The Exceptionally Soft X-ray Spectrum of the Low-mass Starburst Galaxy NGC 1705

NGC 1705 is one of the optically brightest and best studied dwarf galaxies. It appears to be in the late stage of a major starburst and contains a young super star cluster. Type II supernovae are therefore likely to have been a major effect in the recent evolution of this galaxy and are likely to have produced a superbubble whose affects on the low-density ambient interstellar medium can be ideally studied. ROSAT PSPC observations of this galaxy reveal two striking blobs of X-ray emission embedded in \Ha loops which can be interpreted as both sides of the upper plumes of the same superbubble. These sources are a surprise. They are much softer than those observed from other starburst dwarf galaxies, and are so soft that they should have been blocked if the observed Galactic HI column density were uniformly distributed across NGC 1705 or if the sources were embedded in the HI disk of NGC 1705. In addition, the total X-ray luminosity in the ROSAT energy band of 1.2x10^{38} erg s^{-1} is low in comparison to similar objects. We discuss possible models for the two X-ray peaks in NGC 1705 and find that the sources most likely originate from relatively cool gas of one single superbubble in NGC 1705. The implications of the exceptional softness of these sources are addressed in terms of intrinsic properties of NGC 1705 and the nature of the foreground Galactic absorption.Comment: 7 pages, 2 ps-figures, LATEX-file; accepted for publication in ApJ.Letter

Selected Topics In Tort Law

This speaker series took place over several days during the Spring semester of 1990. The Special Problems of Causation in Toxic Tort Cases lecture given by Sheila L. Birnbaum, Partner in the New York City firm Skadden, Arps, Slate, Meagher, & Flom. (Tuesday, January 23, 1990) Damage Recovery in Toxic Tort Suits lecture given by Sheila L. Binbaum, Partner in the New York City firm Skadden, Arps, Slate, Meagher, & Flom. (Tuesday, January 30, 1990) Methods and Roles in Tort Lawmaking lecture given by The Honorable Robert Keeton, Langdell Professor Emeritus at Harvard Law School, U.S. District Court Judge for D. Mass. (Tuesday, February 13 and February 20, 1990) Procedural Innovations in and outside of the Courts and the Special Problems of Dignitary Torts lecture given by Richard Delgado, Professor of Law at the University of Wisconsin. (Date unknown) The Future of Tort Law lecture given by Deborah R. Hensler, Research Director of the Institute for Civil Justice at the RAND Corporation. (Date unknown

Carbohydrate Catabolism in Phaeobacter inhibens DSM 17395, a Member of the Marine Roseobacter Clade

Since genome analysis did not allow unambiguous reconstruction of transport, catabolism, and substrate-specific regulation for several important carbohydrates in Phaeobacter inhibens DSM 17395, proteomic and metabolomic analyses of N-acetylglucosamine-, mannitol-, sucrose-, glucose-, and xylose-grown cells were carried out to close this knowledge gap. These carbohydrates can pass through the outer membrane via porins identified in the outer membrane fraction. For transport across the cytoplasmic membrane, carbohydrate-specific ABC transport systems were identified. Their coding genes mostly colocalize with the respective "catabolic" and "regulatory" genes. The degradation of N-acetylglucosamine proceeds via N-acetylglucosamine-6-phosphate and glucosamine-6-phosphate directly to fructose-6-phosphate; two of the three enzymes involved were newly predicted and identified. Mannitol is catabolized via fructose, sucrose via fructose and glucose, glucose via glucose-6-phosphate, and xylose via xylulose-5-phosphate. Of the 30 proteins predicted to be involved in uptake, regulation, and degradation, 28 were identified by proteomics and 19 were assigned to their respective functions for the first time. The peripheral degradation pathways feed into the Entner-Doudoroff (ED) pathway, which is connected to the lower branch of the Embden-Meyerhof-Parnas (EMP) pathway. The enzyme constituents of these pathways displayed higher abundances in P. inhibens DSM 17395 cells grown with any of the five carbohydrates tested than in succinate-grown cells. Conversely, gluconeogenesis is turned on during succinate utilization. While tricarboxylic acid (TCA) cycle proteins remained mainly unchanged, the abundance profiles of their metabolites reflected the differing growth rates achieved with the different substrates tested. Homologs of the 74 genes involved in the reconstructed catabolic pathways and central metabolism are present in various Roseobacter clade members

BCS pairing in a trapped dipolar Fermi gase

We present a detailed study of the BCS pairing transition in a trapped polarized dipolar Fermi gas. In the case of a shallow nearly spherical trap, we find the decrease of the transition temperature as a function of the trap aspect ratio and predict the existence of the optimal trap geometry. The latter corresponds to the highest critical temperature of the BCS transition for a given number of particles. We also derive the phase diagram for an ultracold trapped dipolar Fermi gases in the situation, where the trap frequencies can be of the order of the critical temperature of the BCS transition in the homogeneous case, and find the critical value of the dipole-dipole interaction energy, below which the BCS transition ceases to exist. The critical dipole strength is obtained as a function of the trap aspect ratio. Alternatively, for a given dipole strength there is a critical value of the trap anisotropy for the BCS state to appear. The order parameter calculated at criticality, exhibits nover non-monotonic behavior resulted from the combined effect of the confining potential and anisotropic character of the interparticle dipole-dipole interation.Comment: 14 pages, 3 figure

Anthracimycin activity against contemporary methicillin-resistant Staphylococcus aureus.

Anthracimycin is a recently discovered novel marine-derived compound with activity against Bacillus anthracis. We tested anthracimycin against an expanded panel of Staphylococcus aureus strains in vitro and in vivo. All strains of S. aureus tested, including methicillin-susceptible, methicillin-resistant (MRSA) and vancomycin-resistant strains of S. aureus, were susceptible to anthracimycin at MIC values of ⩽0.25 mg l(-1). Although its postantibiotic effects were minimal, anthracimycin exhibited potent and rapid bactericidal activity, with a >4-log kill of USA300 MRSA within 3 h at five times its MIC. At concentrations significantly below the MIC, anthracimycin slowed MRSA growth and potentiated the bactericidal activity of the human cathelicidin, LL-37. The bactericidal activity of anthracimycin was somewhat mitigated in the presence of 20% human serum, and the compound was minimally toxic to human cells, with an IC50 (inhibitory concentration 50)=70 mg l(-1) against human carcinoma cells. At concentrations near the MIC, anthracimycin inhibited S. aureus nucleic acid synthesis as determined by optimized macromolecular synthesis methodology, with inhibition of DNA and RNA synthesis occurring in the absence of DNA intercalation. Anthracimycin at a single dose of 1 or 10 mg kg(-1) was able to protect mice from MRSA-induced mortality in a murine peritonitis model of infection. Anthracimycin provides an interesting new scaffold for future development of a novel MRSA antibiotic

Production of a chromium Bose-Einstein condensate

The recent achievement of Bose-Einstein condensation of chromium atoms [1] has opened longed-for experimental access to a degenerate quantum gas with long-range and anisotropic interaction. Due to the large magnetic moment of chromium atoms of 6 {$\mu$}B, in contrast to other Bose- Einstein condensates (BECs), magnetic dipole-dipole interaction plays an important role in a chromium BEC. Many new physical properties of degenerate gases arising from these magnetic forces have been predicted in the past and can now be studied experimentally. Besides these phenomena, the large dipole moment leads to a breakdown of standard methods for the creation of a chromium BEC. Cooling and trapping methods had to be adapted to the special electronic structure of chromium to reach the regime of quantum degeneracy. Some of them apply generally to gases with large dipolar forces. We present here a detailed discussion of the experimental techniques which are used to create a chromium BEC and alow us to produce pure condensates with up to {$10^5$} atoms in an optical dipole trap. We also describe the methods used to determine the trapping parameters.Comment: 17 pages, 9 figure

The Sensitivity of Harassment to Orbit: Mass Loss from Early-Type Dwarfs in Galaxy Clusters

We conduct a comprehensive numerical study of the orbital dependence of harassment on early-type dwarfs consisting of 168 different orbits within a realistic, Virgo-like cluster, varying in eccentricity and pericentre distance. We find harassment is only effective at stripping stars or truncating their stellar disks for orbits that enter deep into the cluster core. Comparing to the orbital distribution in cosmological simulations, we find that the majority of the orbits (more than three quarters) result in no stellar mass loss. We also study the effects on the radial profiles of the globular cluster systems of early-type dwarfs. We find these are significantly altered only if harassment is very strong. This suggests that perhaps most early-type dwarfs in clusters such as Virgo have not suffered any tidal stripping of stars or globular clusters due to harassment, as these components are safely embedded deep within their dark matter halo. We demonstrate that this result is actually consistent with an earlier study of harassment of dwarf galaxies, despite the apparent contradiction. Those few dwarf models that do suffer stellar stripping are found out to the virial radius of the cluster at redshift=0, which mixes them in with less strongly harassed galaxies. However when placed on phase-space diagrams, strongly harassed galaxies are found offset to lower velocities compared to weakly harassed galaxies. This remains true in a cosmological simulation, even when halos have a wide range of masses and concentrations. Thus phase-space diagrams may be a useful tool for determining the relative likelihood that galaxies have been strongly or weakly harassed.Comment: 17 pages, 13 figures, Accepted to MNRAS 8th September 201

The sensitivity of harassment to orbit: Mass loss from early-type dwarfs in galaxy clusters

We conduct a comprehensive numerical study of the orbital dependence of harassment on early-type dwarfs consisting of 168 different orbits within a realistic, Virgo-like cluster, varying in eccentricity and pericentre distance. We find harassment is only effective at stripping stars or truncating their stellar discs for orbits that enter deep into the cluster core. Comparing to the orbital distribution in cosmological simulations, we find that the majority of the orbits (more than three quarters) result in no stellar mass loss. We also study the effects on the radial profiles of the globular cluster systems of early-type dwarfs. We find these are significantly altered only if harassment is very strong. This suggests that perhaps most early-type dwarfs in clusters such as Virgo have not suffered any tidal stripping of stars or globular clusters due to harassment, as these components are safely embedded deep within their dark matter halo. We demonstrate that this result is actually consistent with an earlier study of harassment of dwarf galaxies, despite the apparent contradiction. Those few dwarf models that do suffer stellar stripping are found out to the virial radius of the cluster at redshift = 0, which mixes them in with less strongly harassed galaxies. However when placed on phase-space diagrams, strongly harassed galaxies are found offset to lower velocities compared to weakly harassed galaxies. This remains true in a cosmological simulation, even when haloes have a wide range of masses and concentrations. Thus phase-space diagrams may be a useful tool for determining the relative likelihood that galaxies have been strongly or weakly harassed