An assessment on potential long-term health effects caused by antibiotic resistance marker genes in genetically modified organisms based on antibiotic usage and resistance patterns in Norway.

Source at https://vkm.no/Usage of antibiotics selects for resistant bacteria, resulting in reduced treatment options, and increased morbidity and mortality from microbial infections. Development of resistance in susceptible bacteria can occur through spontaneous mutation or horizontal gene transfer (HGT). Our current understanding of resistance development in bacterial pathogens is more descriptive than predictive in nature. That is, whereas the acquisition or development of new resistance determinants in bacteria can be retrospectively described relatively easily at the molecular, species and geographical distribution levels, the initial horizontal transfer events, the resistance gene donor, and the environmental location and conditions that produced the first generation of the resistant bacteria remain largely unknown. Without this latter knowledge and without a clear understanding of directional selection and genetic drift in natural bacterial populations, it is impossible to predict accurately further resistance development occurring through HGT. Some of the antibiotic resistance marker (ARM) genes used in the production of genetically modified organisms (GMO) encode resistance to antibiotics in clinical and veterinary use. Thus, concerns have been raised that the large-scale release of such genes in commercialized GMOs may increase the rate of, and broaden the locations where, bacteria horizontally acquire resistance genes

Нейроендокринний супровід поліваріантних ефектів біоактивної води Нафтуся на рівень хронічного стресу у жінок з різним оваріальним статусом

Проанализированы изменения нейроэндокринных показателен, сопутствующие поливариантным эффектам биоактивной воды Нафтуся курорта Трускавец на уровень хронического стресса у женщин детородного возраста с различным овариальным статусом. Обнаружена значительная (R=0,59) каноническая корреляционная связь между динамикой нейро-гормонального индекса стресса, с одной стороны, и вегетативной реактивности, лютеинизирующего гормона, тиреотропного гормона, тироксина и прогестерона - с другой стороны.The changes in neuroendocrine parameters, concomitant multivariate effects of bioactive water Naftussya spa Truskavets to the level of chronic stress in women of childbearing age with different ovarian status. A significant (R=0,59) canonical correlation between the dynamics of the neuro-hormonal index of stress, on the one hand, and autonomic reactivity, luteinizing hormone, thyroid-stimulating hormone, thyroxine and progesterone - the other side

Wildlife as Source of Zoonotic Infections

Zoonoses with a wildlife reservoir represent a major public health problem, affecting all continents

Impact on health when sugar is replaced with intense sweeteners in soft drinks, ‘saft’ and nectar. Opinion of Vitenskapskomiteen for mattrygghet Norwegian Scientific Commitee for Food Safety

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Risk assessment on the use of triclosan in cosmetics. Prepared by the Scientific Committee in cooperation with the Panel on Biological Hazards and the Panel on Food Additives, Flavourings, Processing Aids, Materials in contact with Food and Cosmetics

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Incidence trend and risk factors for campylobacter infections in humans in Norway

BACKGROUND: The objectives of the study were to evaluate whether the increase in incidence of campylobacteriosis observed in humans in Norway from 1995 to 2001 was statistically significant and whether different biologically plausible risk factors were associated with the incidence of campylobacteriosis in the different counties in Norway. METHODS: To model the incidence of domestically acquired campylobacteriosis from 1995 to 2001, a population average random effect poisson model was applied (the trend model). To case data and assumed risk-factor/protective data such as sale of chicken, receiving treated drinking water, density of dogs and grazing animals, occupation of people in the municipalities and climatic factors from 2000 and 2001, an equivalent model accounting for geographical clustering was applied (the ecological model). RESULTS: The increase in incidence of campylobacteriosis in humans in Norway from 1995 to 2001 was statistically significant from 1998. Treated water was a protective factor against Campylobacter infections in humans with an IRR of 0.78 per percentage increase in people supplied. The two-level modelling technique showed no evidence of clustering of campylobacteriosis in any particular county. Aggregation of data on municipality level makes interpretation of the results at the individual level difficult. CONCLUSION: The increase in incidence of Campylobacter infections in humans from 1995 to 2001 was statistically significant from 1998. Treated water was a protective factor against Campylobacter infections in humans with an IRR of 0.78 per percentage increase in people supplied. Campylobacter infections did not appear to be clustered in any particular county in Norway

Risikovurdering av ”energidrikker” med koffein, taurin, glukuronolakton, inositol og vitaminer.

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