The role of competitiveness as mediating effect of environmental uncertainty on performance of fisheries companies

Current research purpose to analyze and explain the influence of environmental uncertainty on competitiveness and fishery company performance, then also aims to examine the mediating role of competitiveness. This research uses a quantitative approach, with data collection using questionnaires. The sampling in this study was determined based on criteria represented by 3 people at the management level of 19 fishing companies (i.e. directors, operational managers, and supervisors), thus a total sample of 57 managers in the fisheries company. Data analysis and hypothesis testing in this current research using generalized Structured Component Analysis (GSCA). Research findings indicate a positive and significant influence between environmental uncertainty on competitiveness and fishery company performance. Similarly, the competitiveness has a positive and significant effect on fishery company performance. Lasty, competitiveness has a role as partial mediation of the influence environmental uncertainty toward fishery company performance. The practical implications of the results of this study are the importance of fishing companies to adapt to environmental uncertainties in order to create competitiveness and improve company performance.Penelitian saat ini bertujuan menganalisis dan mejelaskan pengaruh ketidakpastian lingkungan terhadap daya saing dan kinerja perusahaan perikanan, selanjutnya bertujuan menguji peran mediasi daya saing. Penelitian ini menggunakan pendekatan kuantitatif, dengan pengumpulan data menggunakan kuesioner. Penentuan sampel studi ini berdasarkan kriteria, yang diwakili 3 orang pada level manajemen dari 19 perusahaan perikanan yaitu direksi, manajer operasional dan pengawas, sehingga besarnya sampel ditetapkan sebanyak 57 manajer perusahaan perikanan. Analisis data dan pengujian hipotesis menggunakan Generalized Structured Component Analysis (GSCA). Hasil penelitian ini menunjukkan adanya pengaruh positif dan signifikan antara ketidakpastian lingkungan terhadap daya saing dan kinerja perusahaan perikanan. Demikian pula, daya saing berpengaruh positif signifikan terhadap kinerja perusahaan perikanan. Akhirnya, daya saing terbukti berperan sebagai mediasi parsial pengaruh antara ketidakpastian lingkungan dengan kinerja perusahaan perikanan. Implikasi praktis dari hasil studi ini pentingnya perusahaan perikanan untuk beradapatasi dengan ketidakpastian lingkungan agar dapat menciptakan daya saing dan meningkatkan kinerja perusahaan

PENGARUH PARTISIPASI MANAJER DALAM PENYUSUNAN ANGGARAN DAN PENGGUNAAN INFORMATION TECHNOLOGY TERHADAP KINERJA MANAJER (STUDI KASUS PADA INDUSTRI PERHOTELAN DI KENDARI)

The research’s aim is to find out the positive impact of manager’s participation in budgeting on performance and the impact of information technology implementation on relation between manager’s participation in budgeting and performance. The object of this research are managers hotels in Kendari which participate in budgeting and the hotel is already implement information technology. The population consists of 62 managers. Technique of collecting sample used jugmend sampling. The analysis uses multiple linear regression application, the moderating regression analysis.The results show that managers’ participation in budgeting has positive impact on managers’ performance, but information technology has no strengthening impact on the relation between manager’s participation in budgeting and performance due to its low usage. Managers’ participation in budgeting was proven to be having positive impact on managers’ performance, so it would be better if managers’ participation in budgeting is increased. Though information technology has not been maximally used by hotel industry in Kendari, it would also be better if the company starts to take the benefit of information technology available in the company, because at the moment the company must be able to accommodate the need of the global market, especially for the hotel industry

Investigation of relationship between musculoskeletal disorders and working conditions among workers at a pharmaceutical industry in Iran (2011-2012)

Musculoskeletal disorders may be observed in all industries and professions and most of these disorders are related to the back, upper and lower extremities of the body organs. In Pharmaceutical industry, almost lack of standard ergonomic conditions and sometimes can cause outbreaks of diseases and musculoskeletal disorders in various parts of the body. The aim of this study was to determine the relationship between musculoskeletal disorders and working on the packaging section of the pharmaceutical industry. The Nordic questionnaire and Rula method were used for collection of data and 392 workers were selected as the subjects of study. Based on the results of this study, (28.5%) of workers working in Packaging Unit complained of severe pain and discomfort in their neck, (23.7%) in their shoulder, (27.9%) in their hand and wrist and (33.2%) complained of severe pain in their back. The results indicate that workers in this industry could show musculoskeletal disorders based on age, education, gender and working conductions

A versatile and robust cell purification system with an RNA-only circuit composed of microRNA-responsive ON and OFF switches

２つの合成mRNAスイッチを活用した純度の高い細胞選別システムの開発. 京都大学プレスリリース. 2022-01-06.Synthetic gene circuits that improve stem cell quality. 京都大学プレスリリース. 2022-01-06.Human induced pluripotent stem cells (iPSCs) are promising cell resources for cell therapy and drug discovery. However, iPSC-derived differentiated cells are often heterogenous and need purification using a flow cytometer, which has high cost and time consumption for large-scale purification. MicroRNAs (miRNAs) can be used as cell selection markers, because their activity differs between cell types. Here, we show miRNA-responsive ON and OFF switch mRNAs for robust cell purification. The ON switch contains a miRNA-target sequence after the polyadenylate tail, triggering translational activation by sensing the target miRNA. By designing RNA-only circuits with miRNA-ON and -OFF switch mRNAs that encode a lethal ribonuclease, Barnase, and its inhibitor, Barstar, we efficiently purified specific cell types, including human iPSCs and differentiated cardiomyocytes, without flow cytometry. Synthetic mRNA circuits composed of ON and OFF switches provide a safe, versatile, and time-saving method to purify various cell types for biological and clinical applications

Am80, a retinoic acid receptor agonist, activates the cardiomyocyte cell cycle and enhances engraftment in the heart

ヒトiPS細胞由来心筋細胞の生着能改善に向けた新しい方法. 京都大学プレスリリース. 2023-07-14.Am80, a retinoic acid receptor agonist, activates cell cycle in induced cardiomyocytes and enhances heart tissue engraftment. 京都大学プレスリリース. 2023-07-14.Human induced pluripotent stem cell-derived (hiPSC) cardiomyocytes are a promising source for regenerative therapy. To realize this therapy, however, their engraftment potential after their injection into the host heart should be improved. Here, we established an efficient method to analyze the cell cycle activity of hiPSC cardiomyocytes using a fluorescence ubiquitination-based cell cycle indicator (FUCCI) system. In vitro high-throughput screening using FUCCI identified a retinoic acid receptor (RAR) agonist, Am80, as an effective cell cycle activator in hiPSC cardiomyocytes. The transplantation of hiPSC cardiomyocytes treated with Am80 before the injection significantly enhanced the engraftment in damaged mouse heart for 6 months. Finally, we revealed that the activation of endogenous Wnt pathways through both RARA and RARB underlies the Am80-mediated cell cycle activation. Collectively, this study highlights an efficient method to activate cell cycle in hiPSC cardiomyocytes by Am80 as a means to increase the graft size after cell transplantation into a damaged heart

ERRγ enhances cardiac maturation with T-tubule formation in human iPSC-derived cardiomyocytes

ヒトのiPS細胞から新生児レベルまで成熟した心筋細胞を作製する. 京都大学プレスリリース. 2021-06-21.Lowering the cost of heart cell therapies. 京都大学プレスリリース. 2021-06-21.One of the earliest maturation steps in cardiomyocytes (CMs) is the sarcomere protein isoform switch between TNNI1 and TNNI3 (fetal and neonatal/adult troponin I). Here, we generate human induced pluripotent stem cells (hiPSCs) carrying a TNNI1[EmGFP] and TNNI3[mCherry] double reporter to monitor and isolate mature sub-populations during cardiac differentiation. Extensive drug screening identifies two compounds, an estrogen-related receptor gamma (ERRγ) agonist and an S-phase kinase-associated protein 2 inhibitor, that enhances cardiac maturation and a significant change to TNNI3 expression. Expression, morphological, functional, and molecular analyses indicate that hiPSC-CMs treated with the ERRγ agonist show a larger cell size, longer sarcomere length, the presence of transverse tubules, and enhanced metabolic function and contractile and electrical properties. Here, we show that ERRγ-treated hiPSC-CMs have a mature cellular property consistent with neonatal CMs and are useful for disease modeling and regenerative medicine

Spillovers through backward linkages and the export performance of business services. Evidence from a sample of Italian firms

We provide evidence on the role of spillovers through vertical linkages in service firms' internationalisation process. We combine input-output coefficients with region-level information on downstream manufacturing sector exports to build a measure of spillovers through backward linkages, which we assess as a systematic determinant of Italian BS firms' export status. Once considered firm and sector specificities, export spillovers especially matter for exporting to high-income economies outside Europe. This finding originates from higher sunk costs stemming from greater distance to the destination market and tougher competition within the destination market. Furthermore, the spillovers' geographical scope is mainly local. We thus contribute to international business theory by generalising existing evidence from case studies on the importance of buyer-supplier relationships for service firms' internationalisation across several BS sectors. Our research carries important implications for international business practices as well, as joining networks with internationalised customers may play an important role in enhancing BS firms' exports, regardless of the BS supplied. © 2013 Elsevier Ltd