonia and Paroxysmal Dyskinesias: Under-Recognized Movement Disorders in Domestic Animals? A Comparison with Human Dystonia/Paroxysmal Dyskinesias

Dystonia is defined as a neurological syndrome characterized by involuntary sustained or intermittent muscle contractions causing twisting, often repetitive movements, and postures. Paroxysmal dyskinesias are episodic movement disorders encompassing dystonia, chorea, athetosis, and ballism in conscious individuals. Several decades of research have enhanced the understanding of the etiology of human dystonia and dyskinesias that are associated with dystonia, but the pathophysiology remains largely unknown. The spontaneous occurrence of hereditary dystonia and paroxysmal dyskinesia is well documented in rodents used as animal models in basic dystonia research. Several hyperkinetic movement disorders, described in dogs, horses and cattle, show similarities to these human movement disorders. Although dystonia is regarded as the third most common movement disorder in humans, it is often misdiagnosed because of the heterogeneity of etiology and clinical presentation. Since these conditions are poorly known in veterinary practice, their prevalence may be underestimated in veterinary medicine. In order to attract attention to these movement disorders, i.e., dystonia and paroxysmal dyskinesias associated with dystonia, and to enhance interest in translational research, this review gives a brief overview of the current literature regarding dystonia/paroxysmal dyskinesia in humans and summarizes similar hereditary movement disorders reported in domestic animals