Data Note: Job Seekers with Disabilities at One-Stop Career Centers: An Examination of Registration for Wagner-Peyser Funded Employment Services, 2002 to 2009

The Wagner-Peyser Act of 1933 established a nationwide system of public employment services, known as the Employment Service. Via the Workforce Investment Act of 1998, the Employment Service was made part of the One-Stop Career Center service-delivery system. Wagner-Peyser is a primary source of funding for these centers, which make employment services available to all people, including those with disabilities. There are currently 1,800+ comprehensive One-Stop Career Centers throughout the United States, as well as satellite and affiliate centers

Data Note: Job Seekers with Disabilities at One-Stop Career Centers: An Examination of Registration for Wagner-Peyser Funded Employment Services from 2002 to 2007

The Wagner-Peyser Act of 1933 established a nationwide system of public employment services, known as the Employment Service. Wagner-Peyser funds are a primary source of funding for the services of One-Stop Career Centers that provide employment services available to all people, including people with disabilities. This data note examines trends on a national and state-by-state basis in the number and percentage of job seekers who self-identified as having disabilities who register for Wagner-Peyser Employment Services

招待発表（1） 観客の運命 ―三つの関係―

Theories about the reception of works of art, whether as a reading or as a performance experience, have recently attracted wide critical attention. Japanese culture has a unique contribution to make in this area. Discussions of the magical component of the act of seeing (miru), found for example in folkloric-based theories of contemporary scholars such as Ikeda Y asaburo or Tsuchihashi Yutaka, or the classical aesthetic of the relation of the audience\u27s experience to that of the performer as expounded in the middle ages by Zeami are but two important Japanese approaches to performance theory.This paper focusses on the audience experience as established through three separate relationships. The first binds the participant to the time and place (ba) of performance and to the unique concatenation of events which comprise it. The second is the relationship between the identity of the story teller ("actor") as himself and that of the character or characters in his story, as this relationship is perceived by the spectator. This relationship is of special importance to a theatrical tradition such as that of Japan, were the classical stage arts are, in a sense, extensions of various storytelling arts (katari) and the role of the actor an extension of that of the storyteller. The final relationship follows from the previous two and unites the spectator and the act of seeing to the performer and the reciprocal or mirror act of being seen. Through quotations from Japanese scholars, critics, and those actively engaged in the performing arts, my discussion attempts to show how broadly based can be a theory of audience experience which draws upon evidence found in the Japanese performing arts

Aldohaloketenes and the Stereochemistry of Aldohaloketene Cycloadditions

The objective of this research problem was to synthesize aldohaloketenes and investigate the chemistry of this new class of ketenes

A Statistical Social Network Model for Consumption Data in Food Webs

We adapt existing statistical modeling techniques for social networks to study consumption data observed in trophic food webs. These data describe the feeding volume (non-negative) among organisms grouped into nodes, called trophic species, that form the food web. Model complexity arises due to the extensive amount of zeros in the data, as each node in the web is predator/prey to only a small number of other trophic species. Many of the zeros are regarded as structural (non-random) in the context of feeding behavior. The presence of basal prey and top predator nodes (those who never consume and those who are never consumed, with probability 1) creates additional complexity to the statistical modeling. We develop a special statistical social network model to account for such network features. The model is applied to two empirical food webs; focus is on the web for which the population size of seals is of concern to various commercial fisheries.Comment: On 2013-09-05, a revised version entitled "A Statistical Social Network Model for Consumption Data in Trophic Food Webs" was accepted for publication in the upcoming Special Issue "Statistical Methods for Ecology" in the journal Statistical Methodolog

Impact of Janus Kinase Inhibition with Tofacitinib on Fundamental Processes of Bone Healing

Both inflammatory diseases like rheumatoid arthritis (RA) and anti-inflammatory treatment of RA with glucocorticoids (GCs) or non-steroidal anti-inflammatory drugs (NSAIDs) negatively influence bone metabolism and fracture healing. Janus kinase (JAK) inhibition with tofacitinib has been demonstrated to act as a potent anti-inflammatory therapeutic agent in the treatment of RA, but its impact on the fundamental processes of bone regeneration is currently controversially discussed and at least in part elusive. Therefore, in this study, we aimed to examine the effects of tofacitinib on processes of bone healing focusing on recruitment of human mesenchymal stromal cells (hMSCs) into the inflammatory microenvironment of the fracture gap, chondrogenesis, osteogenesis and osteoclastogenesis. We performed our analyses under conditions of reduced oxygen availability in order to mimic the in vivo situation of the fracture gap most optimal. We demonstrate that tofacitinib dose-dependently promotes the recruitment of hMSCs under hypoxia but inhibits recruitment of hMSCs under normoxia. With regard to the chondrogenic differentiation of hMSCs, we demonstrate that tofacitinib does not inhibit survival at therapeutically relevant doses of 10-100 nM. Moreover, tofacitinib dose-dependently enhances osteogenic differentiation of hMSCs and reduces osteoclast differentiation and activity. We conclude from our data that tofacitinib may influence bone healing by promotion of hMSC recruitment into the hypoxic microenvironment of the fracture gap but does not interfere with the cartilaginous phase of the soft callus phase of fracture healing process. We assume that tofacitinib may promote bone formation and reduce bone resorption, which could in part explain the positive impact of tofacitinib on bone erosions in RA. Thus, we hypothesize that it will be unnecessary to stop this medication in case of fracture and suggest that positive effects on osteoporosis are likely

The In Vitro Human Fracture Hematoma Model - A Tool for Preclinical Drug Testing

The aim of the study was to establish an in vitro fracture hematoma (FH) model, which mimics the in vivo situation of the human fracture gap in order to assess drug efficacy and effectiveness for the treatment of fracture healing disorders. Therefore, human peripheral blood and mesenchymal stromal cells (MSCs) were coagulated to produce in vitro FH models, incubated in osteogenic medium under normoxia/hypoxia, and analyzed for cell composition, gene expression and cytokine/chemokine secretion. To evaluate the model, we studied the impact of dexamethasone (impairing fracture healing) and deferoxamine (promoting fracture healing). Under hypoxic conditions, MSCs represented the predominant cell population, while the frequencies of leukocytes decreased. Marker gene expression of osteogenesis, angiogenesis, inflammation, migration and hypoxic adaptation increased significantly over time and compared to normoxia while cytokine/chemokine secretion remained unchanged. Finally, dexamethasone favored the frequency of immune cells compared to MSCs, suppressed osteogenic and pro-angiogenic gene expression and enhanced the secretion of inflammatory cytokines. Conversely, deferoxamine favored the frequency of MSCs over that of immune cells and enhanced the expression of the osteogenic marker RUNX2 and markers of the hypoxic adaptation. In summary, we demonstrate that hypoxia is an important factor for in vitro modeling the initial phase of fracture healing, that both fracture-healing disrupting and promoting substances can influence the in vitro model comparable to the in vivo situation. Therefore, we conclude that our model is able to mimic in part the human FH and to reduce the number of animal experiments in early preclinical studies

Taijiquan the 'Taiji World' way: Towards a cosmopolitan vision of ecology.

In this article, we present a case study analysis of data gathered on the practice of the art of Taijiquan (Tai Chi Chuan) in one UK context. Our interest in looking at this physical culture was in exploring if/how physical cultures of shared embodied experience and practice may help “sow the seeds of environmental awareness”. In so doing, we illustrate certain affinities between this interpretation of the art and Beck’s idea of a “cosmopolitan vision of ecology”. We present an analysis of documentary and interview data of one English Taijiquan organisation and how it currently promotes the idea of interconnectedness, wellbeing and an alternative meta-narrative for living through the practice of Taijiquan. We conclude that, while further research is needed, there is evidence that a cosmopolitan vision for ecology is emerging in physical cultures such as Taijiquan

Flatfishes (Pleuronectiformes)

Document has 135 pages

Nordic fisheries and aquaculture:Socio-economic importance of nitrogen nutrient load in the environment

This report contributes to the understanding of how the the socio-economic contribution of Nordic fisheries/aquaculture are affected by the environment and environmental management, with focus on nitrogen. The report contains two case studies of how the socio-economic contribution of Danish/Swedish cod fishery in the Western Baltic Sea are affected by the nitrogen in the sea, and on how salmon growth rates in aquaculture in the Bokna Fiord are affected by nitrogen concentration. A Nordic workshop was held with the title: Fisheries, aquaculture and the marine environment: Environmental challenges and regulation, with focus on nitrogen. The finding of the case studies was presented at the workshop, together with presentations made by invited speakers on the role of nutrients and their management for Nordic fisheries/aquaculture. The discussion at the workshop is summarized in this report