Obesidad

La obesidad es actualmente el problema relacionado con la alimentación más común entre los animales de compañía en los países desarrollados. Entre un 25 y un 40% de las mascotas padecen sobrepeso u obesidad, y esta proporción parece tender a aumentar

Análisis tributario de las farmacias oficinales como explotaciones unipersonales

La obra tiene por objeto realizar el análisis tributario de la actividad farmacéutica desarrollada en el ámbito de una farmacia oficinal por un farmacéutico organizado como explotación unipersonal.Facultad de Ciencias Económica

Responsabilidad tributaria del síndico en los concursos y las quiebras ante el Fisco Nacional y el Fisco de la provincia de Buenos Aires

El presente trabajo tiene por objeto el análisis de la responsabilidad tributaria que tiene el síndico en los procesos concursales regulados por la Ley de Concursos y Quiebras N° 24.522 ante los organismos de recaudación, tanto a nivel nacional, ante la Administración Federal de Ingresos Públicos (AFIP), como a nivel provincial, ante la Agencia de Recaudación de la Provincia de Buenos Aires (ARBA).Facultad de Ciencias Económicas (FCE

Vulneración de los derechos sexuales y reproductivos de las mujeres: la violencia obstétrica

Máster Universitario en Estudios de Género y Políticas de Igualda

Environmental wireless sensor network

"REALnet" és una xarxa de sensors sense fils ubicada al Campus del Baix Llobregat de la UPC. Els sensors d'aquesta xarxa mesuren diferents magnituds físiques. La informació mesurada pels sensors ha de ser recollida i mostrada a través d'Internet. En aquest projecte, s'ha desenvolupat un lloc web on es pot trobar la informació dels sensors. Per fer aquest lloc web accessible des d'Internet, s'ha implementat un servidor web a l'EPSC. A més a més, el programa responsable d'obtenir la informació dels sensors i guardar-la en la base de dades, s'ha modificat per tal d'adaptar-lo als requisits del projecte. Finalment, el sistema desenvolupat s'ha provat i testejat per comprovar el seu correcte funcionament

Carbon monoxide reduces neuropathic pain and spinal microglial activation by inhibiting nitric oxide synthesis in mice

Background: Carbon monoxide (CO) synthesized by heme oxygenase 1 (HO-1) exerts antinociceptive effects during inflammation but its role during neuropathic pain remains unknown. Our objective is to investigate the exact contribution of CO derived from HO-1 in the modulation of neuropathic pain and the mechanisms implicated. Methodology/Principal Findings: We evaluated the antiallodynic and antihyperalgesic effects of CO following sciatic nerve injury in wild type (WT) or inducible nitric oxide synthase knockout (NOS2-KO) mice using two carbon monoxide-releasing molecules (CORM-2 and CORM-3) and an HO-1 inducer (cobalt protoporphyrin IX, CoPP) daily administered from days 10 to 20 after injury. The effects of CORM-2 and CoPP on the expression of HO-1, heme oxygenase 2 (HO-2), neuronal nitric oxide synthase (NOS1) and NOS2 as well as a microglial marker (CD11b/c) were also assessed at day 20 after surgery in WT and NOS2-KO mice. In WT mice, the main neuropathic pain symptoms induced by nerve injury were significantly reduced in a time-dependent manner by treatment with CO-RMs or CoPP. Both CORM-2 and CoPP treatments increased HO-1 expression in WT mice, but only CoPP stimulated HO-1 in NOS2-KO animals. The increased expression of HO-2 induced by nerve injury in WT, but not in NOS2-KO mice, remains unaltered by CORM-2 or CoPP treatments. In contrast, the over-expression of CD11b/c, NOS1 and NOS2 induced by nerve injury in WT, but not in NOS2-KO mice, were significantly decreased by both CORM-2 and CoPP treatments. These data indicate that CO alleviates neuropathic pain through the reduction of spinal microglial activation and NOS1/NOS2 over-expression. Conclusions/Significance: This study reports that an interaction between the CO and nitric oxide (NO) systems is taking place following sciatic nerve injury and reveals that increasing the exogenous (CO-RMs) or endogenous (CoPP) production of CO may represent a novel strategy for the treatment of neuropathic pain

Genetic control of neuronal activity enhances axonal growth only on permissive substrates

Abstract Background Neural tissue has limited regenerative ability. To cope with that, in recent years a diverse set of novel tools has been used to tailor neurostimulation therapies and promote functional regeneration after axonal injuries. Method In this report, we explore cell-specific methods to modulate neuronal activity, including opto- and chemogenetics to assess the effect of specific neuronal stimulation in the promotion of axonal regeneration after injury. Results Opto- and chemogenetic stimulations of neuronal activity elicited increased in vitro neurite outgrowth in both sensory and cortical neurons, as well as in vivo regeneration in the sciatic nerve, but not after spinal cord injury. Mechanistically, inhibitory substrates such as chondroitin sulfate proteoglycans block the activity induced increase in axonal growth. Conclusions We found that genetic modulations of neuronal activity on both dorsal root ganglia and corticospinal motor neurons increase their axonal growth capacity but only on permissive environments