Uneven distribution of ventilation in acute respiratory distress syndrome

INTRODUCTION: The aim of this study was to assess the volume of gas being poorly ventilated or non-ventilated within the lungs of patients treated with mechanical ventilation and suffering from acute respiratory distress syndrome (ARDS). METHODS: A prospective, descriptive study was performed of 25 sedated and paralysed ARDS patients, mechanically ventilated with a positive end-expiratory pressure (PEEP) of 5 cmH(2)O in a multidisciplinary intensive care unit of a tertiary university hospital. The volume of poorly ventilated or non-ventilated gas was assumed to correspond to a difference between the ventilated gas volume, determined as the end-expiratory lung volume by rebreathing of sulphur hexafluoride (EELV(SF6)), and the total gas volume, calculated from computed tomography images in the end-expiratory position (EELV(CT)). The methods used were validated by similar measurements in 20 healthy subjects in whom no poorly ventilated or non-ventilated gas is expected to be found. RESULTS: EELV(SF6 )was 66% of EELV(CT), corresponding to a mean difference of 0.71 litre. EELV(SF6 )and EELV(CT )were significantly correlated (r(2 )= 0.72; P < 0.001). In the healthy subjects, the two methods yielded almost identical results. CONCLUSION: About one-third of the total pulmonary gas volume seems poorly ventilated or non-ventilated in sedated and paralysed ARDS patients when mechanically ventilated with a PEEP of 5 cmH(2)O. Uneven distribution of ventilation due to airway closure and/or obstruction is likely to be involved

Ausbau des DLR-Standorts Jülich: Aktionsraum für CSP-Versuchsanlagen im Pilotmaßstab

Posterbeitrag zum aktuellen Stand des Ausbaus des DLR-Standorts Jülich. Es werden das Ausbaukonzept und einige konkrete Maßnahmen beschrieben

Virtual single-photon transition interrupted: time-gated optical gain and loss

The response of matter to an optical excitation consists essentially of absorption and emission. Traditional spectroscopy accesses the frequency-resolved and time-integrated response, while the temporal evolution stays concealed. However, we will demonstrate here that the temporal evolution of a virtual single-photon transition can be mapped out by a second pulsed electromagnetic field. The resulting optical signal shows previously unexpected optical gain and loss, which can be gated and controlled via the relative delay of the electromagnetic fields. The model presented here can be applied to any system that assumes a two-level character through near-resonant optical dipole excitation, whether they are of atomic, molecular or even solid-state nature. These theoretical observations are in excellent qualitative agreement with our transient absorption spectroscopy study in helium. The presented results can act as starting point for a new scheme for creating optical gain, which is a prerequisite for the operation of lasers. It may be possible to open the doors to spectral regions, which were difficult to access until now, e.g. in the extreme ultraviolet.Comment: 15 pages, 4 figure

Теория и практика работы экспертных советов при вице- губернаторе Томской области

Предмет исследования- деятельность экспертного совета при вице - губернаторе Томской области по научно-образовательному комплексу и инновационной политике, объект исследования-научно-образовательный комплекс. Тема является актуальной,так как это инновационная форма управления.Целью работы является разработка рекомендаций для более эффективной работы.Subject of study is activity of the expert council under the vice-governorfor of the Tomsk region for the educational complex, the object of study is educational complex. The Theme is actual, because it is innovative form of management. Target of he work is development of recommendations for more effective work

Dilepton Spectra from Decays of Light Unflavored Mesons

The invariant mass spectrum of the $e^{+}e^{-}$ and $\mu ^{+}\mu ^{-}$ pairs from decays of light unflavored mesons with masses below the $\phi (1020)$-meson mass to final states containing along with a dilepton pair one photon, one meson, and two mesons are calculated within the framework of the effective meson theory. The results can be used for simulations of the dilepton spectra in heavy-ion collisions and for experimental searches of dilepton meson decays.Comment: 73 pages, 19 figures, 3 tables, REVTeX, new references adde

Dynamic simulation tool for a performance evaluation and sensitivity study of a parabolic trough collector system with concrete thermal energy storage

Plant developers of parabolic trough collector (PTC) systems for industrial steam generation face various challenges. Some of the main challenges are availability of land, buildings in the vicinity of the plant that cast shadows on the collectors as well as land restrictions. The typical north-south collector axis alignment in many cases may not be possible due to limits of available ground. These were challenges that were faced in the planning phase for installing a PTC plant on the premises of the KEAN Soft Drinks Ltd factory in Limassol, Cyprus. As these issues cannot be avoided they must be accounted for by the plant developer, especially when a performance guarantee is given. This work presents, amongst other things, factors that should be analysed in order to predict the energy yield in the planning phase as best as possible by using a simulation model. In the sensitivity study presented in this paper, several effects on the energy yield were investigated theoretically. These effects include: Tracking inaccuracy, non-parallel collector row axis orientations as well as north-south vs. east-west collector alignment. A dynamic simulation model developed by the Solar-Institut Jülich (SIJ) [1] was further developed and used for the analysis. The simulation model features a deviation between the measured and simulated oil temperature at the collector outlet of only 1.5 K (rms). The findings are presented in this paper and give an insight into the effectiveness of mid-sized PTC systems for the industry sector

Operational experience and behaviour of a parabolic trough collector system with concrete thermal energy storage for process steam generation in Cyprus

As part of the transnational research project EDITOR, a parabolic trough collector system (PTC) with concrete thermal energy storage (C-TES) was installed and commissioned in Limassol, Cyprus. The system is located on the premises of the beverage manufacturer KEAN Soft Drinks Ltd. and its function is to supply process steam for the factory’s pasteurisation process [1]. Depending on the factory’s seasonally varying capacity for beverage production, the solar system delivers between 5 and 25 % of the total steam demand. In combination with the C-TES, the solar plant can supply process steam on demand before sunrise or after sunset. Furthermore, the C-TES compensates the PTC during the day in fluctuating weather conditions. The parabolic trough collector as well as the control and oil handling unit is designed and manufactured by Protarget AG, Germany. The C-TES is designed and produced by CADE Soluciones de Ingeniería, S.L., Spain. In the focus of this paper is the description of the operational experience with the PTC, C-TES and boiler during the commissioning and operation phase. Additionally, innovative optimisation measures are presented

Электропривод регулирующей трубопроводной арматуры на базе синхронного двигателя с постоянными магнитами

Цель работы – создание нового поколения регулирующих взрывозащищенных электроприводов с минимальными габаритными размерами, массой и себестоимостью, не уступающих по точности регулирования и функциональным характеристикам регулирующим электроприводам производства других фирм. В процессе работы был произведен расчет и выбор электропривода. Проведено моделирование и анализ работы привода в разных режимах.The purpose of the work is to create a new generation of regulating explosion-proof electric drives with minimum overall dimensions, weight and cost, which are not inferior in regulation accuracy and functional characteristics to regulating electric drives produced by other companies. During operation electric drive was calculated and selected. Simulation and analysis of the drive operation in different modes were carried out

The missing link: Bordetella petrii is endowed with both the metabolic versatility of environmental bacteria and virulence traits of pathogenic Bordetellae

Gross R, Guzman CA, Sebaihia M, et al. The missing link: Bordetella petrii is endowed with both the metabolic versatility of environmental bacteria and virulence traits of pathogenic Bordetellae. BMC Genomics. 2008;9(1): 449.Background: Bordetella petrii is the only environmental species hitherto found among the otherwise host-restricted and pathogenic members of the genus Bordetella. Phylogenetically, it connects the pathogenic Bordetellae and environmental bacteria of the genera Achromobacter and Alcaligenes, which are opportunistic pathogens. B. petrii strains have been isolated from very different environmental niches, including river sediment, polluted soil, marine sponges and a grass root. Recently, clinical isolates associated with bone degenerative disease or cystic fibrosis have also been described. Results: In this manuscript we present the results of the analysis of the completely annotated genome sequence of the B. petrii strain DSMZ12804. B. petrii has a mosaic genome of 5,287,950 bp harboring numerous mobile genetic elements, including seven large genomic islands. Four of them are highly related to the clc element of Pseudomonas knackmussii B13, which encodes genes involved in the degradation of aromatics. Though being an environmental isolate, the sequenced B. petrii strain also encodes proteins related to virulence factors of the pathogenic Bordetellae, including the filamentous hemagglutinin, which is a major colonization factor of B. pertussis, and the master virulence regulator BvgAS. However, it lacks all known toxins of the pathogenic Bordetellae. Conclusion: The genomic analysis suggests that B. petrii represents an evolutionary link between free-living environmental bacteria and the host-restricted obligate pathogenic Bordetellae. Its remarkable metabolic versatility may enable B. petrii to thrive in very different ecological niches

Natural products in modern life science

With a realistic threat against biodiversity in rain forests and in the sea, a sustainable use of natural products is becoming more and more important. Basic research directed against different organisms in Nature could reveal unexpected insights into fundamental biological mechanisms but also new pharmaceutical or biotechnological possibilities of more immediate use. Many different strategies have been used prospecting the biodiversity of Earth in the search for novel structure–activity relationships, which has resulted in important discoveries in drug development. However, we believe that the development of multidisciplinary incentives will be necessary for a future successful exploration of Nature. With this aim, one way would be a modernization and renewal of a venerable proven interdisciplinary science, Pharmacognosy, which represents an integrated way of studying biological systems. This has been demonstrated based on an explanatory model where the different parts of the model are explained by our ongoing research. Anti-inflammatory natural products have been discovered based on ethnopharmacological observations, marine sponges in cold water have resulted in substances with ecological impact, combinatory strategy of ecology and chemistry has revealed new insights into the biodiversity of fungi, in depth studies of cyclic peptides (cyclotides) has created new possibilities for engineering of bioactive peptides, development of new strategies using phylogeny and chemography has resulted in new possibilities for navigating chemical and biological space, and using bioinformatic tools for understanding of lateral gene transfer could provide potential drug targets. A multidisciplinary subject like Pharmacognosy, one of several scientific disciplines bridging biology and chemistry with medicine, has a strategic position for studies of complex scientific questions based on observations in Nature. Furthermore, natural product research based on intriguing scientific questions in Nature can be of value to increase the attraction for young students in modern life science