Multiplying video mixer system

A multiplying video mixer system including a digital signal generator for generating at least one overlay signal and an attribute control bit corresponding to each of a plurality of pixels. A background signal generator generates input background signals to which the attribute control bits are applied to effect the input background signals with a desired opaque/transparent attribute. At least one video multiplier multiplies the overlay attribute signals and background signals to produce an output video signal having an amplitude equal to the product of the amplitudes of the overlay and background signals

Increased Osteoclastogenesis in Mice Lacking the Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1

Alterations in bone remodeling are a major public health issue, as therapeutic options for widespread bone disorders such as osteoporosis and tumor-induced osteolysis are still limited. Therefore, a detailed understanding of the regulatory mechanism governing bone cell differentiation in health and disease are of utmost clinical importance. Here we report a novel function of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), a member of the immunoglobulin superfamily involved in inflammation and tumorigenesis, in the physiologic regulation of bone remodeling. Assessing the expression of all members of the murine Ceacam family in bone tissue and marrow, we found CEACAM1 and CEACAM10 to be differentially expressed in both bone-forming osteoblasts and bone-resorbing osteoclasts. While Ceacam10-deficient mice displayed no alteration in structural bone parameters, static histomorphometry demonstrated a reduced trabecular bone mass in mice lacking CEACAM1. Furthermore, cellular and dynamic histomorphometry revealed an increased osteoclast formation in Ceacam1-deficient mice, while osteoblast parameters and the bone formation rate remained unchanged. In line with these findings, we detected accelerated osteoclastogenesis in Ceacam1-deficient bone marrow cells, while osteoblast differentiation, as determined by mineralization and alkaline phosphatase assays, was not affected. Therefore, our results provide in vivo and in vitro evidence for a physiologic role of CEACAM1 in the regulation of osteoclastogenesis

Axel Gehrmann: Der professionelle Lehrer. Muster der Begründung - empirische Rekonstruktion. Opladen: Leske und Budrich 2003 (513 S.) [Rezension]

Rezension von: Axel Gehrmann: Der professionelle Lehrer. Muster der Begründung - empirische Rekonstruktion. Opladen: Leske und Budrich 2003 (513 S.; ISBN 3-8100-3803-2; 35,00 EUR)