Ehara, Natsuhiko

Furukawa, Yutaka

Hatani, Takeshi

Kaji, Shuichiro

Kim, Kitae

Kinoshita, Makoto

Kitai, Takeshi

Kobori, Atsushi

Tani, Tomoko

Elsevier - Publisher Connector 

E853
JACC March 12, 2013
Volume 61, Issue 10
Imaging
high-risk plaQue characTerisTics in Type ii diaBeTic paTienTs: evaluaTion By coronary cT 
angiography
Poster Contributions
Poster Sessions, Expo North
Saturday, March 09, 2013, 10:00 a.m.-10:45 a.m.
Session Title: Imaging: CT/Multimodality II
Abstract Category: 20. Imaging: CT/Multimodality
Presentation Number: 1141-344
Authors: Takeshi Hatani, Shuichiro Kaji, Kitae Kim, Takeshi Kitai, Natsuhiko Ehara, Atsushi Kobori, Makoto Kinoshita, Tomoko Tani, Yutaka Furukawa, 
Kobe City Medical Center General Hospital, Kobe, Japan
Background: Patients with type 2 diabetes mellitus (DM) are at high risk for coronary artery disease (CAD), but noninvasive measurement of CAD 
extent and severity has not been well investigated. Low attenuation non-calcified plaque, luminal stenosis and positive remodeling measured by 
coronary CT angiography (CCTA) are related to adverse outcomes. The purpose of this study was to compare lesion characteristics of CAD assessed by 
CCTA between diabetic and non-diabetic patients.
methods: A total of 364 consecutive patients with suspected CAD (219 males, 64±12 years) underwent 64-slice CCTA and 4863 coronary 
segments were analyzed. Of these, 127 (35%) patients had type 2 DM. Enrolled patients had an intermediate to high pre-test probability of 
obstructive CAD. We evaluated the numbers of coronary segments with coronary atherosclerotic plaques and the plaque characteristics, including 
significant luminal stenosis (≥70%), positive remodeling, and spotty calcification. Numbers of calcified (≥120HU), non-calcified (<120HU), and low 
attenuation (<60HU) plaque were also evaluated.
results: There were no significant differences in age, gender, prevalence of hypertension, and LDL-cholesterol level between DM and non-DM 
patients. HbA1C was significantly higher in DM than in non-DM patients (7.9% vs. 5.8%, p<0.001). CCTA revealed that DM patients had a higher 
number of coronary segments with significant luminal stenosis (1.02 vs. 0.62 segments per patient, p<0.05), non-calcified plaque (2.42 vs. 1.53 
segments per patient, p<0.001), low attenuation plaque (0.33 vs. 0.16 per patient, p=0.03), positive remodeling (1.24 vs. 0.76 segments per 
patient, p=0.004) as compared to non-DM patients, whereas no such differences were observed for calcified plaque and spotty calcification.
conclusions: High-risk coronary plaques were more frequently detected in DM patients by CCTA than in non-DM patients. CCTA screening may be 
useful for enhanced risk stratification in DM patients.


HIGH-RISK PLAQUE CHARACTERISTICS IN TYPE II DIABETIC PATIENTS: EVALUATION BY CORONARY CT ANGIOGRAPHY 

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HIGH-RISK PLAQUE CHARACTERISTICS IN TYPE II DIABETIC PATIENTS: EVALUATION BY CORONARY CT ANGIOGRAPHY

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