1,123 research outputs found
Experimental observation of nonlinear Thomson scattering
A century ago, J. J. Thomson showed that the scattering of low-intensity
light by electrons was a linear process (i.e., the scattered light frequency
was identical to that of the incident light) and that light's magnetic field
played no role. Today, with the recent invention of ultra-high-peak-power
lasers it is now possible to create a sufficient photon density to study
Thomson scattering in the relativistic regime. With increasing light intensity,
electrons quiver during the scattering process with increasing velocity,
approaching the speed of light when the laser intensity approaches 10^18
W/cm^2. In this limit, the effect of light's magnetic field on electron motion
should become comparable to that of its electric field, and the electron mass
should increase because of the relativistic correction. Consequently, electrons
in such high fields are predicted to quiver nonlinearly, moving in figure-eight
patterns, rather than in straight lines, and thus to radiate photons at
harmonics of the frequency of the incident laser light, with each harmonic
having its own unique angular distribution. In this letter, we report the first
ever direct experimental confirmation of these predictions, a topic that has
previously been referred to as nonlinear Thomson scattering. Extension of these
results to coherent relativistic harmonic generation may eventually lead to
novel table-top x-ray sources.Comment: including 4 figure
Metal-macrofauna interactions determine microbial community structure and function in copper contaminated sediments
Peer reviewedPublisher PD
Delayed oral LY333013 rescues mice from highly neurotoxic, lethal doses of Papuan Taipan (Oxyuranus scutellatus) venom
There is an unmet need for economical snakebite therapies with long shelf lives
that are effective even with delays in treatment. The orally bioavailable, heat-stable, secretory
phospholipase A2 (sPLA2) inhibitor, LY333013, demonstrates antidotal characteristics for severe
snakebite envenoming in both field and hospital use. A murine model of lethal envenoming
by a Papuan taipan (Oxyuranus scutellatus) demonstrates that LY333013, even with delayed oral
administration, improves the chances of survival. Furthermore, LY333013 improves the performance
of antivenom even after it no longer reverses neurotoxic signs. Our study is the first demonstration
that neurotoxicity from presynaptic venom sPLA2S can be treated successfully, even after the window
of therapeutic antivenom has closed. These results suggest that sPLA2 inhibitors have the potential
to reduce death and disability and should be considered for the initial and adjunct treatment of
snakebite envenoming. The scope and capacity of the sPLA2 inhibitors ability to achieve these
endpoints requires further investigation and development effortsUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)UCR::Vicerrectoría de Docencia::Salud::Facultad de Microbiologí
Unconfined Aquifer Flow Theory - from Dupuit to present
Analytic and semi-analytic solution are often used by researchers and
practicioners to estimate aquifer parameters from unconfined aquifer pumping
tests. The non-linearities associated with unconfined (i.e., water table)
aquifer tests makes their analysis more complex than confined tests. Although
analytical solutions for unconfined flow began in the mid-1800s with Dupuit,
Thiem was possibly the first to use them to estimate aquifer parameters from
pumping tests in the early 1900s. In the 1950s, Boulton developed the first
transient well test solution specialized to unconfined flow. By the 1970s
Neuman had developed solutions considering both primary transient storage
mechanisms (confined storage and delayed yield) without non-physical fitting
parameters. In the last decade, research into developing unconfined aquifer
test solutions has mostly focused on explicitly coupling the aquifer with the
linearized vadose zone. Despite the many advanced solution methods available,
there still exists a need for realism to accurately simulate real-world aquifer
tests
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An improved methodology for the recovery of Zea mays and other large crop pollen, with implications for environmental archaeology in the Neotropics
We present a simple sieving methodology to aid the recovery of large cultigen pollen grains, such as maize (Zea mays L.), manioc (Manihot esculenta Crantz), and sweet potato (Ipomoea batatas L.), among others, for the detection of food production using fossil pollen analysis of lake sediments in the tropical Americas. The new methodology was tested on three large study lakes located next to known and/or excavated pre-Columbian archaeological sites in South and Central America. Five paired samples, one treated by sieving, the other prepared using standard methodology, were compared for each of the three sites. Using the new methodology, chemically digested sediment samples were passed through a 53 µm sieve, and the residue was retained, mounted in silicone oil, and counted for large cultigen pollen grains. The filtrate was mounted and analysed for pollen according to standard palynological procedures. Zea mays (L.) was recovered from the sediments of all three study lakes using the sieving technique, where no cultigen pollen had been previously recorded using the standard methodology. Confidence intervals demonstrate there is no significant difference in pollen assemblages between the sieved versus unsieved samples. Equal numbers of exotic Lycopodium spores added to both the filtrate and residue of the sieved samples allow for direct comparison of cultigen pollen abundance with the standard terrestrial pollen count. Our technique enables the isolation and rapid scanning for maize and other cultigen pollen in lake sediments, which, in conjunction with charcoal and pollen records, is key to determining land-use patterns and the environmental impact of pre-Columbian societies
An approach for a negotiation model inspired on social networks
Supporting group decision-making in ubiquitous contexts is a complex
task that needs to deal with a large amount of factors to be successful. Here
we propose an approach for a negotiation model to support the group decisionmaking
process specially designed for ubiquitous contexts. We propose a new
look into this problematic, considering and defining strategies to deal with important
points such as the type of attributes in the multi-criteria problem and
agents' reasoning. Our model uses a social networking logic due to the type of
communication employed by the agents as well as to the type of relationships
they build as the interactions occur. Our approach intends to support the ubiquitous
group decision-making process in a similar way to the real process, which
simultaneously preserves the amount and quality of intelligence generated in
face-to-face meetings and is adapted to be used in a ubiquitous context.This work is part-funded by ERDF - European Regional Development Fund through
the COMPETE Programme (operational programme for competitiveness) and by
National Funds through the FCT - Fundação para a Ciência e a Tecnologia (Portuguese
Foundation for Science and Technology) within project FCOMP-01-0124-
FEDER-028980 (PTDC/EEISII/1386/2012) and SFRH/BD/89697/2012.info:eu-repo/semantics/publishedVersio
What are we measuring? A critique of range of motion methods currently in use for Dupuytren's disease and recommendations for practice
Background: Range of motion is the most frequently reported measure used in practice to evaluate outcomes.
A goniometer is the most reliable tool to assess range of motion yet, the lack of consistency in reporting prevents comparison between studies. The aim of this study is to identify how range of motion is currently assessed and reported in Dupuytren’s disease literature. Following analysis recommendations for practice will be made to enable consistency in future studies for comparability. This paper highlights the variation in range of motion reporting in Dupuytren’s disease.
Methods: A Participants, Intervention, Comparison, Outcomes and Study design format was used for the search strategy and search terms. Surgery, needle fasciotomy or collagenase injection for primary or recurrent Dupuytren’s disease in adults were included if outcomes were monitored using range of motion to record change. A literature search was performed in May 2013 using subject heading and free-text terms to also capture electronic publications ahead of print. In total 638 publications were identified and following screening 90 articles met the inclusion criteria. Data was extracted and entered onto a spreadsheet for analysis. A thematic analysis was carried out to establish any duplication, resulting in the final range of motion measures identified.
Results: Range of motion measurement lacked clarity, with goniometry reportedly used in only 43 of the 90 studies, 16 stated the use of a range of motion protocol. A total of 24 different descriptors were identified describing range of motion in the 90 studies. While some studies reported active range of motion, others reported passive or were unclear. Eight of the 24 categories were identified through thematic analysis as possibly describing the same measure, ‘lack of joint extension’ and accounted for the most frequently used. Conclusions: Published studies lacked clarity in reporting range of motion, preventing data comparison and
meta-analysis. Percentage change lacks context and without access to raw data, does not allow direct comparison of baseline characteristics. A clear description of what is being measured within each study was required. It is recommended that range of motion measuring and reporting for Dupuytren’s disease requires consistency to address issues that fall into 3 main categories:-
Definition of terms
Protocol statement
Outcome reportin
Two specific mutations are prevalent causes of recessive retinitis pigmentosa in North American patients of Jewish ancestry.
PURPOSE: Retinitis pigmentosa is a Mendelian disease with a very elevated genetic heterogeneity. Most mutations are responsible for less than 1% of cases, making molecular diagnosis a multigene screening procedure. In this study, we assessed whether direct testing of specific alleles could be a valuable screening approach in cases characterized by prevalent founder mutations.
METHODS: We screened 275 North American patients with recessive/isolate retinitis pigmentosa for two mutations: an Alu insertion in the MAK gene and the p.Lys42Glu missense in the DHDDS gene. All patients were unrelated; 35 reported Jewish ancestry and the remainder reported mixed ethnicity.
RESULTS: We identified the MAK and DHDDS mutations homozygously in only 2.1% and 0.8%, respectively, of patients of mixed ethnicity, but in 25.7% and 8.6%, respectively, of cases reporting Jewish ancestry. Haplotype analyses revealed that inheritance of the MAK mutation was attributable to a founder effect.
CONCLUSION: In contrast to most mutations associated with retinitis pigmentosa-which are, in general, extremely rare-the two alleles investigated here cause disease in approximately one-third of North American patients reporting Jewish ancestry. Therefore, their screening constitutes an alternative procedure to large-scale tests for patients belonging to this ethnic group, especially in time-sensitive situations.Genet Med 17 4, 285-290
Acute kidney disease and renal recovery : consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup
Consensus definitions have been reached for both acute kidney injury (AKI) and chronic kidney disease (CKD) and these definitions are now routinely used in research and clinical practice. The KDIGO guideline defines AKI as an abrupt decrease in kidney function occurring over 7 days or less, whereas CKD is defined by the persistence of kidney disease for a period of > 90 days. AKI and CKD are increasingly recognized as related entities and in some instances probably represent a continuum of the disease process. For patients in whom pathophysiologic processes are ongoing, the term acute kidney disease (AKD) has been proposed to define the course of disease after AKI; however, definitions of AKD and strategies for the management of patients with AKD are not currently available. In this consensus statement, the Acute Disease Quality Initiative (ADQI) proposes definitions, staging criteria for AKD, and strategies for the management of affected patients. We also make recommendations for areas of future research, which aim to improve understanding of the underlying processes and improve outcomes for patients with AKD
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