Pinguicula rosmarieae Casper, Bussmann & T.Henning (Lentibulariaceae), a new butterwort from the Amotape-Huancabamba Zone (northern Peru)

The insectivorous genus Pinguicula occurs along the whole Andean mountain chain from Colombia-Venezuela in the north to Tierra del Fuego in the south with a short interruption in the Peruvian-Chilean desert range. This paper describes a new and striking species of Pinguicula that occurs in the south-eastern part of the Amotape-Huancabamba Zone in north Peru. It grows either as a lithophyte on moist rocks or as an epiphyte on Polylepis multijuga Pilg. in the wet highlands of the Cordillera Central. Pinguicula rosmarieae Casper, Bussmann & T.Henning, sp. nov. is clearly distinguished by a basal rosette of ovate-obovate leaves spread out flat on the ground and especially by a two-partite corolla with a straight uniform tube-spur complex, two features unknown from other Andean Pinguicula species. The morphological similarity to P. calyptrata Kunth is discussed and the habitat and distribution of P. rosmarieae are characterised

Complex floral behavior of an angiosperm family

Segundo-Ortin & Calvo provide a comprehensive overview of the many aspects of plant behavior examined to date. In our view, multiple lines of evidence make it difficult to deny plant sentience. We add further evidence to support the conclusion that plants are sentient organisms. As in animals, the behavior of plants can be seen and studied as an evolutionary trait, subject to and a consequence of increasing complexity in the interactions of plants with their environment. Our example is the evolution of floral behavior in Loasaceae, where complex patterns of stamen movement have co-evolved in interaction with specialized pollinators

A new striking and critically endangered species of Nasa (Loasaceae, Cornales) from North Peru

Nasa angeldiazioides sp. nov. is described and illustrated. The species is restricted to two forest remnants on the western slope of the northern Peruvian Andes (Dept. Lambayeque) where it is found in the undergrowth of primary forest. The new taxon shows a unique leaf morphology in the family Loasaceae. Molecular and morphological data show that the new species belongs to the Nasa triphylla group. Since the relic forests of the north-western Andes are increasingly threatened by the effects of climate change, i.e. droughts and wildfires, the new species already faces imminent extinction

Sample data processing in an additive and reproducible taxonomic workflow by using character data persistently linked to preserved individual specimens

We present the model and implementation of a workflow that blazes a trail in systematic biology for the re-usability of character data (data on any kind of characters of pheno- and genotypes of organisms) and their additivity from specimen to taxon level. We take into account that any taxon characterization is based on a limited set of sampled individuals and characters, and that consequently any new individual and any new character may affect the recognition of biological entities and/or the subsequent delimitation and characterization of a taxon. Taxon concepts thus frequently change during the knowledge generation process in systematic biology. Structured character data are therefore not only needed for the knowledge generation process but also for easily adapting characterizations of taxa. We aim to facilitate the construction and reproducibility of taxon characterizations from structured character data of changing sample sets by establishing a stable and unambiguous association between each sampled individual and the data processed from it. Our workflow implementation uses the European Distributed Institute of Taxonomy Platform, a comprehensive taxonomic data management and publication environment to: (i) establish a reproducible connection between sampled individuals and all samples derived from them; (ii) stably link sample-based character data with the metadata of the respective samples; (iii) record and store structured specimen-based character data in formats allowing data exchange; (iv) reversibly assign sample metadata and character datasets to taxa in an editable classification and display them and (v) organize data exchange via standard exchange formats and enable the link between the character datasets and samples in research collections, ensuring high visibility and instant re-usability of the data. The workflow implemented will contribute to organizing the interface between phylogenetic analysis and revisionary taxonomic or monographic work

The EDIT Platform for Cybertaxonomy - an integrated software environment for biodiversity research data management

The Platform for Cybertaxonomy [1], developed as part of the EU Network of Excellence EDIT (European Distributed Institute of Taxonomy), is an open-source software framework covering the full breadth of the taxonomic workflow, from fieldwork to publication [2]. It provides a number of tools for full, customized access to taxonomic data, editing and management, and collaborative team work. At the core of the platform is the Common Data Model [3], offering a comprehensive information model covering all relevant data domains: names and classifications, descriptive data (morphological and molecular), media, geographic information, literature, specimens, persons, and external resources [4]. The model adheres to community standards developed by the Biodiversity Information Standards organization TDWG [5]. Apart from its role as a software suite supporting the taxonomic workflow, the platform is a powerful information broker for a broad range of taxonomic data providing solid and open interfaces including a Java programmer’s library and a CDM Rest Service Layer. In the context of the DFG-funded "Additivity" project ("Achieving additivity of structured taxonomic character data by persistently linking them to preserved individual specimens", DFG project number 310530378), we are developing components for capturing and processing formal descriptions of specimens as well as algorithms for aggregating data from individual specimens in order to compute species-level descriptions [6]. Well-defined and agreed descriptive vocabularies referring to structures, characters and character states are instrumental in ensuring the consistency and comparability of measurements. This will be addressed with a new EDIT Platform module for specifying vocabularies based on existing ontologies for descriptive data. To ensure that these vocabularies can be re-used in different contexts, we are planning an interface to the Terminology Service developed by the German Federation for Biological Data (GFBio) [7]. The Terminology Service provides a semantic standards aware and harmonised access point for distributed or locally stored ontologies required for biodiversity research data management, archiving and publication processes [8]. The interface will work with a new OWL export function of the CDM library, which provides EDIT Platform vocabularies in a format that can be read by the import module of the Terminology Service. In addition, the EDIT Platform will be equipped with the ability to import semantic concepts from the Terminology Service using its API and keeping a persistent link to the original concept. With an active pipeline between the EDIT Platform and the GFBio Terminology Service, terminologies originating from the taxonomic research process can be re-used in different research contexts as well as for the semantic annotation and integration of existing research data processed by the GFBio archiving and data publication infrastructure. KEYWORDS: taxonomic computing, descriptive data, terminology, inference REFERENCES: 1. EDIT Platform for Cybertaxonomy. http://www.cybertaxonomy.org (accessed 17 May 2018). 2. Ciardelli, P., Kelbert, P., Kohlbecker, A., Hoffmann, N., Güntsch, A. & Berendsohn, W. G., 2009. The EDIT Platform for Cybertaxonomy and the Taxonomic Workflow: Selected Components, in: Fischer, S., Maehle, E., Reischuk, R. (Eds.): INFORMATIK 2009 – Im Focus das Leben. GI-Edition: Lecture Notes in Informatics (LNI) – Proceedings 154. Köllen Verlag, Bonn, pp. 28;625-638. 3. Müller, A., Berendsohn, W. G., Kohlbecker, A., Güntsch, A., Plitzner, P. & Luther, K., 2017. A Comprehensive and Standards-Aware Common Data Model (CDM) for Taxonomic Research. Proceedings of TDWG 1: e20367. https://doi.org/10.3897/tdwgproceedings.1.20367. 4. EDIT Common Data Model. https://dev.e-taxonomy.eu/redmine/projects/edit/wiki/CommonDataModel (accessed 17 May 2018). 5. Biodiversity Information Standards TDWG. http://www.tdwg.org/ (accessed 17 May 2018). 6. Henning T., Plitzner P., Güntsch A., Berendsohn W. G., Müller A. & Kilian N., 2018. Building compatible and dynamic character matrices – Current and future use of specimen-based character data. Bot. Lett. https://doi.org/10.1080/23818107.2018.1452791. 7. Diepenbroek, M., Glöckner, F., Grobe, P., Güntsch, A., Huber, R., König-Ries, B., Kostadinov, I., Nieschulze, J., Seeger, B.; Tolksdorf, R. & Triebel, D., 2014. Towards an Integrated Biodiversity and Ecological Research Data Management and Archiving Platform: The German Federation for the Curation of Biological Data (GFBio), in: Plödereder, E., Grunske, L., Schneider, E., Ull, D. (Eds.): Informatik 2014 – Big Data Komplexität meistern. GI-Edition: Lecture Notes in Informatics (LNI) – Proceedings 232. Köllen Verlag, Bonn, pp. 1711-1724. 8. Karam, N., Müller-Birn, C., Gleisberg, M., Fichtmüller, D., Tolksdorf, R., & Güntsch, A., 2016. A Terminology Service Supporting Semantic Annotation, Integration, Discovery and Analysis of Interdisciplinary Research Data. Datenbank-Spektrum, 16(3), 195–205. https://doi.org/10.1007/s13222-016-0231-8

3D-conformal-intensity modulated radiotherapy with compensators for head and neck cancer: clinical results of normal tissue sparing

BACKGROUND: To investigate the potential of parotic gland sparing of intensity modulated radiotherapy (3D-c-IMRT) performed with metallic compensators for head and neck cancer in a clinical series by analysis of dose distributions and clinical measures. MATERIALS AND METHODS: 39 patients with squamous cell cancer of the head and neck irradiated using 3D-c-IMRT were evaluable for dose distribution within PTVs and at one parotid gland and 38 patients for toxicity analysis. 10 patients were treated primarily, 29 postoperatively, 19 received concomittant cis-platin based chemotherapy, 20 3D-c-IMRT alone. Initially the dose distribution was calculated with Helax (® )and photon fluence was modulated using metallic compensators made of tin-granulate (n = 22). Later the dose distribution was calculated with KonRad (® )and fluence was modified by MCP 96 alloy compensators (n = 17). Gross tumor/tumor bed (PTV 1) was irradiated up to 60–70 Gy, [5 fractions/week, single fraction dose: 2.0–2.2 (simultaneously integrated boost)], adjuvantly irradiated bilateral cervical lymph nodes (PTV 2) with 48–54 Gy [single dose: 1.5–1.8]). Toxicity was scored according the RTOG scale and patient-reported xerostomia questionnaire (XQ). RESULTS: Mean of the median doses at the parotid glands to be spared was 25.9 (16.3–46.8) Gy, for tin graulate 26 Gy, for MCP alloy 24.2 Gy. Tin-granulate compensators resulted in a median parotid dose above 26 Gy in 10/22, MCP 96 alloy in 0/17 patients. Following acute toxicities were seen (°0–2/3): xerostomia: 87%/13%, dysphagia: 84%/16%, mucositis: 89%/11%, dermatitis: 100%/0%. No grade 4 reaction was encountered. During therapy the XQ forms showed °0–2/3): 88%/12%. 6 months postRT chronic xerostomia °0–2/3 was observed in 85%/15% of patients, none with °4 xerostomia. CONCLUSION: 3D-c-IMRT using metallic compensators along with inverse calculation algorithm achieves sufficient parotid gland sparing in virtually all advanced head and neck cancers. Since the concept of lower single (and total) doses in the adjuvantly treated volumes reduces acute morbidity 3D-c-IMRT nicely meets demands of concurrent chemotherapy protocols

Rotational IMRT techniques compared to fixed gantry IMRT and Tomotherapy: multi-institutional planning study for head-and-neck cases

<p>Abstract</p> <p>Background</p> <p>Recent developments enable to deliver rotational IMRT with standard C-arm gantry based linear accelerators. This upcoming treatment technique was benchmarked in a multi-center treatment planning study against static gantry IMRT and rotational IMRT based on a ring gantry for a complex parotid gland sparing head-and-neck technique.</p> <p>Methods</p> <p>Treatment plans were created for 10 patients with head-and-neck tumours (oropharynx, hypopharynx, larynx) using the following treatment planning systems (TPS) for rotational IMRT: Monaco (ELEKTA VMAT solution), Eclipse (Varian RapidArc solution) and HiArt for the helical tomotherapy (Tomotherapy). Planning of static gantry IMRT was performed with KonRad, Pinnacle and Panther DAO based on step&shoot IMRT delivery and Eclipse for sliding window IMRT. The prescribed doses for the high dose PTVs were 65.1Gy or 60.9Gy and for the low dose PTVs 55.8Gy or 52.5Gy dependend on resection status. Plan evaluation was based on target coverage, conformity and homogeneity, DVHs of OARs and the volume of normal tissue receiving more than 5Gy (V_5Gy). Additionally, the cumulative monitor units (MUs) and treatment times of the different technologies were compared. All evaluation parameters were averaged over all 10 patients for each technique and planning modality.</p> <p>Results</p> <p>Depending on IMRT technique and TPS, the mean CI values of all patients ranged from 1.17 to 2.82; and mean HI values varied from 0.05 to 0.10. The mean values of the median doses of the spared parotid were 26.5Gy for RapidArc and 23Gy for VMAT, 14.1Gy for Tomo. For fixed gantry techniques 21Gy was achieved for step&shoot+KonRad, 17.0Gy for step&shoot+Panther DAO, 23.3Gy for step&shoot+Pinnacle and 18.6Gy for sliding window.</p> <p>V_5Gyvalues were lowest for the sliding window IMRT technique (3499 ccm) and largest for RapidArc (5480 ccm). The lowest mean MU value of 408 was achieved by Panther DAO, compared to 1140 for sliding window IMRT.</p> <p>Conclusions</p> <p>All IMRT delivery technologies with their associated TPS provide plans with satisfying target coverage while at the same time respecting the defined OAR criteria. Sliding window IMRT, RapidArc and Tomo techniques resulted in better target dose homogeneity compared to VMAT and step&shoot IMRT. Rotational IMRT based on C-arm linacs and Tomotherapy seem to be advantageous with respect to OAR sparing and treatment delivery efficiency, at the cost of higher dose delivered to normal tissues. The overall treatment plan quality using Tomo seems to be better than the other TPS technology combinations.</p

Genetic factors influencing a neurobiological substrate for psychiatric disorders

A retrospective meta-analysis of magnetic resonance imaging voxel-based morphometry studies proposed that reduced gray matter volumes in the dorsal anterior cingulate and the left and right anterior insular cortex-areas that constitute hub nodes of the salience network-represent a common substrate for major psychiatric disorders. Here, we investigated the hypothesis that the common substrate serves as an intermediate phenotype to detect genetic risk variants relevant for psychiatric disease. To this end, after a data reduction step, we conducted genome-wide association studies of a combined common substrate measure in four population-based cohorts (n = 2271), followed by meta-analysis and replication in a fifth cohort (n = 865). After correction for covariates, the heritability of the common substrate was estimated at 0.50 (standard error 0.18). The top single-nucleotide polymorphism (SNP) rs17076061 was associated with the common substrate at genome-wide significance and replicated, explaining 1.2% of the common substrate variance. This SNP mapped to a locus on chromosome 5q35.2 harboring genes involved in neuronal development and regeneration. In follow-up analyses, rs17076061 was not robustly associated with psychiatric disease, and no overlap was found between the broader genetic architecture of the common substrate and genetic risk for major depressive disorder, bipolar disorder, or schizophrenia. In conclusion, our study identified that common genetic variation indeed influences the common substrate, but that these variants do not directly translate to increased disease risk. Future studies should investigate gene-by-environment interactions and employ functional imaging to understand how salience network structure translates to psychiatric disorder risk