Private transform subestation of 15 MVA project

[ES] Características y cálculos de una subestación transformadora privada que suministrará tres posiciones de salida de línea subterránea de 6kV. Concreta elementos básicos requeridos, ubicación concreta, costes. Incluye planos y tablas

Estudio de motilidad ocular, agudeza visual, visión binocular y calidad de vida en pacientes con glaucoma congénito

El glaucoma congénito primario (GCP) es una patología poco frecuente. Este tipo de glaucoma se caracteriza por la corta edad al diagnóstico, la mala respuesta al tratamiento médico y el alto requerimiento de cirugías antiglaucomatosas. Una vez alcanzado el control de la presión intraocular, un factor importante que influye en el pronóstico visual final es la aparición de la ambliopía. Es fundamental la evaluación de la agudeza visual, de la refracción y de las posibles causas de ambliopía, como la anisometropía y el estrabismo, puesto que permite completar el tratamiento integral de estos pacientes, crítico en la edad en que se ve afectado su desarrollo por la enfermedad, incrementando su pronóstico visual a largo plazo.

Influence of Body Composition on Arterial Stiffness in Middle-Aged Adults: Healthy UAL Cross-Sectional Study

Background and objectives: Several anthropometric and body composition parameters have been linked to arterial stiffness (AS) as a biomarker of cardiovascular disease. However, little is known about which of these closely related factors is more strongly associated with AS. The aim of the present study was to analyze the relationship of different anthropometric and body composition parameters with AS in middle-aged adults. Materials and Methods: This cross-sectional study included 186 middle-aged participants (85 women, 101 men; age = 42.8 ± 12.6 years) evaluated as part of the Healthy UAL study, a population study conducted at the University of Almería with the main purpose of analyzing the etiology and risk factors associated with cardio-metabolic diseases. Anthropometric measures included neck, waist, and hip circumferences, as well as the waist-to-height ratio (WHtr). Bioimpedance-derived parameters included fat-free mass index (FFMI), fat mass index (FMI), and percent of body fat (%BF). AS was measured by pulse wave velocity (PWV). The relationships of interest were examined through stepwise regression analyses in which age and sex were also introduced as potential confounders. Results: Neck circumference (in the anthropometric model; R2: 0.889; β: age = 0.855, neck = 0.204) and FFMI (in the bio-impedance model; R2: 0.891; β: age = 0.906, FFMI = 0.199) emerged as significant cross-sectional predictors of AS. When all parameters were included together (both anthropometry and bio-impedance), both neck circumference and FFMI appeared again as being significantly associated with AS (R2: 0.894; β: age = 0.882, FFMI = 0.126, neck = 0.093). Conclusion: It was concluded that FFMI and neck circumference are correlated with AS regardless of potential confounders and other anthropometric and bioimpedance-derived parameters in middle-aged adults

Evolución trófica del Lago Cocibolca

Se realizaron análisis de datos fisicoquímicos y biológicos del fitoplancton de muestreos realizados en 1994, 1997, 2002 y 2003 por investigadores del CIRA-UNAN en diferentes puntos del Lago Cocibolca. Los resultados revelan un incremento en los niveles de nutrientes, especialmente fósforo y nitrógeno a partir de 1994 y hasta el 2003. El progresivo enriquecimiento orgánico del Lago Cocibolca está produciendo cambios cuantificables en su condición trófica expresada en un aumento de la biomasa algal (Clorofila-a), una disminución en el número de taxa y una evidente dominancia de especies fitoplanctónicas tolerantes a los cambios tróficos. Una conclusión importante de este análisis es que, de acuerdo a la aplicación del Índice de Estado Trófico de Carlson, el lago Cocibolca se cataloga, actualmente, como un lago eutrófico. Esta condición podría llevar a este importante cuerpo de agua a un deterioro de la calidad de sus agua

Modelos atencionales y educación

El desarrollo de la atención es esencial para el de otros procesos cognitivos, asimismo es un indicador para predecir el nivel cognitivo en la niñez. En especial se ha comprobado tanto en niños como en adultos, que a mayor capacidad de atención mejor ejecución en las tareas cognitivas. Debido a la importancia que la atención tiene en la adquisición de aprendizajes, el objetivo de este trabajo es el de revisar aquellos modelos atencionales más representativos y realizar un análisis sobre la importancia que la atención tiene en el proceso de aprendizajeDevelopment of attention is essential for the development of other cognitive processes. In addition, it is a predictor of cognitive development during childhood. In particular, it has been found in both children and adults that the higher the attentional ability, the better the performance in cognitive tasks. This paper provides an overview of the most representative attentional models. The importance of attention in the process of learning it is also analyse

Role of 5 α -dihydrotestosterone in testicular development of gilthead seabream following finasteride administration

In teleosts, spermatogenesis is regulated by pituitary gonadotropins and sex steroids. 5α-dihydrotestosterone (DHT), derived from testosterone (T) through the action of 5α-reductase, has recently been suggested to play a physiologically important role in some fish species. In this study, gilthead seabream, Sparus aurata L., males received an implant of 1μg T/g body mass (bm) or vehicle alone and, 7 days later, 1 mg finasteride (FIN, an inhibitor of 5α-reductase)/kg bm or vehicle. Serum levels of T, 11-ketotestosterone (11KT), DHT and 17β-estradiol (E2), and the mRNA levels of the main enzymes involved in their synthesis, were analysed. T promoted a transient increase in the serum levels of T, 11KT and E2 but a decrease in those of DHT at day 15 following T injection, in accordance with the up-regulation of mRNA levels of the enzymes involved in T transformation to 11KT (coding genes: cyp11b1 and hsd11b) and the down-regulation of mRNA levels of the enzyme responsible for T transformation to DHT (coding gene:srd5a). Interestingly, a similar effect was observed when FIN was in- jected. However, when fish were injected with T and FIN successively (T + FIN), control levels were not re-covered at the end of the experimental period (28 days). DHT seems to regulate E2 serum levels via the down-regulation of mRNA levels of aromatase (coding gene:cyp19a1a), which is needed for the transformation of T into E2. The testis histology, together with the proliferative rates recorded upon T, FIN or T + FIN treatment, suggests that DHT is involved in the onset of the meiotic phase of spermatogenesis.Versión del edito

Antitumoral effect of Ocoxin on acute myeloid leukemia

This is an open-access article distributed under the terms of the Creative Commons Attribution License.Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy whose incidence is growing in developed countries. In the relapse setting, very limited therapeutic options are available and in most cases only palliative care can be offered to patients. The effect of a composite formulation that contains several antioxidants, Ocoxin Oral solution (OOS), was tested in this condition. When analyzed in vitro, OOS exhibited anti-AML action that was both time and dose dependent. In vivo OOS induced a ralentization of tumor growth that was due to a decrease in cell proliferation. Such effect could, at least partially, be due to an increase in the cell cycle inhibitor p27, although other cell cycle proteins seemed to be altered. Besides, OOS induced an immunomodulatory effect through the induction of IL6. When tested in combination with other therapeutic agents normally used in the treatment of AML patients, OOS demonstrated a higher antiproliferative action, suggesting that it may be used in combination with those standard of care treatments to potentiate their antiproliferative action in the AML clinic.This work was partially supported by Catalysis S.L. as well as the Ministry of Economy and Competitiveness of Spain (BFU2012-39151). E.D.-R was supported by the Spanish Association for Cancer Research (AECC). Our cancer Research Institute and the work carried out at our laboratory receive support from the European Community through the regional development funding program (FEDER) and from the Fundación Ramón Areces.Peer Reviewe

Financial Literacy and Financial Fragility in Mexico

Alfabetización Financiera y Fragilidad Financiera en MéxicoEl objetivo de esta investigación es analizar la relación entre la fragilidad financiera de los mexicanos y las siguientes variables: alfabetización financiera, ahorro, tenencia de activos, shocks financieros, educación financiera e inclusión financiera. También se identifican las características socioeconómicas y demográficas asociadas a la fragilidad financiera. Se utiliza un modelo Probit dicotómico estimado con datos de la Encuesta Nacional de Inclusión Financiera, 2021. Los resultados muestran que la alfabetización financiera, el ahorro (formal e informal), la educación financiera y la tenencia de activos se relacionan negativamente con la probabilidad de ser financieramente frágil. Los altos ingresos y la tenencia de ahorros formales e informales son los predictores más robustos de fragilidad financiera, con un efecto marginal de -9.40%, -5.34% y -5.27%, respectivamente. La probabilidad de ser financieramente frágil está relacionada con bajos ingresos y bajo nivel educativo, así como haber experimentado sobreendeudamiento en el último año. Los hallazgos pueden ser de utilidad para el diseño de estrategias de educación financiera que brinden a la población capacitación y de esta forma protección contra la disminución de ingresos.The objective of this research is to analyze the relationship between Mexicans’ financial fragility and the following variables: financial literacy, savings, assets owning, financial shocks, financial education, and financial inclusion. Likewise, socioeconomic and demographic characteristics associated with financial fragility are identified. The dichotomous Probit model is used for the analysis, estimated with data from the 2021 National Survey of Financial Inclusion. The results show that financial literacy, savings (formal and informal), financial education and possession of assets are negatively related to the probability of being financially fragile. High income and holding formal and informal savings are the most robust predictors of financial fragility, with a marginal effect of -9.40%, -5.34% and -5.27%, respectively. The probability of being considered financially fragile is related to low income and a low educational level, plus having overspent in the last year. The findings can be useful for financial education strategies design, to provide the population financial training in resources administration and protection against income decrease

Integral field spectroscopy of HII regions in M33

Integral field spectroscopy (IFS) is presented for star forming regions in M33. A central area of 300 x 500 pc^2 and the external HII region IC 132, at a galactocentric distance {\sim} 19arcmin (4.69 kpc) were observed with the Potsdam Multi Aperture Spectrophotometer (PMAS) instrument at the 3.5 m telescope of the Calar Alto Hispano- Alem\'an observatory (CAHA). The spectral coverage goes from 3600 A to 1{\mu}m to include from [OII]{\lambda}3727 A to the near infrared lines required for deriving sulphur electron temperature and abundance diagnostics. Local conditions within individual HII regions are presented in the form of emission line fluxes and physical conditions for each spatial resolution element (spaxel) and for segments with similar H{\alpha} surface brightness. A clear dichotomy is observed when comparing the central to outer disc HII regions. While the external HII region has higher electron temperature plus larger H{\beta} equivalent width, size and excitation, the central region has higher extinction and metal content. The dichotomy extends to the BPT diagnostic diagrams that show two orthogonal broad distributions of points. By comparing with pseudo-3D photoionization models we conclude that the bulk observed differences are probably related to a different ionization parameter and metallicity. Wolf-Rayet features are detected in IC 132, and resolved into two concentrations whose integrated spectra were used to estimate the characteristic number of WR stars. No WR features were detected in the central HII regions despite their higher metallicity.Comment: 72 pages, 37 figure

Characterization of the cyanobacterium Oscillatoria sp. isolated from extreme sulphureous water from Los Baños de la Hedionda (S Spain)

Los Baños de la Hedionda (Málaga, S Spain) is a natural sulphureous spa (150-200 µM sulphide). Although this high sulphide levels can affect the photosynthetic process, there are numerous photosynthetic microorganisms inhabiting the spa. Among them, we isolated a strain of the cyanobacterium Oscillatoria sp., a genus well known by its tolerance to sulphide. Objectives Firstly, to analyze the photosynthetic characteristics and growth rate of the isolated strain, as well as the effect of the presence of sulphide in both processes. Secondly, to determine the limit of genetic adaptation of this strain to sulphide. Methods The resistance of the isolated strain to sulphide was studied by analyzing the effect of increasing sulphide levels (up to 1600 µM) on photosynthetic performance and growth. The limit of genetic adaptation was explored using an evolutionary experimental design named as ratchet protocol. This design allows discerning the maximum capacity of genetic adaptation of Oscillatoria sp. to the exposure of increasing doses of sulphide Conclusions The strain showed maximum growth rates at 200 µM sulphide although reduced rates can be found up to 800 µM sulphide. A significant increase in resistance was achieved in all derived populations during the ratchet experiment (surviving at sulphide concentrations higher than 2 mM). Moreover, they showed different evolutionary potential to adapt to sulphide, depending on historical contingency.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.Spanish Ministry of Science and Innovation through CGL2014-53682-P project. Predoctoral State Grant from Scientific and Technical Research and Innovation Plan, Spanish Ministry of Economy, Industry and Competitiveness I+D+i ECC/1402/2013, 201