326 research outputs found
ARA290 : a novel treatment for neuropathic pain in sarcoidosis
The general aim of this thesis is to investigate small fiber neuropathy in sarcoidosis and to asses whether ARA290 is a possible new agent to treat the neuropathic complaints in sarcoidosis population.
The results of the various ARA290 trials in painful sarcoidosis are discussed. Painful neuropathy is common, difficult to treat complication.The limited efficacy of current treatment options dictates a rationalized design of novel compounds. ARA290 treatment was consistently associated with a significant improvement of neuropathic pain symptoms in sarcoidosis patients, evidenced by a decrease in pain scores on validated questionnaires. Moreover,ARA290 treatment resulted in significant increases in corneal nerve fibers, improved sensory pain thresholds,improved quality of life and physical functioning. Given the excellent safety profile while reducing neuropathy symptoms,the prospects of ARA290 treatment in sarcoidosis related neuropathy seem promising.The long lasting beneficial effects of ARA290 on both pain related and non pain related symptoms in sarcoidosis patients prompt additional studies on potential disease modifying properties of ARA290. The data collected so far suggest that ARA290 will be equally effective in SFN associated with other syndromes, including diabetes mellitus.LUMC / Geneeskund
Do the Unidentified EGRET Sources Trace Annihilating Dark Matter in the Local Group?
In a cold dark matter (CDM) framework of structure formation, the dark matter
haloes around galaxies assemble through successive mergers with smaller haloes.
This merging process is not completely efficient, and hundreds of surviving
halo cores, or {\it subhaloes}, are expected to remain in orbit within the halo
of a galaxy like the Milky Way. While the dozen visible satellites of the Milky
Way may trace some of these subhaloes, the majority are currently undetected. A
large number of high-velocity clouds (HVCs) of neutral hydrogen {\it are}
observed around the Milky Way, and it is plausible that some of the HVCs may
trace subhaloes undetected in the optical. Confirming the existence of
concentrations of dark matter associated with even a few of the HVCs would
represent a dramatic step forward in our attempts to understand the nature of
dark matter. Supersymmetric (SUSY) extensions of the Standard Model of particle
physics currently suggest neutralinos as a natural well-motivated candidate for
the non-baryonic dark matter of the universe. If this is indeed the case, then
it may be possible to detect dark matter indirectly as it annihilates into
neutrinos, photons or positrons. In particular, the centres of subhaloes might
show up as point sources in gamma-ray observations. In this work we consider
the possibility that some of the unidentified EGRET -ray sources trace
annihilating neutralino dark matter in the dark substructure of the Local
Group. We compare the observed positions and fluxes of both the unidentified
EGRET sources and the HVCs with the positions and fluxes predicted by a model
of halo substructure, to determine to what extent any of these three
populations could be associated.Comment: 12 Pages, 4 figures, to appear in a special issue of ApSS. Presented
at "The Multiwavelength Approach to Unidentified Gamma-Ray Sources" (Hong
Kong, June 1 - 4, 2004; Conference organizers: K.S. Cheng and G.E. Romero
Experimental manipulation shows that the white wing patch in collared flycatchers is a male sexual ornament
Descriptive analysis suggests that a conspicuous white wing patch in dichromatic (black and white) pied and collared flycatchers is under sexual selection. Here, we use an experimental approach to test whether this trait is indeed the target of selection. We caught 100 collared flycatcher Ficedula albicollis males soon after their arrival on the breeding site. We reduced (blackened) part of the white wing patch in half of these males and recorded their mating success and within and extra-pair offspring production. Reduction of the size of the white wing patch lowered a male's probability to attract a secondary social female, but not a primary female. However, primary females paired to males with a reduced wing patch were smaller (in tarsus), suggesting that male choice of partner or female-female competition over mates occurs in this species. The probability of pairing with a primary female (but not other components of male reproductive success) declined with arrival time (proxied by the date of capture). Males with a reduced wing patch size tended to sire less extra-pair offspring, although this relationship was reversed in one of the three study plots, suggesting that mating dynamics are context dependent. While our findings show that wing patch size is the target of sexual selection, the pathways and the strength of selection on this ornament differed markedly from a previous descriptive study. Nonexperimental studies of sexual selection in the wild may overestimate its importance because male fitness and ornamentation both depend positively on environmental conditions
Bilateral proximal tibia fracture
A bilateral fracture of the proximal tibia is rare in children. We describe a girl with a bilateral fracture just distal of the epiphyseal plate after minimal trauma
Dynamical and chemical evolution of NGC1569
Blue Compact Dwarf and Dwarf Irregular galaxies are generally believed to be
unevolved objects, due to their blue colors, compact appearance and large gas
fractions. Many of these objects show an ongoing intense burst of star
formation or have experienced it in the recent past. By means of 2-D
hydrodynamical simulations, coupled with detailed chemical yields originating
from SNeII, SNeIa, and intermediate-mass stars, we study the dynamical and
chemical evolution of model galaxies with structural parameters similar to
NGC1569, a prototypical starburst galaxy. A burst of star formation with short
duration is not able to account for the chemical and morphological properties
of this galaxy. The best way to reproduce the chemical composition of this
object is by assuming long-lasting episodes of star formation and a more recent
burst, separated from the previous episodes by a short quiescent period. The
last burst of star formation, in most of the explored cases, does not affect
the chemical composition of the galaxy, since the enriched gas produced by
young stars is in a too hot phase to be detectable with the optical
spectroscopy. Models assuming the infall of a big cloud towards the center of
the galaxy reproduce the chemical composition of the NGC1569, but the pressure
exercised by the cloud hampers the expansion of the galactic wind, at variance
with what observed in NGC1569.Comment: 16 pages, 10 figures, A&A accepte
HIPASS High-Velocity Clouds: Properties of the Compact and Extended Populations
A catalog of Southern anomalous-velocity HI clouds at Decl. < +2 deg is
presented, based on data from the HI Parkes All-Sky Survey (HIPASS). The
improved sensitivity (5sigma: T_B = 0.04 K) and resolution (15.5') of the
HIPASS data results in a substantial increase in the number of individual
clouds (1956, as well as 41 galaxies) compared to previous surveys. Most
high-velocity emission features, HVCs, have a filamentary morphology and are
loosely organized into large complexes extending over tens of degrees. In
addition, 179 compact and isolated anomalous-velocity objects, CHVCs, are
identified based on their size and degree of isolation. 25% of the CHVCs
originally classified by Braun & Burton (1999) are reclassified. Both the
entire population of high-velocity emission features and the CHVCs alone have
typical HI masses of ~ 4.5 D(kpc)^2 solar masses and have similar slopes for
their column density and flux distributions. On the other hand, the CHVCs
appear to be clustered and the population can be broken up into three spatially
distinct groups, while the entire population of clouds is more uniformly
distributed with a significant percentage aligned with the Magellanic Stream.
The median velocities are V_GSR = -38 km/s for the CHVCs and -30 km/s for all
of the anomalous-velocity clouds. Based on the catalog sizes, high-velocity
features cover 19% of the southern sky and CHVCs cover 1%. (abridged)Comment: 32 pages, 26 figures in gif format, 2 ascii tables, to appear in the
Jan 2002 issue of The Astronomical Journal, high resolution version available
at http://origins.Colorado.EDU/~mputman/pubs.htm
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