Entrepreneurial imagination: insights from construal level theory for historical entrepreneurship

Entrepreneurial imagination is core to the entrepreneurial process but hard to study in the present. Methodologically, historians have the advantage of reconstructing entrepreneurs’ future thinking in their time. However, traditional historical methodology offers only limited tools to analyse and interpret uncertainty in historical future-oriented sources. In this paper, we suggest that Construal Level Theory (CLT), a theory in social-cognitive psychology, represents a complementary resource to deal with uncertainty and analyse the role of entrepreneurial imagination in evaluating and selecting business opportunities. We elaborate on four manifestations of abstraction suggested by CLT: desirability vs. feasibility, primary vs. secondary aspects, words vs. pictorial representations, and small vs. large categories. We further explain how insights from CLT can raise important questions for source analysis and facilitate comparisons, and then demonstrate it by investigating Thomas Edison’s ego-documents. We conclude by sketching a future interdisciplinary dialogue with entrepreneurship scholars and psychologists

sj-docx-1-spp-10.1177_19485506231164701 – Supplemental material for Psychological Distance Increases Conceptual Generalization

Supplemental material, sj-docx-1-spp-10.1177_19485506231164701 for Psychological Distance Increases Conceptual Generalization by Hadar Ram, Nira Liberman and Christian Unkelbach in Social Psychological and Personality Science</p

Tunable Broad Light Emission from 3D Hollow Bromide Perovskites through Defect Engineering

International audienceHybrid halide perovskites consisting of corner-sharing metal halide octahedra and small cuboctahedral cages filled with counter cations have proven to be prominent candidates for many high-performance optoelectronic devices. The stability limits of their three-dimensional perovskite framework are defined by the size range of the cations present in the cages of the structure. In some cases, the stability of the perovskite-type structure can be extended even when the counterions violate the size and shape requirements, as is the case in the so-called “hollow” perovskites. In this work, we engineered a new family of 3D highly defective yet crystalline “hollow” bromide perovskites with general formula (FA)1–x(en)x(Pb)1–0.7x(Br)3–0.4x (FA = formamidinium (FA+), en = ethylenediammonium (en2+), x = 0–0.44). Pair distribution function analysis shed light on the local structural coherence, revealing a wide distribution of Pb–Pb distances in the crystal structure as a consequence of the Pb/Br-deficient nature and en inclusion in the lattice. By manipulating the number of Pb/Br vacancies, we finely tune the optical properties of the pristine FAPbBr3 by blue shifting the band gap from 2.20 to 2.60 eV for the x = 0.42 en sample. A most unexpected outcome was that at x> 0.33 en incorporation, the material exhibits strong broad light emission (1% photoluminescence quantum yield (PLQY)) that is maintained after exposure to air for more than a year. This is the first example of strong broad light emission from a 3D hybrid halide perovskite, demonstrating that meticulous defect engineering is an excellent tool for customizing the optical properties of these semiconductors

Growing a circular economy with fungal biotechnology: A white paper

publishedVersio

Thermophilic Filamentous Fungus C1-Cell-Cloned SARS-CoV-2-Spike-RBD-Subunit-Vaccine Adjuvanted with Aldydrogel&reg;85 Protects K18-hACE2 Mice against Lethal Virus Challenge

SARS-CoV-2 is evolving with increased transmission, host range, pathogenicity, and virulence. The original and mutant viruses escape host innate (Interferon) immunity and adaptive (Antibody) immunity, emphasizing unmet needs for high-yield, commercial-scale manufacturing to produce inexpensive vaccines/boosters for global/equitable distribution. We developed DYAI-100A85, a SARS-CoV-2 spike receptor binding domain (RBD) subunit antigen vaccine expressed in genetically modified thermophilic filamentous fungus, Thermothelomyces heterothallica C1, and secreted at high levels into fermentation medium. The RBD-C-tag antigen strongly binds ACE2 receptors in vitro. Alhydrogel&reg;&lsquo;85&rsquo;-adjuvanted RDB-C-tag-based vaccine candidate (DYAI-100A85) demonstrates strong immunogenicity, and antiviral efficacy, including in vivo protection against lethal intranasal SARS-CoV-2 (D614G) challenge in human ACE2-transgenic mice. No loss of body weight or adverse events occurred. DYAI-100A85 also demonstrates excellent safety profile in repeat-dose GLP toxicity study. In summary, subcutaneous prime/boost DYAI-100A85 inoculation induces high titers of RBD-specific neutralizing antibodies and protection of hACE2-transgenic mice against lethal challenge with SARS-CoV-2. Given its demonstrated safety, efficacy, and low production cost, vaccine candidate DYAI-100 received regulatory approval to initiate a Phase 1 clinical trial to demonstrate its safety and efficacy in humans