Ultrasensitive investigations of biological systems by fluorescence correlation spectroscopy

Fluorescence correlation spectroscopy (FCS) extracts information about molecular dynamics from the tiny fluctuations that can be observed in the emission of small ensembles of fluorescent molecules in thermodynamic equilibrium. Employing a confocal setup in conjunction with highly dilute samples, the average number of fluorescent particles simultaneously within the measurement volume (similar to1 fl) is minimized. Among the multitude of chemical and physical parameters accessible by FCS are local concentrations, mobility coefficients, rate constants for association and dissociation processes, and even enzyme kinetics. As any reaction causing an alteration of the primary measurement parameters such as fluorescence brightness or mobility can be monitored, the application of this noninvasive method to unravel processes in living cells is straightforward. Due to the high spatial resolution of less than 0.5 mum, selective measurements in cellular compartments, e.g., to probe receptor-ligand interactions on cell membranes, are feasible. Moreover, the observation of local molecular dynamics provides access to environmental parameters such as local oxygen concentrations, pH, or viscosity. Thus, this versatile technique is of particular attractiveness for researchers striving for quantitative assessment of interactions and dynamics of small molecular quantities in biologically relevant systems. (C) 2003 Elsevier Science (USA). All rights reserved

Long Waves in World Industrial Production, Energy Consumption, Innovations, Inventions, and Patents and their Identification by Spectral Analysis

Scientists like to make the irregular regular, to draw curves even in cases where nothing can be seen at all. Periodical wave curves are an excellent means of organizing the unorganized, of arranging the unarranged. Recent studies on long waves in economic development have found a periodicity in the time series of inventions and innovations that works exactly like a clock with an accelerating mechanism. What we have done here is simply to collect some interesting empirical figures and to exploit them by spectral analysis in order to find out whether regularities exist, and if so, whether they are statistically significant

Religion and the Sustainable Development Goals

© 2019, © 2019 Institute for Global Engagement. Religion is a major cultural, social, political, and economic factor in many official development assistance (ODA) recipient countries. After decades of being ignored by global development processes, greater portions of development aid are now channeled via faith-based organizations, and religion is increasingly recognized as a human resource rather than just an obstacle to development. This essay explores the role that faith actors are playing in the Sustainable Development Goals process. It is based upon findings from a research project funded by the UK Arts and Humanities Research Council (AHRC)—“Keeping Faith in 2030: Religions and the SDGs.”.AHR

Religion, populism, and the politics of the Sustainable Development Goals

This article examines the Sustainable Development Goals (SDG) framework as a political project in tension with its universal and multilateral aspirations to serve as a counterbalance to narrow populist visions increasingly dominating global politics. Building upon Laclau and Mouffe’s theory of populism and their notion of ‘radical democracy’, we conceptualise the SDGs as a struggle for hegemony and in competition with other styles of politics, over what counts as ‘development’. This hegemonial struggle plays out in the attempts to form political constituencies behind developmental slogans, and it is here that religious actors come to the fore, given their already established role in organising communities, expressing values and aspirations, and articulating visions of the future. Examining how the SDG process has engaged with faith actors in India and Ethiopia, as well as how the Indian and Ethiopian states have engaged with religion in defining development, we argue that a ‘radical democracy’ of sustainable development requires a more intentional effort at integrating religious actors in the implementation of the SDGs

Features and drivers of citizen participation: Insights from participatory budgeting in three European cities

Participatory budgeting (PB) is a relatively novel approach to the allocation of funds which allows ordinary citizens to become directly involved in how local government money is spent. This study identifies and examines the features and drivers of PB that incentivize citizen participation and the co-production of public services. Our analysis takes a fresh approach by setting PB initiatives in an innovative frame combining a paradigm of ‘ideal’ types of PB and their diachronic constituent phases. The results provide insights for both scholars and policy makers on the key features and drivers of citizen participation through PB. © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group

COVID-19 publications: Database coverage, citations, readers, tweets, news, Facebook walls, Reddit posts

© 2020 The Authors. Published by MIT Press. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.1162/qss_a_00066The COVID-19 pandemic requires a fast response from researchers to help address biological, medical and public health issues to minimize its impact. In this rapidly evolving context, scholars, professionals and the public may need to quickly identify important new studies. In response, this paper assesses the coverage of scholarly databases and impact indicators during 21 March to 18 April 2020. The rapidly increasing volume of research, is particularly accessible through Dimensions, and less through Scopus, the Web of Science, and PubMed. Google Scholar’s results included many false matches. A few COVID-19 papers from the 21,395 in Dimensions were already highly cited, with substantial news and social media attention. For this topic, in contrast to previous studies, there seems to be a high degree of convergence between articles shared in the social web and citation counts, at least in the short term. In particular, articles that are extensively tweeted on the day first indexed are likely to be highly read and relatively highly cited three weeks later. Researchers needing wide scope literature searches (rather than health focused PubMed or medRxiv searches) should start with Dimensions (or Google Scholar) and can use tweet and Mendeley reader counts as indicators of likely importance

Innovation and Requirements for Human Resources

No study of technological innovation can be complete without an investigation of its impacts on human resources. Innovation does not always have a positive effect on human resources, as there are many imbalances between technological innovations and the requirements for such resources. However, without technological innovation it would be nearly impossible, in the long term, to improve working conditions and create opportunities for the development and realization of man's social, cultural, and economic capabilities. Thus the relationship between technological and social innovation is critical to the development of human resources. The present situation with regard to technological and social innovation has arisen from: 1. the growing imbalances between natural and human resources in different regions of the world; 2. the inability of social institutions, using technological strategies, to make better use of human resources, especially in the developing countries; 3. the inability to coordinate socially the innovation cycle of basic innovations in order to make better use of human resources; and 4. the need to improve the quality of human resources and to create suitable conditions for their better use. This report focuses on problems associated with the last two points

BEARS: Radioactive ion beams at LBNL

BEARS (Berkeley Experiments with Accelerated Radioactive Species) is an initiative to develop a radioactive ion-beam capability at Lawrence Berkeley National Laboratory. The aim is to produce isotopes at an existing medical cyclotron and to accelerate them at the 88 inch Cyclotron. To overcome the 300-meter physical separation of these two accelerators, a carrier-gas transport system will be used. At the terminus of the capillary, the carrier gas will be separated and the isotopes will be injected into the 88 inch Cyclotron`s Electron Cyclotron Resonance (ECR) ion source. The first radioactive beams to be developed will include 20-min {sup 11}C and 70-sec {sup 14}O, produced by (p,n) and (p,{alpha}) reactions on low-Z targets. A test program is currently being conducted at the 88 inch Cyclotron to develop the parts of the BEARS system. Preliminary results of these tests lead to projections of initial {sup 11}C beams of up to 2.5 {times} 10{sup 7} ions/sec and {sup 14}O beams of 3 {times} 10{sup 5} ions/sec

Low Momentum Nucleon-Nucleon Interaction and Fermi Liquid Theory

We use the induced interaction of Babu and Brown to derive two novel relations between the quasiparticle interaction in nuclear matter and the unique low momentum nucleon-nucleon interaction V_low k in vacuum. These relations provide two independent constraints on the Fermi liquid parameters of nuclear matter. We derive the full renormalization group equations in the particle-hole channels from the induced interaction. The new constraints, together with the Pauli principle sum rules, define four combinations of Fermi liquid parameters that are invariant under the renormalization group flow. Using empirical values for the spin-independent Fermi liquid parameters, we are able to compute the major spin-dependent ones by imposing the new constraints and the Pauli principle sum rules. The effects of tensor forces are discussed.Comment: 30 pages, 4 figures, uses feynmp.sty (included), minor revisions, to appear in Nucl. Phys.