A data driven approach to landslide susceptibility mapping in Great Britain

Landslides are a geo-hazard which can have significant societal impacts including loss of human life, physical damage to infrastructure and financial loss. The ability to assess where landslides will occur is therefore of great interest for the public good and can be approached both theoretically and empirically. With the ever increasing availability of spatial data, information on landslide events is now much more readily available ranging from initiation point coordinates to high (sub-metre) resolution topographic information and associated derivatives on affected (and unaffected) areas. Coupled with information on the geology of a region, it is possible to build up a detailed location specific profile of past events, all of which may prove useful for informing where future events may occur. We present preliminary results from an assessment of various data to reassess current British landslide susceptibility datasets. These could be used in future to provide additional information to support landslide forecasting. We define susceptibility as: The potential for the occurrence of a hazard within a specified area. This is currently provided for by the BGS GeoSure Landslides product [1] which classifies landslide prone areas on an A-E (low-high) basis, based on heuristics as well as consideration of lithology, discontinuities and slope angle. Data-driven analyses may provide further insights into where and why landslides occur. Using this knowledge, we hope to improve our current landslide susceptibility model. Consequently, this will enable us to be more confident in the identification of areas where landslides may occur in the future

Genome-wide association mapping for root traits in a panel of rice accessions from Vietnam

Background: Despite recent sequencing efforts, local genetic resources remain underexploited, even though they carry alleles that can bring agronomic benefits. Taking advantage of the recent genotyping with 22,000 single-nucleotide polymorphism markers of a core collection of 180 Vietnamese rice varieties originating from provinces from North to South Vietnam and from different agrosystems characterized by contrasted water regimes, we have performed a genome-wide association study for different root parameters. Roots contribute to water stress avoidance and are a still underexploited target for breeding purpose due to the difficulty to observe them. Results: The panel of 180 rice varieties was phenotyped under greenhouse conditions for several root traits in an experimental design with 3 replicates. The phenotyping system consisted of long plastic bags that were filled with sand and supplemented with fertilizer. Root length, root mass in different layers, root thickness, and the number of crown roots, as well as several derived root parameters and shoot traits, were recorded. The results were submitted to association mapping using a mixed model involving structure and kinship to enable the identification of significant associations. The analyses were conducted successively on the whole panel and on its indica (115 accessions) and japonica (64 accessions) subcomponents. The two associations with the highest significance were for root thickness on chromosome 2 and for crown root number on chromosome 11. No common associations were detected between the indica and japonica subpanels, probably because of the polymorphism repartition between the subspecies. Based on orthology with Arabidopsis, the possible candidate genes underlying the quantitative trait loci are reviewed. Conclusions: Some of the major quantitative trait loci we detected through this genome-wide association study contain promising candidate genes encoding regulatory elements of known key regulators of root formation and development

A Conceptual Design and Numerical Analysis for a Small-Scale and Low-Cost Plastic Recycling Machine

A new conceptual design for a small-scale and low-cost plastic recycling machine is generated by combining melting part and compression process. Starting with one of the outstanding requirements is in terms of an affordable-priced machine that can perform two processes with high accuracy and capacity, some issues related to balancing among quality, capacity and cost of machine occurred during a discussion. After implementing various designing methods such as Quality Function Deployment, Reverse Engineering, Morphological Matrix and Pugh Method, an idea of final concept about using an electric oven and hydraulic system to melt down and compress plastic tile which has a dimension of 300x300x9 mm was created. The design of concept is divided into two parts which are mechanical and electrical systems. In a mechanical section, the technical drawing and simulation are made to see how machine performs under operation. Besides, we examined the forces that applied in the moulds to evaluate the strength of the system. In heating and electricity section, we chose electrical components, designed oven parameters and conducted the heating simulation on the mould. In addition, the heating and cooling time was calculated based on the principles of thermodynamics and heat transfer. Furthermore, the manufacturing plan is created to estimate the essential resources producing a certain number of heat-forming machines. In general, the machine needs to be prototyped for controlling its main function and finding practical issues. After that, some improvements could be made to enhance efficiency and increase capacity by designing an optimal mould to more heat absorb and reduce post process, calculate and design more efficient oven, create faster lock mechanism and other improvements for an automatizing machine

Spin-Nematic Squeezed Vacuum in a Quantum Gas

Using squeezed states it is possible to surpass the standard quantum limit of measurement uncertainty by reducing the measurement uncertainty of one property at the expense of another complementary property. Squeezed states were first demonstrated in optical fields and later with ensembles of pseudo spin-1/2 atoms using non-linear atom-light interactions. Recently, collisional interactions in ultracold atomic gases have been used to generate a large degree of quadrature spin squeezing in two-component Bose condensates. For pseudo spin-1/2 systems, the complementary properties are the different components of the total spin vector , which fully characterize the state on an SU(2) Bloch sphere. Here, we measure squeezing in a spin-1 Bose condensate, an SU(3) system, which requires measurement of the rank-2 nematic or quadrupole tensor as well to fully characterize the state. Following a quench through a nematic to ferromagnetic quantum phase transition, squeezing is observed in the variance of the quadratures up to -8.3(-0.7 +0.6) dB (-10.3(-0.9 +0.7) dB corrected for detection noise) below the standard quantum limit. This spin-nematic squeezing is observed for negligible occupation of the squeezed modes and is analogous to optical two-mode vacuum squeezing. This work has potential applications to continuous variable quantum information and quantum-enhanced magnetometry

Risk Factors for Early Mortality From Lung Cancer: Evolution Over the Last 20 Years in the French Nationwide KBP Cohorts

BACKGROUND: The impact of the most recent advances, including targeted therapies and immune checkpoint inhibitors, on early (3-month) mortality in lung cancer is unknown. The aims of this study were to evaluate the real-world rate of and risk factors for early mortality, as well as trends in early mortality over the last 20 years. MATERIALS AND METHODS: The KBP prospective observational multicenter studies have been conducted every 10 years since 2000. These studies collect data on all newly diagnosed patients with lung cancer (all stages and histologies) over 1 year in non-academic public hospital pulmonology or oncology units in France. In this study, we analyzed data on patient and tumor characteristics from participants in the KBP-2020 cohort and compared the characteristics of patients who died within 3 months of diagnosis with those of all other patients within the cohort. We also carried out a comparative analysis with the KBP-2000 and KBP-2010 cohorts. RESULTS: Overall, 8999 patients from 82 centers were included in the KBP-2020 cohort. Three-month survival data were available for 8827 patients, of whom 1792 (20.3%) had died. Risk factors for early mortality were: male sex, age \u3e70 years, symptomatic disease at diagnosis, ever smoker, weight loss \u3e10 kg, poor Eastern Cooperative Oncology Group performance status (≥1), large-cell carcinoma or not otherwise specified, and stage ≥IIIC disease. The overall 3-month mortality rate was found to have decreased significantly over the last 20 years, from 24.7% in KBP-2000 to 23.4% in KBP-2010 and 20.3% in KBP-2020 (P \u3c 0.0001). CONCLUSION: Early mortality among patients with lung cancer has significantly decreased over the last 20 years which may reflect recent improvements in treatments. However, early mortality remained extremely high in 2020, particularly when viewed in light of improvements in longer-term survival. Delays in lung cancer diagnosis and management could contribute to this finding

Type 2 Diabetes Mellitus Duration and Obesity alter the Efficacy of Autologously Transplanted Bone Marrow-derived Mesenchymal Stem/Stromal Cells

Human bone marrow-derived mesenchymal stem/stromal cells (BM-MSCs) represent promising stem cell therapy for the treatment of type 2 diabetes mellitus (T2DM), but the results of autologous BM-MSC administration in T2DM patients are contradictory. The purpose of this study was to test the hypothesis that autologous BM-MSC administration in T2DM patient is safe and that the efficacy of the treatment is dependant on the quality of the autologous BM-MSC population and administration routes. T2DM patients were enrolled, randomly assigned (1:1) by a computer-based system into the intravenous and dorsal pancreatic arterial groups. The safety was assessed in all the treated patients, and the efficacy was evaluated based on the absolute changes in the hemoglobin A1c, fasting blood glucose, and C-peptide levels throughout the 12-month follow-up. Our data indicated that autologous BM-MSC administration was well tolerated in 30 T2DM patients. Short-term therapeutic effects were observed in patients with T2DM duration of <10 years and a body mass index <23, which is in line with the phenotypic analysis of the autologous BM-MSC population. T2DM duration directly altered the proliferation rate of BM-MSCs, abrogated the glycolysis and mitochondria respiration of BM-MSCs, and induced the accumulation of mitochondria DNA mutation. Our data suggest that autologous administration of BM-MSCs in the treatment of T2DM should be performed in patients with T2DM duration <10 years and no obesity. Prior to further confirming the effects of T2DM on BM-MSC biology, future work with a larger cohort focusing on patients with different T2DM history is needed to understand the mechanism underlying our observation

Planar Graph Coloring with Forbidden Subgraphs: Why Trees and Paths Are Dangerous

We consider the problem of coloring a planar graph with the minimum number of colors such that each color class avoids one or more forbidden graphs as subgraphs. We perform a detailed study of the computational complexity of this problem. We present a complete picture for the case with a single forbidden connected (induced or non-induced) subgraph. The 2-coloring problem is NP-hard if the forbidden subgraph is a tree with at least two edges, and it is polynomially solvable in all other cases. The 3-coloring problem is NP-hard if the forbidden subgraph is a path, and it is polynomially solvable in all other cases. We also derive results for several forbidden sets of cycles

The Physics of Hadronic Tau Decays

Hadronic tau decays represent a clean laboratory for the precise study of quantum chromodynamics (QCD). Observables (sum rules) based on the spectral functions of hadronic tau decays can be related to QCD quark-level calculations to determine fundamental quantities like the strong coupling constant, parameters of the chiral Lagrangian, |V_us|, the mass of the strange quark, and to simultaneously test the concept of quark-hadron duality. Using the best available measurements and a revisited analysis of the theoretical framework, the value alpha_s(m_tau) = 0.345 +- 0.004[exp] +- 0.009[theo] is obtained. Taken together with the determination of alpha_s(m_Z) from the global electroweak fit, this result leads to the most accurate test of asymptotic freedom: the value of the logarithmic slope of 1/alpha_s(s) is found to agree with QCD at a precision of 4%. In another approach, the tau spectral functions can be used to determine hadronic quantities that, due to the nonperturbative nature of long-distance QCD, cannot be computed from first principles. An example for this is the contribution from hadronic vacuum polarization to loop-dominated processes like the anomalous magnetic moment of the muon. This article reviews the measurements of nonstrange and strange tau spectral functions and their phenomenological applications.Comment: 89 pages, 32 figures; final version accepted for publication by Reviews of Modern Physic

Testing QCD with Hypothetical Tau Leptons

We construct new tests of perturbative QCD by considering a hypothetical tau lepton of arbitrary mass, which decays hadronically through the electromagnetic current. We can explicitly compute its hadronic width ratio directly as an integral over the e^+ e^- annihilation cross section ratio, R_{e^+e^-}. Furthermore, we can design a set of commensurate scale relations and perturbative QCD tests by varying the weight function away from the form associated with the V-A decay of the physical tau. This method allows the wide range of the R_{e^+e^-} data to be used as a probe of perturbative QCD.Comment: 4 pages, 4 figure