Towards the systematic construction of domain-specific transformation languages

The final publication is available at Springer via http://dx.doi.org/10.1007/978-3-319-09195-2-13Proceedings of 10th European Conference, ECMFA 2014, Held as Part of STAF 2014, York, UK, July 21-25, 2014General-purpose transformation languages, like ATL or QVT, are the basis for model manipulation in Model-Driven Engineering (MDE). However, as MDE moves to more complex scenarios, there is the need for specialized transformation languages for activities like model merging, migration or aspect weaving, or for specific domains of wide use like UML. Such domain-specific transformation languages (DSTLs) encapsulate transformation knowledge within a language, enabling the reuse of recurrent solutions to transformation problems. Nowadays, many DSTLs are built in an ad-hoc manner, which requires a high development cost to achieve a full-featured implementation. Alternatively, they are realised by an embedding into general-purpose transformation or programming languages like ATL or Java. In this paper, we propose a framework for the systematic creation of DSTLs. First, we look into the characteristics of domain-specific transformation tools, deriving a categorization which is the basis of our framework. Then, we propose a domain-specific language to describe DSTLs, from which we derive a ready-to-run workbench which includes the abstract syntax, concrete syntax and translational semantics of the DSTL.This work has been funded by the Spanish Ministry of Economy and Competitivity with project “Go Lite” (TIN2011-24139

Sustainable Financing of Innovative Therapies: A Review of Approaches

The process of innovation is inherently complex, and it occurs within an even more complex institutional environment characterized by incomplete information, market power, and externalities. There are therefore different competing approaches to supporting and financing innovation in medical technologies, which bring their own advantages and disadvantages. This article reviews value- and cost-based pricing, as well direct government funding, and cross-cutting institutional structures. It argues that performance-based risk-sharing agreements are likely to have little effect on the sustainability of financing; that there is a role for cost-based pricing models in some situations; and that the push towards longer exclusivity periods is likely contrary to the interests of industry

Diagnoses and visit length in complementary and mainstream medicine

<p>Abstract</p> <p>Background</p> <p>The demand for complementary medicine (CM) is growing worldwide and so is the supply. So far, there is not much insight in the activities in Dutch CM practices nor in how these activities differ from mainstream general practice. Comparisons on diagnoses and visit length can offer an impression of how Dutch CM practices operate.</p> <p>Methods</p> <p>Three groups of regularly trained physicians specialized in CM participated in this study: 16 homeopathic physicians, 13 physician acupuncturists and 11 naturopathy physicians. Every CM physician was asked to include a maximum of 75 new patients within a period of six months. For each patient an inclusion registration form had to be completed and the activities during a maximum of five repeat visits were subsequently registered. Registrations included patient characteristics, diagnoses and visit length. These data could be compared with similar data from general practitioners (GPs) participating in the second Dutch national study in general practice (DNSGP-2). Differences between CM practices and between CM and mainstream GP data were tested using multilevel regression analysis.</p> <p>Results</p> <p>The CM physicians registered activities in a total of 5919 visits in 1839 patients. In all types of CM practices general problems (as coded in the ICPC) were diagnosed more often than in mainstream general practice, especially fatigue, allergic reactions and infections. Psychological problems and problems with the nervous system were also diagnosed more frequently. In addition, each type of CM physician encountered specific health problems: in acupuncture problems with the musculoskeletal system prevailed, in homeopathy skin problems and in naturopathy gastrointestinal problems. Comparisons in visit length revealed that CM physicians spent at least twice as much time with patients compared to mainstream GPs.</p> <p>Conclusions</p> <p>CM physicians differed from mainstream GPs in diagnoses, partly related to general and partly to specific diagnoses. Between CM practices differences were found on specific domains of complaints. Visit length was much longer in CM practices compared to mainstream GP visits, and such ample time may be one of the attractive features of CM for patients.</p

Raising the Bar: Improving Methodological Rigour in Cognitive Alcohol Research

Background and Aims: A range of experimental paradigms claim to measure the cognitive processes underpinning alcohol use, suggesting that heightened attentional bias, greater approach tendencies and reduced cue-specific inhibitory control are important drivers of consumption. This paper identifies methodological shortcomings within this broad domain of research and exemplifies them in studies focused specifically on alcohol-related attentional bias. Argument and analysis: We highlight five main methodological issues: (i) the use of inappropriately matched control stimuli; (ii) opacity of stimulus selection and validation procedures; (iii) a credence in noisy measures; (iv) a reliance on unreliable tasks; and (v) variability in design and analysis. This is evidenced through a review of alcohol-related attentional bias (64 empirical articles, 68 tasks), which reveals the following: only 53% of tasks use appropriately matched control stimuli; as few as 38% report their stimulus selection and 19% their validation procedures; less than 28% used indices capable of disambiguating attentional processes; 22% assess reliability; and under 2% of studies were pre-registered. Conclusions: Well-matched and validated experimental stimuli, the development of reliable cognitive tasks and explicit assessment of their psychometric properties, and careful consideration of behavioural indices and their analysis will improve the methodological rigour of cognitive alcohol research. Open science principles can facilitate replication and reproducibility in alcohol research

três obras e um percurso romântico

Tese de mestrado, Ciências da Arte e do Património, Universidade de Lisboa, Faculdade de Belas Artes, 2013O volume II com anexos, apenas existe em formato físico, só poderá ser consultado na Biblioteca da FBAULUnder the title “A Monumental Sculpture in Belem: Three Pieces and one Romantic Traject ”, this essay analyses three different sculptures distributed along a route inside Belém, the capital of the Brazilian state of Pará. The purpose of this work is to ascertain the hypothesis of the existence of a sculptural path where the public power used these mechanisms in a conscious manner, hoping to give the city a “modern” look, by the standards of the time. These sculptures are part of an effort to apply a “bellevue” logic in the city. These transformations were possible due to the fact that the city become the central point of the exportation of the Amazon rubber industry, after the decade of 1840. The profits of this industry were the main source behind the increase of the investment in the region, of which said interventions are a good example. This phenomenon become know in historiography as the “Belle Époque” of Belém and it was characterized not only by the sophistication of the local population habits, but also by the gradual adaptation of an eclectic architecture, inspired by the European model of the time. The monuments erected during the timeframe that this essay is analyzing, of which the statues chosen are paradigmatic examples, would be able to create a sense of collective memory, focused on a nationalistic feeling. This feeling would be supported by historiography that would help to divulge a nationalist feeling of pride through this idea of the debt from the people to past “heroes” that exemplified the virtues of a country in search of a national identity. Hence, these monuments would help to support a collective memory that was based in a social construction of reality created by an extremely nationalist historiograph