24 research outputs found
Infrared Behaviour of Propagators and Vertices
We elucidate constraints imposed by confinement and dynamical chiral symmetry
breaking on the infrared behaviour of the dressed-quark and -gluon propagators,
and dressed-quark-gluon vertex. In covariant gauges the dressing of the gluon
propagator is completely specified by P(k^2):= 1/[1+Pi(k^2)], where Pi(k^2) is
the vacuum polarisation. In the absence of particle-like singularities in the
dressed-quark-gluon vertex, extant proposals for the dressed-gluon propagator
that manifest P(k^2=0)=0 and Max[P(k^2)]~10 neither confine quarks nor break
chiral symmetry dynamically. This class includes all existing estimates of
P(k^2) via numerical simulations.Comment: 10 pages, 2 figure
On Renormalized Strong-Coupling Quenched QED in Four Dimensions
We study renormalized quenched strong-coupling QED in four dimensions in
arbitrary covariant gauge. Above the critical coupling leading to dynamical
chiral symmetry breaking, we show that there is no finite chiral limit. This
behaviour is found to be independent of the detailed choice of photon-fermion
proper vertex in the Dyson-Schwinger equation formalism, provided that the
vertex is consistent with the Ward-Takahashi identity and multiplicative
renormalizability. We show that the finite solutions previously reported lie in
an unphysical regime of the theory with multiple solutions and ultraviolet
oscillations in the mass functions. This study supports the assertion that in
four dimensions strong coupling QED does not have a continuum limit in the
conventional sense.Comment: REVTEX 3.0, 15 pages,including 4 eps files comprising 3 figures.
Submitted to Phys. Rev.
Chiral Symmetry Breaking in Quenched Massive Strong-Coupling QED
We present results from a study of subtractive renormalization of the fermion
propagator Dyson-Schwinger equation (DSE) in massive strong-coupling quenched
QED. Results are compared for three different fermion-photon proper vertex
{\it Ans\"{a}tze\/}: bare , minimal Ball-Chiu, and
Curtis-Pennington. The procedure is straightforward to implement and
numerically stable. This is the first study in which this technique is used and
it should prove useful in future DSE studies, whenever renormalization is
required in numerical work.Comment: REVTEX 3.0, 15 pages plus 7 uuencoded PostScript figure
Dynamical chiral symmetry breaking and confinement with an infrared-vanishing gluon propagator?
We study a model Dyson-Schwinger equation for the quark propagator closed
using an {\it Ansatz} for the gluon propagator of the form \mbox{} and two {\it Ans\"{a}tze} for the quark-gluon vertex: the
minimal Ball-Chiu and the modified form suggested by Curtis and Pennington.
Using the quark condensate as an order parameter, we find that there is a
critical value of such that the model does not support dynamical chiral
symmetry breaking for . We discuss and apply a confinement test which
suggests that, for all values of , the quark propagator in the model {\bf is
not} confining. Together these results suggest that this Ansatz for the gluon
propagator is inadequate as a model since it does not yield the expected
behaviour of QCD.Comment: 21 Pages including 4 PostScript figures uuencoded at the end of the
file. Replacement: slight changes of wording and emphasis. ADP-93-215/T133,
ANL-PHY-7599-TH-93, FSU-SCRI-93-108, REVTEX 3.
Renormalization and Chiral Symmetry Breaking in Quenched QED in Arbitrary Covariant Gauge
We extend a previous Landau-gauge study of subtractive renormalization of the
fermion propagator Dyson-Schwinger equation (DSE) in strong-coupling, quenched
QED_4 to arbitrary covariant gauges. We use the fermion-photon proper vertex
proposed by Curtis and Pennington with an additional correction term included
to compensate for the small gauge-dependence induced by the ultraviolet
regulator. We discuss the chiral limit and the onset of dynamical chiral
symmetry breaking in the presence of nonperturbative renormalization. We
extract the critical coupling in several different gauges and find evidence of
a small residual gauge-dependence in this quantity.Comment: REVTEX 3.0, 27 pages including 14 Extended Postscript files
comprising 9 figures. Replacement: discussion of chiral limit corrected, and
some minor typographical errors fixed. To appear in Phys. Rev.
Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure
Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report results from a GWAS meta-analysis of HF comprising 47,309 cases and 930,014 controls. Twelve independent variants at 11 genomic loci are associated with HF, all of which demonstrate one or more associations with coronary artery disease (CAD), atrial fibrillation, or reduced left ventricular function, suggesting shared genetic aetiology. Functional analysis of non-CAD-associated loci implicate genes involved in cardiac development (MYOZ1, SYNPO2L), protein homoeostasis (BAG3), and cellular senescence (CDKN1A). Mendelian randomisation analysis supports causal roles for several HF risk factors, and demonstrates CAD-independent effects for atrial fibrillation, body mass index, and hypertension. These findings extend our knowledge of the pathways underlying HF and may inform new therapeutic strategies
Finishing the euchromatic sequence of the human genome
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure
Abstract: Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report results from a GWAS meta-analysis of HF comprising 47,309 cases and 930,014 controls. Twelve independent variants at 11 genomic loci are associated with HF, all of which demonstrate one or more associations with coronary artery disease (CAD), atrial fibrillation, or reduced left ventricular function, suggesting shared genetic aetiology. Functional analysis of non-CAD-associated loci implicate genes involved in cardiac development (MYOZ1, SYNPO2L), protein homoeostasis (BAG3), and cellular senescence (CDKN1A). Mendelian randomisation analysis supports causal roles for several HF risk factors, and demonstrates CAD-independent effects for atrial fibrillation, body mass index, and hypertension. These findings extend our knowledge of the pathways underlying HF and may inform new therapeutic strategies
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Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure
Abstract: Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report results from a GWAS meta-analysis of HF comprising 47,309 cases and 930,014 controls. Twelve independent variants at 11 genomic loci are associated with HF, all of which demonstrate one or more associations with coronary artery disease (CAD), atrial fibrillation, or reduced left ventricular function, suggesting shared genetic aetiology. Functional analysis of non-CAD-associated loci implicate genes involved in cardiac development (MYOZ1, SYNPO2L), protein homoeostasis (BAG3), and cellular senescence (CDKN1A). Mendelian randomisation analysis supports causal roles for several HF risk factors, and demonstrates CAD-independent effects for atrial fibrillation, body mass index, and hypertension. These findings extend our knowledge of the pathways underlying HF and may inform new therapeutic strategies