Clinical and histological observations of chorioepithelioma and hydatidiform mole

1. Clinical and histological evaluation of so-called chorioepithelioma malignum and hydatidiform mole has been made on the cases treated at the Department of Obstetrics and Gynecology, Okayama University Hospital during the 20year period friom 1939 to 1958. 2. CC has been confirmed to be a poor risk in the treatment than CA and SE. 3. The two-year cure rate and the five-year cure rate yield an approximate value in each of CC, CA and SE, so that the two-year survival would be an ideal index for determination of the prognosis. 4. It may be pointed out that CC would indicate a tendency of a higher gonadotropin content suggestive of the poor prognosis, provided the disease contain a greater number of La-cells comparing to Sy-cells. 5. Metastasis of CA is not so infrequent as has been formerly believed, and there were two cases, which proved to be a typical SE and had metastasis to the vaginal wall. 6. Concerning the last labor preceding the chorioepithelioma, it has been clarified that the disease occurs more frequently following spontaneous abortion rather than after artificial abortion. 7. It is noted that the mole showing a marked proliferation of the trophoblasts entailed CC. However, in order to evaluate a correlation of the histological findings of the mole with chance occurrence of the subsquent CC, further study on the cases is required.</p

Permeability-control on volcanic hydrothermal system: case study for Mt. Tokachidake, Japan, based on numerical simulation and field observation

We investigate a volcanic hydrothermal system by using numerical simulation with three key observables as reference: the magnetic total field, vent temperature, and heat flux. We model the shallow hydrothermal system of Mt. Tokachidake, central Hokkaido, Japan, as a case study. At this volcano, continuous demagnetization has been observed since at least 2008, suggesting heat accumulation beneath the active crater area. The surficial thermal manifestation has been waning since 2000. We perform numerical simulations of heat and mass flow within a modeled edifice at various conditions and calculate associated magnetic total field changes due to the thermomagnetic effect. We focus on the system’s response for up to a decade after permeability is reduced at a certain depth in the modeled conduit. Our numerical simulations reveal that (1) conduit obstruction (i.e., permeability reduction in the conduit) tends to bring about a decrease in vent temperature and heat flux, as well as heat accumulation below the level of the obstruction, (2) the recorded changes cannot be consistently explained by changing heat supply from depth, and (3) caprock structure plays a key role in controlling the location of heating and pressurization. Although conduit obstruction may be caused by either physical or chemical processes in general, the latter seems more likely in the case of Mt. Tokachidake

Temperature and Concentration Distributions in Fixed-bed Catalytic Reactors : Comparison of Calculated with Experimental Results

Fixed-bed catalytic reactors are most widely used for vapor-phase reactions catalyzed by solid particles. Although theoretical studies concerned with the design method have been extensively performed, few systematic experimental substantiations have been presented. The purpose of this paper is to obtain the necessary data for the reactor design and to evaluate the accuracy of the design method. The radial temperature profiles and the mean conversions at various catalyst heights were measured in a 5.0 cm I.D. reactor where the hydrogenation of benzene takes place on a nickel-kieselguhr catalyst. The basic design data, the rate of reaction and the heat transfer characteristics in a fixed bed were also presented. A numerical design method used here is similar to those developed by Smith and Walas with suitable modification. Profiles of temperature and conversion predicted by the numerical method were in good agreement with the experimental data

17β-Hydroxysteroid Dehydrogenase Type 2 Expression Is Induced by Androgen Signaling in Endometrial Cancer.

Endometrial cancer is one of the most common female pelvic cancers and has been considered an androgen-related malignancy. Several studies have demonstrated the anti-cell proliferative effect of androgen on endometrial cancer cells; however, the mechanisms of the anti-cancer effect of androgen remain largely unclear. 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2), which catalyzes the conversion of E2 to E1, is known to be upregulated by androgen treatment in breast cancer cells. In this study, we therefore focused on the role of androgen on estrogen dependence in endometrial cancer. Dihydrotestosterone (DHT) was found to induce 17β-HSD2 mRNA and protein expression in HEC-1B endometrial cancer cells. DHT could also inhibit cell proliferation of HEC-1B when induced by estradiol treatment. In 19 endometrioid endometrial adenocarcinoma (EEA) tissues, intratumoral DHT concentration was measured by liquid chromatography/electrospray tandem mass spectrometry and was found to be significantly correlated with 17β-HSD2 immunohistochemical status. We further examined the correlations between 17β-HSD2 immunoreactivity and clinicopathological parameters in 53 EEA tissues. 17β-HSD2 status was inversely associated with the histological grade, clinical stage, and cell proliferation marker Ki-67, and positively correlated with progesterone receptor expression. 17β-HSD2 status tended to be positively associated with androgen receptor status. In 53 EEA cases, the 17β-HSD2-positive group tended to have better prognosis than that for the negative group with respect to progression-free survival and endometrial cancer-specific survival. These findings suggest that androgen suppresses the estrogen dependence of endometrial cancer through the induction of 17β-HSD2 in endometrial cancer

Hypofractionated stereotactic radiotherapy for acoustic neuromas: safety and effectiveness over 8 years of experience.

Little information is available about long-term outcomes of hypofractionated stereotactic radiotherapy (hypo-FSRT) for acoustic neuromas. In this study, the safety and effectiveness of hypo-FSRT for unilateral acoustic neuroma were reviewed over 8 years of experience at our institution

カテイ ソウゴウ キョウカショ ニ ミラレル イクジ シエン ノ コウサツ

The purpose of this study is to analyze the support for the child care in textbook "Integrated Home Economics" for upper secondary schools. The results were as follows. 1 The guarantee for the rights of the child: The descriptions of the low and the clhild abuse were many, but the background of those were little. 2 The support for the child care: The needs and measures were described mainly. It is difficult for students of upper secondary schools to realize the support for the child care.国立情報学研究所『研究紀要公開支援事業』により電子化

The Build-up of the Colour-Magnitude Relation as a Function of Environment

We discuss the environmental dependence of galaxy evolution based on deep panoramic imaging of two distant clusters taken with Suprime-Cam as part of the PISCES project. By combining with the SDSS data as a local counterpart for comparison, we construct a large sample of galaxies that spans wide ranges in environment, time, and stellar mass (or luminosity). We find that colours of galaxies, especially those of faint galaxies ($M_V>M_V^*+1$), change from blue to red at a break density as we go to denser regions. Based on local and global densities of galaxies, we classify three environments: field, groups, and clusters. We show that the cluster colour-magnitude relation is already built at $z=0.83$. In contrast to this, the bright-end of the field colour-magnitude relation has been vigorously built all the way down to the present-day and the build-up at the faint-end has not started yet. A possible interpretation of these results is that galaxies evolve in the 'down-sizing' fashion. That is, massive galaxies complete their star formation first and the truncation of star formation is propagated to smaller objects as time progresses. This trend is likely to depend on environment since the build-up of the colour-magnitude relation is delayed in lower-density environments. Therefore, we may suggest that the evolution of galaxies took place earliest in massive galaxies and in high density regions, and it is delayed in less massive galaxies and in lower density regions.Comment: 23pages, 19 figures, accepted for publication in MNRA