Star music: the ancient idea of cosmic musicas a philosophical paradox

This thesis regards the ancient Pythagorean-Platonic idea of heavenly harmony as a philosophical paradox: stars are silent, music is not. The idea of ‘star music’ contains several potential opposites, including imagination and sense perception, the temporal and the eternal, transcendence and theophany, and others. The idea of ‘star music’ as a paradox can become a gateway to a different understanding of the universe, and a vehicle for a shift to a new – and yet very ancient – form of consciousness. The ancient Greeks had a holistic form of consciousness, which was continually intermingling with a transpersonal dimension. This ancient state of consciousness was related to a musical understanding of the world, the Pythagorean-Platonic experience of the universe as an ordered cosmos. My research is approached from two angles, namely from the history of ideas and from musicianship, exploring how music is reflected in the world of thought. By reflexive re-reading of the sources, new insights into the nature of musical consciousness are explored. The idea of ‘star music’ can be found throughout the history of music and thought in the West, including Plato’s works and that of other ancient philosophers, through the Middle Ages, the Renaissance, the Romantic era and the twentieth century up to contemporary New Age music. As a conclusion, the paradox of ‘star music’ is connected to an experience of a shared transcendent meaning of music, which can be present in the moment of a musical performance. ‘Star music’ is a living paradox

Primary diffuse large B-cell lymphoma of bone

This thesis describes a study on primary diffuse large B cell lymphoma of bone with large patient numbers in chapter 2. The tumor presents mostly in the long bones. The clinical outcome is usually favorable. We found a trend towards worse survival for the immunoblastic tumor subtype. In chapter three, We studied the MRI characteristics of 29 bone lymphoma patients. The majority of the patients displayed a combination of definite cortical abnormalities and extension to the soft tissue, but up to 31% of the patients showed MRI features that looked radiologically non-aggressive or even benign. In chapter four, we determined the prognostic significance of BCL-6, CD10, MUM1, BCL-2, p53, CD30 and CD44. Applying the Hans__ algorithm, we concluded that 19 out of a cohort of 36 cases displayed a germinal center-like phenotype. No significant influence on survival was found. In chapter five, we investigated genomic alterations in nine cases. We found several recurrent genomic aberrations, but none had statistically significant prognostic influence. The most frequent finding was five cases with gain of 1q (five out of nine cases) and 2p16.1 amplification (four out of nine cases). In chapter six we investigated 50 cases for involvement of aberrant NF-_B activation by performing immunohistochemical stainings. In a minority (19%) of cases, we found substantial nuclear staining of p50. The nuclear expression of p50 was not preferentially detected in non-germinal center or germinal center type cases, or related to an inferior prognosis.Roche, Celgene, Novartis oncology, Medisch centrum haaglandenUBL - phd migration 201

BAIT:A New Medical Decision Support Technology Based on Discrete Choice Theory

We present a novel way to codify medical expertise and to make it available to support medical decision making. Our approach is based on econometric techniques (known as conjoint analysis or discrete choice theory) developed to analyze and forecast consumer or patient behavior; we reconceptualize these techniques and put them to use to generate an explainable, tractable decision support system for medical experts. The approach works as follows: using choice experiments containing systematically composed hypothetical choice scenarios, we collect a set of expert decisions. Then we use those decisions to estimate the weights that experts implicitly assign to various decision factors. The resulting choice model is able to generate a probabilistic assessment for real-life decision situations, in combination with an explanation of which factors led to the assessment. The approach has several advantages, but also potential limitations, compared to rule-based methods and machine learning techniques. We illustrate the choice model approach to support medical decision making by applying it in the context of the difficult choice to proceed to surgery v. comfort care for a critically ill neonate

Study of the acoustic conditioning of the Aula Magna of the Faculty of Law of the Universitat de València. Analysis of the current situation and a proposal for improvement

[EN] The objective of this thesis is to analyse the current state of the Aula Magna of the Faculty of Law of the Universitat de València. This room is used as a lecture hall and for chamber music performances. By measuring in situ the acoustic parameters of the hall the current situation can be analysed. The measurements are performed with an omnidirectional source and 22 receiving points. The measured acoustic parameters are compared to the recommended values, to analyse the current state of the hall. A 3D model is made using AutoCAD2013, the model only consists of 3D-faces. This model is imported in a room acoustics software, Odeon 10.1 Combined. After placing the source and receivers and assigning the materials, the model can be changed to match the reality. By changing the sound absorption coefficients of the materials, the model is adjusted to the measurements in situ. The model is a reliable presentation of the real hall if the results that are simulated by Odeon are the same as the measurements in situ. In the 3D model alterations can be made to improve the hall for a lecture or a chamber music performance. Changes are tested with the recommended values for the acoustical parameters for both usages of the hall. Double-sided tiles with a reflective and absorbent side, together with two movable panels are the proposal to improve the acoustic conditions. When there is a lecture the two movable panels are stored behind the screen and the tiles show the absorbent side. For a chamber music performance the tiles are turned to the reflective side and the two panels are placed on stage. This proposal leads to a significant improvement for both usages of the hall. It is easy to employ and will make a big difference for the experience of the audience.[ES] El objetivo de este Trabajo de fin de Máster es analizar el estado actual del Aula Magna de la Facultad de Derecho de la Universitat de València. Este sitio se emplea como sala de conferencias y para actuaciones de música de cámara. El estado actual se analiza mediante la medición “in situ” de los parámetros acústicos. La toma de datos se realiza con una fuente omnidireccional y 22 puntos de recepción. Después, los parámetros acústicos obtenidos se comparan con los valores recomendados para obtener el estado actual del Aula. También se realiza un modelo en 3D por medio de AutoCAD2013, el modelo se realiza únicamente en caras de sólidos 3D. Después, se importa el modelo a un software de mediciones acústicas, Odeon 10.1 Combined. Una vez colocados los receptores y la fuente, y seleccionados los materiales, el modelo puede ser modificado para ajustarse a la realidad. El ajuste del modelo se realiza modificando los coeficientes de absorción de los materiales, y será una simulación fidedigna de la sala real cuando los resultados ofrecidos por Odeon coincidan con los obtenidos “in situ”. En el modelo en 3D es posible realizar mejoras para optimizar la sala para la lectura de conferencias o para actuaciones de música de cámara. Se realizan pruebas introduciendo los valores recomendados para ambos usos de la sala. Para mejorar las condiciones acústicas se propone el uso de placas de doble cara, que reflejan el sonido por una de ellas y por la otra lo absorben, y también el uso de dos paneles móviles. En caso de que haya una conferencia los paneles se almacenarán tras la pantalla y las placas se usarán por su cara absorbente. Para una actuación de música de cámara las placas se usarán por la parte reflectiva, y los dos paneles se colocarán en la tarima. Esta propuesta conlleva una mejora significativa para ambos usos de la sala, es sencilla de emplear, y supondrá una gran diferencia en la experiencia de los usuarios.Van De Heyning, P. (2015). Study of the acoustic conditioning of the Aula Magna of the Faculty of Law of the Universitat de València. Analysis of the current situation and a proposal for improvement. http://hdl.handle.net/10251/57659.Archivo delegad

The Need to Increase Awareness and Access to Cochlear Implantation

Some degree of disabling hearing loss is present in 466 million people world-wide, representing 5% of the world’s population and the majority of these are adults over 65 years old. Hearing loss is associated with increased risks of social isolation, depression, dementia, stroke, vision loss, diabetes and mortality. It is in the top five causes of years lived with disability in 2015, 2016 and 2017 for males and top 10 for females. Hearing aids are a suitable treatment for mild to moderate loses but for some they do not provide enough benefit. Cochlear implantation is a proven and effective treatment for bilateral severe to profound hearing loss, yet despite good funding in high income countries, the utilisation of CI is poor (less than 10% of suitable patients), especially in the older adult population who arguably need it most. Prevalence data shows that hearing loss increases with age, but the provision of implants in the over 65 s is even lower, despite there being no clinical barriers to older adults receiving a CI. Survey data shows that awareness activities are needed for both professionals and the general population to improve knowledge of what a CI is and how it can help

Optimality and evolution of transcriptionally regulated gene expression

<p>Abstract</p> <p>Background</p> <p>How transcriptionally regulated gene expression evolves under natural selection is an open question. The cost and benefit of gene expression are the driving factors. While the former can be determined by gratuitous induction, the latter is difficult to measure directly.</p> <p>Results</p> <p>We addressed this problem by decoupling the regulatory and metabolic function of the <it>Escherichia coli lac </it>system, using an inducer that cannot be metabolized and a carbon source that does not induce. Growth rate measurements directly identified the induced expression level that maximizes the metabolism benefits minus the protein production costs, without relying on models. Using these results, we established a controlled mismatch between sensing and metabolism, resulting in sub-optimal transcriptional regulation with the potential to improve by evolution. Next, we tested the evolutionary response by serial transfer. Constant environments showed cells evolving to the predicted expression optimum. Phenotypes with decreased expression emerged several hundred generations later than phenotypes with increased expression, indicating a higher genetic accessibility of the latter. Environments alternating between low and high expression demands resulted in overall rather than differential changes in expression, which is explained by the concave shape of the cross-environmental tradeoff curve that limits the selective advantage of altering the regulatory response.</p> <p>Conclusions</p> <p>This work indicates that the decoupling of regulatory and metabolic functions allows one to directly measure the costs and benefits that underlie the natural selection of gene regulation. Regulated gene expression is shown to evolve within several hundreds of generations to optima that are predicted by these costs and benefits. The results provide a step towards a quantitative understanding of the adaptive origins of regulatory systems.</p

Synthesis of Nanofiltration Membrane Developed from Triethanolamine (TEOA) and Trimesoyl Chloride (TMC) for Separation of Xylose from Glucose

Synthesis of thin film composite (TFC) nanofilt ration (NF) membrane has experienced tremendous development since the concept of interfacial polymerisation (IP) was first introduced. One of its new application is on the separation of xylose from glucos e in biomass hydrolysate. In this present study, NF TFC membrane has been produced through interfacial poly merisation by manipulation the concentration of triethanolamine (TEOA) at 35 min reaction time with 0. 15 % w/v of trimesoyl chloride (TMC). The membrane was then characterised in term of their chemical and physical properties, and separation performance between xylose and glucose. The growth of thin layer f ilm depends on concentration of TEOA as the monomer and reaction time. As concentration of TEOA and re action time increased, the layer of the TFC becomes thicker thus decreases the permeability of the membrane. Contradicted to this study, the lowest and the highest permeability were recorded at 4 % w/v of TEOA and 8 % w/v of TEOA at reaction time of 35-min in TMC. The TFC membrane prepared with 4 % w/v TEOA has high in permeate flux, resultant in high xylose separation of 1.3. Low permeate flux but moderate xylose separation factor of 0.93 was obtained for the TFC membrane prepared with 8 % w/v TEOA

Pilot study on patients with Mal de Debarquement syndrome during pregnancy

Aim: To evaluate if patients with Mal de Debarquement syndrome (MdDS) demonstrate different symptom levels or symptom type during pregnancy. Materials & methods: 18 MdDS patients that were or had been pregnant during their condition were recruited to complete a retrospective online questionnaire. Respondents answered questions regarding their basic clinical data, diagnosis, triggers and differences in symptom level and symptom type during pregnancy and before pregnancy. Results: A total of 81.3% reported that their symptoms were reduced during pregnancy compared with before pregnancy. Respondents also reported a different perception of motion and experienced less dizziness while being pregnant. Conclusion: The physiological changes that occur during pregnancy improve the symptoms of patients with MdDS, and this is potentially attributable to the rise in estrogen and progesterone. Lay abstract: Mal de Debarquement syndrome (MdDS) is a rare neurological disorder characterized by a constant sensation of self-motion. More women are affected than men, and subsequently a hormonal implication has been theorized. This study aimed to evaluate if symptoms change in patients with MdDS during their pregnancy. A total of 18 MdDS patients were recruited to complete a retrospective online questionnaire. Among these, 81.3% of respondents reported that their symptoms were lower during pregnancy compared with before pregnancy. Respondents also reported a different perception of motion and experienced less dizziness while being pregnant. Our results support the hypothesis that pregnancy positively influences MdDS symptoms

Collaborative meaning-making in arts-based research: data interpretation with an artist, a physician, and an art historian

This article discusses collaborative meaning-making in arts-based research. It introduces a project in which an artist-researcher invited a physician and an art historian to help to interpret medical students’ hand-made drawings of the female reproductive system and the conception process. The authors elaborated on different viewpoints and modes of talking during the data interpretation, and discussed how these were founded on, and disrupted, their professional roles in various ways. The article discusses how these different viewpoints about the students’ drawings complemented or conflicted with each other. It also discusses the use of associations and humor in these interpretations, and the experiences of emotional discomfort during the process

The effect of physical therapy treatment in patients with subjective tinnitus:A systematic review

Background: Tinnitus is a very common symptom that often causes distress and decreases the patient's quality of life. Apart from the well-known causes, tinnitus can in some cases be elicited by dysfunctions of the cervical spine or the temporomandibular joint (TMJ). To date however, it is unclear whether alleviation of these dysfunctions, by physical therapy treatment, also decreases the tinnitus complaints. Such physical therapy could be an interesting treatment option for patients that are now often left without treatment. Objectives: The aim of this review was to investigate the current evidence regarding physical therapy treatment in patients with tinnitus. Data sources: The online databases Pubmed, Web of Science, Cochrane, and Embase were searched up to March 2016. Two independent reviewers conducted the data extraction and methodological quality assessment. Study eligibility criteria: Only randomized controlled trials and quasi-experimental trials were included in the review. Studies had to be written in English, French, Dutch, or German. Participants and interventions: The included studies investigated the effect of physical therapy treatment modalities on tinnitus severity in patients suffering from subjective tinnitus. Results: Six studies were included in this review, four investigating cervical spine treatment and two investigating TMJ treatment. These studies show positive effects of cervical spine treatment (manipulations, exercises, triggerpoint treatment) on tinnitus severity. Additionally, decrease in tinnitus severity and intensity was demonstrated after TMJ treatment, following splints, occlusal adjustments as well as jaw exercises. Limitations: The risk of bias in the included studies was high, mainly due to lack of randomization, lack of blinding of subjects, therapists, and/or investigators. Additionally, risk of bias is present due to incomplete presentation of the data and selective reporting. A major issue of the reviewed papers is the heterogeneity of the included study populations, treatments and outcome measures, which inhibit data pooling and meta-analysis. Conclusions: Despite the methodological issues in the included studies and the consequent low quality evidence, it is noteworthy that all included studies show positive treatment effects. Before recommendations can be made, these results need to be confirmed in larger, high quality studies, using unambiguous inclusion criteria, state-of-the-art treatment, and high quality outcome measures