Invasion of two widely separated areas of Mexico by Forficula auricularia (Dermaptera: Forficulidae)

Peer reviewe

Papel de la eminencia talámica, el sistema olfativo principal y el sistema olfativo accesorio en la maduración sexual del encéfalo y las manifestaciones clínico-morfológicas del síndrome de Kallmann

El desarrollo de sistema olfativo y la diferenciación sexual del encéfalo, tanto en el hombre como en los animales, están estrechamente relacionados. Actualmente, se describe la imbricación entre la formación del sistema olfativo principal y la migración de las neuronas que sintetizan la hormona liberadora de gonadotrofinas (GnRF). Estas neuronas GnRF se desplazan por los nervios olfatorios, desde la parte medial del epitelio nasal al bulbo olfatorio, continúan por el encéfalo rostral hasta alcanzar el hipotálamo anterior. Por otro lado, el síndrome de Kallmann es un trastorno genético en el cual se combina el hipogonadismo hipogonadotrópico y la anosmia. El hipogonadismo se caracteriza por la ausencia o reducción de los niveles de hormona liberadora de gonadotrofinas y la anosmia la aplasia del bulbo olfatorio. En esta revisión se analizan las estructuras responsables de la maduración del sistema olfativo principal y accesorio, la diferenciación sexual del encéfalo y su relación con todas las manifestaciones clínicas y morfológicas del síndrome Kallmann. The olfactory system development and brain sexual maturation, in man and animals, are closely related. Currently the overlap between the formation of the olfactory system and the migration of neurons that synthesize gonadotropin-releasing hormone (GnRF) are described. The GnRF neurons migrate from the medial portion of the nasal epithelium through the olfactory nerves and the main olfactory bulb to the anterior hypothalamus. Furthermore, Kallmann syndrome (KS) is a genetic disorder in which combines hypogonadotropic hypogonadism and anosmia. Hypogonadism is characterized by the absence or reduced levels of gonadotropin-releasing hormone and anosmia is due to aplasia of the olfactory bulb. The basic clinical manifestations of KS are: anosmia and the absence of puberty. The structures responsible for the maturation of the main and accessory olfactory systems, the sexual differentiation of the brain and its relationship with all the clinical manifestations of Kallmann syndrome are analyzed in this revie

Myeloid-Derived Suppressor Cells Show Different Frequencies in Diabetics and Subjects with Arterial Hypertension

Type 2 diabetes mellitus (DM2) is strongly associated with other comorbidities such as obesity, atherosclerosis, and hypertension. Obesity is associated with sustained low-grade inflammatory response due to the production of proinflammatory cytokines. This inflammatory process promotes the differentiation of some myeloid cells, including myeloid-derived suppressor cells (MDSCs). In this study, two groups of individuals were included: DM2 patients and non-DM2 individuals with similar characteristics. Immunolabeling of CD15+ CD14- and CD33+ HLA-DR-/low was performed from whole peripheral blood, and samples were analyzed by flow cytometry, and frequencies of MDSCs and the relationship of these with clinical variables, cytokine profile (measured by cytometric bead array), and anthropometric variables were analyzed. The frequency of CD33+ HLA-DR-/low MDSCs (that produce IL-10 and TGF-β, according to an intracellular detection) is higher in patients with DM2 (P < 0:05), and there is a positive correlation between the frequency of CD15+ CD14- and CD33+ HLA-DR-/low MDSC phenotypes. DM2 patients have an increased concentration of serum IL-5 (P < 0:05). Also, a negative correlation between the frequency of CD15+CD14- MDSCs and LDL cholesterol was found. Our group of DM2 patients have an increased frequency of mononuclear MDSC CD33+ HLA-DR-/low that produce TGF-β and IL-10. These cytokines have been associated with immune modulation and reduced T cell responses. DM2 and non-DM2 subjects show a similar cytokine profile, but the DM2 patients have anincreased concentration of IL-5

Sobre la importancia de la certificación internacional para los anilladores de aves en Perú

Certification as bird bander implies to validate the level of knowledge and experience of people with regard to a consolidated standard of work in the exercise of capture, banding, handling, and release of birds, in order to promote the safety of the bird, the security of the bander and the quality of the data collected. The North American Banding Council (NABC) is a non-profit organization that includes diverse organizations of research, conservation and management of North American avifauna. Continuing with its mission to promote responsible bird-banding practices under standardized and ethical criteria, in a joint effort with the Centro de Ornitologia y Biodiversidad (CORBIDI) and other related institutions, the first three NABC certification sessions were recently held in Peru. This work tries to answer some of the most frequent questions related to these certification events and the bird banding efforts promoted by the Programa de Anillamiento CORBIDI (PAC).La certificación como anillador de aves consiste en validar el nivel de conocimiento y experiencia de personas frente a un estándar consolidado de trabajo en el ejercicio de la captura, anillado, manejo, y liberación de aves, con el fin de promover la seguridad del ave, la seguridad del anillador y la calidad de los datos colectados. El Consejo Norteamericano de Anillado (NABC) es una organización sin fines de lucro, engloba a diversas organizaciones de investigación, conservación y gestión de la avifauna en Norteamérica. Continuando con su principal misión de promover prácticas responsables de la técnica del anillado de aves bajo criterios estandarizados y éticos, en un trabajo conjunto con el Centro de Ornitología y Biodiversidad (CORBIDI) y otras instituciones afines, entre el 2017 y el 2018 se han desarrollado las tres primeras sesiones de certificación NABC en el Perú. El presente trabajo intenta responder algunas de las preguntas más frecuentes relacionados con estas sesiones de certificación, así como los esfuerzos del anillado de aves promovidos por el Programa de Anillamiento CORBIDI (PAC)

Perfil microbiológico y sensibilidad a antibióticos de microorganismos aislados de infecciones conjuntivales en el Instituto de Oftalmología Fundación Conde de Valenciana. Reporte del año 2012

ResumenIntroducciónLa conjuntiva es el tejido ocular que se infecta con mayor frecuencia. Los agentes patógenos más frecuentes de la conjuntivitis suelen ser los virus y las bacterias. El uso indiscriminado de antibióticos de amplio espectro para tratar la conjuntivitis ha generado microorganismos resistentes.ObjetivoIdentificar los microorganismos más frecuentes aislados de muestras de origen conjuntival y conocer su susceptibilidad antibiótica.Material y métodosRevisión retrospectiva de cultivos provenientes de raspados conjuntivales obtenidos durante el 2012.ResultadosSe obtuvieron 44 muestras de origen conjuntival. Estas provinieron de 21 varones y 23 mujeres. La mediana (25%, 75%) de la edad fue 62 años (39-68). El cultivo fue positivo en 13 de las muestras obtenidas, identificándose 5 microorganismos diferentes. Staphylococcus epidermidis fue el microorganismo aislado con mayor frecuencia (9 cepas). Todas las cepas de S. epidermidis fueron sensibles a vancomicina, gentamicina, cefotaxima, moxifloxacino y ofloxacino. La mayoría de las cepas de S. epidermidis (6/9) mostraron resistencia a múltiples antibióticos.ConclusionesStaphylococcus epidermidis fue el microorganismo aislado con mayor frecuencia en muestras provenientes de infecciones conjuntivales. Todas las cepas de S. epidermidis fueron sensibles a vancomicina, gentamicina y moxifloxacino y la mayoría de ellas fueron multirresistentes a los antibióticos en evaluación.AbstractIntroductionThe conjunctiva is the tissue of the eye that gets infected with more frequency. The most common pathogens of conjunctivitis are viruses and bacteria. The indiscriminate use of broad-spectrum antibiotics to treat conjunctivitis generated resistant microorganisms.ObjectiveIdentify the most common microorganisms isolated from samples of conjunctival origin and know their antibiotic susceptibility.Material and methodsRetrospective review of culture from conjunctival swabs obtained during 2012.ResultsWe collected 44 samples of conjunctival origin. They came from 21 males and 23 women. The median (25%, 75%) of age was 62 years (39-68). The culture was positive in 13 samples, identifying five different microorganisms. Staphylococcus epidermidis was the most common isolated microorganism (9 strains). All strains of S. epidermidis were sensitive to vancomycin, gentamicin, cefotaxime, ofloxacin and moxifloxacin. The multiple antibiotic resistance was identified in the majority of strains of S. epidermidis (6/9).ConclusionsStaphylococcus epidermidis was the most common isolated microorganism from samples of conjuntival infections. All strains of S. epidermidis were sensitive to vancomycin and moxifloxacin and most of them showed multidrug resistance to antibiotics

RB mutation and RAS overexpression induce resistance to NK cell-mediated cytotoxicity in glioma cells

Several theories aim to explain the malignant transformation of cells, including the mutation of tumor suppressors and proto-oncogenes. Deletion of Rb (a tumor suppressor), overexpression of mutated Ras (a proto-oncogene), or both, are sufficient for in vitro gliomagenesis, and these genetic traits are associated with their proliferative capacity. An emerging hallmark of cancer is the ability of tumor cells to evade the immune system. Whether specific mutations are related with this, remains to be analyzed. To address this issue, three transformed glioma cell lines were obtained (Rb(-/-), Ras(V12), and Rb(-/-)/Ras(V12)) by in vitro retroviral transformation of astrocytes, as previously reported. In addition, Ras(V12) and Rb(-/-)/Ras(V12) transformed cells were injected into SCID mice and after tumor growth two stable glioma cell lines were derived. All these cells were characterized in terms of Rb and Ras gene expression, morphology, proliferative capacity, expression of MHC I, Rae1delta, and Rae1alphabetagammadeltaepsilon, mult1, H60a, H60b, H60c, as ligands for NK cell receptors, and their susceptibility to NK cell-mediated cytotoxicity. Our results show that transformation of astrocytes (Rb loss, Ras overexpression, or both) induced phenotypical and functional changes associated with resistance to NK cell-mediated cytotoxicity. Moreover, the transfer of cell lines of transformed astrocytes into SCID mice increased resistance to NK cell-mediated cytotoxicity, thus suggesting that specific changes in a tumor suppressor (Rb) and a proto-oncogene (Ras) are enough to confer resistance to NK cell-mediated cytotoxicity in glioma cells and therefore provide some insight into the ability of tumor cells to evade immune responses.Xunta de GaliciaComisión EuropeaInstituto de Salud Carlos IIIConsejo Nacional de Ciencia y Tecnologia (CONACyT)Consejo Nacional de Ciencia y Tecnologia (CONACyT)FOSSISXunta de Galicia/PXIB208091PRISCIII/CB158340ISCIII/CB180851FOSSIS/18236

Microvascular cutaneous coverage in wounds that expose the Achilles tendon: case report

Achilles tendon rupture, being one of the main tendon ruptures present, surgery being the most favourable option even taking into account complications such as infections and skin necrosis, it is necessary to develop techniques which help to reduce complications and increase benefits. The methods follow-up of 2 cases of patients with skin defects in the region of the Achilles tendon in patients who were treated at the "Luis Guillermo lbarra lbarra" national rehabilitation institute during the period 2020-2021 in the Traumatology service, treated with radial free flap forearm, using the description of the most used flaps in the literature. Results in both cases integrity of the free radial forearm flap in its entirety, functional recovery for walking, ability to put shoes back on, and without the need for reoperation, as well as a high level of satisfaction by patients. Conclusions if we are talking about an Achilles tendon rupture with a significant skin defect, the free radial forearm flap is an adequate option, if we are talking about a complete defect, the composite flap is the best option, remember that the decision on what type of flap will be used will depend on of the size of the lesion

Controlling the polarization and vortex charge of attosecond high-harmonic beams via simultaneous spin–orbit momentum conservation

[EN]Optical interactions are governed by both spin and angular momentum conservation laws, which serve as a tool for controlling light–matter interactions or elucidating electron dynamics and structure of complex systems. Here, we uncover a form of simultaneous spin and orbital angular momentum conservation and show, theoretically and experimentally, that this phenomenon allows for unprecedented control over the divergence and polarization of extreme-ultraviolet vortex beams. High harmonics with spin and orbital angular momenta are produced, opening a novel regime of angular momentum conservation that allows for manipulation of the polarization of attosecond pulses—from linear to circular—and for the generation of circularly polarized vortices with tailored orbital angular momentum, including harmonic vortices with the same topological charge as the driving laser beam. Our work paves the way to ultrafast studies of chiral systems using high-harmonic beams with designer spin and orbital angular momentum.The authors are thankful for useful and productive conversations with E. Pisanty, C. Durfee, D. Hickstein, S. Alperin and M. Siemens. H.C.K. and M.M.M. graciously acknowledge support from the Department of Energy BES Award No. DE-FG02–99ER14982 for the experimental implementation, as well as a MURI grant from the Air Force Office of Scientific Research under Award No. FA9550–16–1–0121 for the theory. J.L.E., N.J.B. and Q.L.N. acknowledge support from National Science Foundation Graduate Research Fellowships (Grant No. DGE-1144083). C.H.-G., J.S.R. and L.P. acknowledge support from Junta de Castilla y León (SA046U16) and Ministerio de Economía y Competitividad (FIS2013–44174-P, FIS2016–75652-P). C.H.-G. acknowledges support from a 2017 Leonardo Grant for Researchers and Cultural Creators, BBVA Foundation. L.R. acknowledges support from Ministerio de Educación, Cultura y Deporte (FPU16/02591). A.P. acknowledges support from the Marie Sklodowska-Curie Grant, Agreement No. 702565. We thankfully acknowledge the computer resources at MareNostrum and the technical support provided by Barcelona Supercomputing Center (RES-AECT-2014–2–0085). This research made use of the high-performance computingresources of the Castilla y León Supercomputing Center (SCAYLE, www.scayle.es),financed by the European Regional Development Fund (ERDF). Certain commercial instruments are identified to specify the experimental study adequately. This does not imply endorsement by the National Institute of Standards and Technology (NIST) or that the instruments are the best available for the purpose

Functional traits determine plant co-occurrence more than environment or evolutionary relatedness in global drylands

Plant–plant interactions are driven by environmental conditions, evolutionary relationships (ER) and the functional traits of the plants involved. However, studies addressing the relative importance of these drivers are rare, but crucial to improve our predictions of the effects of plant–plant interactions on plant communities and of how they respond to differing environmental conditions. To analyze the relative importance of – and interrelationships among – these factors as drivers of plant–plant interactions, we analyzed perennial plant co-occurrence at 106 dryland plant communities established across rainfall gradients in nine countries. We used structural equation modelling to disentangle the relationships between environmental conditions (aridity and soil fertility), functional traits extracted from the literature, and ER, and to assess their relative importance as drivers of the 929 pairwise plant–plant co-occurrence levels measured. Functional traits, specifically facilitated plants’ height and nurse growth form, were of primary importance, and modulated the effect of the environment and ER on plant–plant interactions. Environmental conditions and ER were important mainly for those interactions involving woody and graminoid nurses, respectively. The relative importance of different plant–plant interaction drivers (ER, functional traits, and the environment) varied depending on the region considered, illustrating the difficulty of predicting the outcome of plant–plant interactions at broader spatial scales. In our global-scale study on drylands, plant–plant interactions were more strongly related to functional traits of the species involved than to the environmental variables considered. Thus, moving to a trait-based facilitation/competition approach help to predict that: (1) positive plant–plant interactions are more likely to occur for taller facilitated species in drylands, and (2) plant–plant interactions within woody-dominated ecosystems might be more sensitive to changing environmental conditions than those within grasslands. By providing insights on which species are likely to better perform beneath a given neighbour, our results will also help to succeed in restoration practices involving the use of nurse plants

A Measurement of B Meson Production and Lifetime Using D`− Events in Z0 Decays

A study of B meson decays into D l- X final states is presented. In these events, neutral and charged D mesons originate predominantly from B+ and B0 decays, respectively. The dilution of this correlation due to D** production has been taken into account. From 263700 hadronic Z0 decays collected in 1991 with the DELPHI detector at the LEP collider, 92 D0 --> K- pi+, 35 D+ --> K- pi+ pi+ and 61 D*+ --> D0 pi+ followed by D0 --> K- pi+ or D0 --> K- pi+ pi+ pi-, are found with an associated lepton of the same charge as the kaon. From the D0 l- and D*+ l-, the probability f(d) that a b quark hadronizes into a B- (or B0BAR),meson is found to be 0.44 +/-0.08 +/-0.09, corresponding to a total (B(s) + LAMBDA(b)) hadronization fraction of 0.12(-0.12)+0.24 .By reconstructing the energy of each B meson, the b quark fragmentation is directly measured for the first time. The mean value of the B meson energy fraction is: [X(E)(B)] = 0.695+/-0.015(stat.)+/-0.029(syst.) Reconstructing D-lepton vertices, the following B life-times are measured: tau(B) = 1.27(-0.18)+0.22(stat.)+/-0.15(syst.) ps, where bBAR --> D0 l- X, tau(B) = 1.18(-0.27)+0.39(stat.)+/-0.15(syst.) ps, where BBAR --> D+ l- X, T(B) = 1.19(-0.19)+0.25(stat.)+/-0.15(syst.) ps where BBAR --> D*+ l- X, and an average tau(B) = 1.23(-0.13)+0.14(stat.)+/-0.15(syst.) ps is found. Allowing for decays into D** l- vBAR, the B+ and B0 lifetimes are: tau(B+)= 1.30(0.29)+0.33(stat.)+/-0.15(syst. exp.) +/-0.05(syst. D**) ps, tau(B0)= 1.17(-0.23)+0.29(stat.)+/-0.15(syst. exp.) +/-0.05 (syst. D**) ps, tau(B+)/tau(B0) = 1.11(0.39)+0.51(stat.)+/-0.05(syst. exp.) +/-0.10(syst. D**) ps