Faktor Yang Mempengaruhi Kinerja Pemasaran Di Waralaba ThaiTea Fremlit

Increasingly increasing franchise competition to compete for the existing market causes each industry to establish the right strategy in marketing its products. This study aims to determine product innovation and competitive advantage affect marketing performance. This research uses quantitative research. The population in this study is Thai Tea Fremilt consumers as many as more than 1000 people. The sample in this study was 100 respondents. The instrument used was a questionnaire as many as 21 questionnaire items. The analysis technique used is regression analysis, T test, F test and determination coefficient. The results in this study that product innovation has an effect on marketing performance, competitive advantage also affects marketing performance, then jointly product innovation and competitive advantage affect marketing performance. In addition, 88.2% of the effect of product innovation and competitive advantage on marketing performance. This is because the innovation of a product at Thai Tea Fremilt makes consumers curious, so they try new things at Thai Tea Fremilt that have never been tried before

Uji Pemanfaatan Pupuk Organik Cair Lindi Dengan Penambahan Bakteri Starter Terhadap Pertumbuhan Tanaman Hortikultura (Solanum Melongena dan Capsicum Frutescens)

Air lindi apabila tidak dikelola dengan baik maka akan menimbulkan dampak negatif karena mengandung zat pencemar organik dan anorganik yang tinggi.  Namun, air lindi memilik kandungan unsur hara makro berkadar tinggi. Selain itu, saat ini penggunaan pupuk anorganik yang berlebihan akan mengurangi tingkat kesuburan tanah dan menurunnya produktivitas tanaman. Maka dilakukan penelitian untuk mengolah air lindi yang berasal dari Stasiun Peralihan Antara (SPA) Rangkah Surabaya untuk menghasilkan pupuk cair organik dengan memanfaatkan bakteri starter melalui proses fermentasi. Variabel yang digunakan adalah variasi pengenceran lindi dan penambahan bakteri starter (cair dan bubuk). Tahapan persiapan terdiri atas uji karakteristik lindi awal serta pembuatan media penanaman. Kemudian tahap utama terdiri pembuatan reaktor, proses fermentasi,  uji Total Plate Count (TPC), uji karakteristik hasil fermentasi, dan pengamatan pertumbuhan tanaman dengan pemberian pupuk organik cair lindi. Tanaman yang digunakan sebagai bahan uji adalah terong (Solanum melongena) dan cabai (Capsicum frutescens). Hasil penelitian menunjukkan interaksi antara faktor penambahan bakteri dan pengenceran lindi berpengaruh signifikan terhadap peningkatan amonium dan nitrat hasil fermentasi. Reaktor yang memiliki pengaruh paling signifikan adalah B3 (untuk starter serbuk) dan C3 (untuk starter cair). Sedangkan yang memiliki konsentrasi optimum penambahan bakteri adalah reaktor B3 dan D1. Pemberian pupuk organik cair variasi B3 dan D1 pada tanaman seharusnya memberikan respon cepat terhadap laju pertumbuhan tanaman, namun pada hasil pengamatan di lapangan menunjukkan hasil yang berbeda

Buku Panduan Penatalaksanaan stroke

Buku ini berisi tentang Panduan Penatalaksanaan strok

TERAPI “PAKET BAHAGIA” BERBASIS TEKNOLOGI INFORMASI SEBAGAI TATALAKSANA PERAWATAN PASIEN STROKE DI RUMAH BAGI KELUARGA YANG MERAWAT DAN KADER KESEHATAN DI KELURAHAN PUDAK PAYUNG : PENGABDIAN KEPADA MASYARAKAT

D Insiden stroke di Kota Semarang adalah 5798 pada tahun 2018. Kelurahan Pudak Payung memiliki pasien stroke 40 orang. Hasil penelitian menunjukan bahwa Terapi “Paket BAHAGIA” efektif untuk meningkatkan psikososial pasien. Keluarga dan Kader memerlukan ketrampilan dalam merawat pasien stroke di Kelurahan Pudak Payung. Tujuan kegiatan Pengabdian Kepada Masyarakat adalah meningkatkan ketrampilan kader dan keluarga dalam merawat pasien stroke. Metode kegiatan adalah pelatihan terapi “Paket BAHAGIA” kepada keluarga dan kader dalam merawat pasien stroke dirumah. Pelatihan 60 jam kepada 40 kader Kelurahan Pudak Payung dilakukan oleh tim keperawatan dan tim tehnologi Informasi Lembaga Penelitian dan Pengabdian Kepada Masyarakat Universitas Diponegoro. Pelatihan berbentuk pemberian materi, demonstrasi dan aktifitas mandiri. Hasil aktifitas Pengabdian Kepada Masyarakat menunjukan adanya peningkatan pengetahuan kader dan keluarga tentang stroke dan ketrampilan perawatan pasien stroke di rumah (p<0.05). Pengabdian Kepada Masyarakat dalam pelatihan terapi “Paket BAHAGIA” dapat diaplikasikan kepada masyarakat dalam merawat pasien di ruma

Acetylation, Phosphorylation, Ubiquitination (Oh My!): Following Post-Translational Modifications on the Ubiquitin Road

Ubiquitination is controlled by a series of E1, E2, and E3 enzymes that can ligate ubiquitin to cellular proteins and dictate the turnover of a substrate and the outcome of signalling events such as DNA damage repair and cell cycle. This process is complex due to the combinatorial power of ~35 E2 and ~1000 E3 enzymes involved and the multiple lysine residues on ubiquitin that can be used to assemble polyubiquitin chains. Recently, mass spectrometric methods have identified that most enzymes in the ubiquitination cascade can be further modified through acetylation or phosphorylation under particular cellular conditions and altered modifications have been noted in different cancers and neurodegenerative diseases. This review provides a cohesive summary of ubiquitination, acetylation, and phosphorylation sites in ubiquitin, the human E1 enzyme UBA1, all E2 enzymes, and some representative E3 enzymes. The potential impacts these post-translational modifications might have on each protein function are highlighted, as well as the observations from human disease

Distinct phosphorylation signals drive acceptor versus free ubiquitin chain targeting by Parkin

The RBR E3 ligase parkin is recruited to the outer mitochondrial membrane (OMM) during oxidative stress where it becomes activated and ubiquitinates numerous proteins. Parkin activation involves binding of a phosphorylated ubiquitin (pUb), followed by phosphorylation of the Ubl domain in parkin, both mediated by the OMM kinase, PINK1. How an OMM protein is selected for ubiquitination is unclear. Parkin targeted OMM proteins have little structural or sequence similarity, with the commonality between substrates being proximity to the OMM. Here, we used chimeric proteins, tagged with ubiquitin (Ub), to evaluate parkin ubiquitination of mitochondrial substrates. We find that pUb tethered to the mitochondrial target proteins, Miro1 or CISD1, is necessary for parkin recruitment and essential for target protein ubiquitination. Surprisingly, phosphorylation of parkin is not necessary for the ubiquitination of either Miro1 or CISD1. Thus, parkin lacking its Ubl domain efficiently ubiquitinates a substrate tethered to pUb. Instead, phosphorylated parkin appears to stimulate free Ub-chain formation. We also demonstrate that parkin ubiquitination of pUb-tethered substrates occurs on the substrate, rather than the pUb modification. We propose divergent parkin mechanisms whereby parkin-mediated ubiquitination of acceptor proteins is driven by binding to pre-existing pUb on the OMM protein and subsequent parkin phosphorylation triggers free Ub chain formation. This finding accounts for the broad spectrum of OMM proteins ubiquitinated by parkin and has implications on target design for therapeutics

RAW DATA FILE: In silico drug repurposing using molecular docking and dynamics to target the protein interaction between the SARS-CoV -2 S-glycoprotein and the ACE2 receptor

Vitrual screening project file with raw data and PDB structures of hit compounds in docked conformations</p

Learning needs assessments in continuing professional development: A scoping review

Background: A rigorous learning needs assessment (LNA) is a crucial initial step in the Continuing Professional Development (CPD) process. This scoping review aimed to collate, summarize, and categorize the reported LNA approaches adopted to inform healthcare professional CPD and highlight the gaps for further research. Method: In August 2020, nine bibliographic databases were searched for studies conducted with any health professional grouping, reporting the utilized LNA to inform CPD activities. Two reviewers independently screened the articles for eligibility and charted the data. A descriptive analytical approach was employed to collate, summarize, and categorize the literature. Results: 151 studies were included in the review; the majority adopted quantitative methods in the form of self-assessment surveys. Mixed-methods approaches were reported in only 35 studies. Descriptions of LNA development lacked detail of measures taken to enhance their rigor or robustness. Discussion: These findings do not reflect recommendations offered by the CPD literature. Further investigations are required to evaluate more recently advocated LNA approaches and add to their limited evidence-base. Similarly, the existing support afforded to CPD developers warrants further study in order to identify the necessary resource, infrastructure and expertise essential to design and deliver effective CPD programs.Open Access funding provided by the Qatar National Library

Identification of Suitable Sites for Jatropha curcas L. Bioenergy Plantation Using the AquaCrop Model

Jatropha curcas (JC), as a biofuel plant, has been reported to have various desired characteristics such as high oil content seeds (27&ndash;40%), fast-growth, easy cultivation, drought tolerance, and can be grown on marginal soil and wasteland, requiring fewer nutrients and management and does not interfere with existing food crops, insects, and pest resistance. This investigation was the first study of its type to use climatological data, blue/green water footprints, and JC seed production to identify suitable sites for JC bioenergy plantation using the AquaCrop FAO model across the Khyber Pakhtunkhwa province in northwest Pakistan. The JC seed yield (10 ton/ha) was at a maximum in the districts of Bannu, Karak, Hangu, Kurram, North Waziristan, Lakki Marwat, South Waziristan, and Dera Ismail Khan, in addition to its frontier regions, Tank, Peshawar, Mohmand, Orakzai, Khyber, Kohat, Charsadda, Mardan, Swabi, and Nowshera, respectively. Green water footprint (264 m3/ton of JC seed) and blue water footprint (825 m3/ton) was less in these areas. Furthermore, the results revealed that, depending on climatological circumstances, the southern part of the Khyber Pakhtunkhwa province is more appropriate for JC bioenergy plantation than the northern region. The districts of Bannu, Karak, Hangu, Kurram, North Waziristan, Lakki Marwat, South Waziristan, Dera Ismail Khan, and its frontier regions, Tank, Peshawar, Mohmand, Orakzai, Khyber, and Kohat, in Khyber Pakhtunkhwa province were identified to be the most ideal places for JC bioenergy plantation. As a result, under the Billion Tree Afforestation Project (BTAP) and the Green Pakistan Project, the Forest Department of Khyber Pakhtunkhwa should consider planting JC species in the province&rsquo;s southern region. Furthermore, this research will provide scientific information to government and private sector officials for better management and optimum yield of the JC biofuel crop, as well as for the promotion of energy forestry in Pakistan