1,383 research outputs found

    Interview by Anna Helen Tam

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    What can we learn about immediate memory from the development of children's free recall?

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    We ask the question: Which aspects of immediate memory performance improve with age? In two studies, we reexamine the widely held view that primary memory capacity estimates derived from children's immediate free recall are age invariant. This was done by assessing children's immediate free-recall accuracy while also measuring the order in which they elected to recall items (Experiment 1) and by encouraging children to begin free recall with items from towards the end of the presented list (Experiment 2). Across samples aged between 5 and 8 years we replicated the previously reported age-related changes in free-recall serial position functions when aggregated across all trials of the standard task, including an absence of age differences in the recency portion of this curve. However, we also show that this does not reflect the fact that primary memory capacity is constant across age. Instead, when we incorporate order of report information, clear age differences are evident in the recall of list-final items that are output at the start of a participant's response. In addition, the total amount that individuals recalled varied little across different types of free-recall tasks. These findings have clear implications for the use of immediate free recall as a means of providing potential indices of primary memory capacity and in the study of the development of immediate memory

    Autophagy-Modulating Long Non-coding RNAs (LncRNAs) and Their Molecular Events in Cancer

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    Cancer is a global threat of health. Cancer incidence and death is also increasing continuously because of poor understanding of diseases. Although, traditional treatments (surgery, radiotherapy, and chemotherapy) are effective against primary tumors, death rate is increasing because of metastasis development where traditional treatments have failed. Autophagy is a conserved regulatory process of eliminating proteins and damaged organelles. Numerous research revealed that autophagy has dual sword mechanisms including cancer progressions and suppressions. In most of the cases, it maintains homeostasis of cancer microenvironment by providing nutritional supplement under starvation and hypoxic conditions. Over the past few decades, stunning research evidence disclosed significant roles of long non-coding RNAs (lncRNAs) in the regulation of autophagy. LncRNAs are RNA containing more than 200 nucleotides, which have no protein-coding ability but they are found to be expressed in most of the cancers. It is also proved that, autophagy-modulating lncRNAs have significant impacts on pro-survival or pro-death roles in cancers. In this review, we highlighted the recently identified autophagy-modulating lncRNAs, their signaling transduction in cancer and mechanism in cancer. This review will explore newly emerging knowledge of cancer genetics and it may provide novel targets for cancer therapy

    Spotlight influenza: Laboratory-confirmed seasonal influenza in people with acute respiratory illness: a literature review and meta-analysis, WHO European Region, 2004 to 2017

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    Background: Across the WHO European Region, there are few estimates of the proportion of people seeking medical care for influenza-like illness or acute respiratory infections and who have confirmed seasonal influenza infection when tested for respiratory viruses.Methods: We conducted meta-analyses of data extracted from a) literature review of studies published between 2004 and 2017; b) sentinel data from the European surveillance system (TESSy), pooling within-season estimates by influenza type/subtype, setting (outpatient/inpatient) and age-group, to estimate the proportion of people tested who have laboratory-confirmed medically-attended seasonal influenza in Europe.Results: In the literature review, the pooled proportion for all influenza was 33% (95% CI, 30%-36%), and higher among outpatients (36% [33-40%]) than inpatients (24% [20-29%]). Pooled estimates for all influenza by age group were: 0-17 years, 26% (22-31); 18-64 years, 41% (32-50); ≥65 years, 33% (27-40%). From TESSY data, 33% (31-24%) of outpatients and 24% (21-27%) of inpatients were positive. The highest proportion of influenza A overall was in people aged 18-64 years (22% [16-29%]). By subtype, influenza A(H1N1)pdm09 was highest in 18-64 year-olds (16% [11-21%]) whereas influenza A(H3N2) was highest in those ≥65 years (10% [2-22%]). For influenza B, the highest proportion of infections was those aged 18-64 years (15% [9-24%]). Estimated proportions of confirmed influenza varied across seasons and across countries. Conclusions: Both the literature review and TESSy analyses showed a higher proportion of laboratory-confirmed influenza in non-hospitalised patients, with further variation by influenza type, age-group, country and season

    A Comparison of Benefit Limits in Mental Health

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    This study provides insight to policy makers and stakeholders on how three types of benefits limits on Medicaid-covered mental health services might affect access for consumers diagnosed with severe mental illness. The study used a retrospective cohort design with data for Medicaid-covered, community-based mental health services provided in Ohio during fiscal year 2010. Log-binomial regression was used for the analysis. Results indicate that limits compared have significant, varying consequences based on Medicaid coverage and diagnoses. When constraining Medicaid costs, policy makers should consider how limits will disrupt care and include clinicians in discussions prior to implementatio

    Validation of a sports nutrition knowledge questionnaire for athletes in the United Kingdom and Ireland.

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    Sound general and sports nutrition knowledge in athletes is essential for making appropriate dietary choices. Assessment of nutrition knowledge enables evaluation and tailoring of nutrition education. However, few well-validated tools are available to assess nutrition knowledge in athletes. The objective of the present study was to establish the validity of the Platform to Evaluate Athlete Knowledge Sports - Nutrition Questionnaire (PEAKS-NQ) for use in the United Kingdom and Irish (UK-I) athletes. To confirm content validity, twenty-three sports nutritionists (SNs) from elite, UK-I sports institutes provided feedback on the PEAKS-NQ via a modified Delphi method. After minor changes, the UK-I version of the PEAKS-NQ was administered to UK-I SN from the British Dietetic Association Sport and Exercise Nutrition Register, and elite athletes (EA) training at elite sports institutes in the UK and Ireland. Independent samples -test and independent samples median tests were used to compare PEAKS-NQ total and subsection scores between EA and SN (to assess construct validity). Cronbach's alpha (good ≥ 0⋅7) was used to establish internal consistency. The SN achieved greater overall [SN ( 23) 92⋅3 (9⋅3) EA ( 154): 71⋅4 (10⋅0)%; < 0⋅001] and individual section scores ( < 0⋅001) except Section B, Identification of Food Groups ( = 0⋅07). Largest knowledge differences between SN and EA were in Section D, Applied Sports Nutrition [SN: 88⋅5 (8⋅9) EA: 56⋅7 (14⋅5)%; < 0⋅00]. Overall ES was large (2⋅1), with subsections ranging from 0⋅6 to 2⋅3. Cronbach's alpha was good (0⋅83). The PEAKS-NQ had good content and construct validity, supporting its use to assess nutrition knowledge of UK-I athletes
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