65 research outputs found
Weak Mixing Angle and Higgs Mass in Gauge-Higgs Unification Models with Brane Kinetic Terms
We show that the idea of Gauge-Higgs unification(GHU) can be rescued from the
constraint of weak mixing angle by introducing localized brane kinetic terms in
higher dimensional GHU models with bulk and simple gauge groups. We find that
those terms lead to a ratio between Higgs and W boson masses, which is a little
bit deviated from the one derived in the standard model. From numerical
analysis, we find that the current lower bound on the Higgs mass tends to
prefer to exceptional groups E(6), E(7), E(8) rather than other groups like
SU(3l), SO(2n+1), G(2), and F(4) in 6-dimensional(D) GHU models irrespective of
the compactification scales. For the compactification scale below 1 TeV, the
Higgs masses in 6D GHU models with SU(3l), SO(2n+1), G(2), and F(4) groups are
predicted to be less than the current lower bound unless a model parameter
responsible for re-scaling SU(2) gauge coupling is taken to be unnaturally
large enough. To see how the situation is changed in more higher dimensional
GHU model, we take 7D S^{3}/ Z_{2} and 8D T^{4}/ Z_{2} models. It turns out
from our numerical analysis that these higher dimensional GHU models with gauge
groups except for E(6) can lead to the Higgs boson whose masses are predicted
to be above the current lower bound only for the compatification scale above 1
TeV without taking unnaturally large value of the model parameter, whereas the
Higgs masses in the GHU models with E(6) are compatible with the current lower
bound even for the compatification scale below 1 TeV.Comment: 22 pages, 4 figure
Bone mineral density and fractures in older men with chronic obstructive pulmonary disease or asthma
In 5,541 community dwelling men, chronic obstructive pulmonary disease, or asthma was associated with lower bone mineral density (BMD) at the spine and total hip and an increased risk of vertebral and nonvertebral fractures independent of age, body mass index, and smoking. Men prescribed with corticosteroids had the lowest BMD.
It is unclear whether chronic obstructive pulmonary disease (COPD) is independently associated with BMD and fractures.
In 5,541 men from the Osteoporotic Fractures in Men Study, history of COPD or asthma, current treatment with corticosteroids, BMD, bone loss after 4.5Â years and fractures were ascertained.
Seven hundred fourteen (13%) men reported COPD or asthma, of which 103 were prescribed an oral steroid and 177 an inhaled steroid. Independent of confounders, men prescribed corticosteroids for COPD or asthma had the lowest BMD and a 2-fold increased risk of vertebral osteoporosis compared to men with no history of COPD or asthma (OR 2.13, 95% CI (confidence interval) 1.15â3.93 oral steroids; OR 2.05, 95% CI 1.27â3.31 inhaled steroids). During follow-up, BMD increased at the spine, but there was no difference in bone loss at the hip. However, men with COPD or asthma had a 2.6- and 1.4-fold increased risk of vertebral and nonvertebral fractures, respectively.
Chronic obstructive pulmonary disease or asthma was associated with lower BMD at the spine and hip and increased risk of vertebral and nonvertebral fractures independent of age, clinic site, BMI, and smoking. A history of COPD or asthma may be a useful clinical risk factor to identify patients with osteoporosis
The epidemiology of pertussis in Germany: past and present
<p>Abstract</p> <p>Background</p> <p>Current and past pertussis epidemiology in the two parts of Germany is compared in the context of different histories of vaccination recommendations and coverage to better understand patterns of disease transmission.</p> <p>Methods</p> <p>Available regional pertussis surveillance and vaccination coverage data, supplemented by a literature search for published surveys as well as official national hospital and mortality statistics, were analyzed in the context of respective vaccination recommendations from 1964 onwards.</p> <p>Results</p> <p>Routine childhood pertussis vaccination was recommended in the German Democratic Republic (GDR) from 1964 and in former West German states (FWG) from 1969, but withdrawn from 1974â1991 in FWG. Pertussis incidence declined to <1 case/100.000 inhabitants in GDR prior to reunification in 1991, while in FWG, where pertussis was not notifiable after 1961, incidence was estimated at 160â180 cases/100.000 inhabitants in the 1970s-1980s. Despite recommendations for universal childhood immunization in 1991, vaccination coverage decreased in former East German States (FEG) and increased only slowly in FWG. After introduction of acellular pertussis vaccines in 1995, vaccination coverage increased markedly among younger children, but remains low in adolescents, especially in FWG, despite introduction of a booster vaccination for 9â17 year olds in 2000. Reported pertussis incidence increased in FEG to 39.3 cases/100.000 inhabitants in 2007, with the proportion of adults increasing from 20% in 1995 to 68% in 2007. From 2004â2007, incidence was highest among 5â14 year-old children, with a high proportion fully vaccinated according to official recommendations, which did not include a preschool booster until 2006. Hospital discharge statistics revealed a ~2-fold higher pertussis morbidity among infants in FWG than FEG.</p> <p>Conclusion</p> <p>The shift in pertussis morbidity to older age groups observed in FEG is similar to reports from other countries with longstanding vaccination programs and suggests that additional booster vaccination may be necessary beyond adolescence. The high proportion of fully vaccinated cases in older children in FEG suggests waning immunity 5â10 years after primary immunisation in infancy. The higher incidence of pertussis hospitalisations in infants suggests a stronger force of infection in FWG than FEG. Nationwide pertussis reporting is required for better evaluation of transmission patterns and vaccination policy in both parts of Germany.</p
The role of leadership in salespeopleâs price negotiation behavior
Salespeople assume a key role in defending firmsâ price levels in price negotiations with customers. The degree to which salespeople defend prices should critically depend upon their leadersâ influence. However, the influence of leadership on salespeopleâs price defense behavior is barely understood, conceptually or empirically. Therefore, building on social learning theory, the authors propose that salespeople might adopt their leadersâ price defense behavior given a transformational leadership style. Furthermore, drawing on the contingency leadership perspective, the authors argue that this adoption fundamentally depends on three variables deduced from the motivationâabilityâopportunity (MAO) framework, that is, salespeopleâs learning motivation, negotiation efficacy, and perceived customer lenience. Results of a multi-level model using data from 92 salespeople and 264 salespersonâcustomer interactions confirm these predictions. The first to explore contingencies of salespeopleâs adoption of their transformational leadersâ price negotiation behaviors, this study extends marketing theory and provides actionable guidance to practitioners
The Endoplasmic Reticulum Stress Response in Neuroprogressive Diseases: Emerging Pathophysiological Role and Translational Implications
The endoplasmic reticulum (ER) is the main cellular organelle involved in protein synthesis, assembly and secretion. Accumulating evidence shows that across several neurodegenerative and neuroprogressive diseases, ER stress ensues, which is accompanied by over-activation of the unfolded protein response (UPR). Although the UPR could initially serve adaptive purposes in conditions associated with higher cellular demands and after exposure to a range of pathophysiological insults, over time the UPR may become detrimental, thus contributing to neuroprogression. Herein, we propose that immune-inflammatory, neuro-oxidative, neuro-nitrosative, as well as mitochondrial pathways may reciprocally interact with aberrations in UPR pathways. Furthermore, ER stress may contribute to a deregulation in calcium homoeostasis. The common denominator of these pathways is a decrease in neuronal resilience, synaptic dysfunction and even cell death. This review also discusses how mechanisms related to ER stress could be explored as a source for novel therapeutic targets for neurodegenerative and neuroprogressive diseases. The design of randomised controlled trials testing compounds that target aberrant UPR-related pathways within the emerging framework of precision psychiatry is warranted
Career guidance and the changing world of work: Contesting responsibilising notions of the future.
Career guidance is an educational activity which helps individuals to manage their participation in learning and work and plan for their futures. Unsurprisingly career guidance practitioners are interested in how the world of work is changing and concerned about threats of technological unemployment. This chapter argues that the career guidance field is strongly influenced by a âchanging world of workâ narrative which is drawn from a wide body of grey literature produced by think tanks, supra-national bodies and other policy influencers. This body of literature is political in nature and describes the future of work narrowly and within the frame of neoliberalism. The âchanging world of workâ narrative is explored through a thematic analysis of grey literature and promotional materials for career guidance conferences. The chapter concludes by arguing that career guidance needs to adopt a more critical stance on the âchanging world of workâ and to offer more emancipatory alternatives.N/
Scale development: ten main limitations and recommendations to improve future research practices
Sleep apnea in heart failure: Implications of sympathetic nervous system activation for disease progression and treatment
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