1,104 research outputs found
EFFECTIVELY SEARCHING SPECIMEN AND OBSERVATION DATA WITH TOQE, THE THESAURUS OPTIMIZED QUERY EXPANDER
Todayâs specimen and observation data portals lack a flexible mechanism, able to link up thesaurus-enabled data sources such as taxonomic checklist databases and expand user queries to related terms, significantly enhancing result sets. The TOQE system (Thesaurus Optimized Query Expander) is a REST-like XML web-service implemented in Python and designed for this purpose. Acting as an interface between portals and thesauri, TOQE allows the implementation of specialized portal systems with a set of thesauri supporting its specific focus. It is both easy to use for portal programmers and easy to configure for thesaurus database holders who want to expose their system as a service for query expansions. Currently, TOQE is used in four specimen and observation data portals. The documentation is available from http://search.biocase.org/toqe/
Innovative driftsmodeller i klimatilpasningen:Muligheder og udfordringer i driften af grÞn-blÄ infrastruktur /LAR
New methods for quantification of amoxicillin and clindamycin in human plasma using HPLC with UV detection
OBJECTIVES: We aimed to develop simple and rapid HPLC methods for determination of amoxicillin and clindamycin in human plasma. METHODS: Plasma samples were pretreated by direct deproteinization with acetonitrile and the analytical separation took place on a reverse phase Poroshell 120 EC-C18 column (2.7â
ÎŒm, 2.1âĂâ100â
mm) with a gradient of acetonitrile. UV detection at 229â
nm for amoxicillin and 204â
nm for clindamycin was used for determination of the antibiotics in plasma. RESULTS: The calibration curves were linear over the concentration ranges of 1â100â
mg/L for amoxicillin and 1â15â
mg/L for clindamycin with a correlation coefficient of â„0.98. Intra-assay precisions were all â€15% and the accuracies were within ±15%. The limit of quantification (LOQ) was found to be 0.5â
mg/L for amoxicillin and 1â
mg/L for clindamycin with inter-assay imprecision coefficient of variances (CVs) of 18.7% and 15.6%, respectively. The present HPLC methods were successfully applied on spike-in samples and on plasma samples collected 4â6 and 3.5â5.5â
h after oral antibiotic administration of 500â
mg of amoxicillin and 600â
mg of clindamycin, respectively. CONCLUSIONS: We have developed HPLC methods with UV detection for quantification of amoxicillin and clindamycin in human plasma. The methods are fast, simple and suitable for use in routine settings and clinical studies
Descriptive Data in the EDIT Platform for Cybertaxonomy
This paper describes the integration of structured descriptive data
in the EDIT platform for Cybertaxonomy. The platform is composed of several
software modules supporting the taxonomic workflow from data capture
and storage to publication. Descriptive data play an important role within
the taxonomic work process. The integration of these data via import/export
modules to and from the platform and the publication as natural language
output or as keys are explained
TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication
Association of regional socioeconomic deprivation and rurality with global developmental delay in early childhood: Data from mandatory school entry examinations in Germany
Background:
From birth to young adulthood, health and development of young people are strongly linked to their living situation, including their familyâs socioeconomic position (SEP) and living environment. The impact of regional characteristics on development in early childhood beyond family SEP has been rarely investigated. This study aimed to identify regional predictors of global developmental delay at school entry taking family SEP into consideration.
Method:
We used representative, population-based data from mandatory school entry examinations of the German federal state of Brandenburg in 2018/2019 with n=22,801 preschool children. By applying binary multilevel models, we hierarchically analyzed the effect of regional deprivation defined by the German Index of Socioeconomic Deprivation (GISD) and rurality operationalized as inverted population density of the childrenâs school district on global developmental delay (GDD) while adjusting for family SEP (low, medium and high).
Results:
Family SEP was significantly and strongly linked to GDD. Children with the highest family SEP showed a lower odds for GDD compared to a medium SEP (female: OR=4.26, male: OR=3.46) and low SEP (female: OR=16.58, male: OR=12.79). Furthermore, we discovered a smaller, but additional and independent effect of regional socioeconomic deprivation on GDD, with a higher odds for children from a more deprived school district (female: OR=1.35, male: OR=1.20). However, rurality did not show a significant link to GDD in preschool children beyond family SEP and regional deprivation.
Conclusion:
Family SEP and regional deprivation are risk factors for child development and of particular interest to promote health of children in early childhood and over the life course.Peer Reviewe
X-RED: A Satellite Mission Concept To Detect Early Universe Gamma Ray Bursts
Gamma ray bursts (GRBs) are the most energetic eruptions known in the
Universe. Instruments such as Compton-GRO/BATSE and the GRB monitor on BeppoSAX
have detected more than 2700 GRBs and, although observational confirmation is
still required, it is now generally accepted that many of these bursts are
associated with the collapse of rapidly spinning massive stars to form black
holes. Consequently, since first generation stars are expected to be very
massive, GRBs are likely to have occurred in significant numbers at early
epochs. X-red is a space mission concept designed to detect these extremely
high redshifted GRBs, in order to probe the nature of the first generation of
stars and hence the time of reionisation of the early Universe. We demonstrate
that the gamma and x-ray luminosities of typical GRBs render them detectable up
to extremely high redshifts (z~10-30), but that current missions such as HETE2
and SWIFT operate outside the observational range for detection of high
redshift GRB afterglows. Therefore, to redress this, we present a complete
mission design from the science case to the mission architecture and payload,
the latter comprising three instruments, namely wide field x-ray cameras to
detect high redshift gamma-rays, an x-ray focussing telescope to determine
accurate coordinates and extract spectra, and an infrared spectrograph to
observe the high redshift optical afterglow. The mission is expected to detect
and identify for the first time GRBs with z > 10, thereby providing constraints
on properties of the first generation of stars and the history of the early
Universe.Comment: 14 pages, 10 figures, spie.cls neede
- âŠ