Causality and statistics on the Groenewold-Moyal plane

Quantum theories constructed on the noncommutative spacetime called the Groenewold-Moyal plane exhibit many interesting properties such as Lorentz and CPT noninvariance, causality violation and twisted statistics. We show that such violations lead to many striking features that may be tested experimentally. These theories predict Pauli forbidden transitions due to twisted statistics, anisotropies in the cosmic microwave background radiation due to correlations of observables in spacelike regions and Lorentz and CPT violations in scattering amplitudes.Comment: 12 pages, 1 figure. Based on the talk given by APB at the Workshop "Theoretical and Experimental Aspects of the Spin Statisics Connection and Related Symmetries", Stazione Marittima Conference Center, Trieste, Italy from the 21st to the 25th of October 200

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Cytotoxicity and DNA damage in the neutrophils of patients with sickle cell anaemia treated with hydroxyurea

Hydroxyurea (HU) is the most important advance in the treatment of sickle cell anaemia (SCA) for preventing complications and improving quality of life for patients. However, some aspects of treatment with HU remain unclear, including their effect on and potential toxicity to other blood cells such as neutrophils. This study used the measurement of Lactate Dehydrogenase (LDH) and Methyl ThiazolTetrazolium (MTT) and the comet assay to investigate the cytotoxicity and damage index (DI) of the DNA in the neutrophils of patients with SCA using HU.In the LDH and MTT assays, a cytoprotective effect was observed in the group of patients treated, as well as an absence of toxicity. When compared to patients without the treatment, the SS group (n=20, 13 women and 07 men, aged 18-69 years), and the group of healthy individuals (AA) used as a control group (n=52, 28 women and 24 men, aged 19-60 years), The SSHU group (n=21, 11 women and 10 men, aged 19-63 years) showed a significant reduction (p20 months), demonstrating that despite the cytoprotective effects in terms of cell viability, the use of HU can induce DNA damage in neutrophils

Crustal architecture and geodynamics of North Queensland, Australia: insights from deep seismic reflection profiling

A deep crustal seismic reflection and magnetotelluric survey, conducted in 2007, established the architecture and geodynamic framework of north Queensland, Australia. Results based on the interpretation of the deep seismic data include the discovery of a major, west-dipping, Paleoproterozoic (or older) crustal boundary, considered to be an ancient suture zone, separating relatively nonreflective, thick crust of the Mount Isa Province from thinner, two layered crust to the east. Farther to the east, a second major crustal boundary also dips west or southwest, offsetting the Moho and extending below it, and is interpreted as a fossil subduction zone. Across the region, the lower crust is mostly highly reflective and is subdivided into three mappable seismic provinces, but they have not been tracked to the surface. In the east, the Greenvale and Charters Towers Provinces, part of the Thomson Orogen, have been mapped on the surface as two discrete provinces, but the seismic interpretation raises the possibility that these two provinces are continuous in the subsurface, and also extend northwards to beneath the Hodgkinson Province, originally forming part of an extensive Neoproterozoic– Cambrian passive margin. Continuation of the Thomson Orogen at depth beneath the Hodgkinson and Broken River Provinces suggests that these provinces (which formed in an oceanic environment, possibly as an accretionary wedge at a convergent margin) have been thrust westwards onto the older continental passive margin. The Tasman Line, originally defined to represent the eastern limit of Precambrian rocks in Australia, has a complicated geometry in three dimensions, which is related to regional deformational events during the Paleozoic. Overall, the seismic data show evidence for a continental margin with a long history (Paleoproterozoic to early Mesozoic) but showing only limited outward growth by crustal accretion, because of a repeated history of overthrust shortening during repeated phases of orogenesis