Amorphization of graphite flakes in gray cast iron under tribological load

A gray cast iron disc, which had been submitted to a heavy duty automotive brake test, was examined with energy filtered transmission electron microscopy. A graphite flake in a convenient angular position showed the shear interaction of graphite layers with the iron matrix in nano-scale resolution. Atomic layers of graphite were wedged into the ferritic bulk, allowing the entrance of oxygen and the subsequent formation of magnetite. The exfoliated few-layer graphene batches deformed heavily when forced into the matrix. When Raman spectra from the disc surface, which show distinctive carbonaceous bands, were compared with Raman spectra from graphite subjected to deformation in a shaker mill with different milling times, it could be seen that the shear stress on the brake surface was much more effective to induce disorder than the milling, where compressive and impact forces had been additionally exerted on the sample. During shear load the high anisotropy of elastic modulus in the graphite crystalline structure and the low adhesion between graphite basal planes allowed the exfoliation of wrinkled few-layer grapheme batches, causing the formation of more defect related Raman bands than the mechanical stress during high-energy milling

The Arctic Ocean in CMIP6 Models: Biases and Projected Changes in Temperature and Salinity

We examine the historical evolution and projected changes in the hydrography of the deep basin of the Arctic Ocean in 23 climate models participating in the Coupled Model Intercomparison Project Phase 6 (CMIP6). The comparison between historical simulations and observational climatology shows that the simulated Atlantic Water (AW) layer is too deep and thick in the majority of models, including the multi-model mean (MMM). Moreover, the halocline is too fresh in the MMM. Overall our findings indicate that there is no obvious improvement in the representation of the Arctic hydrography in CMIP6 compared to CMIP5. The climate change projections reveal that the sub-Arctic seas are outstanding warming hotspots, causing a strong warming trend in the Arctic AW layer. The MMM temperature increase averaged over the upper 700 m at the end of the 21st century is about 40% and 60% higher in the Arctic Ocean than the global mean in the SSP245 and SSP585 scenarios, respectively. Salinity in the upper few hundred meters is projected to decrease in the Arctic deep basin in the MMM. However, the spread in projected salinity changes is large and the tendency toward stronger halocline in the MMM is not simulated by all the models. The identified biases and projection uncertainties call for a concerted effort for major improvements of coupled climate models

Das DaZ-spezifische Praktikumsformat der Universität Bielefeld. FörBi – Förderunterricht für Schülerinnen und Schüler nicht deutscher Herkunftssprachen

Die Autor*innen stellen das Projekt FörBi – Förderunterricht für Schülerinnen und Schüler nicht deutscher Herkunftssprachen – an der Universität Bielefeld vor. Lehramtsstudierende der Germanistik und der Anglistik können in diesem Projekt ihr BFP absolvieren. Ziel des Projekts ist es, dass Studierende bereits im Studium erste Einsichten und praktische Lehrerfahrungen im Bereich von unterrichtsbzw. fachintegrierter DaZ-Förderung und DaZ-Diagnostik gewinnen. (DIPF/Orig.

Simulations for CMIP6 With the AWI Climate Model AWI‐CM‐1‐1

The Alfred Wegener Institute Climate Model (AWI‐CM) participates for the first time in the Coupled Model Intercomparison Project (CMIP), CMIP6. The sea ice‐ocean component, FESOM, runs on an unstructured mesh with horizontal resolutions ranging from 8 to 80 km. FESOM is coupled to the Max Planck Institute atmospheric model ECHAM 6.3 at a horizontal resolution of about 100 km. Using objective performance indices, it is shown that AWI‐CM performs better than the average of CMIP5 models. AWI‐CM shows an equilibrium climate sensitivity of 3.2°C, which is similar to the CMIP5 average, and a transient climate response of 2.1°C which is slightly higher than the CMIP5 average. The negative trend of Arctic sea‐ice extent in September over the past 30 years is 20–30% weaker in our simulations compared to observations. With the strongest emission scenario, the AMOC decreases by 25% until the end of the century which is less than the CMIP5 average of 40%. Patterns and even magnitude of simulated temperature and precipitation changes at the end of this century compared to present‐day climate under the strong emission scenario SSP585 are similar to the multi‐model CMIP5 mean. The simulations show a 11°C warming north of the Barents Sea and around 2°C to 3°C over most parts of the ocean as well as a wetting of the Arctic, subpolar, tropical, and Southern Ocean. Furthermore, in the northern middle latitudes in boreal summer and autumn as well as in the southern middle latitudes, a more zonal atmospheric flow is projected throughout the year

The influence of patient characteristics on the alarm rate in intensive care units: a retrospective cohort study

Intensive care units (ICU) are often overflooded with alarms from monitoring devices which constitutes a hazard to both staff and patients. To date, the suggested solutions to excessive monitoring alarms have remained on a research level. We aimed to identify patient characteristics that affect the ICU alarm rate with the goal of proposing a straightforward solution that can easily be implemented in ICUs. Alarm logs from eight adult ICUs of a tertiary care university-hospital in Berlin, Germany were retrospectively collected between September 2019 and March 2021. Adult patients admitted to the ICU with at least 24 h of continuous alarm logs were included in the study. The sum of alarms per patient per day was calculated. The median was 119. A total of 26,890 observations from 3205 patients were included. 23 variables were extracted from patients' electronic health records (EHR) and a multivariable logistic regression was performed to evaluate the association of patient characteristics and alarm rates. Invasive blood pressure monitoring (adjusted odds ratio (aOR) 4.68, 95%CI 4.15-5.29, p < 0.001), invasive mechanical ventilation (aOR 1.24, 95%CI 1.16-1.32, p < 0.001), heart failure (aOR 1.26, 95%CI 1.19-1.35, p < 0.001), chronic renal failure (aOR 1.18, 95%CI 1.10-1.27, p < 0.001), hypertension (aOR 1.19, 95%CI 1.13-1.26, p < 0.001), high RASS (aOR 1.22, 95%CI 1.18-1.25, p < 0.001) and scheduled surgical admission (aOR 1.22, 95%CI 1.13-1.32, p < 0.001) were significantly associated with a high alarm rate. Our study suggests that patient-specific alarm management should be integrated in the clinical routine of ICUs. To reduce the overall alarm load, particular attention regarding alarm management should be paid to patients with invasive blood pressure monitoring, invasive mechanical ventilation, heart failure, chronic renal failure, hypertension, high RASS or scheduled surgical admission since they are more likely to have a high contribution to noise pollution, alarm fatigue and hence compromised patient safety in ICUs

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

Report on skill of CMIP6 models to simulate alkalinity and improved parameterizations for large scale alkalinity distribution

In part one of this deliverable, an ensemble of 14 CMIP6 Earth System Models is evaluated regarding their performance in simulating alkalinity and related parameters. The majority of the models and the multi-model-mean underestimate surface alkalinity compared to climatological observations. Alkalinity biases stemming from the parametrization of calcium carbonate formation and dissolution can be as big as biases stemming from model physics. In part two, we test the sensitivity of parametrizations concerning the carbonate chemistry in the FESOM2.1-REcoM3 and give recommendations for addressing alkalinity biases

Radon Progeny Adsorption on Facial Masks

The radioactive noble gas radon and its short-living progeny are inhaled during respiration, depositing their decay energies in the lungs. These progeny are considered responsible for more than 95% of the total effective dose and are, together with radon, classified as carcinogenic for lung cancer. Consequently, filtration of the progeny could reduce the dose to the lungs. In our study, we investigated the filtration properties of FFP2 versus surgical masks (II R) for radon and its decay products. The masks were attached to a measurement device, which enabled determination of the size distribution of radon progeny, ranging from unattached to clustered progeny. In parallel, it measured the radon activity concentration during experiments. By comparing background measurements without mask and experiments with masks, the percentage of retained unattached radon progeny was determined for FFP2 (98.8 ± 0.6%) and II R masks (98.4 ± 0.7%). For clustered progeny, the retained fraction was 85.2 ± 18.1% for FFP2 and 79.5 ± 22.1% for II R masks while radon was not filtered. We can show that masks are effective in filtering radon progeny and thus are capable of reducing the total effective dose to the lungs