38 research outputs found
Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial
- Author
- Abano Nenette
- Abbdul-saheb Mudhar
- Adedoyin Temi
- Adell Victoria
- Adesina Tolu
- Adie Katja
- Adil-Smith Jennifer
- Ahmad Nasar
- Ahmed Ashraf
- Ahmed Iman
- Al-Mayhani Talal
- Al-Shahi Salman Rustam
- Al-Shahi Salman Rustam
- Alam Mohammad Irfan
- Albazzaz Mo
- Ali Ali
- Alipio Francis
- Allen Christopher
- Allison Joanna
- Amey Isobel
- Amis Elaine
- Amlani Sageet
- Amoils Shannon
- Amor Kelly
- Anderson Rosemary
- Andole Sreeman
- Anjum Talat
- Ankolekar Sandeep
- Annamalai Arunkumar
- Anthony Alpha
- Anversha Ajmal
- Anwar Ijaz
- Anwar Sajjad
- Appleton Jason
- Argandona Lucia
- Armitage Jane
- Ashton Amy
- Atkinson Natalie
- Auld Grace
- Avis Joanne
- Aweid Basaam
- Ayres Georgina
- Azhar Khalid
- Bagnall Caroline
- Baig Farrukh
- Baigent Colin
- Bailey Duncan
- Baird Yolanda
- Bakawala Rehana
- Baker John
- Baker Pauline
- Balazikova Olga
- Balian Linda
- Baliga Vidya
- Balitska Olesia
- Ball Julie
- Ball Margaret
- Ballantine Robert
- Bamford John
- Banaras Azra
- Barber Mark
- Barbon Emma
- Barker James
- Barr Charlotte
- Barrie Elizabeth
- Barron Luke
- Barry Adrian
- Bateman Gavin
- Bates Michelle
- Bathula Rajaram
- Battersby-Wood Emma
- Bayliss Pauline
- Beadle Hannah
- Bearne Helen
- Beaty Teresa
- Beaves Emily
- Bell Angela
- Bell Jo
- Bell Murdina
- Bellfield Ruth
- Beranova Eva
- Bergin Adrian
- Bhakri Harbens
- Bhalla Ajay
- Bharaj Kiranjit
- Bhargava Maneesh
- Bhaskaran Biju
- Bhatnagar Priya
- Bhatnagar Priya
- Birchall Kathryn
- Birns Jonathan
- Black Toby
- Blades Alex
- Blair Caroline
- Blair Caroline
- Blair Gordon
- Blane Sujata
- Blank Catrin
- Blight Adrian
- Board Joanne
- Board Sarah
- Bokhari Maria
- Bond Kirsty
- Bowring Angela
- Boxall Cherish
- Breeds Joanna
- Brew Helen
- Brezitski Maria
- Bridger Hayley
- Brodie Fiona
- Brotherton Lucy
- Broughton David
- Brown Claire
- Brown Ellen
- Brown Pauline
- Brown Sarah
- Bruce David
- Buchanan David
- Buck Amanda
- Buckle Steve
- Buckle Steve
- Buckley Clare
- Bunea George
- Burger Ilse
- Burgess Laura
- Burgess Seona
- Burssens Evelyne
- Butler Adrian
- Butler Donna
- Butler Rebecca
- Butterworth-Cowin Nicola
- Button Denise
- Buxton Jean
- Byrne Anthony
- Cageao Julie
- Caine Sarah
- Campbell Robert
- Carpenter Michael
- Carpio Racquel
- Carrie Johanna
- Cassidy Tim
- Causley Chelsea
- Chadbourn Indra
- Chadha Dinesh
- Chamberlain Angela
- Chan kelly
- Chandrakumar Aberami
- Chapman Kath
- Chapman Nicola
- Charles Bethan
- Chatterjee Kausic
- Chaudhry Afnan
- Chauhan Meena
- Chenna Srikanth
- Cherian Suja
- Cheripelli Bharath Kumar
- Chopra Neha
- Choulerton James
- Choy Lillian
- Clarke Brian
- Clarke Caroline
- Clarke Judith
- Clarke Natasha
- Clarke Rebecca
- Clarke Samantha
- Clarkson Emma
- Clay Caroline
- Clayton Susan
- Clayton-Evans Lisa
- Cluckie Gillian
- Cochrane Helen
- Codd Laura
- Cohen David
- Collins Kayleigh
- Connor Lynda
- Constantin Carmen
- Cook Angela
- Cooper Martin
- Copeland Claire
- Cosier Tracey
- Courtauld Gillian
- Couser Mandy
- Coward Lucy
- Cowie Linda
- Cox Chantel
- Cox Chloe
- Cox Penelope
- Crabtree Karen
- Crawford Pam
- Crawford Susan
- Creeden Robyn
- Crisp Sarah
- Cronin Julie
- Crook Luci
- Crosbie Caroline
- Crouch Nichola
- Crown Rachel
- Crowther Hannah
- Cuddy Sarah
- Cuenoud Larissa
- Cullen Claire
- Culmsee Charlotte
- Cunningham James
- Cunningham Mishell
- Cvoro Vera
- Dacey Lynne
- Dakin Katy
- Dallol Bander
- Dangri Puneet
- Datta Prabal
- Davey Richard
- David Anette
- David Owen
- Davies Caroline
- Davies Ruth
- Davies Silvie
- Davis Fiona
- Davis Michelle
- Day Nicola
- Dayal Nilofer
- De Berker Henry
- Deary Ann
- Denic Hayley
- Dennis Martin
- Dennis Martin S
- Denniss Carol
- Devine Joseph
- Devitt Nicola
- Dewar Richard
- Dhakal Mahesh
- Dhar Saikat
- Dickinson Christina
- Dickson Christine
- Dima Sofia
- Dinsmore Lynn
- Dixon Lynn
- Dobson Tracey
- Dodd Angela
- Dodd Emily
- Doherty Mandy
- Doherty Mandy
- Donaldson Denise
- Donnelly Richard
- Doubal Fergus
- Dow Lindsey
- Downham Susan
- Doyle Clare
- Doyle Donna
- Drever Jonathan
- du Plessis Johann C
- du Plessis Johannes
- Dube Judith
- Duberley Stephen
- Dunn Linda
- Dunne Karen
- Durairaj Ramesh
- Durman Helen
- Dutta Dipankar
- Dynan Kevin
- Edwards Mandy
- Egerton Shuna
- Eglinton Charlotte
- Eglinton Charlotte
- El Tawil Salwa
- Elfandi Khaled
- Elliot Jennifer
- Elliott Emma
- Ellis Sam
- Emberson Jonathan
- Emsley Hedley
- England Timothy
- Epstein Daniel
- Erande Renuka
- Erumere Esther
- Esisi Bernard
- Esisi Bernard
- Esson Derek
- Esson Derek
- Evans Rachel
- Evans Sue
- Eveson David
- Ewing Jordan
- Fathima Razik
- Fawcett Michelle
- Feerick Shez
- Fennelly Ruth
- Ferdinand Phillip
- Findlay Paul
- Finlay Sarah
- Finney Kay
- Fitzell Pauline
- Fitzsimmons Paul
- Fletcher Glyn
- Fletcher Jo
- Fong Rosanna
- Foot Jayne
- Foote Leanne
- Ford Gary
- Foster Eliza
- Fotherby Ken
- Fox Charlotte
- Francia Nina
- Francis Jobbin
- Fraser Ruth
- Fraser Ruth
- Fuller Tracy
- Fulton Ailsa
- Furnace Jacqueline
- Gadapa Naveen
- Gainard Glyn
- Gainsborough Nicola
- Gallagher Jill
- Gallagher Louise
- Gallifent Rachel
- Gamble Ed
- Garcia Tatiana
- Gardener Léjeune
- Garfield-Smith Joanne
- Garside Mark
- Gartrell Imogen
- Gascoyne Rachel
- Gattringer Thomas
- Gautam Nikki
- Gaylard Jane
- Gbadamoshi Lukuman
- Geraghty Olivia
- Ghaly George
- Ghatala Rita
- Ghosh Sandip
- Giallombardo Elio
- Gilham Ellie
- Gilmour Danielle
- Gilzeane Nicola
- Glass Jon
- Gleave Laura
- Glover Rachel
- Godfrey Margi
- Goff Anita
- Goorah Neetish
- Gott Valerie
- Gow Heather
- Graham Carol
- Graham Ruth
- Gray Jane
- Green Carole
- Greenwood Richard
- Gregory Bindu
- Greig Jill
- Grimwood Gemma
- Grocott Jeanette
- Grue Rebecca
- Gulliver Diane
- Guo Fenglin
- Gupwell Karin
- Guthrie Lucy Belle
- Guy Helen
- Guyler Paul
- Hague Adam
- Haider Syed
- Hairsine Brigid
- Hakim Eluzai
- Hall Andrea
- Halse Omid
- Handley Dominic
- Hann Gail
- Hannon Niamh
- Hansen Christian
- Haque Mohammad
- Hardwick Anne
- Harkness Kirsty
- Harrington Frances
- Harrington-Davies Yasmin
- Harrison Louise
- Harrison Melanie
- Harrison Thomas
- Harston George
- Harvey Kirsten
- Harvey Miriam
- Hassan Ahamad
- Hassan Hardi
- Havard Diane
- Hayes Anne
- Hayhoe Helen
- Hayman Rachel
- Hays Carole
- Hazel Beth
- Hedstrom Amanda
- Hedstrom Amanda
- Hemsley Anthony
- Henry Margo
- Herman Jane
- Hervey Simon
- Hewitt Jonathan
- Hiden Joanne
- Hogan Caroline
- Hogg Valerie
- Holden Melinda
- Holmes Clare
- Homan Jane
- Hooley Michaela
- Horan Kathleen
- Horton Sarah
- Hostettler Isabel
- Hove Dionne
- Howaniec Laura
- Howard Gabriella
- Howard Joanne
- Howard Peter
- Howcroft Deborah
- Howe Jo
- Huang Xuya
- Huggett Isabel
- Hughes Chloe
- Hughes Claire
- Hughes Tom
- Humphreys Louise
- Humphries Fiona
- Hunt Benjamin
- Hunt Nicholas
- Hunter Annemarie
- Hunter Neil
- Hurford Frances
- Hurley Jennifer
- Hussain Malik
- Hutchison Aidan
- Hyams Benjamin
- Hyatt Lisa
- Imam Javed
- Ingham Andrea
- Ingram Tanya
- Innes Karen
- Iqbal Arshi
- Iqbal Mohammad Shazad
- Irvine Janice
- Ispoglou Sissy
- Ivatts Simone
- Jackson Benjamin
- Jackson Linda
- Jagger Jenny
- Jagpal Baljit
- James Ali
- James Claire
- James Martin
- Jarapa Rowilson
- Jarrett David
- Jeffs Carol
- Jelley Benjamin
- Jenkins Colin
- Jennings-Preece Karla
- Jeyaraj Naomi
- Jha Ratneshwari
- Jinks Emma
- Johnes Mary
- Johnson Sharon
- Jones Ifan
- Jones Ifan
- Jones Kirsty
- Jones Rachael
- Jones Stephanie
- Jones Terry
- Jones Val
- Jordan Carla
- Jose Deepa
- Jose Josin
- Joshi Yogish
- Joshi Yogish
- Joyson Anu
- Jupp Becky
- Justin Frances
- Kakar Puneet
- Kalathil Latheef
- Kalladka Dheeraj
- Kamara Christine
- Kambafwile Mary
- Kane Ingrid
- Kar Arindam
- Keegan Breffni
- Keeling Elizabeth
- Keenan Samantha
- Kelavkar Shyam
- Kelly Christine
- Kelly Debs
- Kelly Jim
- Kelly Siobhan
- Keltos Marketa
- Kennedy James
- Kennedy Kate
- Kenton Antony
- Kerin Lourda
- Kerr Enda
- Kerr Gillian
- Keshvara Rekha
- Khan Mohammad
- Khan Shagufta
- Khan Usman
- Khan Uzma
- Kibutu Faith
- King Sam
- Kingwell Hayley
- Kini Manohar
- Klaasen Katrina
- Knops Kerstin
- Krishnamoorthy Shrivakumar
- Krishnamurthy Ramesh
- Krishnamurthy Vinodh
- Krishnan Kailash
- Krishnan Manju
- Krommyda Magdalini
- Kullane Sagal
- Kumar Balakrishna
- Kumar Pradeep
- Kunhunny Swapna
- Lam Man Yee
- Lambert Caroline
- Landers Geraldine
- Langhorne Peter
- Lasserson Daniel
- Latter Laura
- Law Zhe
- Lawrence Tara
- Lawson Heidi
- Leason Sandra
- Lee Stephanie
- Leggett Jacqui
- Lenti Giulia
- Lerpiniere Christine
- Lerpiniere Christine
- Licenik Radim
- Lindert Ralf
- Little Victoria
- Littleton Edward
- Ljubez Anja
- Loganathan Thayalini
- Longland Barbara
- Lopez Paula
- Lovelock Caroline
- Lowe Gordon
- Lucas Linda
- Lucas Suzanne
- Luder Robert
- Lyjko Sue
- Maanoosi Mehran
- Maatouk Ahmad
- Macaden Ashish
- MacInnes Brian
- MacLennan Beverly
- Macleod Malcolm
- MacLeod Mary
- MacLiver Linda
- MacRaild Allan
- Maddula Mohana
- Madigan Barbara
- Maguire Holly
- Maguire Stuart
- Maiden Susan
- Majis Arshad
- Majmudar Nikhil
- Makawa Linetty
- Mangion David
- Manning Lisa
- Manoj Aravind
- Mardania Rina
- Marigold James Richard
- Markova Skarlet
- Marks Katherine
- Marsden Tracy
- Marshall Sally
- Martin Irene
- Mashate Sheila
- Mason Cathy
- Mate Abhijit
- Mathieson Philip
- Matias Oliver
- Matthews Christopher
- Maund Bev
- McAlpine Christine
- McArdle Damian
- Mcauley Sean
- McCann Stephanie
- McCarron Mark
- McClelland Beverley
- McCormick Katrina
- McCormick Katrina
- McDonald Shanni
- McDonald Susan
- Mcgee Joanne
- McGhee Caroline
- McGill Connor
- McGrath Aileen
- McIlmoyle James
- McKee Jacqueline
- McLoughlin Alison
- McVerry Ferghal
- Mead Denise
- Mead Gillian
- Meir Julie
- Menon Nisha
- Mercer Lily
- Metcalf Kneale
- Miller Keniesha
- Miller Richard
- Milligan Josette
- Minks David
- Minks David P.
- Miriam Skelton
- Mistri Amit
- Mitchell Jennifer
- Mitra Dipayan
- Mitra Dipayan
- Mohammed Niaz
- Mohd Nor Azlisham
- Mokoena Betty
- Moores Andrew
- Moqsith Mohammed
- Morell Jordi
- Moreton Fiona
- Morgan Debbie
- Moroney Helen
- Morse Bethan
- Moseley Sally
- Motherwell Nichola
- Moynihan Barry
- Mpelembue Mushiya
- Mudd Paul
- Muddegowda Girish
- Muir Keith
- Mukherjee Indranil
- Murali Elodie
- Murphy Peter
- Murray Gordon D
- Musarrat Kashif
- Myint Min
- Naeem Muhammad
- Naing Zin
- Nair Anand
- Nallasivan Arumugam
- Nasar Mohammad
- Nasim Ashraf
- Naylor Charde
- Needle Ann
- Nelson Sandra
- Newby David E
- Newton Sophie
- Ng Kheng Xiong
- Ngo David
- Nguyen Vinh
- Ngwako Mmua
- Ni Hlaing
- Nicholas Paul
- Nicolson Anne
- Niranchanan Rangah
- Nisar Nabeela
- Njoku Kelechi
- Nott Claire
- Nott Claire
- Nozedar Tarn
- Nyabadza Sheila
- O'Brien Eoin
- O'Brien Richard
- O'Brien Richard
- O'Connell Susan
- O'Loughlin Victoria
- O'Reilly Joanna
- O'Toole Sarah
- OConnell Janice
- Oji Nnebuife
- Orath Prabakaran Rajalakshmi
- Orefo Chukwuka
- Orugun Enoch
- Osborn Mairead
- Osborne Emily
- Oshodi Anne
- Osman Ahmed
- Ovington Catherine
- Owings Paula
- Owoyele Emmanuelle
- Owusu-Agyei Peter
- Pai Yogish
- Palmer Jeb
- Papavasileiou Vasileios
- Parakramawansha Ruwan
- Parker Richard
- Parry Anthea
- Parry-Jones Adrian
- Pasco Kath
- Patel Bhavini
- Patel Champa
- Patel Farzana
- Patel Krishna
- Patterson Chris
- Paulton Ruth
- Pawley Corinne
- Peixoto Cassilda
- Penge Justin
- Perez Jane
- Perfitt Rebekah
- Perkins Charlotte
- Perry David
- Perry Jack
- Persad Nicola
- Peters Jenny
- Pettitt Kerry
- Phiri Duke
- Pitt-Ford Alexandra
- Pitt-Kerby Tressy
- Plewa Catherine
- Poku Philip
- Ponnambath Suheil
- Poultney Una
- Pound Susan
- Power Michael
- Pressly Vanessa
- Price Fiona
- Proeschel Harald
- Punekar Shuja
- Punter Martin
- Pusalkar Aparna
- Putterill Janet
- Quinn Leanne
- Quinn Outi
- Qureshi Sammie
- Ragab Suzanne
- Raghunathan Senthil
- Rahman Bithi
- Rai Baljinder
- Raj Sonia
- Rajapakse Anoja
- Rajkumar Chakravarthi
- Ramachandran Sankaranarayana
- Ramadan Hawraman
- Ramshaw Alex
- Rana Pratap
- Randall Marc
- Rashed Khalid
- Rashmi Sindhu
- Ravenhill Garth
- Rayessa Rayessa
- Reckless Ian
- Reddan Julie
- Reddan Julie
- Redgrave Jessica
- Redjep Ozlem
- Remegoso Alda
- Richard Bella
- Richards Emma
- Rinkel Gabriel
- Roberts Josh
- Robinson Matthew
- Robinson Naomi
- Rodgers Alicia
- Rodrigues Mark A
- Rodriguez Aryelly
- Roffe Christine
- Roffe Jack
- Roganova Tatjana
- Rogers Emily
- Rogers Gill
- Rojas Javier
- Ross Sarah
- Roughan Caroline
- Rudd Tony
- Rudenko Hannah
- Saada Janak
- Saastamoinen Kari
- Sajid Mahmud
- Sakka Eleni
- Salehin Maqsud
- Salek-Haddadi Afraim
- Salih Isam
- Sally Moore
- Sandercock Peter A G
- Sangombe Mirriam
- Sangster Graeme
- Sanyal Ranjan
- Sarah Procter
- Sarah Procter
- Sattar Naweed
- Sattar Saira
- Saulat Afaq
- Saulat Afaq
- Schofield Christine
- Schulz Ursula
- Schumacher Natasha
- Schwarz Stefan
- Seagrave Samantha
- Sekaran Lakshmanan
- Sesay Juliana
- Sethuraman Sakthivel
- Shackcloth Daniela
- Shah Alex
- Shah Sweni
- Shahmehri Shahrzad
- Sharma Nikhil
- Sharpe Simon
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- Shaw Louise
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- Shekhar Raj
- Shelton Faye
- Shinh Naval
- Shread Ian
- Shukla Avani
- Siddegowda Prasad
- Siddiq Muhammad
- Siddiqui Amber
- Siddiqui Anwer
- Sigsworth Andrew
- Simon Rohan
- Sims Don
- Singh Arun
- Sinha Devesh
- Skinner Helen
- Slade Peter
- Smart Amanda
- Smith Andrew
- Smith Fiona
- Smith Gemma Marie
- Smith Simon
- Smith Wilma
- Smyth Nigel
- Spencer Jayne
- Sprigg Nikola
- Sprigg Nikola
- Srinivasan Meena
- Stafford Samantha
- Stafford Samantha
- Stanners Andrew
- Steele Amy
- Stephen Jacqueline
- Stephens Claire
- Stevens Angela
- Stevens Stephanie
- Stevenson Sarah
- Stewart Kelvin
- Stocks Kathy
- Stone Andrew
- Storton Sharon
- Strain David
- Subramonian Santhosh
- Sudlow Cathie
- Sudlow Cathie L M
- Sukdeo Varthi
- Sullivan Frank
- Sultan Sulaiman
- Suttling Anne
- Sutton Claire
- Sutton Patrick
- Sutton Victoria
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- Sykes Lucy
- Symonds Stuart
- Szabo Susan
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- Tandy Jane
- Tate Margaret
- Tauro Suzanne
- Tayler Michelle
- Taylor Pat
- Taylor Vicky
- Teal Rachel
- Temple Natalie
- Thant Hlaing
- Thavanesan Kamy
- Thomas Isobel
- Thomas Kelly
- Thomas Philip
- Thomas Sarah
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- Thompson Susan
- Thompson Teresa
- Thompson-Jones Helen
- Thomson Audrey
- Thornthwaite Sarah
- Thorpe Kevin
- Tilley Victoria
- Tiwari Divya
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- Tribbeck Michele
- Trippier Sarah
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- Triscott Claire
- Tryambake Dinesh
- Tucker Laura
- Tucker Susan
- Turfrey Jennifer
- Tysoe Sharon
- Ullah Khalil
- Valentine Stacey
- van Someren Chloe
- Varquez Resti
- Vasileiadis Evangelos
- Vassallo Joseph
- Venter Marius
- Veraque Emelda
- Verrion Anna
- Vettimootal Johnson Venetia
- Vickers Carinna
- Walford Jamie
- Walker Allan
- Walker Marion
- Walker Pauli
- Walker Susannah
- Wallace Aine
- Wallace Rebecca
- Wallace Rebecca
- Walstow Deborah
- Walter Deborah
- Walters Ashleigh
- Wani Mushtaq
- Ward Deborah
- Wardlaw Joanna M
- Watchurst Caroline
- Waterfield Kelly
- Waterfield Kelly
- Watson Fran
- Waugh Dean
- Webb Tom
- Webber Adam
- Webster Timothy
- Weinling Marie
- Weir Nic
- Weir Pauline
- Welch Angela
- Werring David
- Werring David J
- Whitcher Alison
- White James
- White Julie
- White Philip M
- White Susan
- Whiteley William
- Whiteley William N
- Whiteman Jessica
- Whiteman Jessica
- Whiting Robert
- Whittamore Katherine
- Wiggam Ivan
- Wilding Peter
- Wilkes Gwendoline
- Wilkinson Mark
- Willberry Angela
- Williams Carol
- Williams Rebecca
- Williams-Yesson Barbara
- Willmot Mark
- Wilson David
- Wilson Duncan
- Wilson Jenny
- Wilson Lisa
- Wilson Sarah
- Wiltshire Alison
- Wood Diane
- Wood Edith
- Wood Lisa
- Woodward Stephen
- Wright Fiona
- Wroath Belinda
- Wynter Inez
- Yadava Rajendra
- Yip Brigitte
- Young Andrew
- Zachariah George
- Zahoor Tajammal
- Zoe Mellor
- Publication venue
- 'Elsevier BV'
- Publication date
- 22/05/2019
- Field of study
Background
Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy
Prenatal exome sequencing analysis in fetal structural anomalies detected by ultrasonography (PAGE):a cohort study
- Author
- Berry Ian R
- Best Sunayna K
- Carey Georgina K
- Chandler Kate E
- Chitty Lynn
- Cresswell Lara
- Eberhardt Ruth Y
- Edwards Sandra L
- Hamilton Sue
- Henderson Alex
- Holden Simon T
- Homfrey Tessa
- Hurles Matthew E
- Jenkins Lucy
- Keelagher Rebecca
- Kilby Mark
- Lewis Rebecca
- Lord Jenny
- Maher Eamonn
- McMullan Dominic
- Newbury-Ecob Ruth
- Parker Michael
- Prescott Katrina
- Prigmore Elena
- Quarrell Oliver
- Quinlan-Jones Elizabeth
- Ramsden Simon
- Rinck Gabriele
- Roberts Eileen
- Scott Richard H
- Tapon Dagmar
- Tooley Madeleine J
- Vasudevan Pradeep C
- Weber Astrid P
- Wellesley Diana G
- Westwood Paul
- White Helen
- Williams Denise
- Publication venue
- 'Elsevier BV'
- Publication date
- 23/02/2019
- Field of study
Effects of antiplatelet therapy after stroke due to intracerebral haemorrhage (RESTART): a randomised, open-label trial
- Author
- Abano Nenette
- Abbdul-saheb Mudhar
- Adedoyin Temi
- Adell Victoria
- Adesina Tolu
- Adie Katja
- Adil-Smith Jennifer
- Ahmad Nasar
- Ahmed Ashraf
- Ahmed Iman
- Al-Mayhani Talal
- Al-Shahi Salman Rustam
- Alam Mohammad Irfan
- Albazzaz Mo
- Ali Ali
- Alipio Francis
- Allen Christopher
- Allison Joanna
- Amey Isobel
- Amis Elaine
- Amlani Sageet
- Amoils Shannon
- Amor Kelly
- Anderson Rosemary
- Andole Sreeman
- Anjum Talat
- Ankolekar Sandeep
- Annamalai Arunkumar
- Anthony Alpha
- Anversha Ajmal
- Anwar Ijaz
- Anwar Sajjad
- Appleton Jason
- Argandona Lucia
- Armitage Jane
- Ashton Amy
- Atkinson Natalie
- Auld Grace
- Avis Joanne
- Aweid Basaam
- Ayres Georgina
- Azhar Khalid
- Bagnall Caroline
- Baig Farrukh
- Baigent Colin
- Bailey Duncan
- Baird Yolanda
- Bakawala Rehana
- Baker John
- Baker Pauline
- Balazikova Olga
- Balian Linda
- Baliga Vidya
- Balitska Olesia
- Ball Julie
- Ball Margaret
- Ballantine Robert
- Bamford John
- Banaras Azra
- Barber Mark
- Barbon Emma
- Barker James
- Barr Charlotte
- Barrie Elizabeth
- Barron Luke
- Barry Adrian
- Bateman Gavin
- Bates Michelle
- Bathula Rajaram
- Battersby-Wood Emma
- Bayliss Pauline
- Beadle Hannah
- Bearne Helen
- Beaty Teresa
- Beaves Emily
- Bell Angela
- Bell Jo
- Bell Murdina
- Bellfield Ruth
- Beranova Eva
- Bergin Adrian
- Bhakri Harbens
- Bhalla Ajay
- Bharaj Kiranjit
- Bhargava Maneesh
- Bhaskaran Biju
- Bhatnagar Priya
- Birchall Kathryn
- Birns Jonathan
- Black Toby
- Blades Alex
- Blair Caroline
- Blair Caroline
- Blair Gordon
- Blane Sujata
- Blank Catrin
- Blight Adrian
- Board Joanne
- Board Sarah
- Bokhari Maria
- Bond Kirsty
- Bowring Angela
- Boxall Cherish
- Breeds Joanna
- Brew Helen
- Brezitski Maria
- Bridger Hayley
- Brodie Fiona
- Brotherton Lucy
- Broughton David
- Brown Claire
- Brown Ellen
- Brown Pauline
- Brown Sarah
- Bruce David
- Buchanan David
- Buck Amanda
- Buckle Steve
- Buckle Steve
- Buckley Clare
- Bunea George
- Burger Ilse
- Burgess Laura
- Burgess Seona
- Burssens Evelyne
- Butler Adrian
- Butler Donna
- Butler Rebecca
- Butterworth-Cowin Nicola
- Button Denise
- Buxton Jean
- Byrne Anthony
- Cageao Julie
- Caine Sarah
- Campbell Robert
- Carpenter Michael
- Carpio Racquel
- Carrie Johanna
- Cassidy Tim
- Causley Chelsea
- Chadbourn Indra
- Chadha Dinesh
- Chamberlain Angela
- Chan Kelly
- Chandrakumar Aberami
- Chapman Kath
- Chapman Nicola
- Charles Bethan
- Chatterjee Kausic
- Chaudhry Afnan
- Chauhan Meena
- Chenna Srikanth
- Cherian Suja
- Cheripelli Bharath Kumar
- Chopra Neha
- Choulerton James
- Choy Lillian
- Clarke Brian
- Clarke Caroline
- Clarke Judith
- Clarke Natasha
- Clarke Rebecca
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- Srinivasan Meena
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- Stafford Samantha
- Stanners Andrew
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- Thomas Kelly
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- Triscott Claire
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- Tucker Susan
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- van Someren Chloe
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- Vettimootal Johnson Venetia
- Vickers Carinna
- Walford Jamie
- Walker Allan
- Walker Marion
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- Walker Susannah
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- Wallace Rebecca
- Wallace Rebecca
- Walstow Deborah
- Walter Deborah
- Walters Ashleigh
- Wani Mushtaq
- Ward Deborah
- Wardlaw JM
- Watchurst Caroline
- Waterfield Kelly
- Waterfield Kelly
- Watson Fran
- Waugh Dean
- Webb Tom
- Webber Adam
- Webster Timothy
- Weinling Marie
- Weir Nic
- Weir Pauline
- Welch Angela
- Werring DJ
- Whitcher Alison
- White James
- White Julie
- White PM
- White Susan
- Whiteley WN
- Whiteman Jessica
- Whiteman Jessica
- Whiting Robert
- Whittamore Katherine
- Wiggam Ivan
- Wilding Peter
- Wilkes Gwendoline
- Wilkinson Mark
- Willberry Angela
- Williams Carol
- Williams Rebecca
- Williams-Yesson Barbara
- Willmot Mark
- Wilson David
- Wilson Duncan
- Wilson Jenny
- Wilson Lisa
- Wilson Sarah
- Wiltshire Alison
- Wood Diane
- Wood Edith
- Wood Lisa
- Woodward Stephen
- Wright Fiona
- Wroath Belinda
- Wynter Inez
- Yadava Rajendra
- Yip Brigitte
- Young Andrew
- Zachariah George
- Zahoor Tajammal
- Zoe Mellor
- Publication venue
- 'Elsevier BV'
- Publication date
- 29/06/2019
- Field of study
Background:
Antiplatelet therapy reduces the risk of major vascular events for people with occlusive vascular disease, although it might increase the risk of intracranial haemorrhage. Patients surviving the commonest subtype of intracranial haemorrhage, intracerebral haemorrhage, are at risk of both haemorrhagic and occlusive vascular events, but whether antiplatelet therapy can be used safely is unclear. We aimed to estimate the relative and absolute effects of antiplatelet therapy on recurrent intracerebral haemorrhage and whether this risk might exceed any reduction of occlusive vascular events.
Methods:
The REstart or STop Antithrombotics Randomised Trial (RESTART) was a prospective, randomised, open-label, blinded endpoint, parallel-group trial at 122 hospitals in the UK. We recruited adults (≥18 years) who were taking antithrombotic (antiplatelet or anticoagulant) therapy for the prevention of occlusive vascular disease when they developed intracerebral haemorrhage, discontinued antithrombotic therapy, and survived for 24 h. Computerised randomisation incorporating minimisation allocated participants (1:1) to start or avoid antiplatelet therapy. We followed participants for the primary outcome (recurrent symptomatic intracerebral haemorrhage) for up to 5 years. We analysed data from all randomised participants using Cox proportional hazards regression, adjusted for minimisation covariates. This trial is registered with ISRCTN (number ISRCTN71907627).
Findings:
Between May 22, 2013, and May 31, 2018, 537 participants were recruited a median of 76 days (IQR 29–146) after intracerebral haemorrhage onset: 268 were assigned to start and 269 (one withdrew) to avoid antiplatelet therapy. Participants were followed for a median of 2·0 years (IQR [1·0– 3·0]; completeness 99·3%). 12 (4%) of 268 participants allocated to antiplatelet therapy had recurrence of intracerebral haemorrhage compared with 23 (9%) of 268 participants allocated to avoid antiplatelet therapy (adjusted hazard ratio 0·51 [95% CI 0·25–1·03]; p=0·060). 18 (7%) participants allocated to antiplatelet therapy experienced major haemorrhagic events compared with 25 (9%) participants allocated to avoid antiplatelet therapy (0·71 [0·39–1·30]; p=0·27), and 39 [15%] participants allocated to antiplatelet therapy had major occlusive vascular events compared with 38 [14%] allocated to avoid antiplatelet therapy (1·02 [0·65–1·60]; p=0·92).
Interpretation:
These results exclude all but a very modest increase in the risk of recurrent intracerebral haemorrhage with antiplatelet therapy for patients on antithrombotic therapy for the prevention of occlusive vascular disease when they developed intracerebral haemorrhage. The risk of recurrent intracerebral haemorrhage is probably too small to exceed the established benefits of antiplatelet therapy for secondary prevention
Effects of antiplatelet therapy after stroke due to intracerebral haemorrhage (RESTART): a randomised, open-label trial
- Author
- Abano Nenette
- Abbdul-saheb Mudhar
- Adedoyin Temi
- Adell Victoria
- Adesina Tolu
- Adie Katja
- Adil-Smith Jennifer
- Ahmad Nasar
- Ahmed Ashraf
- Ahmed Iman
- Al-Mayhani Talal
- Al-Shahi Salman Rustam
- Alam Mohammad Irfan
- Albazzaz Mo
- Ali Ali
- Alipio Francis
- Allen Christopher
- Allison Joanna
- Amey Isobel
- Amis Elaine
- Amlani Sageet
- Amoils Shannon
- Amor Kelly
- Anderson Rosemary
- Andole Sreeman
- Anjum Talat
- Ankolekar Sandeep
- Annamalai Arunkumar
- Anthony Alpha
- Anversha Ajmal
- Anwar Ijaz
- Anwar Sajjad
- Appleton Jason
- Argandona Lucia
- Armitage Jane
- Ashton Amy
- Atkinson Natalie
- Auld Grace
- Avis Joanne
- Aweid Basaam
- Ayres Georgina
- Azhar Khalid
- Bagnall Caroline
- Baig Farrukh
- Baigent Colin
- Bailey Duncan
- Baird Yolanda
- Bakawala Rehana
- Baker John
- Baker Pauline
- Balazikova Olga
- Balian Linda
- Baliga Vidya
- Balitska Olesia
- Ball Julie
- Ball Margaret
- Ballantine Robert
- Bamford John
- Banaras Azra
- Barber Mark
- Barbon Emma
- Barker James
- Barr Charlotte
- Barrie Elizabeth
- Barron Luke
- Barry Adrian
- Bateman Gavin
- Bates Michelle
- Bathula Rajaram
- Battersby-Wood Emma
- Bayliss Pauline
- Beadle Hannah
- Bearne Helen
- Beaty Teresa
- Beaves Emily
- Bell Angela
- Bell Jo
- Bell Murdina
- Bellfield Ruth
- Beranova Eva
- Bergin Adrian
- Bhakri Harbens
- Bhalla Ajay
- Bharaj Kiranjit
- Bhargava Maneesh
- Bhaskaran Biju
- Bhatnagar Priya
- Birchall Kathryn
- Birns Jonathan
- Black Toby
- Blades Alex
- Blair Caroline
- Blair Caroline
- Blair Gordon
- Blane Sujata
- Blank Catrin
- Blight Adrian
- Board Joanne
- Board Sarah
- Bokhari Maria
- Bond Kirsty
- Bowring Angela
- Boxall Cherish
- Breeds Joanna
- Brew Helen
- Brezitski Maria
- Bridger Hayley
- Brodie Fiona
- Brotherton Lucy
- Broughton David
- Brown Claire
- Brown Ellen
- Brown Pauline
- Brown Sarah
- Bruce David
- Buchanan David
- Buck Amanda
- Buckle Steve
- Buckle Steve
- Buckley Clare
- Bunea George
- Burger Ilse
- Burgess Laura
- Burgess Seona
- Burssens Evelyne
- Butler Adrian
- Butler Donna
- Butler Rebecca
- Butterworth-Cowin Nicola
- Button Denise
- Buxton Jean
- Byrne Anthony
- Cageao Julie
- Caine Sarah
- Campbell Robert
- Carpenter Michael
- Carpio Racquel
- Carrie Johanna
- Cassidy Tim
- Causley Chelsea
- Chadbourn Indra
- Chadha Dinesh
- Chamberlain Angela
- Chan Kelly
- Chandrakumar Aberami
- Chapman Kath
- Chapman Nicola
- Charles Bethan
- Chatterjee Kausic
- Chaudhry Afnan
- Chauhan Meena
- Chenna Srikanth
- Cherian Suja
- Cheripelli Bharath Kumar
- Chopra Neha
- Choulerton James
- Choy Lillian
- Clarke Brian
- Clarke Caroline
- Clarke Judith
- Clarke Natasha
- Clarke Rebecca
- Clarke Samantha
- Clarkson Emma
- Clay Caroline
- Clayton Susan
- Clayton-Evans Lisa
- Cluckie Gillian
- Cochrane Helen
- Codd Laura
- Cohen David
- Collins Kayleigh
- Connor Lynda
- Constantin Carmen
- Cook Angela
- Cooper Martin
- Copeland Claire
- Cosier Tracey
- Courtauld Gillian
- Couser Mandy
- Coward Lucy
- Cowie Linda
- Cox Chantel
- Cox Chloe
- Cox Penelope
- Crabtree Karen
- Crawford Pam
- Crawford Susan
- Creeden Robyn
- Crisp Sarah
- Cronin Julie
- Crook Luci
- Crosbie Caroline
- Crouch Nichola
- Crown Rachel
- Crowther Hannah
- Cuddy Sarah
- Cuenoud Larissa
- Cullen Claire
- Culmsee Charlotte
- Cunningham James
- Cunningham Mishell
- Cvoro Vera
- Dacey Lynne
- Dakin Katy
- Dallol Bander
- Dangri Puneet
- Datta Prabal
- Davey Richard
- David Anette
- David Owen
- Davies Caroline
- Davies Ruth
- Davies Silvie
- Davis Fiona
- Davis Michelle
- Day Nicola
- Dayal Nilofer
- De Berker Henry
- Deary Ann
- Denic Hayley
- Dennis MS
- Denniss Carol
- Devine Joseph
- Devitt Nicola
- Dewar Richard
- Dhakal Mahesh
- Dhar Saikat
- Dickinson Christina
- Dickson Christine
- Dima Sofia
- Dinsmore Lynn
- Dixon Lynn
- Dobson Tracey
- Dodd Angela
- Dodd Emily
- Doherty Mandy
- Doherty Mandy
- Donaldson Denise
- Donnelly Richard
- Doubal Fergus
- Dow Lindsey
- Downham Susan
- Doyle Clare
- Doyle Donna
- Drever Jonathan
- du Plessis Johannes
- Dube Judith
- Duberley Stephen
- Dunn Linda
- Dunne Karen
- Durairaj Ramesh
- Durman Helen
- Dutta Dipankar
- Dynan Kevin
- Edwards Mandy
- Egerton Shuna
- Eglinton Charlotte
- Eglinton Charlotte
- El Tawil Salwa
- Elfandi Khaled
- Elliot Jennifer
- Elliott Emma
- Ellis Sam
- Emberson Jonathan
- Emsley Hedley
- England Timothy
- Epstein Daniel
- Erande Renuka
- Erumere Esther
- Esisi Bernard
- Esisi Bernard
- Esson Derek
- Esson Derek
- Evans Rachel
- Evans Sue
- Eveson David
- Ewing Jordan
- Fathima Razik
- Fawcett Michelle
- Feerick Shez
- Fennelly Ruth
- Ferdinand Phillip
- Findlay Paul
- Finlay Sarah
- Finney Kay
- Fitzell Pauline
- Fitzsimmons Paul
- Fletcher Glyn
- Fletcher Jo
- Fong Rosanna
- Foot Jayne
- Foote Leanne
- Ford Gary
- Foster Eliza
- Fotherby Ken
- Fox Charlotte
- Francia Nina
- Francis Jobbin
- Fraser Ruth
- Fraser Ruth
- Fuller Tracy
- Fulton Ailsa
- Furnace Jacqueline
- Gadapa Naveen
- Gainard Glyn
- Gainsborough Nicola
- Gallagher Jill
- Gallagher Louise
- Gallifent Rachel
- Gamble Ed
- Garcia Tatiana
- Gardener Léjeune
- Garfield-Smith Joanne
- Garside Mark
- Gartrell Imogen
- Gascoyne Rachel
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- Sarah Procter
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- Siddiq Muhammad
- Siddiqui Amber
- Siddiqui Anwer
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- Sims Don
- Singh Arun
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- Skinner Helen
- Slade Peter
- Smart Amanda
- Smith Andrew
- Smith Fiona
- Smith Gemma Marie
- Smith Simon
- Smith Wilma
- Smyth Nigel
- Spencer Jayne
- Sprigg N
- Srinivasan Meena
- Stafford Samantha
- Stafford Samantha
- Stanners Andrew
- Steele Amy
- Stephen J
- Stephens Claire
- Stevens Angela
- Stevens Stephanie
- Stevenson Sarah
- Stewart Kelvin
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- Strain David
- Subramonian Santhosh
- Sudlow CLM
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- Sultan Sulaiman
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- Sutton Claire
- Sutton Patrick
- Sutton Victoria
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- Taylor Vicky
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- Thant Hlaing
- Thavanesan Kamy
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- Thomas Kelly
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- Triscott Claire
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- Verrion Anna
- Vettimootal Johnson Venetia
- Vickers Carinna
- Walford Jamie
- Walker Allan
- Walker Marion
- Walker Pauli
- Walker Susannah
- Wallace Aine
- Wallace Rebecca
- Wallace Rebecca
- Walstow Deborah
- Walter Deborah
- Walters Ashleigh
- Wani Mushtaq
- Ward Deborah
- Wardlaw JM
- Watchurst Caroline
- Waterfield Kelly
- Waterfield Kelly
- Watson Fran
- Waugh Dean
- Webb Tom
- Webber Adam
- Webster Timothy
- Weinling Marie
- Weir Nic
- Weir Pauline
- Welch Angela
- Werring DJ
- Whitcher Alison
- White James
- White Julie
- White PM
- White Susan
- Whiteley WN
- Whiteman Jessica
- Whiteman Jessica
- Whiting Robert
- Whittamore Katherine
- Wiggam Ivan
- Wilding Peter
- Wilkes Gwendoline
- Wilkinson Mark
- Willberry Angela
- Williams Carol
- Williams Rebecca
- Williams-Yesson Barbara
- Willmot Mark
- Wilson David
- Wilson Duncan
- Wilson Jenny
- Wilson Lisa
- Wilson Sarah
- Wiltshire Alison
- Wood Diane
- Wood Edith
- Wood Lisa
- Woodward Stephen
- Wright Fiona
- Wroath Belinda
- Wynter Inez
- Yadava Rajendra
- Yip Brigitte
- Young Andrew
- Zachariah George
- Zahoor Tajammal
- Zoe Mellor
- Publication venue
- 'Elsevier BV'
- Publication date
- 29/06/2019
- Field of study
Background:
Antiplatelet therapy reduces the risk of major vascular events for people with occlusive vascular disease, although it might increase the risk of intracranial haemorrhage. Patients surviving the commonest subtype of intracranial haemorrhage, intracerebral haemorrhage, are at risk of both haemorrhagic and occlusive vascular events, but whether antiplatelet therapy can be used safely is unclear. We aimed to estimate the relative and absolute effects of antiplatelet therapy on recurrent intracerebral haemorrhage and whether this risk might exceed any reduction of occlusive vascular events.
Methods:
The REstart or STop Antithrombotics Randomised Trial (RESTART) was a prospective, randomised, open-label, blinded endpoint, parallel-group trial at 122 hospitals in the UK. We recruited adults (≥18 years) who were taking antithrombotic (antiplatelet or anticoagulant) therapy for the prevention of occlusive vascular disease when they developed intracerebral haemorrhage, discontinued antithrombotic therapy, and survived for 24 h. Computerised randomisation incorporating minimisation allocated participants (1:1) to start or avoid antiplatelet therapy. We followed participants for the primary outcome (recurrent symptomatic intracerebral haemorrhage) for up to 5 years. We analysed data from all randomised participants using Cox proportional hazards regression, adjusted for minimisation covariates. This trial is registered with ISRCTN (number ISRCTN71907627).
Findings:
Between May 22, 2013, and May 31, 2018, 537 participants were recruited a median of 76 days (IQR 29–146) after intracerebral haemorrhage onset: 268 were assigned to start and 269 (one withdrew) to avoid antiplatelet therapy. Participants were followed for a median of 2·0 years (IQR [1·0– 3·0]; completeness 99·3%). 12 (4%) of 268 participants allocated to antiplatelet therapy had recurrence of intracerebral haemorrhage compared with 23 (9%) of 268 participants allocated to avoid antiplatelet therapy (adjusted hazard ratio 0·51 [95% CI 0·25–1·03]; p=0·060). 18 (7%) participants allocated to antiplatelet therapy experienced major haemorrhagic events compared with 25 (9%) participants allocated to avoid antiplatelet therapy (0·71 [0·39–1·30]; p=0·27), and 39 [15%] participants allocated to antiplatelet therapy had major occlusive vascular events compared with 38 [14%] allocated to avoid antiplatelet therapy (1·02 [0·65–1·60]; p=0·92).
Interpretation:
These results exclude all but a very modest increase in the risk of recurrent intracerebral haemorrhage with antiplatelet therapy for patients on antithrombotic therapy for the prevention of occlusive vascular disease when they developed intracerebral haemorrhage. The risk of recurrent intracerebral haemorrhage is probably too small to exceed the established benefits of antiplatelet therapy for secondary prevention
Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity.
- Author
- Aanensen David M
- Abudahab Khalil
- Acheson Erwan
- Adams Alexander
- Adams Helen
- Adriaenssens Evelien M
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad SY
- Alam Mohammad T
- Alcolea-Medina Adela
- Alderton Alex
- Alikhan Nabil-Fareed
- Allan John
- Allara Elias
- Amato Roberto
- Andersson Monique
- Angyal Adrienn
- Aranday-Cortes Elihu
- Ariani Cristina
- Asad Hibo
- Asamaphan Patawee
- Ashworth Jordan
- Atkinson Laura
- Attwood Stephen
- Auckland Cressida
- Awan Ali R
- Aydin Alp
- Baker David J
- Baker Paul
- Balcazar Carlos E
- Ball Jonathan
- Barton Edward
- Bashton Matthew
- Batra Rahul
- Baxter Laura
- Beale Mathew A
- Beaver Charlotte
- Beckett Angela
- Beer Robert
- Beggs Andrew
- Bell Andrew
- Bellis Katherine L
- Berger Duncan J
- Berriman Matt
- Berry Lisa
- Berry Louise
- Betancor Gilberto
- Betteridge Emma
- Bewshea Claire M
- Bibby David
- Bicknell Kelly
- Birchley Alec
- Bird Paul
- Bishop Chloe
- Blane Beth
- Bolt Frances
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Boyd Olivia
- Boyes John
- Bradley Declan T
- Bradshaw Daniel
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgewater Hannah E
- Brooks Tony T
- Broos Alice
- Brown Julianne Rose
- Brown Paul E
- Brown Rebecca
- Brunker Kirstyn
- Bucca Giselda
- Buck David
- Buddenborg Sarah K
- Bull Matthew
- Bull Matthew
- Burton-Fanning Shirelle
- Butcher Ethan
- Caddy Sarah L
- Caller Laura G
- Campbell Sharon
- Carlile Matthew
- Carmichael Stephen N
- Casey Anna
- Castellano Sergi
- Chalker Vicki
- Chand Meera
- Chapman Michael R
- Chappell Joseph G
- Charalampous Themoula
- Charles Ian G
- Chaudhry Yasmin
- Chauhan Anoop J
- Cheng Jeffrey KJ
- Churcher Carol M
- Clark Gemma
- Coll Francesc
- Collins Jennifer
- Colquhoun Rachel
- Colquhoun Rachel M
- Connor Thomas R
- Connor Thomas R
- Constantinidou Chrystala
- Coombes Jason
- Corden Sally
- Cormie Claire
- Cortes Nicholas
- Cortes Nick
- Cottrell Simon
- Coupland Lindsay J
- Cowell Angela
- Cox Alison
- Craine Noel
- Cronin Michelle
- Crooke Derrick
- Curran Martin D
- Curran Tanya
- da Silva Filipe Ana
- da Silva Filipe Ana
- Dabrera Gavin
- Danesh John
- Darby Alistair C
- Davidson Rose K
- Davies Alisha
- Davis Thomas
- de Cesare Mariateresa
- De Lacy Elen
- de Oliveira Martins Leonardo
- de Silva Thushan I
- Debebe Johnny
- Dervisevic Samir
- Dewar Rebecca
- Dias Joana
- Diaz Maria
- Dibling Thomas
- Dorman Matthew J
- Downing Fatima
- Drury Eleanor
- du Plessis Louis
- Duckworth Nichola
- Dyal Patricia L
- Eccles Richard
- Edgeworth Jonathan
- Edwards Sue
- Eldirdiri Sahar
- Ellaby Nicholas
- Ellard Sian
- Elliott Scott
- Eltringham Gary
- Elumogo Ngozi
- Essex Sarah
- Evans Cariad
- Evans Johnathan M
- Eyre David
- Fairley Derek J
- Fallon Karlie
- Farbos Audrey
- Farr Ben
- Feltwell Theresa
- Fina Laia
- Findlay Jacqueline
- Fisher Chloe L
- Fleming Vicki M
- Forrest Leysa M
- Forrest Sally
- Foulser Luke
- Francois Sarah
- Fraser Christophe
- Freeman Timothy M
- Frost Lucy R
- Fuller William
- Gallagher Eileen
- Gallagher Michael D
- Garcia-Casado Maria V
- Gaskin Amy
- Gatica-Wilcox Bree
- Gavriil Artemis
- Geidelberg Lily
- Geidelberg Lily
- Gemmell Matthew
- Georgana Iliana
- George Ryan P
- Gifford Laura
- Gilbert Lauren
- Gill Harmeet K
- Gilroy Rachel AJ
- Girgis Sophia T
- Glaysher Sharon
- Golubchik Tanya
- Goncalves Sonia
- Goodfellow Ian
- Goodfellow Ian G
- Goodwin Scott
- Graham Clive
- Graham Lee
- Grammatopoulos Dimitris
- Green Angie
- Green Luke R
- Greenaway Jane
- Gregory Richard
- Griffith Luke
- Groves Danielle C
- Groves Natalie
- Guest Martyn
- Gulliver Huw
- Gutierrez Ana Victoria
- Hadjirin Nazreen F
- Haldenby Sam T
- Hale Antony D
- Hall Grant
- Halstead Fenella
- Hamilton William L
- Haque Tanzina
- Harper Katherine L
- Harris Kathryn Ann
- Harrison Ewan M
- Harrison Ian
- Harrison James W
- Hartman Hassan
- Hattersley Andrew
- Heaney Judith
- Helmer Thomas
- Hesketh Andrew R
- Heyburn David
- Higginson Ellen E
- Hill Verity
- Hill Verity
- Hilvers Ember
- Hiscox Julian A
- Holden Matthew TG
- Holmes Alison
- Holmes Christopher
- Holmes Nadine
- Hoosdally Sarah
- Hopes Richard
- Hosmillo Myra
- Houldcroft Charlotte J
- Howe Robin
- Howson-Wells Hannah C
- Hubb Jonathan
- Hughes Joseph
- Hughes Margaret
- Hunter Adam D
- Hutchings Stephanie
- Impey Robert
- Irish-Tavares Dianne
- Iturriza-Gomara Miren
- Jackson Ben
- Jackson Ben
- Jackson David A
- Jackson David K
- Jackson Kathryn A
- Jahun Aminu S
- James Keith
- Jamrozy Dorota
- Jarrett Ruth
- Jeffries Aaron R
- Jesudason Natasha
- Jesudason Natasha G
- John Michaela
- Johnson Kate
- Johnson Natasha
- Johnson Rob
- Johnson Robert
- Johnston Ian
- Jones Hannah
- Jones Katie
- Jones Rachel
- Jones Sophie
- Jorgensen David
- Jorgensen David
- Joseph Amelia
- Justice Anita
- Kane Leanne
- Kay Gemma L
- Kay Sally
- Keatley Jon-Paul
- Keeley Alexander J
- Kenyon Anita
- Kermack Leanne M
- Khakh Manjinder
- Khokhar Fahad A
- Kidd Stephen
- Kingsley Robert A
- Kitchen Christine
- Knight Bridget A
- Kolyva Anastasia
- Koshy Cherian
- Kraemer Moritz
- Kristiansen Mark
- Kumziene-Summerhayes Sara
- Kwiatkowski Dominic
- Lackenby Angie
- Langford Cordelia
- Lawniczak Mara
- Le-Viet Thanh
- Lee David
- Lee Jack CD
- Letchford Laura
- Levene Nick
- Levett Lisa J
- Li Kathy
- Li Kathy K
- Liggett Steven
- Lindsey Benjamin B
- Lister Michelle M
- Livett Rich
- Lloyd Allyson
- Lo Stephanie
- Loh Joshua
- Loman Nicholas J
- Loman Nicholas J
- Loose Matthew W
- Loveson Katie F
- Lowe Hannah
- Lucaci Anita O
- Ludden Catherine
- Lynch Jessica
- Lyons Ronan A
- Macfarlane-Smith Louissa R
- Machin Nicholas W
- MacIntyre-Cockett George
- Madona Pinglawathee
- Maes Mailis
- Mahungu Tabitha W
- Mair Daniel
- Maksimovic Joshua
- Manesis Nikos
- Manley Robin
- Manso Carmen
- Marchbank Angela
- Martincorena Inigo
- Martinez-Nunez Rocio T
- Masoli Jane AH
- Mason Jenifer
- Mather Alison E
- Mbisa Tamyo
- McCluggage Kathryn
- McClure Patrick C
- McCrone John T
- McCrone JT
- McGuigan Samantha
- McHugh Martin P
- McKenna James P
- McKerr Caoimhe
- McMinn Liz
- McMurray Claire
- Meader Emma J
- Meadows Lizzie
- Menegazzo Mirko
- Meredith Luke W
- Merrick Ian
- Mestek-Boukhibar Lamia
- Miah Shahjahan
- Michell Stephen L
- Michelsen Michelle L
- Molnar Zoltan
- Monaghan Lynn
- Mookerjee Siddharth
- Moore Catherine
- Moore Catrin
- Moore Christopher
- Moore Nathan
- Morgan Mari
- Morgan Sian
- Mori Matilde
- Moses Samuel
- Muir Peter
- Munn Robert
- Myers Richard
- Nascimento Fabricia F
- Nascimento Fabricia F
- Naydenova Plamena
- Neaverson Alexandra S
- Nebbia Gaia
- Nelson Andrew
- Nelson Charlotte
- Nelson Rachel
- Nicholls Sam
- Nicholls Samuel M
- Nichols Jenna
- Niebel Marc O
- Niola Paola
- Nomikou Kyriaki
- O'Toole Elaine
- O'Toole Áine
- Orton Richard J
- Osman Husam
- Ott Sascha
- O’Grady Justin
- O’Toole Áine
- Pacchiarini Nicole
- Pacchiarini Nicole
- Padgett Debra
- Page Andrew J
- Palmer Sophie
- Palmer Steve
- Panchbhaya Yasmin N
- Pandey Sarojini
- Park Naomi
- Parker Matthew D
- Parmar Surendra
- Parr Yasmin A
- Parsons Paul J
- Partridge David G
- Pascall David J
- Patel Gaurang
- Patel Minal
- Patel Vineet
- Paterson Steve
- Payne Brendan AI
- Peacock Sharon J
- Pearson Clare
- Perry Malorie
- Peto Timothy
- Pinckert Malte L
- Platt Steven
- Plimmer Amy
- Poplawski Radoslaw
- Potter Will
- Prakash Reenesh
- Prestwood Liam
- Price Anna
- Price Anna
- Price James
- Puethe Christoph
- Pybus Oliver
- Pybus Oliver G
- Pymont Hannah M
- Quail Mike
- Quick Joshua
- Raghwani Jayna
- Ragonnet-Cronin Manon
- Rainbow Lucille
- Rajatileka Shavanthi
- Rambaut Andrew
- Rambaut Andrew
- Ramsay Mary
- Randell Paul A
- Raviprakash Veena
- Raza Mohammad
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- Tang Julian
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- Trebes Amy
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- Tucker Rachel M
- Turtle Lance
- Tutill Helena J
- Underwood Anthony P
- Unnikrishnan Meera
- Vamos Edith E
- Vasylyeva Tetyana
- Vattipally Sreenu
- Vipond Ian B
- Volz Erik
- Volz Erik M
- Wain John
- Walsh Sarah
- Wang Dennis
- Wantoch Michelle
- Warne Ben
- Warwick-Dugdale Joanna
- Wastenge Elizabeth
- Watkins Joanne
- Watts Joanne
- Waugh Sheila
- Webber Mark A
- Weeks Sam
- Weldon Danni
- Whitehead Mark
- Williams Charlotte A
- Williams Chris
- Williams David
- Williams Rachel J
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen A
- Willingham Iona
- Wilson Harry D
- Wise Emma
- Workman Trudy
- Wright Victoria
- Wyles Matthew
- Wyllie Sarah
- Yakovleva Anna
- Yasir Muhammad
- Yeats Corin A
- Yew Wen C
- Young Gregory R
- Young Jamie
- Yu Xiaoyu
- Zarebski Alex
- Publication venue
- Cell
- Publication date
- 01/09/2020
- Field of study
Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
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- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
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- Ashcroft Kevin
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- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
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- Atkinson Andrea
- Atkinson Barry
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- Huynh Sandy
- Hyde David
- Hynds Christopher
- Idlebird Devincent G.
- Iliev Ilian
- Imbro Paula
- Imo Kelvin C.
- Inacio Nicole
- Inagaki Naomi
- Ince Michael
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- Isak Amber
- Isherwood Judith
- Ishibashi Akiko
- Ishikawa Sabine K.
- Ishizaki Hinako
- Isozaki Emi
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- Ito Fumiaki
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- Itoh Takehiko
- Iwakawa Shinobu
- Iwatate Mariko
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- Izatt Janet
- Izmajlowicz Monica
- Izumiyama Tomohiro
- Jacintho Mark
- Jackson Laronda R.
- Jackson Terri
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- Jaeger Sara
- Jaffe David B.
- Jahn Niels
- Jaklevic Joseph
- Jaklevic Michael
- James Kent W.
- Jareborg Niclas
- Jarek Michael
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- Jeffery Grant
- Jeffery Kim
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- Jekosch Kerstin
- Jenkins Lee
- Jett Jamie
- Jewett Phillip E.
- Jia Jia
- Jia Jia
- Jia Nan
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- Jiang Lu
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- Kou Zhaohui
- Kovar Christie L.
- Krawczyk Marie-Claude
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- Kruchowski Scott S.
- Kube Michael
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- Li Changfeng
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- Lorensuhewa Lorna M.
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- Lowenstein Michael G.
- Lowry Stephen
- Lozado Ryan J.
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- Lucier Raymond L.
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- MacLean Christine
- Madabhushi Ramki
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- McMurray Kimberly
- McMurray Kimberly L.
- McNinch Jenny
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- Mehta Nalini
- Meidi Patrick
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- Munidasa Mala
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- Murayama Yuji
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- Nagamine Kentaro
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- Nair Seema R.
- Naka Maho
- Nakagawa Masayo
- Nakagawa Saori
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- Nakato Eriko
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- Nankervis Colin E.
- Naranjo Cleo M.
- Nash William
- Naylor Jerome
- Nazareth Lynne V.
- Neal Dearl D.
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- Nelson Catherine
- Nelson David O.
- Nelson Deborah A.
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- Nusbaum Chad
- Nwaokelemeh Ogechi O.
- Nwokenkwo Stanley
- O\u27Donnell Paula
- O\u27Donovan Daniel
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- O\u27Loughlin Jennifer
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- Obayashi Izumi
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- Okui Michiyo
- Okumura Reina
- Okwuonu Geoffrey O.
- Okwuonu Kenneth C.
- Olarnpunsagoon Alisa
- Olivas Jason
- Oliver Hayley
- Oliver Karen
- Olsen Anne S.
- Olson Maynard V.
- Omotosho Bamidele
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- Ovcharenko Ivan
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- Oviedo Rodolfo J.
- Ow David
- Ozawa Ritsuko
- Ozersky Philip
- Pace Araceli C.
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- Pasternak Shiran
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- Patel Ritesh
- Patel Shripa
- Patel Vishal V.
- Patrick James
- Paul Heidie A.
- Paul Shelia
- Paulson Edward
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- Pearce Alexandra
- Pearman Charlene
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- Peng Vivian
- Peng Yi
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- Peng Ze
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- Pennacchio Len A.
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- Percy Chantel
- Perez Agapito
- Perez Lesette M.
- Perito Andrew
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- Pourrajabi Nima M.
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- Qin Xiang
- Quail Michael
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- Ridler Kerry
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- Sasaki Takashi
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- Saurin William
- Savery Glenford G.
- Sawada Nori
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- Scarpelli Claude
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- Schatzkamer Kyriena L.
- Scherer Steven Edward
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- Siepel Adam C.
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- Sonnhammer Erik
- Sonnhammer Erik
- Sorelle Richard P.
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- Sudbrak Ralf
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- Sulston John
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- Sun Hui
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- Sun Yongqiao
- Sun Yu
- Sun Yue
- Sutherland Grant R.
- Sutherland Robert D.
- Sutton Angelica E.
- Svatek Amanda F.
- Svetz Jessica
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- Takano Nobuhiro
- Takaoka Tori
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- Takenaka Tracy
- Talamas Jessica
- Tam Serena
- Tamerisa Kavitha S.
- Tamirisa Aparna
- Tan Olivia
- Tan Steven
- Tan Xinyu
- Tan Xinyu
- Tang Hongli
- Tang Xiangjun
- Tansey Jennifer
- Tao Ran
- Tapia Roxanne
- Taring Elizabeth
- Tatsuyama Miho
- Tatum Owatha I.
- Taudien Stefan
- Taylor Amy
- Taylor Christina C.
- Taylor Gillian
- Taylor Kate
- Taylor Ruth
- Taylor Sam
- Taylor Susan
- Taylor Tineace R.
- Taylor Todd Duane
- Tchuinga Pierre
- Tee Louise
- Telford Ethan Brett
- Tenzin Pema
- Terada Yoriko
- Terry Astrid
- Tesfaye Senait
- Tesmer Judith G.
- Tester Julieanne
- Thayer Nina
- Theaker Andrew
- Theil James
- Theodore Joumathe
- Thexton David
- Thies Stephanie
- Thomas Craig
- Thomas Daniel
- Thomas Daryl J.
- Thomas Karen
- Thomas Nicole
- Thomas Paulette
- Thomas Ruth
- Thomas Shereen
- Thommai Roselin
- Thompson Linda S.
- Thorne Rachel Diane
- Thorpe Andrea
- Thorpe Karen
- Thoulutsang Yama
- Threadgold Glen
- Thurston Scott
- Tian Chaoguang
- Tian Chaoguang
- Tian Wei
- Tian Yan
- Tian Yong
- Tian Yuqing
- Tice Hope
- Tighe Damon
- Tin-Wollam Aye M.
- Tinsley Emma
- Tochigi Miwako
- Togashi Naoko
- Tomizawa Iori
- Tomlinson Chad
- Tong Jingli
- Topham Kerri
- Torcaso Bill
- Torney David C.
- Totoki Yasushi
- Towey Sarah
- Toyoda Atsushi
- Tracey Alan
- Tran Ly Thanh
- Tran-Gyamfi Mary
- Trani Lee
- Trankiem Margie
- Trask Barbara J.
- Travers Johnathan
- Trejos Zulma Y.
- Treuhaft Marianne
- Trevino Brenda Kaye
- Tromans Anthony
- Trong Stephan
- Trumbower Heather
- Tsai Ming
- Tsamla Tsamla
- Tsolas Jason
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- Tsukamoto Yumi
- Tsuruoka Hiromi
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- Tu Yuefeng
- Tubby Ben
- Tufarelli Cristina
- Turner Heidi
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- Tynan Katherine
- Ueland Stephanie
- Ueng Samantha
- Ukegbu Ogechi Nkemdirim
- Ulanovsky Levy E.
- Un Chun
- Ung Quyen
- Upson Darren
- Urban Jeremy B.
- Ureta-Vidal Abel
- Ureta-Vidal Abel
- Usmani Kamran
- Ustaszewska Anna
- Uyama Nozomi
- Valas Ruben E.
- Valdez Michelle
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- Vargas Michelle
- Vargo Charles E.
- Vartanian Steffan
- Vasquez Lydia I.
- Vassiliev Helen
- Vastrik Imre
- Vaudin Mark
- Veil Rose
- Veklerov Eugene
- Velasco Nelson
- Velasquez Lisa
- Venkataranan Vijay
- Vera Virginia A.
- Verduzco Daniel
- Vergez Lisa
- Vico Virginie
- Viknaraja Ramya
- Villasana Donna M.
- Vine Wendy
- Viswanathan Vijay
- Vo Andy
- Vo Nu
- Voak Paul
- Vollenhoven David
- Wada Hiromi
- Wagner Mark
- Wagner-McPherson Caryn
- Waldron Lenee
- Waligorski Jason E.
- Walker Davian L.
- Walker Keya
- Walker Sarah
- Wall Melanie
- Wall Randy E.
- Wallace John
- Wallis Justine
- Wallis Michelle
- Walsh Jennifer
- Walsham Natalie
- Wan Ma
- Wang Chunyan
- Wang Dong
- Wang Feng
- Wang Guangxin
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- Wang Guihai
- Wang Hongjuan
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- Wang Huifeng
- Wang Huifeng
- Wang Jian
- Wang Jian
- Wang Jian
- Wang Jie
- Wang Jing
- Wang Jingqiang
- Wang Jingqiang
- Wang Jinhua
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- Wang Jun
- Wang Jun
- Wang Jun
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- Wang Lijie
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- Wang Xuegang
- Wang Yan
- Wang Yimin
- Wang Ying
- Wang Ying
- Wang Yuanyuan
- Wangchuck Tsering
- Wangdi Tsering
- Ward-Moore Stephanie
- Warren Graham
- Warren James T.
- Warry Georgina
- Watanabe Hidemi
- Watanabe Saki
- Waterston Robert H.
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- Watt Nicola
- Webb Anthony
- Webb Jeannette
- Webber Caleb
- Weber Ryan J.
- Wehri Edward
- Wei Shulin
- Wei Xuehong
- Weidenbach Richard
- Weinstock George
- Weinstock Keith
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- Weissenbach Jean
- Wells Alan
- Wells Sarah
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- Wen Gaiping
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- Weng Li
- Wenning Sarah
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- West Tony
- Wetterstrand Kris
- Wheatley Angela
- Wheatley Carl
- Wheeler David A.
- Wheeler Gideon
- Wheeler Jeremy
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- White P. Scott
- White Scott P.
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- Whiteley Matthew
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- Whittaker Charles
- Whittaker Pamela
- Wickremasinghe Manosha I.
- Widaa Sara
- Wiegel Sarah
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- Wilkinson Jane
- Wilkinson Jane
- Wilkinson Paul
- Willey David
- Williams Albert L.
- Williams Andy
- Williams Bill
- Williams Gabrielle A.
- Williams Leanne
- Williamson Angela L.
- Williamson Helen
- Wills Patricia L.
- Wills Richard
- Wilmer Tamsin
- Wilming Laurens
- Wilson Brian
- Wilson Gareth
- Wilson Margaret
- Wilson Nyree
- Wilson Piers
- Wilson Richard K.
- Wilson Siobhan
- Wilson Steve
- Wilson Wendy
- Wincker Patrick
- Window Philip
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- Winzar Claire
- Witt James
- Wleczyk Regina
- Wobus Fred
- Woessner Jeffrey
- Wohldmann Patty
- Wollard Jessica
- Womack Andrew W.
- Wong Benjamin
- Wong Gane K-S
- Wood Diane
- Wood Emma
- Wood Joe
- Wooden Hailey S.
- Wooden Steven H.
- Woodeson Sharon
- Woodfine Kathryn
- Woodmansey Rebecca
- Woods Eric
- Woodwark Cara
- Wooster Richard
- Worley Kim Carlyle
- Woyke Tanja
- Wray Matthew
- Wray Paul
- Wright Charmain
- Wright Debbie
- Wright Kathrine
- Wright Kristin
- Wright Rita A.
- Wu Chungen
- Wu Dongying
- Wu Jiaqian
- Wu Jung-Rung
- Wu Kevin
- Wu Qingfa
- Wu Qingfa
- Wu Ruiming
- Wu Xiao
- Wu Xiaojing
- Wu Zaining
- Wyatt Julia
- Wycoff-Montenegro Melissa
- Wylie Kris
- Wyman Dudley
- Wyman Stacia
- Xi Yan
- Xi Yingying
- Xie Fei
- Xie Gary
- Xie Jane
- Xiong Hui
- Xiong Yuqing
- Xu Alex
- Xu Jing
- Xu Jing
- Xu Ruqin
- Xu Shuhua
- Xu Wei
- Xu Xinlai
- Xu Yan
- Xu Yuning
- Xu Zhihong
- Xu Zuyuan
- Xuan Yali
- Xuan Zhenyu
- Xue Rui
- Yada Tetsushi
- Yadav Shailendra
- Yakub Syed
- Yamamoto Lynn
- Yamamoto Noriko
- Yamamoto Yuko
- Yamashita Yasue
- Yamazaki Satoru
- Yang Hao
- Yang Huanming
- Yang Huanming
- Yang Joan
- Yang Shiaw-Pyng
- Yang Shudong
- Yang Xiaonan
- Yang Xiaonan
- Yang Xiaoping
- Yang Yongkui
- Yano Candance
- Yao Zhijian
- Yao Zhijian
- Yaspo Marie-Laure
- Ye Chen
- Yeager Shane
- Yeh Mimi
- Yen Jennifer
- Yeshitela Rahel Retta
- Yoakum Martin
- Yokobata Kathy
- Yokoyama Jennifer
- Yonezawa Miho
- Yoon Lillienne
- Yoon Vivienne
- Yoshida Satoru
- You Bo
- Young Geneva
- Young Louise
- Young Shelia
- Younger Ruth
- Yu Bing
- Yu Charles
- Yu Fuli
- Yu Jun
- Yu Jun
- Yu Jun
- Yuan Kaiwen
- Yuan Ye
- Yuan Yida
- Yue Shujie
- Yumae Brian
- Yun Rui
- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
- Zhang Caimin
- Zhang Fengmei
- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Recommended from our members
The contribution of X-linked coding variation to severe developmental disorders
- Author
- Abbs Steve
- Akawi Nadia
- Albaba Shadi
- Allen Zoe
- Armstrong Ruth
- Azam Tara
- Baker Duncan
- Balasubramanian Meena
- Banka Siddharth
- Baple Emma
- Baptista Júlia
- Baralle Diana
- Barnicoat Angela
- Beleza Ana
- Bennett Christopher
- Berg Jonathan
- Bernhard Birgitta
- Blair Edward
- Blyth Moira
- Bodek Simon
- Borras Silvia
- Bourn David
- Bradley Lisa
- Bradley Therese
- Bradshaw Kirsty
- Brady Angela
- Breen Catherine
- Brewer Carole
- Briggs Tracy
- Brooks Claire
- Burkitt-Wright Emma
- Burn John
- Busby Louise
- Butler Rachel
- Callaway Alison
- Campbell Jennifer
- Canham Natalie
- Carmichael Jenny
- Cassidy Emma J.
- Castle Bruce
- Chandler Kate
- Cilliers Deirdre
- Clark Caroline
- Clarke Angus
- Clasper Susan
- Clayton-Smith Jill
- Cleary Elaine
- Clement Emma
- Clowes Virginia
- Coates Andrea
- Cole Trevor
- Comerford Joanne
- Cooper Nicola
- Cooper-Charles Lisa
- Corrin Sian
- Cox Helen
- Crosby Charlene
- Dabir Tabib
- Daniels Stacey
- Davidson Rosemarie
- Dean John
- Deshpande Charu
- Dixit Abhijit
- Dobbie Angus
- Donaldson Alan
- Donnai Dian
- Donnelly Deirdre
- Douglas Andrew
- Douzgou Sofia
- Dunn Carolyn
- Eason Jacqueline
- Eberhardt Ruth Y.
- Ellis Ian
- Elmslie Frances
- Faravelli Francesca
- Firth Helen V.
- Fisher Richard
- FitzPatrick David R.
- Flinter Frances
- Foulds Nicola
- Fry Andrew
- Gallone Giuseppe
- Gardiner Carol
- Gardner Eugene J.
- Gaunt Lorraine
- Ghali Neeti
- Gibbons Richard
- Goudie David
- Green Andrew
- Greenhalgh Lynn
- Haines Rebecca
- Harrison Rachel
- Hellens Steve
- Henderson Alex
- Hewitt Sarah
- Hills Alison
- Hobson Emma
- Holden Simon
- Holder Muriel
- Holder Susan
- Homfray Tessa
- Howard Emma
- Humphreys Mervyn
- Hunt David
- Hurles Matthew E.
- Hurst Jane
- Ibitoye Rita
- Irving Melita
- Islam Lily
- Izatt Louise
- Jackson Andrew
- Jackson Eilidh
- Jarvis Joanna
- Jenkins Lucy
- Jewell Rosalyn
- Jin Huilin
- Johnson Diana
- Jones Elizabeth
- Jones Wendy
- Josifova Dragana
- Joss Shelagh
- Kamath Arveen
- Kaplanis Joanna
- Keelagher Rebecca
- Kerr Bronwyn
- Kharbanda Mira
- Kini Usha
- Kinning Esther
- Kivuva Emma
- Kraus Alison
- Kumar V.K.Ajith
- Lachlan Katherine
- Lahiri Nayana
- Lam Wayne
- Lampe Anne
- Langley Claire
- Lees Melissa
- Lester Tracy
- Lim Derek
- Longman Cheryl
- Loughlin Sam
- Low Karen
- Lynch Sally
- Magee Alex
- Male Alison
- Mansour Sahar
- Marks Karen
- Martin Hilary C.
- Mavrak Eleni
- McCann Emma
- McConnell Vivienne
- McEntagart Meriel
- McGowan Ruth
- McKee Shane
- McLean Joanne
- McMullan Dominic
- McNerlan Susan
- McQuaid Shirley
- McRae Jeremy
- McWilliam Catherine
- Mercer Catherine
- Metcalfe Kay
- Miedzybrodzka Zosia
- Mohammed Shehla
- Molenda Aneta
- Montgomery Tara
- Moore David
- Morrison Patrick J.
- Morrogh Deborah
- Morton Jenny
- Mugalaasi Hood
- Mullaney Brendan
- Murday Victoria
- Mutch Stacey
- Naik Swati
- Nemeth Andrea
- Neville Matthew D. C.
- Newbury-Ecob Ruth
- Niemi Mari E. K.
- Norman Andrew M.
- Ong Kai-Ren
- Osio Deborah
- Owens Martina
- O’Driscoll Mary
- Park Soo-Mi
- Parker Michael
- Paterson Joan
- Pilz Daniela
- Porteous Mary
- Pottinger Caroline
- Poulton Joanna
- Prescott Katrina
- Price Sue
- Procter Annie
- Quarrell Oliver
- Ragge Nicola
- Rankin Julia
- Raymond Lucy
- Rea Gillian
- Reavey Eleanor
- Reid Evan
- Robert Leema
- Roberts Eileen
- Ross Alison
- Rosser Elisabeth
- Roworth Wendy
- Ruddy Deborah
- Ryten Mina
- Saggar Anand
- Samocha Kaitlin E.
- Sampson Julian
- Sandford Richard
- Sansbury Francis
- Sarkar Ajoy
- Scott Richard
- Scurr Ingrid
- Searle Claire
- Shannon Nora
- Sharif Abid
- Shaw-Smith Charles
- Shears Debbie
- Sheridan Eamonn
- Side Lucy
- Sifrim Alejandro
- Simonic Ingrid
- Smith Audrey
- Smithson Sarah
- Splitt Miranda
- Stewart Alison
- Stewart Fiona
- Stewart Helen
- Stinton Victoria
- Straub Volker
- Suri Mohnish
- Swale Andrew
- Tatton-Brown Kate
- Tavares Ana Lisa Taylor
- Temple I. Karen
- Tennant Stephen
- Thomson Jenny
- Tischkowitz Marc
- Tobias Edward
- Tooley Madeleine
- Turner Claire
- Turnpenny Peter
- Turton Sarah
- Tysoe Carolyn
- Varghese Vinod
- Vasudevan Pradeep
- Vogt Julie
- Wakeling Emma
- Weber Astrid
- Wellesley Diana
- Whiteford Margo
- Wilkie Andrew
- Williams Denise
- Williams Nicola
- Willoughby Josh
- Wilson Louise
- Woods Geoff
- Wright Caroline F.
- Wright Michael
- Wright Ronnie
- Yau Shu
- Zwolinski Simon
- Publication venue
- Nature Communications
- Publication date
- 27/01/2021
- Field of study
Abstract: Over 130 X-linked genes have been robustly associated with developmental disorders, and X-linked causes have been hypothesised to underlie the higher developmental disorder rates in males. Here, we evaluate the burden of X-linked coding variation in 11,044 developmental disorder patients, and find a similar rate of X-linked causes in males and females (6.0% and 6.9%, respectively), indicating that such variants do not account for the 1.4-fold male bias. We develop an improved strategy to detect X-linked developmental disorders and identify 23 significant genes, all of which were previously known, consistent with our inference that the vast majority of the X-linked burden is in known developmental disorder-associated genes. Importantly, we estimate that, in male probands, only 13% of inherited rare missense variants in known developmental disorder-associated genes are likely to be pathogenic. Our results demonstrate that statistical analysis of large datasets can refine our understanding of modes of inheritance for individual X-linked disorders
Delayed mucosal anti-viral responses despite robust peripheral inflammation in fatal COVID-19
- Author
- Adeniji Kayode
- Agranoff Daniel
- Agwuh Ken
- Ahmed Katie A.
- Ail Dhiraj
- Aldera Erin L.
- Alegria Ana
- Alex Beatrice
- Allen Sam
- Andrikopoulos Petros
- Angus Brian
- Armstrong Jane A.
- Ashish Abdul
- Ashworth Milton
- Asiimwe Innocent G.
- Atkinson Dougal
- Bach Benjamin
- Baillie J.Kenneth
- Bakshi Siddharth
- Barclay Wendy S.
- Bari Shahedal
- Barlow Gavin
- Barlow Samantha L.
- Barnass Stella
- Barrett Nicholas
- Bassford Christopher
- Basude Sneha
- Baxter David
- Beadsworth Michael
- Bernatoniene Jolanta
- Berridge John
- Berry Colin
- Best Nicola
- Bogaert Debby
- Booth Laura
- Bothma Pieter
- Brennan Benjamin
- Brittain-Long Robin
- Bullock Katie
- Bulteel Naomi
- Burden Tom
- Burtenshaw Andrew
- Carlucci Nicola
- Carracedo Alejandra Doce
- Carson Gail
- Caruth Vikki
- Cass Emily
- Catterall Benjamin W.A.
- Chadwick David
- Chadwick David
- Chambler Duncan
- Chand Meera
- Chechi Kanta
- Chee Nigel
- Chikowore Primrose
- Child Jenny
- Chukkambotla Srikanth
- Clark Jordan J.
- Clark Richard
- Clark Tom
- Clarke Emily A.
- Clohisey Sara
- Cole Sarah
- Cole Sarah
- Collini Paul
- Connor Marie
- Cooke Graham S.
- Cooper Louise
- Cosgrove Catherine
- Coutts Audrey
- Cox Helen
- Cupitt Jason
- Cutino-Moguel Maria-Teresa
- da Silva Filipe Ana
- Dalton Jo
- Dark Paul
- Davis Christopher
- Davis Christopher
- Dawson Chris
- de Silva Thushan
- Dervisevic Samir
- Dincarslan Oslem
- Docherty Annemarie B.
- Donegan Cara
- Donnelly Lorna
- Donnison Phil
- Donohue Chloe
- dos Santos Correia Gonçalo
- Douthwaite Sam
- Drake Thomas M.
- Drummond Andrew
- Dumas Marc-Emmanuel
- Dunn Chris
- Dunning Jake
- DuRand Ingrid
- Dushianthan Ahilanadan
- Dyer Philip
- Dyer Tristan
- Elliott Angela
- Evans Anthony
- Evans Cariad
- Eziefula Chi
- Fairfield Cameron J.
- Fawkes Angie
- Fegan Chrisopher
- Finch Lorna
- Finn Adam
- Fisher Lewis W.S.
- Flaherty Lisa
- Fletcher Tom
- Foster Terry
- Fullerton Duncan
- Gamble Carrol
- Garcia-Dorival Isabel
- Garg Atul
- Garg Sanjeev
- Gilchrist Tammy
- Girvan Michelle
- Gkrania-Klotsas Effrossyni
- Godden Jo
- Goldsmith Arthur
- Graham Clive
- Grammatikopoulos Tassos
- Green Christoper A.
- Greenhalf William
- Griffin Julian L.
- Griffiths Fiona
- Gunning Philip
- Gupta Rishi K.
- Hafezi Katarzyna
- Halpin Sophie
- Hardwick Hayley
- Hardwick Hayley E.
- Hardy Elaine
- Harrison Ewen M.
- Harrison Janet
- Hartley Catherine
- Hartshorn Stuart
- Harvey Daniel
- Havalda Peter
- Hawcutt Daniel B.
- Hendry Ross
- Ho Wai
- Hobrok Maria
- Hodgson Luke
- Holden Karl
- Holmes Anthony
- Horby Peter W.
- Hormis Anil
- Howard Joanne
- Ijaz Samreen
- Jackson Clare
- Jacobs Michael
- Jain Susan
- Jennings Paul
- Jensen Rebecca L.
- Jones Christopher B.
- Jones Trevor R.
- Kaliappan Agilan
- Kasipandian Vidya
- Kegg Stephen
- Kelsey Michael
- Kendall Jason
- Kerrison Caroline
- Kerslake Ian
- Khandaker Shadia
- Khoo Saye
- King Katharine
- Kiy Robyn T.
- Klenerman Paul
- Knight Stephen R.
- Knight Susan
- Koch Oliver
- Koduri Gouri
- Koshy George
- Koukorava Chrysa
- Laha Shondipon
- Lahnsteiner Eva
- Laird Steven
- Lake Annette
- Lant Suzannah
- Larkin Susan
- Latawiec Diane
- Lavelle-Langham Lara
- Law Andrew
- Law Andrew
- Lee James
- Leeming Gary
- Lefteri Daniella
- Leiner Tamas
- Lett Lauren
- Lewis Matthew R.
- Liew Felicity
- Liggi Sonia
- Lillie Patrick
- Lim Wei Shen
- Limb James
- Linnett Vanessa
- Little Jeff
- Livoti Lucia A.
- Lyttle Mark
- MacGillivray Louise
- Maclean Alan
- MacMahon Michael
- MacNaughton Emily
- Mancini Maria
- Mankregod Ravish
- Marsh Laura
- Maslen Lynn
- Massey Hannah
- Masson Huw
- Matovu Elijah
- Maziere Nicole
- McCafferty Sarah
- McCullough Katherine
- McDonald Sarah
- McDonald Sarah E.
- McEvoy Laurence
- McEwen Ruth
- McLauchlan John
- Mclean Kenneth A.
- Meda Manjula
- Mentzer Alexander J.
- Merson Laura
- Metelmann Soeren
- Meynert Alison M.
- Miah Nahida S.
- Middleton Joanna
- Mills Gary
- Minton Jane
- Mitchell Joyce
- Mohandas Kavya
- Mok Quen
- Moon James
- Moore Elinoor
- Moore Shona C.
- Moore Shona C.
- Moore Shona C.
- Morgan Patrick
- Morrice Kirstie
- Morris Craig
- Mortimore Katherine
- Moses Samuel
- Mpenge Mbiye
- Mulla Rohinton
- Murphy Derek
- Murphy Ellen G.
- Murphy Lee
- Murphy Michael
- Nagarajan Thapas
- Nagel Megan
- Nelson Mark
- Norman Lisa
- Norris Lillian
- Norris Lucy
- Noursadeghi Mahdad
- O?Shea Matthew K.
- Olanipekun Michael
- Oosthuyzen Wilna
- Oosthuyzen Wilna
- Openshaw Peter J.M.
- Openshaw Peter J.M.
- Osagie Anthonia
- Ostermann Marlies
- Otahal Igor
- Pais Mark
- Palmarini Massimo
- Palmieri Carlo
- Palmieri Carlo
- Panchatsharam Selva
- Papakonstantinou Danai
- Papineni Padmasayee
- Paraiso Hassan
- Patel Brij
- Pattison Natalie
- Paxton William A.
- Penrice-Randal Rebekah
- Pepperell Justin
- Peters Mark
- Phull Mandeep
- Pilgrim Jack
- Pintus Stefania
- Pius Riinu
- Planche Tim
- Plotkin Daniel
- Pollakis Georgios
- Pooni Jagtur Singh
- Post Frank
- Price David
- Price Nicholas
- Prince Tessa
- Prout Rachel
- Rae Nikolas
- Rambaut Andrew
- Reschreiter Henrik
- Reynolds Tim
- Reynolds Will
- Richardson Neil
- Ridley P. Matthew
- Roberts Devender
- Roberts Mark
- Roberts Stephanie
- Robertson David L.
- Rose Alistair
- Rousseau Guy
- Ruge Bobby
- Russell Clark D.
- Russell Clark D.
- Ryan Brendan
- Sales Debby
- Saluja Taranprit
- Sancho-Shimizu Vanessa
- Sands Caroline J.
- Saviciute Egle
- Schmid Matthias L.
- Scott Janet T.
- Scott-Brown James
- Semple Malcolm G.
- Semple Malcolm G.
- Shah Aarti
- Shankar-Hari Manu
- Shanmuga Prad
- Sharma Anil
- Shaw Catherine A.
- Shaw Victoria
- Shaw Victoria E.
- Shawcross Anna
- Shears Rebecca K.
- Sidhu Jasmin K.
- Sigfrid Louise
- Siggins Matthew K.
- Sizer Jeremy
- Small Benjamin
- Smith Richard
- Snelson Catherine
- Solomon Tom
- Spencer Rebecca G.
- Spittle Nick
- Sriskandan Shiranee
- Staines Nikki
- Stambach Tom
- Stewart Richard
- Stuart David
- Subramaniam Krishanthi S.
- Subudhi Pradeep
- Summers Charlotte
- Swann Olivia V.
- Szakmany Tamas
- Szemiel Agnieska
- Taggart Aislynn
- Tait Sarah
- Takats Zoltan
- Takis Panteleimon
- Tanianis-Hughes Jolanta
- Tatham Kate
- Tedder Richard S.
- Thomas Jo
- Thomas Jordan
- Thompson A.A. Roger
- Thompson Chris
- Thompson Robert
- Thomson Emma C.
- Thomson Emma C.
- Thwaites Ryan S.
- Thwaites Ryan S.
- Tridente Ascanio
- Trochu Erwan
- Tupper-Carey Darell
- Turtle Lance
- Turtle Lance C.W.
- Twagira Mary
- Uruchurtu Ashley S.S.
- Vallotton Nick
- van Tonder Libby
- Vancheeswaran Rama
- Vincent Rachel
- Vincent-Smith Lisa
- Visuvanathan Shico
- Vuylsteke Alan
- Waddy Sam
- Wake Rachel
- Walden Andrew
- Welters Ingeborg
- Wham Murray
- Whitehouse Tony
- Whittaker Paul
- Whittington Ashley
- Wijesinghe Meme
- Wilcock Eve
- Williams Martin
- Wilson Lawrence
- Winchester Stephen
- Wiselka Martin
- Wolverson Adam
- Wootton Daniel G.
- Workman Andrew
- Wrobel Nicola
- Yates Bryan
- Ying Antonia
- Young Peter
- Zambon Maria
- Zhang J. Eunice
- Publication venue
- Oxford University Press
- Publication date
- 22/12/2023
- Field of study
Background
While inflammatory and immune responses to SARS-CoV-2 infection in peripheral blood are extensively described, responses at the upper respiratory mucosal site of initial infection are relatively poorly defined. We sought to identify mucosal cytokine/chemokine signatures that distinguished COVID-19 severity categories, and relate these to disease progression and peripheral inflammation.
Methods
We measured 35 cytokines and chemokines in nasal samples from 274 patients hospitalised with COVID-19. Analysis considered the timing of sampling during disease, as either the early (0-5 days post-symptom onset) or late (6-20 days post-symptom onset).
Results
Patients that survived severe COVID-19 showed IFN-dominated mucosal immune responses (IFN-γ, CXCL10 and CXCL13) early in infection. These early mucosal responses were absent in patients that would progress to fatal disease despite equivalent SARS-CoV-2 viral load. Mucosal inflammation in later disease was dominated by IL-2, IL-10, IFN-γ, and IL-12p70, which scaled with severity but did not differentiate patients who would survive or succumb to disease. Cytokines and chemokines in the mucosa showed distinctions from responses evident in the peripheral blood, particularly during fatal disease.
Conclusions
Defective early mucosal anti-viral responses anticipate fatal COVID-19 but are not associated with viral load. Early mucosal immune responses may define the trajectory of severe COVID-19
Viral coinfections in hospitalized coronavirus disease 2019 patients recruited to the international severe acute respiratory and emerging infections consortium WHO clinical characterisation protocol UK study
- Author
- Adeniji Kayode
- Agranoff Daniel
- Agwuh Ken
- Ahmed Katie A.
- Ail Dhiraj
- Aldera Erin L.
- Alegria Ana
- Allen Sam
- Angus Brian
- Armstrong Jane A.
- Ashish Abdul
- Ashworth Milton
- Asiimwe Innocent G.
- Atkinson Dougal
- Baillie J. Kenneth
- Baillie J. Kenneth
- Bakshi Siddharth
- Barclay Wendy S.
- Bari Shahedal
- Barlow Gavin
- Barlow Samantha L.
- Barnass Stella
- Barrett Nicholas
- Bassford Christopher
- Basude Sneha
- Baxter David
- Beadsworth Michael
- Bernatoniene Jolanta
- Berridge John
- Berry Colin
- Best Nicola
- Bogaert Debby
- Booth Laura
- Bothma Pieter
- Brennan Benjamin
- Brittain-Long Robin
- Bullock Katie
- Bulteel Naomi
- Burden Tom
- Burtenshaw Andrew
- Carlucci Nicola
- Carracedo Alejandra Doce
- Caruth Vikki
- Cass Emily
- Catterall Benjamin W. A.
- Chadwick David
- Chadwick David
- Chambler Duncan
- Chand Meera
- Chechi Kanta
- Chee Nigel
- Child Jenny
- Chukkambotla Srikanth
- Clark Jordan J.
- Clark Richard
- Clark Tom
- Clarke Emily A.
- Clohisey Sara
- Cole Sarah
- Cole Sarah
- Collini Paul
- Connor Marie
- Cooke Graham S.
- Cooper Louise
- Cosgrove Catherine
- Coutts Audrey
- Cox Helen
- Cupitt Jason
- Cutino-Moguel Maria-Teresa
- Dalton Jo
- Dark Paul
- Davis Chris
- Davis Christopher
- Dawson Chris
- de Silva Thushan
- Dervisevic Samir
- Dincarslan Oslem
- Docherty Annemarie B.
- Donegan Cara
- Donnelly Lorna
- Donnison Phil
- Donohue Chloe
- dos Santos Correia Gonçalo
- Douthwaite Sam
- Drake Thomas M.
- Drummond Andrew
- Dumas Marc-Emmanuel
- Dunn Chris
- Dunning Jake
- DuRand Ingrid
- Dushianthan Ahilanadan
- Dyer Philip
- Dyer Tristan
- Elliott Angela
- Evans Anthony
- Evans Cariad
- Eziefula Chi
- Fairfield Cameron J.
- Fawkes Angie
- Fegan Chrisopher
- Filipe Ana da Silva
- Finch Lorna
- Finn Adam
- Fisher Lewis W. S.
- Flaherty Lisa
- Fletcher Tom
- Foster Terry
- Fullerton Duncan
- Gamble Carrol
- Garcia-Dorival Isabel
- Garg Atul
- Garg Sanjeev
- Garg Sanjeev
- Gilchrist Tammy
- Girvan Michelle
- Gkrania-Klotsas Effrossyni
- Godden Jo
- Goldsmith Arthur
- Graham Clive
- Grammatikopoulos Tassos
- Green Christoper A.
- Greenhalf William
- Griffin Julian L.
- Griffiths Fiona
- Gunning Philip
- Gunson Rory
- Gupta Rishi K.
- Hafezi Katarzyna
- Halpin Sophie
- Hardwick Hayley
- Hardwick Hayley E.
- Hardy Elaine
- Harrison Ewen M.
- Harrison Janet
- Hartley Catherine
- Hartshorn Stuart
- Harvey Daniel
- Havalda Peter
- Hawcutt Daniel B.
- Hendry Ross
- Hiscox Julian A.
- Ho Antonia
- Ho Antonia Ying Wai
- Hobrok Maria
- Hodgson Luke
- Holden Karl
- Holmes Anthony
- Horby Peter W.
- Hormis Anil
- Howard Joanne
- Ijaz Samreen
- Jackson Clare
- Jacobs Michael
- Jain Susan
- Jennings Paul
- Jensen Rebecca L.
- Jones Christopher B.
- Jones Trevor R.
- Kaliappan Agilan
- Kasipandian Vidya
- Keating Seán
- Kegg Stephen
- Kelsey Michael
- Kendall Jason
- Kerrison Caroline
- Kerslake Ian
- Khandaker Shadia
- Khoo Saye
- King Katharine
- Kiy Robyn T.
- Klenerman Paul
- Knight Stephen R.
- Knight Susan
- Koch Oliver
- Koduri Gouri
- Koshy George
- Koukorava Chrysa
- Laha Shondipon
- Lahnsteiner Eva
- Laird Steven
- Lake Annette
- Lant Suzannah
- Larkin Susan
- Latawiec Diane
- Lavelle-Langham Lara
- Law Andrew
- Law Andrew
- Lee James
- Leeming Gary
- Lefteri Daniella
- Leiner Tamas
- Lett Lauren
- Lewis Matthew R.
- Liggi Sonia
- Lillie Patrick
- Lim Wei Shen
- Limb James
- Linnett Vanessa
- Little Jeff
- Livoti Lucia A.
- Lyttle Mark
- MacGillivray Louise
- Maclean Alan
- MacLean Alasdair
- MacMahon Michael
- MacNaughton Emily
- Mancini Maria
- Mankregod Ravish
- Marsh Laura
- Maslen Lynn
- Massey Hannah
- Masson Huw
- Matovu Elijah
- Maziere Nicole
- McCafferty Sarah
- McCullough Katherine
- McDonald Sarah
- McDonald Sarah E.
- McDonald Sarah E.
- McEvoy Laurence
- McEwen Ruth
- McLauchlan John
- Mclean Kenneth A.
- Meda Manjula
- Mentzer Alexander J.
- Merson Laura
- Metelmann Soeren
- Meynert Alison M.
- Miah Nahida S.
- Middleton Joanna
- Mills Gary
- Minton Jane
- Mirfenderesky Mariyam
- Mitchell Joyce
- Mohandas Kavya
- Mok Quen
- Moon James
- Moore Elinoor
- Moore Shona C.
- Moore Shona C.
- Morgan Patrick
- Morrice Kirstie
- Morris Craig
- Mortimore Katherine
- Moses Samuel
- Mpenge Mbiye
- Mulla Rohinton
- Murphy Derek
- Murphy Ellen G.
- Murphy Lee
- Murphy Michael
- Nagarajan Thapas
- Nagel Megan
- Nelson Mark
- Norman Lisa
- Norris Lillian
- Norris Lucy
- Noursadeghi Mahdad
- O'Shea Matthew K.
- Olanipekun Michael
- Oosthuyzen Wilna
- Oosthuyzen Wilna
- Openshaw Peter J. M.
- Openshaw Peter J. M.
- Osagie Anthonia
- Ostermann Marlies
- Otahal Igor
- Pais Mark
- Palmarini Massimo
- Palmieri Carlo
- Palmieri Carlo
- Panchatsharam Selva
- Papakonstantinou Danai
- Papineni Padmasayee
- Paraiso Hassan
- Pascall David
- Patel Brij
- Pattison Natalie
- Paxton William A.
- Penrice-Randal Rebekah
- Pepperell Justin
- Peters Mark
- Phull Mandeep
- Pilgrim Jack
- Pintus Stefania
- Pius Riinu
- Planche Tim
- Plotkin Daniel
- Pollakis Georgios
- Pooni Jagtur Singh
- Post Frank
- Price David
- Price Nicholas
- Prince Tessa
- Prout Rachel
- Rae Nikolas
- Rambaut Andrew
- Reschreiter Henrik
- Reynolds Tim
- Reynolds Will
- Richardson Neil
- Ridley P Matthew
- Roberts Devender
- Roberts Mark
- Roberts Stephanie
- Robertson David L.
- Rose Alistair
- Rousseau Guy
- Ruge Bobby
- Russell Clark D.
- Ryan Brendan
- Sales Debby
- Saluja Taranprit
- Sancho-Shimizu Vanessa
- Sands Caroline J.
- Saviciute Egle
- Schmid Matthias L.
- Scott Janet T.
- Scott-Brown James
- Semple Malcolm G.
- Semple Malcolm G.
- Shah Aarti
- Shankar-Hari Manu
- Shanmuga Prad
- Sharma Anil
- Shaw Catherine A.
- Shaw Victoria
- Shaw Victoria E.
- Shawcross Anna
- Shears Rebecca K.
- Sigfrid Louise
- Sizer Jeremy
- Small Benjamin
- Smith Richard
- Snelson Catherine
- Solomon Tom
- Spencer Rebecca G.
- Spittle Nick
- Sriskandan Shiranee
- Staines Nikki
- Stambach Tom
- Stewart Richard
- Stuart David
- Subramaniam Krishanthi S.
- Subudhi Pradeep
- Summers Charlotte
- Swann Olivia V.
- Szakmany Tamas
- Szemiel Agnieska
- Taggart Aislynn
- Tait Sarah
- Takats Zoltan
- Takis Panteleimon
- Tanianis-Hughes Jolanta
- Tatham Kate
- Tedder Richard S.
- Thomas Jo
- Thomas Jordan
- Thompson A. A. Roger
- Thompson Chris
- Thompson Robert
- Thomson Emma C.
- Thwaites Ryan S.
- Tonder Libby van
- Tridente Ascanio
- Trochu Erwan
- Tupper-Carey Darell
- Turtle Lance C.W.
- Twagira Mary
- Vallotton Nick
- Vancheeswaran Rama
- Vincent-Smith Lisa
- Vink Elen
- Visuvanathan Shico
- Vuylsteke Alan
- Waddy Sam
- Wake Rachel
- Walden Andrew
- Welters Ingeborg
- Wham Murray
- Whitehouse Tony
- Whittaker Paul
- Whittington Ashley
- Wijesinghe Meme
- Wilcock Eve
- Williams Martin
- Wilson Lawrence
- Winchester Stephen
- Wiselka Martin
- Wolverson Adam
- Wootton Daniel G.
- Workman Andrew
- Wrobel Nicola
- Yates Bryan
- Young Peter
- Zambon Maria
- Zhang J. Eunice
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 30/11/2022
- Field of study
Background
We conducted this study to assess the prevalence of viral coinfection in a well characterized cohort of hospitalized coronavirus disease 2019 (COVID-19) patients and to investigate the impact of coinfection on disease severity.
Methods
Multiplex real-time polymerase chain reaction testing for endemic respiratory viruses was performed on upper respiratory tract samples from 1002 patients with COVID-19, aged <1 year to 102 years old, recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK study. Comprehensive demographic, clinical, and outcome data were collected prospectively up to 28 days post discharge.
Results
A coinfecting virus was detected in 20 (2.0%) participants. Multivariable analysis revealed no significant risk factors for coinfection, although this may be due to rarity of coinfection. Likewise, ordinal logistic regression analysis did not demonstrate a significant association between coinfection and increased disease severity.
Conclusions
Viral coinfection was rare among hospitalized COVID-19 patients in the United Kingdom during the first 18 months of the pandemic. With unbiased prospective sampling, we found no evidence of an association between viral coinfection and disease severity. Public health interventions disrupted normal seasonal transmission of respiratory viruses; relaxation of these measures mean it will be important to monitor the prevalence and impact of respiratory viral coinfections going forward
Heterozygous Variants in KMT2E Cause a Spectrum of Neurodevelopmental Disorders and Epilepsy.
- Author
- Abou Jamra Rami
- Accogli Andrea
- Ahmed Munaza
- Aitken Stuart
- Akawi Nadia
- Alvi Mohsan,
- Ambridge Kirsty
- Amburgey Kimberly
- Anderlid Britt Marie
- Anjum Uruj
- Archer Hayley
- Armstrong Ruth
- Awada Jana
- Azzarello-Burri Silvia
- Balasubramanian Meena
- Banka Siddharth
- Baralle Diana
- Barnicoat Angela
- Barrett Daniel
- Barrett Jeffrey
- Basinger Alice
- Batstone Paul
- Baty David
- Baxter Samantha
- Bayzetinova Tanya
- Bennett Chris
- Berg Jonathan
- Bernhard Birgitta
- Bevan A. Paul
- Bianchini Claudia,
- Bird Lynne
- Bitner-Glindzicz Maria
- Blair Edward
- Blyth Moira
- Bohanna David
- Bourdon Louise
- Bourn David
- Bradley Lisa
- Brady Angela,
- Brent Simon
- Brewer Carole
- Brunstrom Kate
- Buchert Rebecca
- Bunyan David
- Burn John
- Canham Natalie
- Carré Wilfrid
- Castle Bruce
- Ceulemans Sophia
- Chandler Kate
- Charles Perrine
- Chatzimichali Elena
- Cilliers Deirdre
- Clarke Angus
- Clasper Susan
- Clayton Stephen
- Clayton-Smith Jill
- Clowes Virginia
- Coates Andrea
- Cole Trevor
- Colgiu Irina
- Collins Amanda
- Collinson Morag
- Connell Fiona
- Cooper Nicola
- Cox Helen
- Cresswell Lara
- Cross Gareth
- Crow Yanick
- Culliton Lisa
- Currò Aurora
- Dabir Tabib
- Davidson Rosemarie
- Davies Sally
- de Vries Dylan
- Dean John
- Demurger Florence
- Deshpande Charu
- Devlin Gemma
- Dixit Abhijit
- Dobbie Angus
- Donaldson Alan
- Donnai Dian
- Donnelly Carina
- Donnelly Deirdre
- Douglas Angela
- Douzgou Sofia
- Dowling James,
- Duban-Bedu Bénédicte
- Dubourg Christèle
- Duncan Alexis
- D’Alessandro Mariella
- Eason Jacqueline
- Eiset Saga Elise
- Ellard Sian
- Ellis Ian
- Elmslie Frances
- Escobar Luis
- Evans Karenza
- Everest Sarah
- Faundes Víctor
- Fendick Tina
- Ferrarini Alessandra
- Firth Helen
- Fisher Richard
- Fitzgerald Tomas
- Fitzpatrick David
- Flinter Frances
- Foulds Nicola
- Fry Andrew
- Fryer Alan
- Gardiner Carol
- Gaunt Lorraine
- Ghali Neeti
- Gibbons Richard
- Gill Harinder
- Goodship Judith
- Goudie David
- Gray Emma
- Green Andrew
- Greene Philip
- Greenhalgh Lynn
- Gribble Susan
- Haack Tobias,
- Harrison Lucy
- Harrison Rachel
- Harrison Victoria
- Hashim Mona
- Hawkins Rose
- He Liu
- Heide Solveig
- Helbig Ingo
- Helbig Katherine,
- Hellens Stephen
- Henderson Alex
- Heredia Raul
- Hewitt Sarah
- Hildyard Lucy
- Hobson Emma
- Holden Simon
- Holder Muriel
- Holder Susan
- Hollingsworth Georgina
- Homfray Tessa
- Humphreys Mervyn
- Hurles Matthew,
- Hurst Jane
- Hutton Ben
- Héron Delphine
- Ingram Stuart
- Irving Melita
- Isidor Bertrand
- Islam Lily
- Jackson Andrew
- Jarvis Joanna
- Jenkins Lucy
- Johnson Diana
- Jonasson Amy
- Jones Elizabeth
- Jones Philip,
- Jones Wendy
- Joset Pascal
- Josifova Dragana
- Joss Shelagh
- Kaemba Beckie
- Kaplanis Joanna
- Kazembe Sandra
- Kelsell Rosemary
- Keren Boris
- Kerr Bronwyn
- King Daniel
- Kingston Helen
- Kini Usha
- Kinning Esther
- Kirby Gail
- Kirk Claire
- Kivuva Emma
- Kok Fernando
- Kraus Alison
- Krishnappa Netravathi
- Kroes Hester
- Kumar Dhavendra
- Kumar V.
- Lachlan Katherine
- Lam Wayne
- Lampe Anne
- Langman Caroline
- Lavillaureix Alinoë
- Lees Melissa
- Lim Derek
- Longman Cheryl
- Lowther Gordon
- Lu Xin
- Luria Victor
- Lynch Sally
- Maas Saskia
- Maegawa Gustavo H.B.
- Magee Alex
- Maher Eddy
- Male Alison
- Mansour Sahar
- Marcelis Carlo L.M.
- Mark Paul
- Marks Karen
- Martin Katherine,
- Mason Laura
- Masruha Marcelo
- Maye Una
- McCann Emma
- McConnell Vivienne
- McEntagart Meriel
- McGowan Ruth
- McKay Kirsten
- McKee Shane
- McLaughlin Heather
- McMullan Dominic
- McNerlan Susan
- McRae Jeremy
- McWalter Kirsty
- McWilliam Catherine
- Mehta Sarju
- Melchinger Esther
- Mercimek-Andrews Saadet
- Metcalfe Kay
- Middleton Anna
- Miedzybrodzka Zosia
- Miles Emma
- Mohammed Shehla
- Montgomery Tara
- Moore David
- Morgan Sian,
- Morton Jenny
- Mugalaasi Hood
- Murday Victoria
- Murphy Helen
- Naik Swati
- Nava Caroline
- Nellåker Chris
- Nemeth Andrea
- Nevitt Louise
- Newbury-Ecob Ruth
- Norman Andrew
- Ogilvie Caroline
- Ong Kai-Ren
- O’Donnell-Luria Anne
- O’Shea Rosie
- Pais Lynn
- Park Soo-Mi
- Parker Michael
- Patel Chirag
- Paterson Joan
- Payne Stewart
- Pendziwiat Manuela
- Perrett Daniel
- Person Richard,
- Phipps Julie
- Pilz Daniela,
- Pollard Martin
- Pottinger Caroline
- Poulton Joanna
- Pratt Norman
- Prescott Katrina
- Price Sue
- Pridham Abigail
- Prigmore Elena
- Procter Annie
- Purnell Hellen
- Quarrell Oliver
- Ragge Nicola
- Rahbari Raheleh
- Rajan Diana
- Ramelli Gian Paolo
- Ramos Luiza L.P.
- Randall Josh
- Rankin Julia
- Rauch Anita
- Raymond Lucy
- Reavey Caitlin
- Renieri Alessandra
- Rice Debbie
- Rieß Angelika
- Robert Leema
- Roberts Eileen
- Roberts Gillian
- Roberts Jonathan
- Roberts Paul
- Rodan Lance,
- Ross Alison
- Rosser Elisabeth
- Saggar Anand
- Samant Shalaka
- Sampson Julian
- Sanchez-Valle Amarilis
- Sandford Richard
- Sarkar Ajoy
- Sattar Shifteh
- Saunders Carol
- Schwarz Niklas
- Schweiger Susann
- Scott Richard
- Scurr Ingrid
- Selby Ann
- Seller Anneke
- Sequeira Cheryl
- Shannon Nora
- Sharif Saba
- Shaw-Smith Charles
- Shearing Emma
- Shears Debbie
- Sheridan Eamonn
- Sifrim Alejandro
- Simonic Ingrid
- Singh Tarjinder
- Singzon Roldan
- Skitt Zara
- Smith Audrey
- Smith Kath
- Smithson Sarah
- Smol Thomas
- Sneddon Linda
- Splitt Miranda
- Squires Miranda
- Srour Myriam
- Steindl Katharina
- Stewart Fiona
- Stewart Helen
- Straub Volker
- Suri Mohnish
- Sutton Vivienne
- Sveden Abigail
- Swaminathan Ganesh Jawahar
- Sweeney Elizabeth
- Syrbe Steffen
- Tatton-Brown Kate
- Taylor Cat
- Taylor Jenny
- Taylor Rohan
- Tein Mark
- Telegrafi Aida
- Temple I. Karen
- Thiffault Isabelle
- Thomson Jenny
- Tischkowitz Marc
- Tivey Adrian
- Tomkins Susan
- Torokwa Audrey
- Trauner Doris
- Treacy Becky
- Turner Claire
- Turnpenny Peter
- Tysoe Carolyn
- van der Linden Helio
- van Koningsbruggen Silvana
- Vandersteen Anthony,
- Varghese Vinod
- Vasudevan Pradeep
- Vijayarangakannan Parthiban
- Villard Laurent
- Vogel Ida
- Vogt Julie
- Wakeling Emma
- Wallwark Sarah
- Waters Jonathon
- Weber Astrid
- Weber Yvonne
- Wellesley Diana
- Wentzensen Ingrid
- Whiteford Margo
- Widaa Sara
- Widjaja Elysa
- Wilcox Sarah
- Wilkinson Emily
- Williams Denise
- Williams Nicola
- Wilson Louise
- Wood Jordan
- Woods Geoff
- Wragg Christopher
- Wright Caroline
- Wright Michael
- Yates Laura
- Yau Michael
- Zak Jaroslav
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
We delineate a KMT2E-related neurodevelopmental disorder on the basis of 38 individuals in 36 families. This study includes 31 distinct heterozygous variants in KMT2E (28 ascertained from Matchmaker Exchange and three previously reported), and four individuals with chromosome 7q22.2-22.23 microdeletions encompassing KMT2E (one previously reported). Almost all variants occurred de novo, and most were truncating. Most affected individuals with protein-truncating variants presented with mild intellectual disability. One-quarter of individuals met criteria for autism. Additional common features include macrocephaly, hypotonia, functional gastrointestinal abnormalities, and a subtle facial gestalt. Epilepsy was present in about one-fifth of individuals with truncating variants and was responsive to treatment with anti-epileptic medications in almost all. More than 70% of the individuals were male, and expressivity was variable by sex; epilepsy was more common in females and autism more common in males. The four individuals with microdeletions encompassing KMT2E generally presented similarly to those with truncating variants, but the degree of developmental delay was greater. The group of four individuals with missense variants in KMT2E presented with the most severe developmental delays. Epilepsy was present in all individuals with missense variants, often manifesting as treatment-resistant infantile epileptic encephalopathy. Microcephaly was also common in this group. Haploinsufficiency versus gain-of-function or dominant-negative effects specific to these missense variants in KMT2E might explain this divergence in phenotype, but requires independent validation. Disruptive variants in KMT2E are an under-recognized cause of neurodevelopmental abnormalities