On stochastic imitation dynamics in large-scale networks

We consider a broad class of stochastic imitation dynamics over networks, encompassing several well known learning models such as the replicator dynamics. In the considered models, players have no global information about the game structure: they only know their own current utility and the one of neighbor players contacted through pairwise interactions in a network. In response to this information, players update their state according to some stochastic rules. For potential population games and complete interaction networks, we prove convergence and long-lasting permanence close to the evolutionary stable strategies of the game. These results refine and extend the ones known for deterministic imitation dynamics as they account for new emerging behaviors including meta-stability of the equilibria. Finally, we discuss extensions of our results beyond the fully mixed case, studying imitation dynamics where agents interact on complex communication networks.Comment: Extended version of conference paper accepted at ECC 201

KoKoN – Ein Expertenwalkthrough zu digitalen Lehr-Kooperationen im Kontext der Nationalen Bildungsplattform

... Für die erfolgreiche Umsetzung digitalgestützter Lehre nehmen sowohl hochschulinterne als auch -übergreifende Kooperationen einen immer höheren ... Stellenwert ein. Die damit einhergehende Vernetzung und das Zusammenwirken verschiedener Bildungsanbieter bilden die Grundlage des lebenslangen Lernens sowie der bildungsbereichübergreifenden Gestaltung von individuellen Bildungsbiografien (vgl. Schleifenbaum, & Walther, 2015). Die Anbahnung und Durchführung von insbesondere digitalen Lehr-Kooperationen erfordern über reine IT-Kenntnisse hinausgehende Kompetenzen seitens der Lehrenden. Für gelingende Kooperationsprozesse zwischen Lehrenden sind daher weitere Facetten digitaler Kompetenz erforderlich, wie bspw. bzgl. der Durchführung von Kommunikationsund Kooperationsprozessen im digitalen Raum, des Aufbaus einer eigenen digitalen Lehr- und Forscher:innen-Identität sowie der Reflexion des eigenen digitalen Lehr-Handelns (Eichhorn, Müller, & Tillmann, 2017; Eichhorn, 2020). [Aus: Herausforderungen für die digitalgestützte Hochschullehre

Polygenic Risk Modelling for Prediction of Epithelial Ovarian Cancer Risk

Funder: Funding details are provided in the Supplementary MaterialAbstractPolygenic risk scores (PRS) for epithelial ovarian cancer (EOC) have the potential to improve risk stratification. Joint estimation of Single Nucleotide Polymorphism (SNP) effects in models could improve predictive performance over standard approaches of PRS construction. Here, we implemented computationally-efficient, penalized, logistic regression models (lasso, elastic net, stepwise) to individual level genotype data and a Bayesian framework with continuous shrinkage, “select and shrink for summary statistics” (S4), to summary level data for epithelial non-mucinous ovarian cancer risk prediction. We developed the models in a dataset consisting of 23,564 non-mucinous EOC cases and 40,138 controls participating in the Ovarian Cancer Association Consortium (OCAC) and validated the best models in three populations of different ancestries: prospective data from 198,101 women of European ancestry; 7,669 women of East Asian ancestry; 1,072 women of African ancestry, and in 18,915 BRCA1 and 12,337 BRCA2 pathogenic variant carriers of European ancestry. In the external validation data, the model with the strongest association for non-mucinous EOC risk derived from the OCAC model development data was the S4 model (27,240 SNPs) with odds ratios (OR) of 1.38(95%CI:1.28–1.48,AUC:0.588) per unit standard deviation, in women of European ancestry; 1.14(95%CI:1.08–1.19,AUC:0.538) in women of East Asian ancestry; 1.38(95%CI:1.21-1.58,AUC:0.593) in women of African ancestry; hazard ratios of 1.37(95%CI:1.30–1.44,AUC:0.592) in BRCA1 pathogenic variant carriers and 1.51(95%CI:1.36-1.67,AUC:0.624) in BRCA2 pathogenic variant carriers. Incorporation of the S4 PRS in risk prediction models for ovarian cancer may have clinical utility in ovarian cancer prevention programs.</jats:p

Das Studienassistenzsystem gOPAL: Unterstützung Studierender in der Studieneingangsphase

Studieren heißt mehr als das Lernen komplexer Fachinhalte. Es bedeutet, den eigenen Alltag neu zu denken, Lerntechniken weiterzuentwickeln, normative Voraussetzungen des Studienfaches zu kennen oder neue Wege der Selbstorganisation zu entdecken und schrittweise in das Campusleben einzutauchen. Studier-fähigkeit als Metakompetenz für ein erfolgreiches Studium heißt auch, die universitären Abläufe, Strukturen und Kulturen zu kennen und den Campus als einen vertrauten Ort wahrzunehmen. Fraglich bleibt, wie diese Vertrautheit geschaffen werden kann. Viele Studierende erhalten den Großteil der für sie relevanten Informationen zu Beginn des Studiums, bspw. im Rahmen von Erstsemesterveranstaltungen, was in Anbetracht der Informationsfülle zu Überforderung führen kann. Mit gOPAL wurde im Rahmen des Studienerfolgsprojektes Mobiles Studienassistenzsystem (SAS) ein Online-Dienst für Studierende in der Studieneingangsphase aus MINT- (Mathematik, Informatik, Naturwissenschaft und Technik) und Lehramtsstudiengängen entwickelt. Durch gOPAL erhalten Studierende innerhalb der Studieneingangsphase (die ersten beiden Semester eines Studiums) kontinuierlich relevante Informationen zu Studienablauf, Fachinhalten, Studienstrategien sowie zu Strukturen und Unterstützungsangeboten an der Technischen Universität (TU) Dresden. Der Beitrag liefert detaillierte Einblicke in die Konzeption, Umsetzung und Evaluation des Studienassistenzsystems. Es werden die Inhalte und der Aufbau von gOPAL sowie die Reaktionen der Zielgruppe auf den Online-Dienst beleuchtet. Zudem wird das Konzept der Gamifizierung dargestellt, welches handlungsleitend für die systematische Entwicklung des Systems ist. [Aus der Einleitung

KoKoN – Ein Expertenwalkthrough zu digitalen Lehr-Kooperationen im Kontext der Nationalen Bildungsplattform

... Für die erfolgreiche Umsetzung digitalgestützter Lehre nehmen sowohl hochschulinterne als auch -übergreifende Kooperationen einen immer höheren ... Stellenwert ein. Die damit einhergehende Vernetzung und das Zusammenwirken verschiedener Bildungsanbieter bilden die Grundlage des lebenslangen Lernens sowie der bildungsbereichübergreifenden Gestaltung von individuellen Bildungsbiografien (vgl. Schleifenbaum, & Walther, 2015). Die Anbahnung und Durchführung von insbesondere digitalen Lehr-Kooperationen erfordern über reine IT-Kenntnisse hinausgehende Kompetenzen seitens der Lehrenden. Für gelingende Kooperationsprozesse zwischen Lehrenden sind daher weitere Facetten digitaler Kompetenz erforderlich, wie bspw. bzgl. der Durchführung von Kommunikationsund Kooperationsprozessen im digitalen Raum, des Aufbaus einer eigenen digitalen Lehr- und Forscher:innen-Identität sowie der Reflexion des eigenen digitalen Lehr-Handelns (Eichhorn, Müller, & Tillmann, 2017; Eichhorn, 2020). [Aus: Herausforderungen für die digitalgestützte Hochschullehre

KoKoN – Ein Expertenwalkthrough zu digitalen Lehr-Kooperationen im Kontext der Nationalen Bildungsplattform

... Für die erfolgreiche Umsetzung digitalgestützter Lehre nehmen sowohl hochschulinterne als auch -übergreifende Kooperationen einen immer höheren ... Stellenwert ein. Die damit einhergehende Vernetzung und das Zusammenwirken verschiedener Bildungsanbieter bilden die Grundlage des lebenslangen Lernens sowie der bildungsbereichübergreifenden Gestaltung von individuellen Bildungsbiografien (vgl. Schleifenbaum, & Walther, 2015). Die Anbahnung und Durchführung von insbesondere digitalen Lehr-Kooperationen erfordern über reine IT-Kenntnisse hinausgehende Kompetenzen seitens der Lehrenden. Für gelingende Kooperationsprozesse zwischen Lehrenden sind daher weitere Facetten digitaler Kompetenz erforderlich, wie bspw. bzgl. der Durchführung von Kommunikationsund Kooperationsprozessen im digitalen Raum, des Aufbaus einer eigenen digitalen Lehr- und Forscher:innen-Identität sowie der Reflexion des eigenen digitalen Lehr-Handelns (Eichhorn, Müller, & Tillmann, 2017; Eichhorn, 2020). [Aus: Herausforderungen für die digitalgestützte Hochschullehre

OVERVIEW OF THE RESEARCH ACTIVITIES IN EARTHQUAKE ENGINEERING AND SEISMIC RISK ASSESSMENT WITHIN THE JOINT FRAMEWORK CEA-EDF-FRAMATOME-IRSN

International audienceThe French nuclear community is highly active in the field of earthquake engineering and more precisely, regarding seismic risk assessment. Among the existing safety-oriented frameworks, there is one which involves not only nuclear operators such as Electricité de France (EDF), the French Sustainable Energies and Atomic Energy Commission (CEA) and FRAMATOME, but also the French technical support organization which is the Institute for Radiological Protection and Nuclear Safety (IRSN). Within this framework, research activities are conducted, aiming to enhance knowledge in order to improve nuclear safety of either existing or new facilities. These activities deal with topics and challenging issues that appear to be significant in the seismic risk assessment process. More precisely, they aim to better assess the seismic margins when available, to better understand the beyond-design behavior of nuclear buildings or related equipment and to improve the necessary knowledge to produce robust seismic hazard assessment studies. The main objective of this paper is to give an overview of the past, ongoing, and future joint activities carried out by CEA-EDF-FRAMATOME-IRSN and will especially highlight main findings and future challenges and opportunities in the field of seismic safety of nuclear facilities. To reach the objective, technical focus will be made during the presentation

Overview of the research activities in earthquake engineering and seismic risk assessment within the joint framework cea-edf-framatome-irsn

International audienceThe French nuclear community is highly active in the field of earthquake engineering and more precisely, regarding seismic risk assessment. Among the existing safety-oriented frameworks, there is one which involves not only nuclear operators such as Electricité de France (EDF), the French Sustainable Energies and Atomic Energy Commission (CEA) and FRAMATOME, but also the French technical support organization which is the Institute for Radiological Protection and Nuclear Safety (IRSN). Within this framework, research activities are conducted, aiming to enhance knowledge in order to improve nuclear safety of either existing or new facilities. These activities deal with topics and challenging issues that appear to be significant in the seismic risk assessment process. More precisely, they aim to better assess the seismic margins when available, to better understand the beyond-design behavior of nuclear buildings or related equipment and to improve the necessary knowledge to produce robust seismic hazard assessment studies. The main objective of this paper is to give an overview of the past, ongoing, and future joint activities carried out by CEA-EDF-FRAMATOME-IRSN and will especially highlight main findings and future challenges and opportunities in the field of seismic safety of nuclear facilities. To reach the objective, technical focus will be made during the presentation

Overview of the research activities in earthquake engineering and seismic risk assessment within the joint framework cea-edf-framatome-irsn

International audienceThe French nuclear community is highly active in the field of earthquake engineering and more precisely, regarding seismic risk assessment. Among the existing safety-oriented frameworks, there is one which involves not only nuclear operators such as Electricité de France (EDF), the French Sustainable Energies and Atomic Energy Commission (CEA) and FRAMATOME, but also the French technical support organization which is the Institute for Radiological Protection and Nuclear Safety (IRSN). Within this framework, research activities are conducted, aiming to enhance knowledge in order to improve nuclear safety of either existing or new facilities. These activities deal with topics and challenging issues that appear to be significant in the seismic risk assessment process. More precisely, they aim to better assess the seismic margins when available, to better understand the beyond-design behavior of nuclear buildings or related equipment and to improve the necessary knowledge to produce robust seismic hazard assessment studies. The main objective of this paper is to give an overview of the past, ongoing, and future joint activities carried out by CEA-EDF-FRAMATOME-IRSN and will especially highlight main findings and future challenges and opportunities in the field of seismic safety of nuclear facilities. To reach the objective, technical focus will be made during the presentation

Overview of the research activities in earthquake engineering and seismic risk assessment within the joint framework CEA-EDF-FRAMATOME-IRSN

International audienceThe French nuclear community is highly active in the field of earthquake engineering and more precisely, regarding seismic risk assessment. Among the existing safety-oriented frameworks, there is one which involves not only nuclear operators such as Electricité de France (EDF), the French Sustainable Energies and Atomic Energy Commission (CEA) and FRAMATOME, but also the French technical support organization which is the Institute for Radiological Protection and Nuclear Safety (IRSN). Within this framework, research activities are conducted, aiming to enhance knowledge in order to improve nuclear safety of either existing or new facilities. These activities deal with topics and challenging issues that appear to be significant in the seismic risk assessment process. More precisely, they aim to better assess the seismic margins when available, to better understand the beyond-design behavior of nuclear buildings or related equipment and to improve the necessary knowledge to produce robust seismic hazard assessment studies. The main objective of this paper is to give an overview of the past, ongoing, and future joint activities carried out by CEA-EDF-FRAMATOME-IRSN and will especially highlight main findings and future challenges and opportunities in the field of seismic safety of nuclear facilities. To reach the objective, technical focus will be made during the presentation