ConStance: Modeling Annotation Contexts to Improve Stance Classification

Manual annotations are a prerequisite for many applications of machine learning. However, weaknesses in the annotation process itself are easy to overlook. In particular, scholars often choose what information to give to annotators without examining these decisions empirically. For subjective tasks such as sentiment analysis, sarcasm, and stance detection, such choices can impact results. Here, for the task of political stance detection on Twitter, we show that providing too little context can result in noisy and uncertain annotations, whereas providing too strong a context may cause it to outweigh other signals. To characterize and reduce these biases, we develop ConStance, a general model for reasoning about annotations across information conditions. Given conflicting labels produced by multiple annotators seeing the same instances with different contexts, ConStance simultaneously estimates gold standard labels and also learns a classifier for new instances. We show that the classifier learned by ConStance outperforms a variety of baselines at predicting political stance, while the model's interpretable parameters shed light on the effects of each context.Comment: To appear at EMNLP 201

Acacia trees on the cultural landscapes of the Red Sea Hills

This paper examines interactions between five pastoral nomadic culture groups of the Egyptian and Sudanese Red Sea Hills and the acacia trees Acacia tortilis (Forssk.) Hayne subsp. tortilis and subsp. raddiana growing in their arid environments. A. tortilis is described as a keystone species both ecologically and culturally: the trees play such critical roles in ecosystems and social groups that their removal would greatly impact both systems. Interviews in the field with the Semitic, Arabic-speaking Ma‘aza and Ababda, and the Cushitic, Beja, Bidhaawyeet-speaking Bishaari, Amar Ar and Hadandawa nomads probed the cultural and ecological contexts of acacias in pastoral nomadism, revealing deep insight into traditional ecological knowledge and traditional perceptions and uses of the trees. The paper describes how this knowledge guides pastoral decision-making, with acacias as a particularly critical component of the pastoral livelihood in both normal and stressful circumstances. A. tortilis is the most important reliable vegetation resource for nomads while also providing fuel and other useful products, ecosystem services for people and animals, and increased biodiversity by providing diverse microhabitats and resources for other species. We describe aspects of kinship, territorial organization, spiritual beliefs and tribal law underlying the significance of trees on the cultural landscape. We discuss environmental and economic challenges to human/tree relationships and to pastoral livelihoods. We challenge views of nomads as agents of ecological destruction, and propose maintenance and restoration of traditional pastoralism as viable alternatives in dryland development.publishedVersio

Evaluation of Trends in Diabetes Care in a Patient-centered Medical Home

Background: The patient-centered medical home (PCMH) is a model used in primary care to achieve effective management of chronic diseases. The Augusta University Health Family Medicine Center (AUFMC), a PCMH recognized by the National Committee for Quality Assurance, has implemented strategies to manage its patient population with diabetes. The present study evaluated the effects of these interventions through trend analysis of selected diabetic core measures by use of a qualified clinical data registry, the Practice Partner Research Network. Methods: For this retrospective study, de-identified data were abstracted for adult patients with diabetes for the period of 2013-2015. Process and outcome measures were determined for selected diabetic core measures, based on the 2015 American Diabetes Association and Physician Quality Reporting System of the Centers for Medicaid and Medicare (CMS). These measures included glycated hemoglobin (HbA1c), blood pressure (BP), low-density lipoprotein cholesterol (LDL), urine microalbumin (Um), diabetic foot and eye exams, and influenza and pneumococcal vaccinations. These values were analyzed by the CochranArmitage test for trends over time to determine the proportions of patients at the recommended goals. Results: Over time, there were increasing trends for patients who were at the goals for frequencies of HbA1c, Um, LDL, pneumococcal vaccinations, and diabetic retinal exams. Conclusions: Since AUFMC achieved PCMH recognition status, efforts to improve the management of patients with diabetes have yielded positive outcomes and valuable lessons. Areas of strength include utilization of the diabetes registry, education by regular providers, tailored use of electronic health records for patient education and physician documentation, and appropriate utilization of all team members. Trend analysis indicated that targeted diabetic interventions contributed to improved outcomes in selected diabetic core measures

Gut microbial communities of hybridising pygmy angelfishes reflect species boundaries

Hybridisation and introgression of eukaryotic genomes can generate new species or subsume existing ones, with direct and indirect consequences for biodiversity. An understudied component of these evolutionary forces is their potentially rapid effect on host gut microbiomes, and whether these pliable microcosms may serve as early biological indicators of speciation. We address this hypothesis in a field study of angelfishes (genus Centropyge), which have one of the highest prevalence of hybridisation within coral reef fish. In our study region of the Eastern Indian Ocean, the parent fish species and their hybrids cohabit and display no differences in their diet, behaviour, and reproduction, often interbreeding in mixed harems. Despite this ecological overlap, we show that microbiomes of the parent species are significantly different from each other in form and function based on total community composition, supporting the division of parents into distinct species, despite the confounding effects of introgression acting to homogenize parent species identity at other molecular markers. The microbiome of hybrid individuals, on the other hand, are not significantly different to each of the parents, instead harbouring an intermediate community composition. These findings suggest that shifts in gut microbiomes may be an early indicator of speciation in hybridising species

Parkinson’s disease: an inquiry into the etiology and treatment

Parkinson’s disease affects over one million people in the United States. Although there have been remarkable advances in uncovering the pathogenesis of this disabling disorder, the etiology is speculative. Medical treatment and operative procedures provide symptomatic relief only. Compression of the cerebral peduncle of the midbrain by the posterior cerebral artery in a patient with Parkinson’s Disease (Parkinson’s Disease) was noted on magnetic resonance imaging (MRI) scan and at operation in a patient with trigeminal neuralgia. Following the vascular decompression of the trigeminal nerve, the midbrain was decompressed by mobilizing and repositioning the posterior cerebral artery The patient's Parkinson's signs disappeared over a 48-hour period. They returned 18 months later with contralateral peduncle compression. A blinded evaluation of MRI scans of Parkinson's patients and controls was performed. MRI scans in 20 Parkinson's patients and 20 age and sex matched controls were evaluated in blinded fashion looking for the presence and degree of arterial compression of the cerebral peduncle. The MRI study showed that 73.7 percent of Parkinson's Disease patients had visible arterial compression of the cerebral peduncle. This was seen in only 10 percent of control patients (two patients, one of whom subsequently developed Parkinson’s Disease); thus 5 percent. Vascular compression of the cerebral peduncle by the posterior cerebral artery may be associated with Parkinson’s Disease in some patients. Microva-scular decompression of that artery away from the peduncle may be considered for treatment of Parkinson’s Disease in some patients

Capsular profiling of the Cronobacter genus and the association of specific Cronobacter sakazakii and C. malonaticus capsule types with neonatal meningitis and necrotizing enterocolitis

Background: Cronobacter sakazakii and C. malonaticus can cause serious diseases especially in infants where they are associated with rare but fatal neonatal infections such as meningitis and necrotising enterocolitis. Methods: This study used 104 whole genome sequenced strains, covering all seven species in the genus, to analyse capsule associated clusters of genes involved in the biosynthesis of the O-antigen, colanic acid, bacterial cellulose, enterobacterial common antigen (ECA), and a previously uncharacterised K-antigen. Results: Phylogeny of the gnd and galF genes flanking the O-antigen region enabled the defining of 38 subgroups which are potential serotypes. Two variants of the colanic acid synthesis gene cluster (CA1 and CA2) were found which differed with the absence of galE in CA2. Cellulose (bcs genes) were present in all species, but were absent in C. sakazakii sequence type (ST) 13 and clonal complex (CC) 100 strains. The ECA locus was found in all strains. The K-antigen capsular polysaccharide Region 1 (kpsEDCS) and Region 3 (kpsMT) genes were found in all Cronobacter strains. The highly variable Region 2 genes were assigned to 2 homology groups (K1 and K2). C. sakazakii and C. malonaticus isolates with capsular type [K2:CA2:Cell+] were associated with neonatal meningitis and necrotizing enterocolitis. Other capsular types were less associated with clinical infections. Conclusion: This study proposes a new capsular typing scheme which identifies a possible important virulence trait associated with severe neonatal infections. The various capsular polysaccharide structures warrant further investigation as they could be relevant to macrophage survival, desiccation resistance, environmental survival, and biofilm formation in the hospital environment, including neonatal enteral feeding tubes

Serendipitous Discovery of PSR J1431-6328 as a Highly-Polarized Point Source with the Australian SKA Pathfinder

We identified a highly-polarized, steep-spectrum radio source in a deep image with the Australian Square Kilometre Array Pathfinder (ASKAP) telescope at 888 MHz. After considering and rejecting a stellar origin for this source, we discovered a new millisecond pulsar (MSP) using observations from the Parkes radio telescope. This pulsar has period 2.77 ms and dispersion measure 228.27 pc/cm**3. Although this pulsar does not yet appear to be particularly remarkable, the short spin period, wide profile and high dispersion measure do make it relatively hard to discover through traditional blind periodicity searches. Over the course of several weeks we see changes in the barycentric period of this pulsar that are consistent with orbital motion in a binary system, but the properties of any binary need to be confirmed by further observations. While even a deep ASKAP survey may not identify large numbers of new MSPs compared to the existing population, it would be competitive with existing all-sky surveys and could discover interesting new MSPs at high Galactic latitude without the need for computationally-expensive all-sky periodicity searches.Comment: ApJ, in pres

A synthesis of potential impairment assessment tools for Para dressage classification

The key aim of classification in Para sport is to try and ensure that competitors are grouped so that they compete against others with impairments that cause a similar level of activity limitation within a specific sport. This synthesis aimed to identify existing, valid, and reliable, impairment assessment tools to measure eligible impairments that influence an individual’s ability to compete at Para dressage. A multi-stage approach was employed, where a systematic search of professional databases of impairment assessment tools first identified 35 tools for Para dressage. Then, a search strategy was developed, based on these 35 tools, and 305 scientific articles were identified from academic databases up to September 2021. From here, impairment assessment tools were evaluated and refined in a two�stage process using known performance determinants for Para dressage and then an assessment of their reliability, validity and practical usability. This resulted in the selection of impairment assessment tools, which included measures of muscle tone, strength, coordination, sitting balance, and trunk function. From this synthesis, we present a novel process by which impairment assessment tools were selected, refined, and critically examined using knowledge of performance determinants for dressage, the views and experiences of stakeholders, and reliability and validity of tools. The processes described here could be applied to the development of evidence-based classification systems across a range of Para sports