57 research outputs found
Decadal and multi-decadal variability of Labrador Sea Water in the north-western North Atlantic Ocean derived from tracer distributions: Heat budget, ventilation, and advection
Time series of profiles of potential temperature, salinity, dissolved oxygen, and planetary potential vorticity at intermediate depths in the Labrador Sea, the Irminger Sea, and the Iceland Basin have been constructed by combining the hydrographic sections crossing the sub-arctic gyre of the North Atlantic Ocean from the coast of Labrador to Europe, occupied nearly annually since 1990, and historic hydrographic data from the preceding years since 1950. The temperature data of the last 60 years mainly reflect a multi-decadal variability, with a characteristic time scale of about 50 years. With the use of a highly simplified heat budget model it was shown that this long-term temperature variability in the Labrador Sea mainly reflects the long-term variation of the net heat flux to the atmosphere. However, the analysis of the data on dissolved oxygen and planetary potential vorticity show that convective ventilation events, during which successive classes of Labrador Sea Water (LSW) are formed, occurring on decadal or shorter time scales. These convective ventilation events have performed the role of vertical mixing in the heat budget model, homogenising the properties of the intermediate layers (e.g. temperature) for significant periods of time. Both the long-term and the near-decadal temperature signals at a pressure of 1500 dbar are connected with successive deep LSW classes, emphasising the leading role of Labrador Sea convection in running the variability of the intermediate depth layers of the North Atlantic. These signals are advected to the neighbouring Irminger Sea and Iceland Basin. Advection time scales, estimated from the 60 year time series, are slightly shorter or of the same order as most earlier estimates, which were mainly based on the feature tracking of the spreading of the LSW(94) class formed in the period 1989-1994 in the Labrador Sea
Role of Macroscopic Particles in Deep-Sea Oxygen Consumption
Macroscopic particles (\u3e 500 ”g), including marine snow, large migrating zooplankton, and their fast-sinking fecal pellets, represent primary vehicles of organic carbon flux from the surface to the deep sea. In contrast, freely suspended microscopic particles such as bacteria and protists do not sink, and they contribute the largest portion of metabolism in the upper ocean. In bathy- and abyssopelagic layers of the ocean (2,000-6,000 m), however, microscopic particles may not dominate oxygen consumption. In a section across the tropical Atlantic, we show that macroscopic particle peaks occurred frequently in the deep sea, whereas microscopic particles were barely detectable. In 10 of 17 deep-sea profiles (\u3e 2,000 m depth), macroscopic particle abundances were more strongly cross-correlated with oxygen deficits than microscopic particles, suggesting that biomass bound to large particles dominates overall deep-sea metabolism
Impact of sarcopenia on survival and late toxicity in head and neck cancer patients treated with radiotherapy
Background and purpose: Sarcopenia is emerging as an adverse prognostic factor for survival and complication risk in cancer patients. This study aims to determine the impact of sarcopenia on survival and late toxicity in a large cohort of head and neck squamous cell carcinoma (HNSCC) patients treated with definitive (chemo)radiotherapy ((C)RT). Materials and methods: HNSCC patients treated with definitive (C)RT from January 2007 to June 2016 were included. Sarcopenia was assessed from radiation planning computed tomography (CT) scans using skeletal muscles at level C3. The impact of sarcopenia on overall survival (OS) and disease-free survival (DFS) was evaluated using the KaplanâMeier method. Multivariable association models were developed to assess the impact of sarcopenia on late toxicity. Results: The study population was composed of 750 HNSCC patients. Cut-off values for sarcopenia were set at SMI < 42.4 cm2/m2 (men) and <30.6 cm2/m2 (women) corresponding lowest gender specific quartile. Sarcopenic patients had significantly poorer survival rates, especially those with lower performance status and locally advanced disease. In oropharyngeal cancer patients, survival was more determined by p16 status than by sarcopenia. In multivariable analysis, sarcopenia was associated with worse OS (HR 0.72, p = 0.012) and DFS (HR 0.67, p = 0.001). In multivariable association models, sarcopenia was associated with physician-rated xerostomia six months after treatment (OR 1.65, p = 0.027) and physician-rated dysphagia six and twelve months after treatment (OR 2.02, p = 0.012 and 2.51, p = 0.003, respectively). Conclusion: Sarcopenia in HNSCC patients receiving definitive (C)RT is an independent prognostic factor for worse survival outcomes and is associated with physician-rated toxicity
The GEOTRACES Intermediate Data Product 2014
The GEOTRACES Intermediate Data Product 2014 (IDP2014) is the first publicly available data product of the international GEOTRACES programme, and contains data measured and quality controlled before the end of 2013. It consists of two parts: (1) a compilation of digital data for more than 200 trace elements and isotopes (TEIs) as well as classical hydrographic parameters, and (2) the eGEOTRACES Electronic Atlas providing a strongly inter-linked on-line atlas including more than 300 section plots and 90 animated 3D scenes. The IDP2014 covers the Atlantic, Arctic, and Indian oceans, exhibiting highest data density in the Atlantic. The TEI data in the IDP2014 are quality controlled by careful assessment of intercalibration results and multi-laboratory data comparisons at cross-over stations. The digital data are provided in several formats, including ASCII spreadsheet, Excel spreadsheet, netCDF, and Ocean Data View collection. In addition to the actual data values the IDP2014 also contains data quality flags and 1-? data error values where available. Quality flags and error values are useful for data filtering. Metadata about data originators, analytical methods and original publications related to the data are linked to the data in an easily accessible way. The eGEOTRACES Electronic Atlas is the visual representation of the IDP2014 data providing section plots and a new kind of animated 3D scenes. The basin-wide 3D scenes allow for viewing of data from many cruises at the same time, thereby providing quick overviews of large-scale tracer distributions. In addition, the 3D scenes provide geographical and bathymetric context that is crucial for the interpretation and assessment of observed tracer plumes, as well as for making inferences about controlling processes
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Analyses of pig genomes provide insight into porcine demography and evolution
For 10,000âyears pigs and humans have shared a close and complex relationship. From domestication to modern breeding practices, humans have shaped the genomes of domestic pigs. Here we present the assembly and analysis of the genome sequence of a female domestic Duroc pig (Sus scrofa) and a comparison with the genomes of wild and domestic pigs from Europe and Asia. Wild pigs emerged in South East Asia and subsequently spread across Eurasia. Our results reveal a deep phylogenetic split between European and Asian wild boars âŒ1 million years ago, and a selective sweep analysis indicates selection on genes involved in RNA processing and regulation. Genes associated with immune response and olfaction exhibit fast evolution. Pigs have the largest repertoire of functional olfactory receptor genes, reflecting the importance of smell in this scavenging animal. The pig genome sequence provides an important resource for further improvements of this important livestock species, and our identification of many putative disease-causing variants extends the potential of the pig as a biomedical model
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