The Abolitionists and the South, 1831-1861

Within the American antislavery movement, abolitionists were distinct from others in the movement in advocating, on the basis of moral principle, the immediate emancipation of slaves and equal rights for black people. Instead of focusing on the immediatists as products of northern culture, as many previous historians have done, Stanley Harrold examines their involvement with antislavery action in the South--particularly in the region that bordered the free states. How, he asks, did antislavery action in the South help shape abolitionist beliefs and policies in the period leading up to the Civil War? Harrold explores the interaction of northern abolitionist, southern white emancipators, and southern black liberators in fostering a continuing antislavery focus on the South, and integrates southern antislavery action into an understanding of abolitionist reform culture. He discusses the impact of abolitionist missionaries, who preached an antislavery gospel to the enslaved as well as to the free. Harrold also offers an assessment of the impact of such activities on the coming of the Civil War and Reconstruction. He is most convincing about the singular role that Southern abolitionists and Northern ones operating in the slaveholding region played in shaping the crusade, a topic long misperceived. Those who study American reform will need this revisionist work. -- Bertram Wyatt-Brown, University of Florida Harrold reminds historians of antebellum reform that a number of Northern abolitionists left the comfort of middle-class parlors to join coadjutors in the South and risk violence, imprisonment, and death. . . . Argues forcefully that abolitionism must be viewed from the perspective of the contested Southern borderlands. -- Civil War History Harrold’s bold, revisionist account of abolitionism in the antebellum period challenges the overwhelming emphasis in abolitionist scholarship on the movement’s northern, and specifically New England, origins and influences. -- Florida Historical Quarterly Assigns a crucial role to southern abolitionists in shaping policy and causing proslavery forces in the South to react, eventually to secede from the Union. -- Georgia Historical Quarterly This is a path-breaking work that will significantly alter interpretations of abolitionism. -- James L. Huston, Oklahoma State University Forces the reader to reopen a number of crucial questions concerning antislavery activities across the spectrum of the movement. -- JASAT Challenges fundamental historiographical assumptions regarding the abolitionists’ impact on the southern states and their role in causing the Civil War. -- Journal of American History A thoroughly researched, well-written, and thought provoking study that should take its place among required reading in the study of American abolitionism. -- Southern Historianhttps://uknowledge.uky.edu/upk_united_states_history/1006/thumbnail.jp

The alpha-globin super-enhancer acts in an orientation-dependent manner

Individual enhancers are defined as short genomic regulatory elements, bound by transcription factors, and able to activate cell-specific gene expression at a distance, in an orientation-independent manner. Within mammalian genomes, enhancer-like elements may be found individually or within clusters referred to as locus control regions or super-enhancers (SEs). While these behave similarly to individual enhancers with respect to cell specificity, distribution and distance, their orientation-dependence has not been formally tested. Here, using the α-globin locus as a model, we show that while an individual enhancer works in an orientation-independent manner, the direction of activity of a SE changes with its orientation. When the SE is inverted within its normal chromosomal context, expression of its normal targets, the α-globin genes, is severely reduced and the normally silent genes lying upstream of the α-globin locus are upregulated. These findings add to our understanding of enhancer-promoter specificity that precisely activate transcription

The α-globin super-enhancer acts in an orientation-dependent manner

Individual enhancers are defined as short genomic regulatory elements, bound by transcription factors, and able to activate cell-specific gene expression at a distance, in an orientation-independent manner. Within mammalian genomes, enhancer-like elements may be found individually or within clusters referred to as locus control regions or super-enhancers (SEs). While these behave similarly to individual enhancers with respect to cell specificity, distribution and distance, their orientation-dependence has not been formally tested. Here, using the α-globin locus as a model, we show that while an individual enhancer works in an orientation-independent manner, the direction of activity of a SE changes with its orientation. When the SE is inverted within its normal chromosomal context, expression of its normal targets, the α-globin genes, is severely reduced and the normally silent genes lying upstream of the α-globin locus are upregulated. These findings add to our understanding of enhancer-promoter specificity that precisely activate transcription

Race, Slavery, and the Expression of Sexual Violence in Louisa Picquet, The Octoroon

Historically, victims of sexual violence have rarely left written accounts of their abuse, so while sexual violence has long been associated with slavery in the United States, historians have few accounts from formerly enslaved people who experienced it first-hand. Through a close reading of the narrative of Louisa Picquet, a survivor of sexual violence in Georgia and Louisiana, this article reflects on the recovery of evidence of sexual violence under slavery through amanuensis-recorded testimony, the unintended evidence of survival within the violent archive of female slavery, and the expression of “race” as an authorial device through which to demonstrate the multigenerational nature of sexual victimhood

Alterations to Melanocortinergic, GABAergic and Cannabinoid Neurotransmission Associated with Olanzapine-Induced Weight Gain

Background/Aim: Second generation antipsychotics (SGAs) are used to treat schizophrenia but can cause serious metabolic side-effects, such as obesity and diabetes. This study examined the effects of low to high doses of olanzapine on appetite/ metabolic regulatory signals in the hypothalamus and brainstem to elucidate the mechanisms underlying olanzapineinduced obesity. Methodology/Results: Levels of pro-opiomelanocortin (POMC), neuropeptide Y (NPY) and glutamic acid decarboxylase (GAD65, enzyme for GABA synthesis) mRNA expression, and cannabinoid CB1 receptor (CB1R) binding density (using [ 3 H]SR-141716A) were examined in the arcuate nucleus (Arc) and dorsal vagal complex (DVC) of female Sprague Dawley rats following 0.25, 0.5, 1.0 or 2.0 mg/kg olanzapine or vehicle (36/day, 14-days). Consistent with its weight gain liability, olanzapine significantly decreased anorexigenic POMC and increased orexigenic NPY mRNA expression in a dose-sensitive manner in the Arc. GAD65 mRNA expression increased and CB1R binding density decreased in the Arc and DVC. Alterations to neurotransmission signals in the brain significantly correlated with body weight and adiposity. The minimum dosage threshold required to induce weight gain in the rat was 0.5 mg/kg olanzapine. Conclusions: Olanzapine-induced weight gain is associated with reduced appetite-inhibiting POMC and increased NPY. This study also supports a role for the CB1R and GABA in the mechanisms underlying weight gain side-effects, possibly b