DOS DÉCADAS DE EDUCACIÓN DE PERSONAS ADULTAS Y PARTICIPACIÓN EN L’HORTA DE VALÈNCIA (ESPAÑA)

La educación de personas adultas es un mecanismo de (re)socialización tardía laboral y cultural. Puede reproducir y legitimar el sistema económico y social dominante, pero también puede generar resistencias al mismo. Estas contradicciones se ven reflejadas en la investigación realizada mediante entrevistas en profundidad a integrantes de diferentes Centros de Formación de Personas Adultas de L’Horta de València (España) en dos tandas con veinte años de diferencia (1999-2020), lo que permite adquirir una mayor comprensión de la interconexión entre educación y participación desde una perspectiva diacrónica. Como resultado se observa que en el sistema educativo la participación es un objetivo a conseguir más que una realidad efectiva pues, aunque se desarrollan iniciativas creativas y alternativas, esto se realiza, sobre todo, por y desde el profesorado

La inclusión laboral de las personas con discapacidad desde la Administración Pública Responsable en la Comunidad Valenciana

En la presente coyuntura socioeconómica, la posibilidad de inclusión a través del empleo de las personas con discapacidad es importante no solo por las posibilidades de autonomía económica, sino también por las oportunidades de socialización. Sobre esta base, y considerando que las empresas socialmente responsables asumen la inclusión de estas personas en sus plantillas como una posibilidad de crecimiento y de diferenciación, en el texto se analiza, de manera descriptiva, el papel que las administraciones públicas (AA. PP.) autonómicas, con competencias en la materia, pueden, deben y están haciendo para fomentar la responsabilidad social corporativa (RSC) y la gestión de la inclusión laboral de las personas con discapacidad. A partir de la discusión teórica y de la revisión de las políticas desarrolladas, se pretende dar respuesta a las siguientes cuestiones de fondo: ¿Cómo se está atendiendo la pluralidad en las empresas desde las administraciones públicas? ¿Son la RSC y la gestión de las personas con discapacidad modas pasajeras o por el contrario pueden resultar un instrumento válido de inclusión de estas personas dentro de los espacios de trabajo? Llegando a la conclusión de que esto solo será posible desde una RSC estratégica e integradora. : At the present socio-economic juncture, the possibility of inclusion through the employment of people with disability is important not only because of the possibilities of economic autonomy, but also because of the opportunities for socialization. On this basis and considering that socially responsible companies take on the inclusion of these people in their workforce as a possibility of growth and differentiation, in the text is analyzed, in a descriptive way, the role that the autonomous Public Administrations (AA. PP.), with competences in the area, can, should and are doing to promote Corporate Social Responsibility (CSR) and management for the labor inclusion of people with disability. Based on the theoretical discussion and the review of the policies developed, is to provide replies to the following substantive questions: How is diversity being addressed in companies by public administrations? Are CSR and people with disability management fads or, on the contrary, can they be a valid instrument for the inclusion of these people within work spaces? Concluding that this will only be possible from a strategic and inclusive CSR

Hombres en cuidado. Narraciones de cuidadores masculinos informales en Valencia

Presentamos los resultados de una investigación inédita en el marco territorial de la Comunidad Valenciana. Ésta se desarrolló por la Universidad de Valencia, desde agosto de 2016 y hasta un año después, con financiación del Ayuntamiento de Valencia La investigación pretendía observar como perciben su propio rol de cuidador, los hombres que desarrollan habitualmente esta función de manera informal en su entorno familiar. De igual modo, conocer cuáles son los factores psico-sociales que comprende la acción de cuidar y qué consecuencias positivas puede reportarles la atención a personas en situación de dependencia. Así, se ha podido comprobar como, a pesar de que los hombres utilizan con mayor asiduidad los resursos y servicios (tanto públicos como privados) disponibles; también es cierto que el cuidado reporta un valor tanto al individuo que lo ejerce como al que lo recibe; y constituye un beneficio evidente al colectivo (economía del cuidado).We present the results of an unpublished research in the territorial framework of the Valencian Community. This was developed by the University of Valencia, from August 2016 and until a year later, with funding from the City of Valencia The research sought to observe how they perceive their own role as caretaker, the men who habitually develop this function in an informal way in their family environment. In the same way, to know the psycho-social factors that understand the action of caring and what positive consequences can be reported to people in a situation of dependence. Thus, it has been possible to see how, although men use more assiduously the Resursos and services (both public and private) available; It is also true that care reports a value both to the individual who exerts it and to the one who receives it; And it constitutes an obvious benefit to the collective (economy of the care)

Eco-friendly isolation and characterization of nanochitin from different origins by microwave irradiation: optimization using response surface methodology

[EN] The extraction of nanochitin from marine waste has attracted great industrial interest due to its unique properties, namely biodegradability, biocompatibility and as a functional reinforcing agent. Conventional acid hydrolysis isolation of nanochitin requires high temperatures and acid concentration, time and energy. Herein, for the first time, microwave irradiation method was used as an eco-friendly approach to isolate nanochitin from different sources. The isolation conditions were optimized through an experimental Box-Behnken design using surface response methodology. The data showed optimal conditions of 1 M HCl, 10.00 min and 124.75 W to obtain lobster nanocrystals; 1 M HCl, 14.34 min and 50.21 W to obtain shrimp nanocrystals; and 1 M HCl, 29.08 min and 54.08 W to obtain squid pen nanofibres, reducing time and HCl concentration. The obtained isolation yields where of 85.30, 79.92 and 80.59 % for lobster, shrimp and squid, respectively. The morphology of the nanochitins was dependent of the chitin origin, and the lengths of the nanochitins were of 314.74, 386.12 and > 900 nm for lobster, shrimp and squid pen, respectively. The thermal stability of the ensuing nanochitins was maintained after treatment. The results showed that nanochitin could be obtained by using an eco-friendly approach like microwave irradiation.The authors would like to thank the Basque Government (scholarship of young researchers training and project IT1008-16) for supporting financially this research and their gratitude for technical and human support provided by SGIker (UPV/EHU/ERDF, EU). S.C.M.F. is the recipient of an E2S UPPA Research Partnership Chair (MANTA: Marine Materials) supported by the “Investissements d’Avenir” French program managed by ANR (ANR-16-IDEX-0002), the R ́egion Nouvelle-Aquitaine and the Communaut ́e d’Agglom ́eration du Pays Basque, France

Synergistic DNA-damaging effect in multiple myeloma with the combination of zalypsis, bor tezomib and dexamethasone

Despite new advances in multiple myeloma treatment and the consequent improvement in overall survival, most patients relapse or become refractory to treatment. This suggests that new molecules and combinations that may further inhibit important survival pathways for these tumor cells are needed. In this context, zalypsis is a novel compound, derived from marine organisms, with a powerful preclinical anti-myeloma effect based on the sensitivity of malignant plasma cells to DNA-damage induction; and it has already been tested in a phase I/II clinical trial in multiple myeloma. We hypothesized that the addition of this compound to the combination of bortezomib plus dexamethasone may improve efficacy with acceptable toxicity. The triple combination demonstrated strong synergy and higher efficacy compared with double combinations; not only in vitro, but also ex vivo and, especially, in in vivo experiments. The triple combination triggers cell death, mainly through a synergistic induction of DNA damage and a decrease in the nuclear localization of nuclear factor kappa B. Our findings support the clinical evaluation of this combination for relapsed and refractory myeloma patients.This work was in part funded by the Spanish ISCIII-FIS (PI 15/0067 and PI15/02156) and FEDER, the Spanish RTICC (RD12/0036/0058), "Asociación Española Contra el Cancer" (AECC, GCB120981SAN), the regional Council from “Castilla y León” (GRS 1175/A/15 and FIC335U14) and a research grant from Pharmamar SAU. MMS were also supported by the Network of Centers for Regenerative Medicine and Cellular Therapy from Castilla y León, Spain. A-A López-Iglesias was supported by a grant from the Spanish Society of Hematology and Hemotherapy.Peer Reviewe

De Nueva España a México : El universo musical mexicano entre centenarios (1517-1917)

742 págs. Imágenes color y b/n. Partituras musicales.El fenómeno de las conmemoraciones culturales siempre ha sido un terreno abonado para la producción cultural y artística del que se han valido los Estados para ofrecer interpretaciones legitimadoras e ideologizadas de la historia, articuladas en torno a las ideas de memoria, nación y progreso. El presente volumen, resultado de una triple conmemoración (el centenario de la Revolución Mexicana y la publicación de la primera historia de la música en México de Alba Herrera –1917–, por un lado; y la llegada del militar andaluz Francisco Hernández de Córdoba a la costa de la península del Yucatán –1517–, por otro), presenta una visión retrospectiva de la historia musical mexicana a lo largo de esas cuatro centurias. Frente a la rígida división cronológica impuesta por ciertas narrativas, se ofrece así una noción inclusiva, actual e informada del universo musical mexicano en toda su multiplicidad y riqueza de matices, integrando las épocas colonial e independiente como lo que realmente son: partes constitutivas de la memoria musical, histórica, cultural y política del país, con las luces y las sombras propias de cualquier otro periodo

COVID-19 Severity and Survival over Time in Patients with Hematologic Malignancies: A Population-Based Registry Study

Mortality rates for COVID-19 have declined over time in the general population, but data in patients with hematologic malignancies are contradictory. We identified independent prognostic factors for COVID-19 severity and survival in unvaccinated patients with hematologic malignancies, compared mortality rates over time and versus non-cancer inpatients, and investigated post COVID-19 condition. Data were analyzed from 1166 consecutive, eligible patients with hematologic malignancies from the population-based HEMATO-MADRID registry, Spain, with COVID-19 prior to vaccination roll-out, stratified into early (February–June 2020; n = 769 (66%)) and later (July 2020–February 2021; n = 397 (34%)) cohorts. Propensity-score matched non-cancer patients were identified from the SEMI-COVID registry. A lower proportion of patients were hospitalized in the later waves (54.2%) compared to the earlier (88.6%), OR 0.15, 95%CI 0.11–0.20. The proportion of hospitalized patients admitted to the ICU was higher in the later cohort (103/215, 47.9%) compared with the early cohort (170/681, 25.0%, 2.77; 2.01–3.82). The reduced 30-day mortality between early and later cohorts of non-cancer inpatients (29.6% vs. 12.6%, OR 0.34; 0.22–0.53) was not paralleled in inpatients with hematologic malignancies (32.3% vs. 34.8%, OR 1.12; 0.81–1.5). Among evaluable patients, 27.3% had post COVID-19 condition. These findings will help inform evidence-based preventive and therapeutic strategies for patients with hematologic malignancies and COVID-19 diagnosis.Depto. de MedicinaFac. de MedicinaTRUEFundación Madrileña de Hematología y HemoterapiaFundación Leucemia y LinfomaAsociación Madrileña de Hematología y Hemoterapiapu

Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks : The GR@ACE project

Introduction: Large variability among Alzheimer's disease (AD) cases might impact genetic discoveries and complicate dissection of underlying biological pathways. Methods: Genome Research at Fundacio ACE (GR@ACE) is a genome-wide study of dementia and its clinical endophenotypes, defined based on AD's clinical certainty and vascular burden. We assessed the impact of known AD loci across endophenotypes to generate loci categories. We incorporated gene coexpression data and conducted pathway analysis per category. Finally, to evaluate the effect of heterogeneity in genetic studies, GR@ACE series were meta-analyzed with additional genome-wide association study data sets. Results: We classified known AD loci into three categories, which might reflect the disease clinical heterogeneity. Vascular processes were only detected as a causal mechanism in probable AD. The meta-analysis strategy revealed the ANKRD31-rs4704171 and NDUFAF6-rs10098778 and confirmed SCIMP-rs7225151 and CD33-rs3865444. Discussion: The regulation of vasculature is a prominent causal component of probable AD. GR@ACE meta-analysis revealed novel AD genetic signals, strongly driven by the presence of clinical heterogeneity in the AD series