Hacia un modelo de comunicación interpersonal de sustentación interactivo-simbólica e incomunicabilidad

El objetivo de este ensayo es proponer un modelo de comunicación interpersonal que sirva como referente para entender la forma en la que puede construirse la acción colectiva; tomando en cuenta elementos lingüísticos que forman parte del Interaccionismo Simbólico de Herbert Blumer, considerando también otras posturas teóricas como la Ontología del Lenguaje, la Argumentación, la Otredad y la denominada Incomunicabilidad de Charlie Galibert

Propuesta para reducir el congestionamiento vehicular aplicando la metodología HCM 2010 en la Autopista Ramiro Prialé en el Tramo de la Av. Los Laureles - Av. Las Torres, Lima - 2023

En este trabajo de investigación tiene como objetivo principal sugerir mejoras en base a la metodología HCM 2010 para la disminución de la fricción vehicular de las intersecciones de la Autopista Ramiro Prialé en el tramo de la Av. Los Laureles - Av. Las Torres de la ciudad de Lima, 2023, mientras que como objetivos específicos Identificar las características particulares que influyen en la congestión vehicular de la Autopista Ramiro Prialé que abarca los tramos desde la Avenida Los Laureles hasta la Avenida Las Torres en la ciudad de Lima, evaluar la capacidad vehicular en los cruces viales de la Autopista Ramiro Prialé, dentro del tramo que abarca desde la Avenida Los Laureles hasta la Avenida Las Torres en la ciudad de Lima y finalmente determinar los niveles de servicio mediante la metodología HCM 2010 de la Autopista Ramiro Prialé, dentro del tramo que abarca desde la Avenida Los Laureles hasta la Avenida Las Torres, con el fin de evaluar la eficiencia y fluidez del tráfico en esa área. Proponer las medidas y acciones que actualmente se deberían de aplicar para el control del flujo vehicular en la Autopista Ramiro Prialé, dentro del tramo que abarca desde la Avenida Los Laureles hasta la Avenida Las Torres, con el propósito de identificar su grado de efectividad y su contribución a la reducción del tráfico. El método utilizado fue un diseño descriptivo, no experimental, la técnica fue la observación directa, se consideraron como instrumentos los manuales de observación y las hojas de registro para el conteo vehicular. A través de la metodología anterior se obtuvieron datos de la autopista Ramiro Prialé, con anchos de carriles entre los 3.30 m ,3.00 m, 2.80 m y 2.70 m, así mismo en el conteo de la capacidad vehicular, se definió que el período pico se da entre las 07:00 am, 11:00 am, 12:00 pm, 03:00 pm y 06:00 pm, mientras que el resumen del conteo vehicular arroja un total de 22680 unidades. A su vez el nivel de servicio calculado para las avenidas con la implementación de la metodología HCM será de tipo E.The general objective of this research work is to propose improvements based on the HCM 2010 methodology to reduce traffic congestion at the intersections of the Ramiro Prialé Highway in the section of Av. Los Laureles-Av. Las Torres in the city of Lima, 2023, while as specific objectives Identify the particular characteristics that influence the traffic congestion of the Ramiro Prialé Highway that covers the sections from Avenida Los Laureles to Avenida Las Torres in the city of Lima, evaluate the vehicle capacity at the road intersections of the Ramiro Prialé Highway, within the section that extends from Avenida Los Laureles to Avenida Las Torres in the city of Lima and finally determine the service levels using the HCM 2010 methodology of the Ramiro Highway Prialé, within the section that extends from Avenida Los Laureles to Avenida Las Torres, in order to evaluate the efficiency and fluidity of traffic in that area. Propose the measures and actions that must currently be applied to control vehicular flow on the Ramiro Prialé Highway, within the section that extends from Avenida Los Laureles to Avenida Las Torres, with the purpose of identifying their degree of effectiveness and their contribution. to the reduction of traffic. The method used was a descriptive, non-experimental design, the technique was direct observation, observation manuals and record sheets for vehicle counting will be considered as instruments. Through the previous methodology, data were obtained from the Ramiro Prialé highway, with lane widths between 3.30 m, 3.00 m, 2.80 m and 2.70 m, likewise in the vehicle capacity count, it is defined that the peak period occurs between 07:00 am, 11:00 am, 12:00 pm, 03:00 pm and 06:00 pm, while the summary of the vehicle count shows a total of 22,680 units. In turn, the service level calculated for the avenues with the implementation of the HCM methodology will be type E.Trabajo de Suficiencia Profesiona

Municipal distribution of bladder cancer mortality in Spain: Possible role of mining and industry

BACKGROUND: Spain shows the highest bladder cancer incidence rates in men among European countries. The most important risk factors are tobacco smoking and occupational exposure to a range of different chemical substances, such as aromatic amines. METHODS: This paper describes the municipal distribution of bladder cancer mortality and attempts to "adjust" this spatial pattern for the prevalence of smokers, using the autoregressive spatial model proposed by Besag, York and Molliè, with relative risk of lung cancer mortality as a surrogate. RESULTS: It has been possible to compile and ascertain the posterior distribution of relative risk for bladder cancer adjusted for lung cancer mortality, on the basis of a single Bayesian spatial model covering all of Spain's 8077 towns. Maps were plotted depicting smoothed relative risk (RR) estimates, and the distribution of the posterior probability of RR>1 by sex. Towns that registered the highest relative risks for both sexes were mostly located in the Provinces of Cadiz, Seville, Huelva, Barcelona and Almería. The highest-risk area in Barcelona Province corresponded to very specific municipal areas in the Bages district, e.g., Suría, Sallent, Balsareny, Manresa and Cardona. CONCLUSION: Mining/industrial pollution and the risk entailed in certain occupational exposures could in part be dictating the pattern of municipal bladder cancer mortality in Spain. Population exposure to arsenic is a matter that calls for attention. It would be of great interest if the relationship between the chemical quality of drinking water and the frequency of bladder cancer could be studied

Nucleotides in neuroregeneration and neuroprotection

AbstractBrain injury generates the release of a multitude of factors including extracellular nucleotides, which exhibit bi-functional properties and contribute to both detrimental actions in the acute phase and also protective and reparative actions in the later recovery phase to allow neuroregeneration. A promising strategy toward restoration of neuronal function is based on activation of endogenous adult neural stem/progenitor cells. The implication of purinergic signaling in stem cell biology, including regulation of proliferation, differentiation, and cell death has become evident in the last decade. In this regard, current strategies of acute transplantation of ependymal stem/progenitor cells after spinal cord injury restore altered expression of P2X4 and P2X7 receptors and improve functional locomotor recovery. The expression of both receptors is transcriptionally regulated by Sp1 factor, which plays a key role in the startup of the transcription machinery to induce regeneration-associated genes expression. Finally, general signaling pathways triggered by nucleotide receptors in neuronal populations converge on several intracellular kinases, such as PI3K/Akt, GSK3 and ERK1,2, as well as the Nrf-2/heme oxigenase-1 axis, which specifically link them to neuroprotection. In this regard, regulation of dual specificity protein phosphatases can become novel mechanism of actions for nucleotide receptors that associate them to cell homeostasis regulation.This article is part of the Special Issue entitled ‘Purines in Neurodegeneration and Neuroregeneration’

Seguridad y violencia en el Estado de México. Nota generales para un acercamiento

Este libro tiene como uno de sus objetivos principales impulsar un ejercicio académico de tipo prevención del tema seguridad y violencia en el estado de México a través de las notas generales para un acercamiento

Combined Stress Conditions in Melon Induce Non-additive Effects in the Core miRNA Regulatory Network

[EN] Climate change has been associated with a higher incidence of combined adverse environmental conditions that can promote a significant decrease in crop productivity. However, knowledge on how a combination of stresses might affect plant development is still scarce. MicroRNAs (miRNAs) have been proposed as potential targets for improving crop productivity. Here, we have combined deep-sequencing, computational characterization of responsive miRNAs and validation of their regulatory role in a comprehensive analysis of response of melon to several combinations of four stresses (cold, salinity, short day, and infection with a fungus). Twenty-two miRNA families responding to double and/or triple stresses were identified. The regulatory role of the differentially expressed miRNAs was validated by quantitative measurements of the expression of the corresponding target genes. A high proportion (ca. 60%) of these families (mainly highly conserved miRNAs targeting transcription factors) showed a non-additive response to multiple stresses in comparison with that observed under each one of the stresses individually. Among those miRNAs showing non-additive response to stress combinations, most interactions were negative, suggesting the existence of functional convergence in the miRNA-mediated response to combined stresses. Taken together, our results provide compelling pieces of evidence that the response to combined stresses cannot be easily predicted from the study individual stresses.This work was supported by grants PID2019-104126RB-I00 (GG), PIE2019-103998GB-I00 (SE), and AGL2017-85563-C2-1R (BP) funded byMCIN/Spain's Agencia Estatal de Investigacion (AEI) and "ERDF A way of making Europe" and by PROMETEO projects 2019/012 (SE) and 2017/078 and 2021/072 (BP) (to promote excellence groups) by the Conselleria d'Educacio, Investigacio, Cultura i Esports (Generalitat Valenciana). JM-M (ACIF-2017-114) and AH-A (ACIF-2021-202) are recipients of a predoctoral contract from the Generalitat Valenciana.Villalba-Bermell, P.; Marquez-Molins, J.; Marques, M.; Hernandez-Azurdia, AG.; Corell-Sierra, J.; Picó Sirvent, MB.; Monforte Gilabert, AJ.... (2021). Combined Stress Conditions in Melon Induce Non-additive Effects in the Core miRNA Regulatory Network. Frontiers in Plant Science. 12:1-15. https://doi.org/10.3389/fpls.2021.769093S1151

Reversion of epigenetically mediated BIM silencing overcomes chemoresistance in Burkitt lymphoma

In Burkitt lymphoma/leukemia (BL), achievement of complete remission with first-line chemotherapy remains a challenging issue, as most patients who respond remain disease-free, whereas those refractory have few options of being rescued with salvage therapies. The mechanisms underlying BL chemoresistance and how it can be circumvented remain undetermined. We previously reported the frequent inactivation of the proapoptotic BIM gene in B-cell lymphomas. Here we show that BIM epigenetic silencing by concurrent promoter hypermethylation and deacetylation occurs frequently in primary BL samples and BL-derived cell lines. Remarkably, patients with BL with hypermethylated BIM presented lower complete remission rate (24% vs 79%; P = .002) and shorter overall survival (P = .007) than those with BIM-expressing lymphomas, indicating that BIM transcriptional repression may mediate tumor chemoresistance. Accordingly, by combining in vitro and in vivo studies of human BL-xenografts grown in immunodeficient RAG2(-/-)γc(-/-) mice and of murine B220(+)IgM(+) B-cell lymphomas generated in Eμ-MYC and Eμ-MYC-BIM(+/-) transgenes, we demonstrate that lymphoma chemoresistance is dictated by BIM gene dosage and is reversible on BIM reactivation by genetic manipulation or after treatment with histone-deacetylase inhibitors. We suggest that the combination of histone-deacetylase inhibitors and high-dose chemotherapy may overcome chemoresistance, achieve durable remission, and improve survival of patients with BL