1,319 research outputs found
Evidence for Non-Hydrostatic Gas from the Cluster X-ray to Lensing Mass Ratio
Using a uniform analysis procedure, we measure spatially resolved weak
gravitational lensing and hydrostatic X-ray masses for a sample of 18 clusters
of galaxies. We find a radial trend in the X-ray to lensing mass ratio: at
r2500 we obtain a ratio MX/ML=1.03+/-0.07 which decreases to MX/ML=0.78+/-0.09
at r500. This difference is significant at 3 sigma once we account for
correlations between the measurements. We show that correcting the lensing mass
for excess correlated structure outside the virial radius slightly reduces, but
does not eliminate this trend. An X-ray mass underestimate, perhaps due to
nonthermal pressure support, can explain the residual trend. The trend is not
correlated with the presence or absence of a cool core. We also examine the
cluster gas fraction and find no correlation with ML, an important result for
techniques that aim to determine cosmological parameters using the gas
fraction.Comment: 8 pages, minor modifications, accepted for publication in MNRA
Attractor Solutions in f(T) Cosmology
In this paper, we explore the cosmological implications of interacting dark
energy model in a torsion based gravity namely . Assuming dark energy
interacts with dark matter and radiation components, we examine the stability
of this model by choosing different forms of interaction terms. We consider
three different forms of dark energy: cosmological constant, quintessence and
phantom energy. We then obtain several attractor solutions for each dark energy
model interacting with other components. This model successfully explains the
coincidence problem via the interacting dark energy scenario.Comment: 10 pages, 23 figures, version accepted for publication in European
Physical Journal C (2012
Karyology of three evolutionarily hexaploid southern African species of yellowfish, Labeobarbus Rüppel, 1836 (Cyprinidae)
The karyotypes of three species of yellowfish, namely Labeobarbus marequensis (A. Smith, 1841), L. capensis (A. Smith, 1841) and L. polylepis (Boulenger, 1907), were examined by Giemsa staining using an approach improved for the description of high chromosome numbers. In each case, 2n = 150; no heteromorphic chromosomes were detected; chromosomes in all morphological categories ranged smoothly from large to small, with no distinctly large submetacentric pairs; and metacentric chromosomes showed little variation in size. Labeobarbus marequensis had 26 metacentric (m), 44 submetacentric (sm), 42 subtelocentric (st) and 38 acrocentric (a) chromosomes and a fundamental number (FN) of 262; L. capensis had 16 m, 58 sm, 42 st and 34 a chromosomes and FN = 266; and L. polylepis had 18 m, 60 sm, 42 st and 30 a chromosomes and FN = 270. These results, combined with published literature, imply that Labeobarbus Rüppel, 1836 is an evolutionarily hexaploid African lineage and support its removal from synonymy with the evolutionarily tetraploid Asian genus Tor Gray, 1834. A review of fundamental numbers for conspecific Labeobarbus species examined in different studies implicated karyological technique as a confounding factor in assessing details of karyotypes, leading to recommendations for future karyological studies of barbine fishes. Potential synapomorphies are pointed out in karyological characters of species within Labeobarbus
A Novel Hypothesis for Thalidomide-Induced Limb Teratogenesis: Redox Misregulation of the NF-κB Pathway
Several hypotheses have been proposed to explain the mechanisms of thalidomide teratogenesis, although none adequately accounts for the observed malformations and explains the basis for species specificity. Recent observations that thalidomide increases the production of free radicals and elicits oxidative stress, coupled with new insights into the redox regulation of nuclear transcription factors, lead to the suggestion that thalidomide may act through redox misregulation of the limb outgrowth pathways. Oxidative stress, as marked by glutathione depletion/oxidation and a shift in intracellular redox potential toward the positive, occurs preferentially in limbs of thalidomide-sensitive rabbits, but not in resistant rats. DNA binding of nuclear factor κ-B (NF-κB), a redox-sensitive transcription factor and key regulator of limb outgrowth, was shown to be significantly attenuated in rabbit limb cells and could be restored following the addition of a free radical spin-trapping agent, phenyl N-tert-butyl nitrone. The inability of NF-κB to bind to its DNA promoter results in the failure of limb cells to express fibroblast growth factor (FGF)-10 and twist in the limb progress zone (PZ) mesenchyme, which in turn attenuates expression of FGF-8 in the apical ectodermal ridge (AER). Failure to establish an FGF-10/FGF-8 feedback loop between the PZ and AER results in the truncation of limb outgrowth. We hypothesize that species-selective alterations in redox microenvironment caused by free radical production from thalidomide results in attenuation of the NF-κB-mediated gene expression that is responsible for limb outgrowth.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/63400/1/152308604771978291.pd
Search for Anisotropy of Ultra-High Energy Cosmic Rays with the Telescope Array Experiment
We study the anisotropy of Ultra-High Energy Cosmic Ray (UHECR) events
collected by the Telescope Array (TA) detector in the first 40 months of
operation. Following earlier studies, we examine event sets with energy
thresholds of 10 EeV, 40 EeV, and 57 EeV. We find that the distributions of the
events in right ascension and declination are compatible with an isotropic
distribution in all three sets. We then compare with previously reported
clustering of the UHECR events at small angular scales. No significant
clustering is found in the TA data. We then check the events with E>57 EeV for
correlations with nearby active galactic nuclei. No significant correlation is
found. Finally, we examine all three sets for correlations with the large-scale
structure of the Universe. We find that the two higher-energy sets are
compatible with both an isotropic distribution and the hypothesis that UHECR
sources follow the matter distribution of the Universe (the LSS hypothesis),
while the event set with E>10 EeV is compatible with isotropy and is not
compatible with the LSS hypothesis at 95% CL unless large deflection angles are
also assumed. We show that accounting for UHECR deflections in a realistic
model of the Galactic magnetic field can make this set compatible with the LSS
hypothesis.Comment: 10 pages, 9 figure
Prioritization and management recommendations of pediatric urology conditions during the COVID-19 pandemic
PAK1 Protein Expression in the Auditory Cortex of Schizophrenia Subjects
Deficits in auditory processing are among the best documented endophenotypes in schizophrenia, possibly due to loss of excitatory synaptic connections. Dendritic spines, the principal post-synaptic target of excitatory projections, are reduced in schizophrenia. p21-activated kinase 1 (PAK1) regulates both the actin cytoskeleton and dendritic spine density, and is a downstream effector of both kalirin and CDC42, both of which have altered expression in schizophrenia. This study sought to determine if there is decreased auditory cortex PAK1 protein expression in schizophrenia through the use of quantitative western blots of 25 schizophrenia subjects and matched controls. There was no significant change in PAK1 level detected in the schizophrenia subjects in our cohort. PAK1 protein levels within subject pairs correlated positively with prior measures of total kalirin protein in the same pairs. PAK1 level also correlated with levels of a marker of dendritic spines, spinophilin. These latter two findings suggest that the lack of change in PAK1 level in schizophrenia is not due to limited sensitivity of our assay to detect meaningful differences in PAK1 protein expression. Future studies are needed to evaluate whether alterations in PAK1 phosphorylation states, or alterations in protein expression of other members of the PAK family, are present in schizophrenia
Mg-chelatase H subunit affects ABA signaling in stomatal guard cells, but is not an ABA receptor in Arabidopsis thaliana
Mg-chelatase H subunit (CHLH) is a multifunctional protein involved in chlorophyll synthesis, plastid-to-nucleus retrograde signaling, and ABA perception. However, whether CHLH acts as an actual ABA receptor remains controversial. Here we present evidence that CHLH affects ABA signaling in stomatal guard cells but is not itself an ABA receptor. We screened ethyl methanesulfonate-treated Arabidopsis thaliana plants with a focus on stomatal aperture-dependent water loss in detached leaves and isolated a rapid transpiration in detached leaves 1 (rtl1) mutant that we identified as a novel missense mutant of CHLH. The rtl1 and CHLH RNAi plants showed phenotypes in which stomatal movements were insensitive to ABA, while the rtl1 phenotype showed normal sensitivity to ABA with respect to seed germination and root growth. ABA-binding analyses using 3H-labeled ABA revealed that recombinant CHLH did not bind ABA, but recombinant pyrabactin resistance 1, a reliable ABA receptor used as a control, showed specific binding. Moreover, we found that the rtl1 mutant showed ABA-induced stomatal closure when a high concentration of extracellular Ca2+ was present and that a knockout mutant of Mg-chelatase I subunit (chli1) showed the same ABA-insensitive phenotype as rtl1. These results suggest that the Mg-chelatase complex as a whole affects the ABA-signaling pathway for stomatal movements
Binary microlensing event OGLE-2009-BLG-020 gives a verifiable mass, distance and orbit predictions
We present the first example of binary microlensing for which the parameter
measurements can be verified (or contradicted) by future Doppler observations.
This test is made possible by a confluence of two relatively unusual
circumstances. First, the binary lens is bright enough (I=15.6) to permit
Doppler measurements. Second, we measure not only the usual 7 binary-lens
parameters, but also the 'microlens parallax' (which yields the binary mass)
and two components of the instantaneous orbital velocity. Thus we measure,
effectively, 6 'Kepler+1' parameters (two instantaneous positions, two
instantaneous velocities, the binary total mass, and the mass ratio). Since
Doppler observations of the brighter binary component determine 5 Kepler
parameters (period, velocity amplitude, eccentricity, phase, and position of
periapsis), while the same spectroscopy yields the mass of the primary, the
combined Doppler + microlensing observations would be overconstrained by 6 + (5
+ 1) - (7 + 1) = 4 degrees of freedom. This makes possible an extremely strong
test of the microlensing solution. We also introduce a uniform microlensing
notation for single and binary lenses, we define conventions, summarize all
known microlensing degeneracies and extend a set of parameters to describe full
Keplerian motion of the binary lenses.Comment: 51 pages, 8 figures, 2 appendices. Submitted to ApJ. Fortran codes
for Appendix B are attached to this astro-ph submission and are also
available at http://www.astronomy.ohio-state.edu/~jskowron/OGLE-2009-BLG-020
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